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A systematic review and meta-analysis of the prevalence of tick-borne SFGR in China from 2000 to 2022.

BACKGROUND: Ticks carry and transmit a wide range of pathogens (bacteria, viruses, and protozoa) that pose significant threats to human and … 0-29.6, Q = 0.21, Q-p = 0.64) were not statistically significant. The most common tick species were Dermacentor silvarum (13%), Ixodes persulcatus (11%) and Haemaphysalis Iongicornis (10%), and the most prevalent SFGR species were Rickettsia raoultii (20%), Rickettsia heilongjiangiensis (11%), and some uncultured species (18%). CONCLUSIONS: This study examin …

Efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of five common tick species infesting dogs in the USA.

BACKGROUND: The efficacy of a novel oral combination product, Simparica Trio™, containing sarolaner, moxidectin and pyrantel was evaluated against five tick species that commonly infest dogs in the USA, Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis and Rhipicephalus sanguineus. METHODS: Laboratory studies were conducted against two different strains of each tick species. In each study, 10 purpose-bred Beagle or mixed-breed dogs were randomly allocated to one of two treatment groups based on pre-treatment host-suitability tick counts. Dogs were infested w…

Closing the gaps between genotype and phenotype in Rickettsia rickettsii.

Rocky Mountain spotted fever (RMSF) caused by Rickettsia rickettsii is a severe rickettsiosis that occurs in nearly every state of the conti … h Rhipicephalus sanguineus ticks and human infections in Arizona, other isolates from the USA where Dermacentor variabilis is thought to be the primary vector, and the isolates primarily associated with Amblyomma ticks from Central and South America. In addition, isolate Hlp#2, which is often considered to be a nonpathogenic isolate of R. rickettsii and close …

BIOLOGICAL METHOD FOR BABESIOSIS DETECTION: THE UNIFIED VERSION IN VIVO.

OBJECTIVE: The aim is to establish a unified version of the biological method for babesiosis detection in vivo. PATIENTS AND METHODS: Materials and methods: samples (n=257) of biological material of different origin were examined. These included: blood samples from patients (n=6) and cattle (n=15); salivary gland homogenates (n=28) from 147 imagoes of ticks of the family Ixodidae, 32 imagoes of Ixodes ricinus and 115 imagoes of Dermacentor reticulates; spleen homogenates (n=63) from mouse-like rodents (Muridae) of the genera Myodes, Microtus, Apodemus and Sylvaemus. In order to cultivate in v…

Molecular epidemiology and phylogenetic analysis of Anaplasma ovis and Anaplasma marginale in Ixodidae infesting livestock in northwestern Iran.

BACKGROUND: Anaplasma marginale and Anaplasma ovis are tick-borne obligate intracellular bacteria causing anaplasmosis in cattle and small r … in 8.3% (2/24) of tick pools. Positive pools were primarily associated with Rhipicephalus spp. and Dermacentor marginatus. According to the results of the statistical analysis a significant association was found between tick species and host type (χ² = 13.87, p = 0.0031), with Hyalomma anatolicum anatolicum more prevalent in sheep (p = 0.001). Tick abundance …

Control of ixodid ticks and prevention of tick-borne diseases in the United States: The prospect of a new Lyme disease vaccine and the continuing problem with tick exposure on residential properties.

In the United States, exposure to human-biting ixodid ticks can occur while spending time on residential properties or in neighborhood green … s; and this tick species co-occurs with other human-biting vectors such as Amblyomma americanum and Dermacentor variabilis. It therefore is important that a new Lyme disease vaccine does not result in reduced use of tick-bite prevention measures, such as tick repellents, permethrin-treated clothing, and frequent tick checks. Another key issue is the continuin …

Epidemiological investigation and genetic characterization of Coxiella burnetii carried by parasitic ticks in the southeastern coastal region of China.

BACKGROUND: The pathogen of Q fever, Coxiella burnetii, can persist in the environment for yearsand it can form infectious aerosols that fac … gher than that in coastal areas (10.22% and 2.60%). The dominant tick species in inland regions was Dermacentor taiwanensis, and higher infection rates were observed in Haemaphysalis Yeni (25.00%), Ixodes sinensis (25.00%), and Amblyomma testudinarium (19.35%). In coastal areas, Haemaphysalis formosensis was the dominant tick species, and Haemaphysalis hystri …

Mining the secreted and membrane transcriptome of Hyalomma dromedarii ticks for identification of potential protective antigens.

BACKGROUND: Members belonging to the tick genus Hyalomma function as a multi-host reservoir for several pathogens and important parasites in … le annotated proteomes of six hard tick species (H. asiaticum, Rhipicephalus sanguineus sensu lato, Dermacentor silvarum, Rhipicephalus microplus, Ixodes scapularis and Haemaphysalis longicornis) in addition to the published H. dromedarii sialotranscriptome. For the common sequences, we predicted the physicochemical properties, secondary structures and antige …

Arthrodesis of the ankle joint in septic osteoarthritis: six years long term outcomes in authors' personal experience.

BACKGROUND: South Downs National Park (SDNP) is UK's most visited National Park, and a focus of tick-borne Lyme disease. The first presumed … as been identified in 33/37 of SDNPs 10 km2 grid squares, Ixodes hexagonus 10/37, H. punctata 7/37, Dermacentor reticulatus 1/37. CONCLUSIONS: Mapping shows tick hazard broadly distributed across SDNP. I. ricinus was most common, but H. punctata's seeming range expansion is concerning. Recommendations: management of small heavily visited high hazard plots (Q …

[Prevalence of spotted fever group rickettsiae infections in ticks and among high-risk populations in the southern margin of the Gurbantunggut Desert in Xinjiang Uygur Autonomous Region].

OBJECTIVE: To investigate the prevalence of spotted fever group rickettsiae (SFGR) infections in free-living ticks and among high-risk popul … including R. sibirica, which shared 99.81% (515/516) sequence homology with the strain detected in Dermacentor sinicus from China; R. massiliae, which shared 99.80% (509/510) sequence homology with the strain detected in Rhipicephalus sanguineus from Ethiopia; R. raoultii, which shared 100.00% (516/516) sequence homology with the strain detected in Hyalomma …

Monitoring Risk: Tick and Borrelia burgdorferi Public Participatory Surveillance in the Canadian Maritimes, 2012-2020.

Ticks are vectors of many diseases, including Lyme disease (Ld). Lyme disease is an emerging disease in Canada caused by infection with the … nd most often on companion animals and humans were I. scapularis (76.9%), Ixodes cookei (10.4%) and Dermacentor variabilis (8.9%). The most common hosts were dogs (60.5%), cats (16.8%) and humans (17.6%). As is typical of passive surveillance tick collections, the majority of ticks recovered were adult females; for I. scapularis 90.2%, 5.3%, 3.9% and 0.6% of …

A Compendium Review of the Global Epidemiology of Ticks and Tick-borne Diseases: Regional Insights from Türkiye.

Vector-borne diseases have historically posed significant threats to plants, humans, domestic animals, and wildlife, with their impact being … nd 50 species from 7 genera in the family Ixodidae (Ixodes - 17 species, Rhipicephalus - 8 species, Dermacentor - 4 species, Hyalomma - 9 species, Haemaphysalis - 8 species, Alloceraea - 1 species and Amblyomma - 3 species). Notably, the genera Hyalomma and Ixodes have been reported as the most frequently associated with human infestations in Türkiye, highlig …

Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective.

A standard goal of medicinal chemists has been to discover efficient and potent drug candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. In this review, we collectively represent the current boron-containing drug candidates, boron-containing retinoids, benzoxaboroles, aminoboronic acid, carboran

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… Compound 48 demonstrated 97.6% therapeutic efficacy after 24 h, with 95.3% residual efficacy against American dog ticks ( Dermacentor variabilis ) on day 30 and 100% residual efficacy against cat fleas ( Ctenocephalides felis ) on day 32 after a single oral dose of 50 mg/kg in dogs. ( Scheme 12 ). …

Biology and Diseases of Dogs

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Integumentary System

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Hematology and Immune-Related Disorders

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Disorders of the Gastrointestinal System

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Diseases of the Nervous System

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RESEARCH COMMUNICATIONS OF THE 34th ECVIM-CA CONGRESS.

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