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Regulation of body fluid volume and electrolyte concentrations in spaceflight.

Despite a number of difficulties in performing experiments during weightlessness, a great deal of information has been obtained concerning t … s that are only partly successful in reducing the postflight orthostatic intolerance experienced by astronauts and cosmonauts. More complete knowledge of these processes can be expected to produce countermeasures that are even more successful, as well as expand our comprehension of the range of adaptability of human physiologic processes.

Blunt body paradox and improved application of transient growth framework.

The "Reshotko-Tumin transition criterion" based on optimal transient growth successfully correlates laboratory measurements of roughness induced transition over blunt body configurations. Even though transient growth has not been conclusively linked to the measured onset of transition, the above correlation denotes the only available physics-based model for subcritical transition in blunt body flows, since the latter do not support any modal instabilities at typical experimental conditions. Unlike other established models based on empirical curve fits that are valid for a specific subclass of

Management of Treatment-Related Infectious Complications in High-Risk Hemato-Oncological Patients via Telemedicine.

BACKGROUND: Infectious complications, especially febrile neutropenia, in hemato-oncological patients are associated with considerable morbidity, mortality and expenses. Remote monitoring of physiological functions and thus early detection of adverse events via telemedicine could improve the safety of these high-risk patients and save financial resources by shortening the time-to-antibiotics. METHODS: Patients undergoing active cancer treatment in high risk of acquiring severe infection are selected and enrolled in this project. Each patient receives a digital blood pressure monitor, an infrar

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… and more simple definition takes telemedicine as a tool to deliver health care to populations with limited access to care by using telecommunications technology. 2 Initially, the concept was developed by the National Aeronautics and Space Administration (NASA) in the 1970s to assist in the care of astronauts …

CD4+ lymphocyte responses to pulmonary infection with Mycobacterium tuberculosis in naïve and vaccinated BALB/c mice.

The Biostack experiments I and II were flown on board the Apollo 16 and 17 command modules in order to obtain information on the biological … adiation conditions inside of spacecrafts, necessary to secure a maximum possible protection to the astronauts.

Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers.

ALX 111 [parathyroid hormone (1-84) - NPS Allelix, recombinant human parathyroid hormone, rhPTH (1-84), PREOS] is a full-length, recombinant … NPS Pharmaceuticals using Millenium Biologix' OSTEO Mini-Lab System. Under space flight conditions, astronauts experience a loss in bone density at a rate up to ten times faster than that of earth-bound patients with osteoporosis, and it was hoped that this study would indicate the mechanism of action of ALX 111 at cellular and genetic levels. The results of …

The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms.

In the framework of space flight, the risk of radiation carcinogenesis is considered a "red" risk due to the high likelihood of occurrence as well as the high potential impact on the quality of life in terms of disease-free survival after space missions. The cyclic AMP response element-binding protein (CREB) is overexpressed both in haematological malignancies and solid tumours and its expression and function are modulated following irradiation. The CREB protein is a transcription factor and member of the CREB/activating transcription factor (ATF) family. As such, it has an essential role in a

Effects of exosomes from different origins on osteoclasts.

Abnormal osteoclast function is closely related to the development of osteolytic diseases such as osteoporosis and tumor bone metastasis, which seriously affects patients' quality of life. The cellular microenvironment is complex and variable, and exosomes, as an important pathway mediating intercellular communication, can be secreted by a variety of cells in the human body, which carry "cargo" that can affect the biological function of recipient cells. Osteoclasts receive a variety of cellular exosomes to regulate and influence the body's bone homeostasis. In this narrative review, we summari

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… Prolonged bone weightlessness can cause severe disuse osteoporosis, which is common in patients who are bedridden for long periods of time or in astronauts in space. …

Optimal Control Theory for Personalized Therapeutic Regimens in Oncology: Background, History, Challenges, and Opportunities.

Optimal control theory is branch of mathematics that aims to optimize a solution to a dynamical system. While the concept of using optimal control theory to improve treatment regimens in oncology is not novel, many of the early applications of this mathematical technique were not designed to work with routinely available data or produce results that can eventually be translated to the clinical setting. The purpose of this review is to discuss clinically relevant considerations for formulating and solving optimal control problems for treating cancer patients. Our review focuses on two of the mo

Modeling osteoporosis to design and optimize pharmacological therapies comprising multiple drug types.

For the treatment of postmenopausal osteoporosis, several drug classes with different mechanisms of action are available. Since only a limited set of dosing regimens and drug combinations can be tested in clinical trials, it is currently unclear whether common medication strategies achieve optimal bone mineral density gains or are outperformed by alternative dosing schemes and combination therapies that have not been explored so far. Here, we develop a mathematical framework of drug interventions for postmenopausal osteoporosis that unifies fundamental mechanisms of bone remodeling and the mec

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… ), medications that contribute to osteoporosis (such as glucocorticoid therapy), lifestyle-dependent factors such as smoking and alcohol consumption, the effects of dietary supplementation of osteoporosis treatment through calcium and vitamin D and effects of microgravity on bone, as experienced by astronauts …

Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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Абстрактный сборник ISEV2022.

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Электронные постеры

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… Decreasing mechanical stimuli during immobilization, muscular debility, and the loss of gravity astronauts encounter, generates bone loss due to decreasing mechanical transduction. …