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The cGAS-STING pathway in senescence and aging-related diseases: mechanisms and therapeutic opportunities.

The cGAS-STING pathway acts as a critical molecular hub connecting genomic instability with cellular senescence. Functioning as a key regulator of the innate immune system, this pathway detects aberrant cytoplasmic DNA to activate downstream inflammatory responses, thereby playing a pivotal role in aging-related diseases. This review systematically explores the core mechanisms by which the cGAS-STING pathway regulates cellular senescence, emphasizing its role in triggering senescence through the recognition of DNA damage signals (e.g., oxidative stress, telomere dysfunction) and promoting para

Pleuropulmonary Changes Induced by Drugs in Patients with Hematologic Diseases

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The next frontier in antibody-drug conjugates: challenges and opportunities in cancer and autoimmune therapy.

Antibody-Drug Conjugates (ADCs) have achieved significant success in cancer therapy by combining the targeting specificity of monoclonal antibodies with cytotoxic payloads. However, the concomitant issue of drug resistance has become increasingly prominent, with primary mechanisms including alterations in target antigen expression, impaired drug transport, and inhibition of cell death pathways. ADCs have also shown emerging therapeutic potential in the treatment of autoimmune diseases; for instance, ABBV-3373 has achieved initial success in this area, yet it also faces unique challenges such a

Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy.

Vitamin C is a water-soluble vitamin introduced through the diet with anti-inflammatory, immunoregulatory, and antioxidant activities. Today … n C supplementation for treating autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) and neoplasms, particularly hematological neoplastic diseases. Vitamin C integration regulates the cytokines microenvironment, modulates immune response to autoantigens and cancer cells, and regulates oxidative stress. Moreover, …

Printing the Pathway Forward in Bone Metastatic Cancer Research: Applications of 3D Engineered Models and Bioprinted Scaffolds to Recapitulate the Bone-Tumor Niche.

Breast cancer commonly metastasizes to bone, resulting in osteolytic lesions and poor patient quality of life. The bone extracellular matrix (ECM) plays a critical role in cancer cell metastasis by means of the physical and biochemical cues it provides to support cellular crosstalk. Current two-dimensional in-vitro models lack the spatial and biochemical complexities of the native ECM and do not fully recapitulate crosstalk that occurs between the tumor and endogenous stromal cells. Engineered models such as bone-on-a-chip, extramedullary bone, and bioreactors are presently used to model cellu

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… Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone Arthritis Rheum. 2008 58 442 455 10.1002/art.23159 18240211 60. Sanchez C. Mazzucchelli G. Lambert C. Comblain F. Depauw E. Henrotin Y. … Regulation of subchondral bone osteoblast metabolism by cyclic compression Arthritis Rheum. 2012 64 1193 1203 10.1002/art.33445 22034083 76. Bianco D. Todorov A. Cengic T. Pagenstert G. Schären S. Netzer C. Hügle T. Geurts J. …

Consensus Recommendations for the Diagnosis and Management of X-Linked Hypophosphatemia in Belgium.

X-linked hypophosphatemia (XLH) is the most common genetic form of hypophosphatemic rickets and osteomalacia. In this disease, mutations in the PHEX gene lead to elevated levels of the hormone fibroblast growth factor 23 (FGF23), resulting in renal phosphate wasting and impaired skeletal and dental mineralization. Recently, international guidelines for the diagnosis and treatment of this condition have been published. However, more specific recommendations are needed to provide guidance at the national level, considering resource availability and health economic aspects. A national multidiscip

High-Dose Intravenous Immunoglobulins in the Treatment of Severe Acute Viral Pneumonia: The Known Mechanisms and Clinical Effects.

The current outbreak of viral pneumonia, caused by novel coronavirus SARS-CoV-2, is the focus of worldwide attention. The WHO declared the COVID-19 outbreak a pandemic event on Mar 12, 2020, and the number of confirmed cases is still on the rise worldwide. While most infected individuals only experience mild symptoms or may even be asymptomatic, some patients rapidly progress to severe acute respiratory failure with substantial mortality, making it imperative to develop an efficient treatment for severe SARS-CoV-2 pneumonia alongside supportive care. So far, the optimal treatment strategy for

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… Arthritis Rheum. (2013) 65:805–14. 10.1002/art.37815 147. Graphou O, Chioti A, Pantazi A, Tsukoura C, Kontopoulou V, Guorgiadou E, et al. Effect of intravenous immunoglobulin treatment on the Th1/Th2 balance in women with recurrent spontaneous abortions. …

Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe.

The consumption of immunoglobulins (Ig) is increasing due to better recognition of antibody deficiencies, an aging population, and new indications. This review aims to examine the various dosing regimens and research developments in the established and in some of the relevant off-label indications in Europe. The background to the current regulatory settings in Europe is provided as a backdrop for the latest developments in primary and secondary immunodeficiencies and in immunomodulatory indications. In these heterogeneous areas, clinical trials encompassing different routes of administration,

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… Arthritis Rheum ( 2001 ) 45 ( 2 ): 191 – 202 . 10.1002/1529-0131(200104)45:2<191::AID-ANR173>3.3.CO;2-U 11324784 67 Edwards CJ Lian TY Badsha H Teh CL Arden N Chng HH . Hospitalization of individuals with systemic lupus erythematosus: characteristics and predictors of outcome . …

The multiple roles of interferon regulatory factor family in health and disease.

Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains essential for interactions with other transcription factors and cofactors. These interactions allow IRFs to modulate a broad spectrum of physiological processes, encompassing host defense, immune response, and cell development. Conversely, their pivotal role in immune regulation implicates them in the pathophysiology of v

Оценка риска возникновения рака пищеварительной системы у пациентов с аутоиммунными заболеваниями: систематический обзор и метаанализ с уделением особого внимания оценке предвзятости.

Появляются новые данные о том, что некоторые аутоиммунные заболевания могут измерять риск возникновения рака пищеварительной системы. Однако ограниченность неэкспериментальных исследований может привести к расхождениям в результатах. Таким образом, цель заключалась в том, чтобы оценить имеющиеся данные и представить скромные оценки на основе пристрастности в отношении связей между селиакальной болезнью (CD), системной волчанкой (SLE), множественным склерозом (MS) и типом 1 диабет (T1D) и различные виды рака пищеварительной системы. МЕТОДЫ: Систематический обзор (PROSPERO: CRD42024553216) был п

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… Risk of malignancy in patients with systemic lupus erythematosus: systematic review and meta-analysis Semin Arthritis Rheum 51 6 2021 1230 1241 34710720 10.1016/j.semarthrit.2021.09.009 30 Belpomme D. Irigaray P. Sasco A.J. …

Усовершенствованная последовательность транскриптомов и искусственный интеллект/машинное обучение (AI/ML) в имитируемом псориазом воспалении кератиноцитов человека.

ВВЕДЕНИЕ: Несмотря на то, что модель Keratinocyte HaCAT использовалась в предыдущих исследованиях для изучения воздействия антипсориатических агентов, по-прежнему отсутствует полное понимание механизма имитируемого имимодом распространения и трансдукции сигналов в псориазных кератиноцитах. ЦЕЛИ: Данное исследование было направлено на изучение молекулярных механизмов и путей, связанных с воспалением, подобным псориазу, в результате IMQ в кератиноцитах человека. МАТЕРИАЛЫ И МЕТОДЫ: Клетки HACAT подвергались воздействию различных концентраций IMQ, чтобы вызвать воспаление, аналогичное тому, котор

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… Semin Arthritis Rheum. 2024;64S:152330. doi: 10.1016/j.semarthrit.2023.152330. Associated Data Supplementary Materials …

Surveillance of the current situation regarding influenza vaccination according to medical oncologists in Japan.

This study aimed to clarify the attitude of oncologists toward influenza vaccination and the current situation and issues regarding influenza vaccination for patients on chemotherapy in Japan. A web-based survey of medical oncologists certified by the Japanese Society of Medical Oncology was conducted between November 1 and December 31, 2019. Of the 1369 medical oncologists who were invited to participate, 415 (30.3%) responded to our survey. The questionnaire comprised 4 sections: "oncologist characteristics," "oncologist attitude toward influenza vaccines and the current status of influenza

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… Ann Rheum Dis . 2006 ; 65 ( 7 ): 913 ‐ 918 . 16322083 10.1136/ard.2005.043943 PMC1798193 35 Maloney DG , Grillo‐López AJ , White CA , et al. IDEC‐C2B8 (rituximab) anti‐CD20 monoclonal antibody therapy in patients with relapsed low‐grade non‐Hodgkin’s lymphoma . …

The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology-a narrative overview of the literature.

Vitamin D is considered to play an important role in musculoskeletal health. It's classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Moreover, there is an abundance of reports highlighting vitamin D deficiency and insufficiency in patients with almost innumerable diseases. Further, it is estimated that mor

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… Semin Arthritis Rheum 2016;45:539-46. 10.1016/j.semarthrit.2015.09.010 98. Zhang H, Zhu XH, Dong W, et al. Vitamin D Status and Patient Outcomes after Knee or Hip Surgery: A Meta-Analysis. Ann Nutr Metab 2018;73:121-30. 10.1159/000490670 99. Nawabi DH, Chin KF, Keen RW, et al. …

Anemia in Chronic obstructive pulmonary disease: Prevalence, pathogenesis, and potential impact.

Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable lifestyle-related disease with high global prevalence. COPD is associated with significant morbidity and mortality worldwide. Comorbidities are important events in the natural history of the disease and have a negative effect on the morbidity and mortality of COPD patients. Cardiac diseases, lung cancer, osteoporosis, and depression are common comorbidities reported for COPD. Recently, anemia has been recognized as a frequent comorbidity in COPD patients. The prevalence of anemia in patients with COPD varies fro

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… Semin Arthritis Rheum. 2009;38:382–8. doi: 10.1016/j.semarthrit.2008.01.006. 40. Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108:3204–9. doi: 10.1182/blood-2006-06-027631. 41. Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, et al. …

The impact of comorbid disease history on all-cause and cancer-specific mortality in myeloid leukemia and myeloma - a Swedish population-based study.

BackgroundComorbidity increases overall mortality in patients diagnosed with hematological malignancies. The impact of comorbidity on cancer … L and myeloma), cerebrovascular conditions, dementia, psychiatric disease (AML, myeloma), liver and rheumatic disease (AML), cardiovascular and pulmonary disease (myeloma). The difference in the probability of cancer-specific death, comparing patients with and without comorbidity, was largest among AML patients ConclusionComorbidities associated with or …

Surgical versus non-surgical treatment for vertebral compression fracture with osteopenia: a systematic review and meta-analysis.

BACKGROUND: Surgical and non-surgical interventions are the two categories for treatment of vertebral compression fractures (VCFs). However, there is clinical uncertainty over optimal management. This study aimed to examine the safety and effectiveness of surgical management for treatment of VCFs with osteopenia compared with non-surgical treatment. METHODS: We conducted a systematic search through electronic databases from inception to June 2014, with no limits on study data or language. Randomized controlled trials (RCTs) evaluating surgical versus non-surgical interventions for treatment o

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… Arthritis Rheum. 2001; 44: 2611–2619. 4. Coleman RE. Skeletal complications of malignancy. Cancer. 1997; 80 (suppl 8): 1588–1594. 5. Li R. Women’s health in exercise and aging: What do we know? Journal of Sport and Health Science. 2014; 3:153–154. 10.1016/j.jshs.2014.06.001 6. …

Which health technologies should be funded? A prioritization framework based explicitly on value for money.

UnlabelledBackgroundDeciding which health technologies to fund involves confronting some of the most difficult choices in medicine. As for other countries, the Israeli health system is faced each year with having to make these difficult decisions. The Public National Advisory Committee, known as 'the Basket Committee', selects new technologies for the basic list of health care that all Israelis are entitled to access, known as the 'health basket'. We introduce a framework for health technology prioritization based explicitly on value for money that enables the main variables considered by deci

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… Arthritis Rheum. 2010;62:2582–2591. doi: 10.1002/art.27580. Taylor WJ, Singh JA, Saag KG, Dalbeth D, MacDonald PA, Edwards NL, Simon LS, Stamp LK, Neogi T, Gaffo AL, Khanna PP, Becker MA, Schumacher HR Jr. …

From Cellular Stress to Systemic Adaptation: The Circadian Clock and Stress Response at Cellular and Systemic Levels.

The stress response is essential for cellular and organismal survival as it acts as a protective and adaptive mechanism to maintain homeostasis. At the organismal level, physical stressors induce responses in mammals that are mediated primarily by the hypothalamic-pituitary-adrenal (HPA) axis, which regulates glucocorticoid secretion. The HPA axis functions as a circadian-regulated, multi-oscillator system, in which the paraventricular nucleus, the pituitary, and the adrenal gland exhibit intrinsic rhythmicity while remaining coordinated by the output from the suprachiasmatic nucleus. Glucocor

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… Circadian rhythms and arthritis Rheum. Dis. Clin. N. Am. 2005 31 115–129, ix–x 10.1016/j.rdc.2004.09.005 15639059 92. Lines C.L. McGrath M.J. Dorwart T. Conn C.S. The integrated stress response in cancer progression: A force for plasticity and resistance Front. …

Детские трудности и аутоиммунные заболевания: глобальный исследовательский ландшафт, < < горячие точки > > , связанные с иммунизацией, и новые тенденции, вытекающие из библиометрического анализа трех баз данных.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Детские трудности все чаще признаются в качестве важного психосоциального воздействия в раннем возрасте, которое может формировать долгосрочную иммунную функцию и способствовать аутоиммунным заболеваниям посредством хронического стресса, регулирования нейроэндокринной дистрибьюции и провокационной активации. Однако структура знаний, " горячих точек " исследований и тенденции в области развития в этой области остаются недостаточно характерными. МЕТОДЫ: С момента создания базы данных по 31 декабря 2025 года публикации, посвященные детским недугам и аутоиммунным з

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BACKGROUND: Childhood adversity is increasingly recognized as an important early-life psychosocial exposure that may shape long-term immune … osomatic Medicine. Keyword analysis identified childhood adversity, depression, multiple sclerosis, rheumatoid arthritis, stress, autoimmune disease, and inflammation as major hotspots. Highly cited publications indicated that the field is rooted in stress biology, psychoneuroimmunology, inflammatory mechanisms, and disease-specific autoimmune research. …

Emerging insights into the gut microbiota as a key regulator of immunity and response to immunotherapy in hepatocellular carcinoma.

The gut microbiota, a complex microbial ecosystem closely connected to the liver via the portal vein, has emerged as a critical regulator of liver health and disease. Numerous studies have underscored its role in the onset and progression of liver disorders, including alcoholic liver disease, metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). This review provides a comprehensive overview of current insights into the influence of the gut microbiota on HCC progre

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… For example, xiayuxue decoction XYXD (which primarily consists of Rheum officinale Baill, Prunus persica (L.) Batsch, and Eupolyphaga sinensis Walker), was found to trigger the immune action of NKT cells against HCC by regulating the gut microbiota. …