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The impaired learning of semantic knowledge following bilateral medial temporal-lobe resection.

The integrity of several aspects of semantic memory (including knowledge of the meaning, lexical status, perception, and pronunciation of words and famous names) was examined in H.M., a patient with anterograde amnesia following bilateral medial temporal-lobe excision. Despite normal memory for such semantic knowledge acquired prior to the onset of his amnesia in 1953, H.M. showed a severe deficit in memory for semantic information encountered subsequently. In combination with the previously reported impairments in new learning shown by H.M., the deficits observed here point to an association

Arteriovenous malformations of the medial temporal lobe. Surgical approach and neuroradiological characterization.

Arteriovenous malformations (AVM's) of the medial temporal lobe frequently involve the basal ganglia and the thalamus and, for this reason, are commonly judged to be inoperable. However, when the medial involvement is limited to the posterolateral part of the thalamus and to the inferior portion of the basal ganglia lateral to the internal capsule, the lesions may be excised safely. Three patients who underwent successful excision of AVM's of this region are presented. A transcortical surgical approach through the inferior portion of the temporal lobe was used to minimize retraction of the tem…

Multilayer Validation Reveals a Glia-Associated Secretome Signature in Temporal Lobe Epilepsy.

Although multi-omics studies have increasingly revealed molecular alterations associated with epilepsy, clinically accessible cerebrospinal … te biomarkers were validated across mouse and human datasets and quantified in CSF of patients with temporal lobe epilepsy (TLE) and non-epileptic controls using enzyme-linked immunosorbent assays. Machine learning models were built to evaluate diagnostic performance and interpretability using SHAP analysis. Six proteins (C-X-C motif chemokine ligand 10 [CXCL10 …

Anterior temporal lobe mediates associative and taxonomic neighborhood effects in lexical processing.

Processing a word's meaning activates some of its semantic neighbors that are related associatively or taxonomically. While prior studies have shown that both types of neighborhoods influence lexical processing, their underlying neural bases remain unclear, particularly regarding the involvement of the Anterior Temporal Lobe (ATL). This study used HD-tDCS to examine the role of the left lateral ATL in how associative and taxonomic semantic neighborhoods influence the lexico-semantic processing of abstract and concrete words. Participants (N = 42) performed a semantic concreteness judgment task…

Увеличение числа либидо после начала бриварского ацетама: доклад по делу Темпорального Лоба Эпилепсии.

Сексуальная дисфункция является широко распространенной коморбидией у пациентов с эпилепсией; она коррелируется с частотой припадков и с правой височной долей эпилепсии и влияет на качество жизни (QOL). Несмотря на ее клиническое значение, сексуальная дисфункция часто недооценивается в клинической практике. Считается, что бриварацетам (БРВ) - лекарство против сединения (АСМ), введенное в последние годы, - имеет мало побочных побочных эффектов для психиатрии, и до настоящего времени не сообщалось о каких-либо связях с сексуальной дисфункцией. Мы сообщаем о случае эпилепсии височной доли, в кото

Совпадение в аннотации оригинала
BACKGROUND: Sexual dysfunction is a common comorbidity in patients with epilepsy; it correlates with seizure frequency and right temporal lobe epilepsy and affects quality of life (QOL). Despite its clinical significance, sexual dysfunction is often underassessed in clinical practice. Brivaracetam (BRV), an anti-seizure medication (ASM) introduced in recent …

Chemogenetic model of acute temporal lobe-like seizures in the area tempestas.

The piriform cortex was identified as a crucial ictogenic trigger zone in the 1980s. Surgical outcome studies in humans likewise suggest that this region contributes to seizure generation. Within the anterior piriform cortex, the "area tempestas (AT)" has been identified as a particularly sensitive site for triggering seizures in rodents and non-human primates. While many studies have examined this region using focal pharmacological manipulations (e.g., drug microinjection) in rodents, within-subject reproducibility has been limited by the need for repeated drug injection into the brain parenc

Sex-specific temporal-lobe functional connectivity alterations in early-onset bipolar disorder.

Sex differences and temporal-lobe abnormalities are well documented in bipolar disorder, yet whether these alterations show sex-specific patterns in early-onset bipolar disorder remains unclear. This study investigated diagnosis- and sex-related alterations in temporal-lobe functional connectivity and their associations with clinical characteristics. Eighty-nine individuals with early-onset bipolar disorder (63 females, 26 males) and 61 healthy controls (36 females, 25 males) underwent resting-state functional magnetic resonance imaging (fMRI). Functional connectivity was calculated using 10 t

Corpora amylacea and glymphatic system in temporal lobe epilepsy patients: Clinicopathological correlation.

OBJECTIVE: Corpora amylacea (CA), now called wasteosomes, are basophilic inclusions associated with aging, neurodegeneration, and impaired glymphatic waste clearance. Their presence is well described in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and related to hippocampal neuronal loss and longer epilepsy duration. Here, we assessed CA deposition in TLE patients submitted to epilepsy surgery with any histological diagnosis and explored its relationship with clinical and neuropsychological variables. Histological signs of the glymphatic system were evaluated. METHODS: Qualitati…

Kainic acid model of temporal lobe epilepsy: Nanoscale oscillations of hippocampal mitochondria.

Mitochondrial dysfunction is increasingly recognized as a central component of epileptogenesis, yet sensitive biophysical markers capable of capturing early mitochondrial alterations remain limited. Kainic acid (KA) model of temporal lobe epilepsy (TLE) is one of the most reliable tools for understanding the mechanisms of epileptogenesis and induces behavioral, electro-physiological, chemical and histological effects that are similar to those observed in patients with TLE. In the present study, we evaluate the nanoscale oscillatory behavior of mitochondria isolated from primary hippocampal neu…

EEG signature orchestrating expression of ictal behavior in mesial temporal lobe epilepsy.

OBJECTIVES: We investigated EEG features differentiating clinical seizures (CSs) from subclinical seizures (SCSs) to explore the mechanisms underlying the generation of ictal behavior in mesial temporal lobe epilepsy (mTLE). METHODS: Peri-ictal state of power spectral density (PSD) within seizure onset zone (SOZ) and propagation zone (PZ) were compared between SCSs and CSs. Functional connectivity was analyzed using the nonlinear correlation coefficient h2, outgoing links (OUT) and ingoing links (IN). The EEG epochs of CSs-early part and SCSs were equally divided into four segments to reveal …

Amygdalar volume asymmetry informs laterality in temporal lobe epilepsy: MRI-SEEG study.

OBJECTIVE: Amygdalar volumes are right-left asymmetric in normal humans. Asymmetric amygdalar hyperplasia is described in temporal lobe epilepsy (TLE), but has unclear lateralizing significance. In this study of TLE patients undergoing stereo-electroencephalography (SEEG) we examined the lateralizing value of amygdalar volume (AV) asymmetry, and its relationship to amygdalar involvement in seizures. METHODS: Amygdalar volumes of 30 TLE patients without radiological hippocampal sclerosis undergoing SEEG were compared to those from a normative database. Devising a novel amygdalar (volume) asymm…

Cardiac structural and molecular alterations in rodent models of temporal lobe epilepsy.

OBJECTIVE: Cardiac structural and molecular changes are prevalent in people with chronic epilepsy, possibly contributing to an increased risk of premature mortality. However, understanding of the underlying pathophysiological mechanisms is limited. Here, we investigated the subacute and chronic changes in cardiac structure and ion channel/exchanger expression in different rodent models of temporal lobe epilepsy (TLE). METHODS: Two models of TLE were used: the kainic acid-induced post-status epilepticus (KASE) model in Wistar rats and the electrical self-sustained status epilepticus (SSSE) mod…

Clinical daily rhythms of seizure in different subtypes of temporal lobe epilepsy.

INTRODUCTION: The relationship between circadian rhythms and seizures in temporal lobe epilepsy (TLE) has been well recognized, but it remains poorly understood how the interaction between the endogenous clock system and seizures may affect seizure patterns and patient management. This study investigates the circadian rhythm patterns of clinical seizures in TLE, with a focus on different subtypes and clinical variables. METHODS: We retrospectively analyzed the seizure rhythms of patients diagnosed with TLE who were admitted to the video-EEG ward. Patients were categorized based on clinical da…

Transcriptomic profiling unveils novel therapeutic options for drug-resistant temporal lobe epilepsy.

BACKGROUND: Epilepsy drug treatments fail in 25-30 % of patients, leading to drug resistance. Temporal lobe epilepsy is the most prevalent subtype associated with drug resistance. Classical drug discovery is a long and extremely costly process with a high failure rate in clinical trials. Drug repurposing is a more cost- and time-effective strategy. Hence, the main objective of this study is to propose drug candidates for the treatment of drug-resistant temporal lobe epilepsy (DR-TLE) through drug repurposing based on transcriptomic profiling. METHODS: Total RNA-sequencing (RNA-Seq) was perfor…