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Probiotics for the treatment of hyperlipidemia: Focus on gut-liver axis and lipid metabolism.

Hyperlipidemia, a metabolic disorder marked by dysregulated lipid metabolism, is a key contributor to the onset and progression of various c … disturbances, ultimately leading to hyperlipidemia. Extensive studies have highlighted the roles of probiotics and Traditional Chinese Medicine (TCM) in restoring gut-liver axis balance and modulating lipid metabolism through regulating the levels of lipopolysaccharides, short-chain fatty acids, and BAs. However, the therapeutic potential of probiotics and T …

Gut Microbiota and Liver Health: Meta-Analysis of Bifidobacterium-Containing Probiotics in NAFLD Management.

Diseases, including cardiovascular disease, type II diabetes, and metabolic syndrome, are leading causes of morbidity and mortality worldwide. Non-alcoholic fatty liver disease (NAFLD) is commonly associated with these conditions through shared pathophysiological mechanisms such as insulin resistance, chronic inflammation, and dyslipidemia. Emerging evidence suggests that probiotic formulations containing Bifidobacterium species may support cardiometabolic health by modulating gut microbiota composition. This meta-analysis aimed to assess the efficacy of Bifidobacterium-containing probiotic co

Assessing the Effect of Probiotics in the Steroidal Module of the Athlete's Biological Passport.

Athletes are increasingly using probiotic supplementation to support their overall health, and it can be particularly beneficial for female athletes in managing recurrent urinary tract infections and bacterial vaginosis. One route of probiotic administration for females is vaginal application, which enables direct modulation of the microbiota. While probiotics are widely recognised for their health benefits, their potential impact on urinary steroidal markers monitored in the Steroidal Module of the Athlete Biological Passport remains unexplored. Given the biological overlap between vaginal an…

Gut-brain-immune interactions: exploring probiotics as a drug delivery platform for neurological disease.

The gut-brain-immune (GBI) axis, connecting gut microbes, neural tissue, and the cells of the immune system, plays a critical role in human … I axis. One of the most promising approaches is the use of live biotherapeutics, such as engineered probiotics, as next-generation drug delivery systems. These live microorganisms can be designed to deliver specific therapeutic compounds to the gut and brain in order to modulate immune responses and reduce inflammation at the source. Probiotics and live biot …

Maternal Administration of Probiotics Augments IL17-Committed γδ T Cells in the Newborn Lung.

The early life period is increasingly being recognized as a window of opportunity to shape immunity, where microbiota and related probiotics have an important impact. Innate γδ T cells are the first T cells generated in utero, populating epithelial tissues such as the lung and contributing to tissue protection through, for example, IL17 production. Here, we studied the influence of maternal microbiota and probiotic supplementation during pregnancy on innate γδ T cells in the lung and thymus of newborn mice. Detailed time-kinetic experiments showed that at birth, the murine lung T cell populati…

The Role of Gut Microbiota in Migraine: Effects of Probiotics, Prebiotics, and Their Combinations.

Migraine, a common neurological disorder affecting about 15% of the global population, severely impacts quality of life and poses a signific … lammation and disrupting gut barrier integrity. This narrative review aims to assess the effects of probiotics, prebiotics, and synbiotics on migraine attack frequency and severity, focusing on their role in modulating gut microbiota. Evidence suggests probiotics may reduce migraine frequency and severity by enhancing gut barrier function and regulating infl …

Compound Probiotics Enhance Performance, Antioxidant Status, and Cecal SCFAs in Post-Molting Broiler Breeders.

This study aimed to investigate the effects of a compound probiotic on production performance and antioxidant capacity in post-molting broiler breeders. A total of 6800 healthy 69-week-old Arbor Acres breeders were randomly allocated to 2 treatment groups (4 replicates of 850 birds each). Both groups were fed an identical basal diet, whereas the drinking water was supplemented with 75 g/t of the compound probiotic for the Experimental group only. The trial included a 7-day adaptation followed by a 49-day experimental period. Results demonstrated that drinking water supplementation with dietary

Patterns of Intravaginal Boric Acid and Probiotics Use Among Patients With Chronic Vulvovaginal Symptoms.

OBJECTIVE: The study aimed to assess the use of boric acid and probiotics among patients treated at a tertiary care vulvovaginal health center. METHODS: The authors conducted a cross-sectional survey of 206 new patients from October 2024 and January 2025. Participants completed a questionnaire on demographics, vulvovaginal history, self-treatment practices, and a Vulvar Quality of Life Index. Descriptive statistics, bivariate analyses, multivariable logistic regression, and subgroup analyses were performed. RESULTS: Fifty percent of participants reported use of boric acid, and 61.2% used pro…

Genetic Code Expansion in Probiotics Enables the Secretion of Covalent Protein Drugs in Mice.

Oral delivery of therapeutic proteins remains a formidable challenge. Although engineered microbes have emerged as promising platforms for localized drug synthesis in the gut, their functional capacity has been restricted to the 20 canonical amino acids, limiting the chemical diversity of biologic payloads. Here, we demonstrate that integrating genetic code expansion (GCE) into bacterial therapy overcomes this fundamental constraint. We engineered the probiotic Escherichia coli Nissle 1917 (EcN) to incorporate the noncanonical amino acid fluorosulfate-l-tyrosine (FSY), enabling in situ secreti

Effectiveness of Probiotics in Managing Oral Halitosis: A Systematic Review of Randomized Controlled Trials.

AIM: Halitosis, characterized by volatile sulfur compound (VSC) production, is a prevalent oral health concern affecting 31.8% of the global population. Conventional treatments such as chlorhexidine-based mouthwashes offer temporary relief, but probiotics have emerged as a promising biological therapy by modulating oral microbiota. We aimed to systematically evaluate the efficacy of probiotic monotherapy in reducing halitosis-related VSC levels and organoleptic test (OLT) scores in randomized controlled trials (RCTs). MATERIALS AND METHODS: A comprehensive database search (PubMed, Scopus, Cli…

Probiotics improve functional performance in patients with osteoarthritis: a randomized placebo-controlled clinical trial.

PURPOSE: Osteoarthritis (OA), a progressive joint degeneration, significantly impairs people's ability to perform everyday tasks. Currently, there are no treatment options to cure OA. OBJECTIVE: To explore the potential of probiotics to improve functional performance in OA patients. TRIAL DESIGN: This study follows a single-center, double-blinded, randomized, placebo-controlled clinical trial design. METHOD: Computer-based randomization assigned 60-75 years old 115 OA patients randomly into placebo (n = 55) and probiotics (n = 60) groups. The probiotic treatment was Vivomix 112 billion, one…

Intestinal Microbiota of Commercial Laying Hens in a Cage-Free System Fed with Probiotics.

The cage-free rearing of laying hens combined with probiotics promotes intestinal health. The aim of this study was to evaluate the effect of adding probiotics on the intestinal microbiota of Isa Brown laying hens raised in a cage-free system. A total of 450 Isa Brown hens, 19 weeks old, were used in a cage-free system over three 28-day cycles in a completely randomized design with five treatments and six replicates, containing 15 birds per pen. The Isa Brown hens were fed a basal ration based on corn and soybean meal; a basal ration plus a single strain of Bacillus subtilis (500 g/t); a basal…

Impact of lactobacillus probiotics on vaccine response in diabetic rats: modulation of inflammatory cytokines.

Lymph nodes are essential for immune function as they contain immune cells that activate responses and filter pathogens from lymph. This study investigates how diabetes-related metabolic challenges affect immune function, focusing on the impact of Lactobacillus probiotics on lymph node responses to meningococcal vaccines in thirty male Albino rats with Streptozotocin-induced diabetes, established two weeks before vaccination. The diabetic rats were divided equally and randomly into three groups: one untreated (UD group), one receiving two shots of the meningococcal vaccine (DM group), and one …

Mixed probiotics modulated gut microbiota to improve spermatogenesis in bisphenol A-exposed male mice.

Bisphenol A (BPA), an environmental endocrine disruptor (EDC), has been implicated in impairing intestinal and male reproductive dysfunction. The efficacy of gut microbiota modulation for BPA-exposed testicular dysfunction has yet to be verified through research. Therefore, this study explored the potential of mixed probiotics in restoring spermatogenesis damage through the gut-testis axis under BPA exposure. We selected two probiotics strains (Lactobacillus rhamnosus and Lactobacillus plantarum) with BPA removal properties in vitro and the BPA-exposed male mice model was established. The prob…

Probiotics as an adjunctive therapy in periodontitis treatment-reality or illusion-a clinical perspective.

Periodontitis, a prevalent oral health issue, involves various microorganisms and clinical effects. This review examines probiotics as adjunctive therapy for periodontitis by analyzing forty clinical studies. Findings showed mixed results due to differences in study design, probiotic types, and clinical parameters; however, probiotics improved outcomes in severe cases. Caution is advised when interpreting these results, as longer follow-up periods reveal variability and potential regression in effects.

Migraine and the microbiota. Can probiotics be beneficial in its prevention? - a narrative review.

Migraine is a recurrent disease of the central nervous system that affects an increasing number of people worldwide causing a continuous inc … s data on the gastrointestinal and oral microbiota in people suffering from migraine and the use of probiotics as a novel therapeutic approach in its treatment.

Probiotics as a Therapeutic Approach for Non-infectious Gastric Ulcer Management: a Comprehensive Review.

A gastric ulcer is a stomach lining or nearby intestine disruption caused by acid and pepsin. Helicobacter pylori (H. pylori) and NSAIDs are … t failure. Considering this, there is a need for an alternative approach to manage it. Fortunately, probiotics, typically Lactobacillus and Bifidobacterium, show potential for healing gastric ulcers, offering a non-invasive alternative to conventional treatments. A notable concern arises from applying probiotic bacteria stemming from the propensity of pathog …

Resistant Starch-Encapsulated Probiotics Attenuate Colorectal Cancer Cachexia and 5-Fluorouracil-Induced Microbial Dysbiosis.

5-Fluorouracil (5-FU) is commonly used as the primary chemotherapy for colorectal cancer (CRC). However, it can lead to unwanted chemoresist … probiotic cocktail (4 × 108 CFUs) plus chemotherapy (T+5-FU+Pro), or resistant-starch-encapsulated probiotics plus chemotherapy (T+5-FU+RS-Pro). T+5-FU and T+5-FU+RS-Pro administration significantly suppressed tumor growth and activated apoptotic cell death in CT26-bearing mice. 5-FU-induced increases in inflammatory cytokines and NF-κB signaling were mitig …

The Hazards of Probiotics on Gut-Derived Pseudomonas aeruginosa Sepsis in Mice Undergoing Chemotherapy.

Pseudomonas aeruginosa (P. aeruginosa) is a leading cause of nosocomial infections associated with a high mortality rate and represents a serious threat to human health and the increasing frequency of antimicrobial resistance. Cancer patients are more vulnerable to invasive infection due to ulcerative lesions in mucosal surfaces and immune suppression secondary to chemotherapy. In our in vitro study, we observed that probiotics have the potential to yield beneficial effects on intestinal epithelial cells infected with P. aeruginosa. Additionally, probiotics were found to confer advantageous ef…

Воздействие биотики на симптомы, связанные с нейродегенеративными заболеваниями, и системное воспаление: систематический обзор.

В последние годы пробиотики как класс биологически активных микроорганизмов все больше привлекают внимание к их потенциалу в лечении нейродегенеративных заболеваний (НДД). Для всесторонней оценки воздействия пробиотики на клинические симптомы и системное регулирование воспаления в различных НИЗ в рамках этого систематического обзора был проведен подробный поиск баз данных по библиотеке, Эмбазе, PubMed и веб-научным базам данных, включая в конечном счете 22 приемлемых выборочных контролируемых испытания (РСТ) с 4 РКТ для болезни Альцгеймера (АД), 10 РКТ для болезни Паркинсона (ПД), 2 РКТ для мн

Совпадение в аннотации оригинала
In recent years, probiotics, as a class of biologically active microorganisms, have increasingly attracted attention for their potential in treating neurodegenerative diseases (NDDs). To comprehensively assess the effects of probiotics on clinical symptoms and systemic inflammation regulation in various NDDs, this systematic review conducted a detailed searc…