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[Comparative research on efficacy of high-pressure Schisandrae Chinensis Fructus decoction pieces and traditional decoction pieces on nonalcoholic fatty liver disease mice based on gut microbiota and metabolomics].

This paper aims to evaluate the feasibility of clinical application of high-pressure Schisandrae Chinensis Fructus decoction pieces(HPSCH) c … , the mice were divided into a blank control group, blank administration group, simple model group, fenofibrate group, SCH group, and HPSCH group. All groups were administered by intragastric administration for four weeks. Body weight changes of mice were recorded, and liver indices were calculated. The levels of blood lipid and liver function index in the se …

Роль альфа-рецептора, активированного пероксидисом, в нейродегенеративных заболеваниях и других неврологических расстройствах: перспективы клинического применения.

Альфа-рецептор, активированный с помощью пероксисом, является членом сверхсемейства суперрецептора ядерного гормона и функционирует в качестве коэффициента транскрипции, связанного с регулированием клеточного метаболизма. Предыдущие исследования показали, что PPARα играет ключевую роль в возникновении и развитии нейродегенеративных заболеваний. Таким образом, альфа-агонисты, работающие на рецепторах, привлекают все большее внимание в качестве потенциальных средств лечения неврологических расстройств. Цель этого обзора состоит в том, чтобы прояснить прогресс в области исследований, касающихся п

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… Fenofibrate is first converted to fenofibric acid by blood and tissue esterases. Fenofibric acid activates PPARα, triggering fatty acid β-oxidation, subsequently inhibiting the expression of glycolytic enzymes (Grabacka et al., 2013). … Normal cells metabolize fenofibrate to fenofibric acid more efficiently than tumor cells; consequently, fenofibric acid does not inhibit mitochondrial respiration. …

Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery. Clinical implications of PPAR agonists span across a wide range of health conditions, including metabolic diseases, chronic inflammatory diseases, infections, autoimmune diseases, neurological and psychiatric disorders, and malignancies. In this review we aim to consolidate exist

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… Likewise, the clinical outcomes from another PPARα agonist, fenofibrate was also optimistic as fenofibrate with UDCA could also improve liver biochemistries, leading to a higher complete response rate [ 206 , 207 , 208 , 209 , 210 ]. … These findings were in line with that of fenofibrate [ 246 ]. …

Fibrates increase human REV-ERBalpha expression in liver via a novel peroxisome proliferator-activated receptor response element.

Fibrates are widely used hypolipidemic drugs that act by modulating the expression of genes involved in lipid and lipoprotein metabolism. Whereas the activation of gene transcription by fibrates occurs via the nuclear receptor peroxisome proliferator-activated receptor-alpha (PPARalpha) interacting with response elements consisting of a direct repeat of the AGGTCA motif spaced by one nucleotide (DR1), the mechanisms of negative gene regulation by fibrates and PPARalpha are largely unknown. In the present study, we demonstrate that fibrates induce the expression of the nuclear receptor Rev-erba

Ketoprofen-induced Photoallergic Reaction.

Dear Editor, Photoallergic reactions are classic T-cell-mediated or delayed-type hypersensitivity reactions of the skin in response to a pho … hould avoid using some drugs such as some NSAIDs (suprofen, tiaprofenic acid), antilipidemic agent (fenofibrate) and sunscreens based on benzophenones (6,9). Physicians and pharmacists should advise patients of the potential risks when topical NSAIDs are applied on the photoexposed skin.

Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies.

BACKGROUND: Patients with high levels of low-density lipoprotein cholesterol (LDL-C) might not tolerate 3-hydroxy-3-methylglutaryl coenzyme … ith nonstatin LLT(s) alone (colesevelam, 10 patients; ezetimibe, 8; niacin extended release, 2; and fenofibrate, 1). After a median treatment duration of 16 weeks, rosuvastatin 5 mg/d+diet was associated with a mean (SD) decrease from baseline in LDL-C of 75 (34) mg/dL (mean [SD] %Delta, -42% [18%]) (P<0.001 vs baseline). After a median treatment duration of …

Otophyma: a case report and review of the literature of lymphedema (elephantiasis) of the ear.

Phymas (swellings, masses, or bulbs) are considered the end-stage of rosacea and mostly affect the nose (rhinophyma), and rarely involve the chin (gnatophyma), the cheek (metophyma), eyelids (blepharophyma), or ears (otophyma). Herein, we report the case of a 57-year-old man who developed unilateral enlargement of his left ear over 2 years. Biopsy revealed changes of rosaceous lymphedema associated with Demodex infestation. Corticosteroid and minocycline therapies resulted in partial reduction of the ear enlargement. Literature review examining for cases of lymphedema (elephantiasis) of the ea

Safety of statins: focus on clinical pharmacokinetics and drug interactions.

Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment. This review summarizes the pharmacokinetic properties of statins and emphasizes their clin

Huanglian wendan decoction attenuates hepatic inflammation and lipogenesis via inhibition of the NF-κB/HDAC1/SREBP-1c axis.

ETHNOPHARMACOLOGICAL RELEVANCE: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatic steatosis accompanied by … oline-deficient (MCD) diet and received HLWDD in either low or high doses through oral gavage, with fenofibrate serving as a positive control. Body weight, liver index, serum levels of alanine aminotransferase and aspartate aminotransferase, serum lipid profiles, and hepatic triglyceride and total cholesterol contents were among the evaluated parameters. H&E, …

Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8+ T Cells in Elderly Humans.

Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously unencountered Ags. The mechanisms that underlie this phenomenon have nonetheless remained unclear. We found that naive CD8+ T cells in elderly humans were prone to apoptosis and proliferated suboptimally in response to stimulation via the TCR. These abnormalities were associated with dysregulated lipid metabolism under homeostatic conditions and enhanced levels of basal activation. Importantly, reversal of the bioenergetic anomalies with l

Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series.

Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral … on/irritability and depression culminating in suicide in a man in his 40s (possible causality). (5) Fenofibrate + rosuvastatin (unknown dose), later combined with atorvastatin were followed in 1 month by aggression/irritability in a male in his 30s (probable causality). (6) Lovastatin (unknown dose and time-course to reaction) was followed by depression, dysc …

Subject index

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… reduction of microalbuminuria in type 2 diabetes, 485–493 Delivery costs, for dialysis patient medications, 917–925 Diabetes Atherosclerosis Intervention Study (DAIS), fenofibrate reduction of microalbuminuria in type 2 diabetes, 485–493 Diabetes mellitus with chronic kidney disease, pharmacists … in management of, 1105–1118 fenofibrate reduction of microalbuminuria progression in, 485–493 with hypertension and heart disease in ESRD, 316–323 management guidelines for dialysis patients, S3:46–48 nonfasting non-HDL cholesterol for dyslipidemia management, 1067–1072 outcomes of percutaneous …

Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action.

The pathways leading specifically to the toxic Aβ42 peptide production, a key event in Alzheimer's disease (AD), are unknown. While searching for pathways that mediate pathological increases of Aβ42, we identified Aftin-4, a new compound that selectively and potently increases Aβ42 compared to DMSO (N2a cells: 7-fold; primary neurons: 4-fold; brain lysates: 2-fold) with an EC(50) of 30 μM. These results were confirmed by ELISA and IP-WB. Using affinity chromatography and mass spectrometry, we identified 3 proteins (VDAC1, prohibitin, and mitofilin) relevant to AD that interact with Aftin-4, bu

Осложнение сульфатида в диабете типа 1 и многоклерозе. Комментарий к делу Рут-Бернштейн, Р. Диабет-ассоциированные аутентические организмы типа 1, Sera и T-Cell Receptor Sequences распознают Myelin Basic Protein: A Novel Peripheral Diabetic Neurophy-Multiple Scleris Connection. Ячейки 2026, 15, 1384.

Интересная статья Рут-Бернштейна [...].

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… Regarding prophylaxis or early treatment, it should be mentioned that both serine supplementation and fenofibrate, which enhances sulfatide levels, should be considered [ 9 ]. … Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient Following Fenofibrate Treatment Case Rep. Med. 2020 2020 6865190 10.1155/2020/6865190 32508930 PMC7245672 …

Nanotherapeutics in the EU: an overview on current state and future directions.

The application of nanotechnology in areas of drug delivery and therapy (ie, nanotherapeutics) is envisioned to have a great impact on public health. The ability of nanotherapeutics to provide targeted drug delivery, improve drug solubility, extend drug half-life, improve a drug's therapeutic index, and reduce a drug's immunogenicity has resulted in the potential to revolutionize the treatment of many diseases. In this paper, we review the liposome-, nanocrystal-, virosome-, polymer therapeutic-, nanoemulsion-, and nanoparticle-based approaches to nanotherapeutics, which represent the most suc

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… nanocrystals significantly reduce its required dose (145 mg) compared with tablets (160 mg) and capsules (200 mg) containing micronized and non-micronized fenofibrate, respectively. 44 Virosomes Virosomes are a drug or vaccine delivery system composed of viral membranes that are reconstituted with … A review of currently available fenofibrate and fenofibric acid formulations. Cardiol Res. 2013;4(2):47–55. doi: 10.4021/cr270w. 45. Yoo JW, Irvine DJ, Discher DE, Mitragotri S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. …

Drug Repurposing for Cancer Treatment: A Comprehensive Review.

Cancer ranks among the primary contributors to global mortality. In 2022, the global incidence of new cancer cases reached about 20 million, while the number of cancer-related fatalities reached 9.7 million. In Saudi Arabia, there were 13,399 deaths caused by cancer and 28,113 newly diagnosed cases of cancer. Drug repurposing is a drug discovery strategy that has gained special attention and implementation to enhance the process of drug development due to its time- and money-saving effect. It involves repositioning existing medications to new clinical applications. Cancer treatment is a therap

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… Antihyperlipidemic Fenofibrate, initially developed for treating hyperlipidemia, has shown anticancer properties in various human cancer types. Fenofibrate activates AMPK, reduces ATP levels, and increases ROS accumulation, leading to apoptosis and inhibition of metastasis in cancer cells. … Fenofibrate also promotes apoptosis and cell cycle arrest by modulating growth factor receptors and NF-κB activity in breast cancer and also inhibiting ERK signaling in lung cancer. …

RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect.

Retinoid X receptor (RXR) heterodimerizes with the PPAR nuclear hormone receptor and regulates its downstream events. We investigated the effects of RXR agonists (LG100754, bexarotene, AGN194204, and LG101506) on lenalidomide's anti-myeloma activity, T cell functions, and the level of glucose and lipids in vivo. Genetic overexpression and CRISPR/Cas9 knockout experiments were conducted in multiple myeloma (MM) cell lines and Jurkat T cell lines to determine the roles of CRBN in RXR-agonist mediated effects. A xenograft mouse model of MM was established to determine the combination effect of LG

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… Administration of PPAR agonists, such as fenofibrate, GW501516 , and troglitazone, resulted in decreased CRBN at the mRNA and protein levels [ 12 ]. … The transduced MM cells were then treated with RXR agonists ( LG100754 or bexarotene) with or without PPAR agonists (PPARα agonist fenofibrate, PPARγ agonist troglitazone, or PPARβ/δ agonist GW501516 ). …

Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.

Nuclear receptors (NRs) are a large family of ligand-dependent transcription factors that regulate the expression of a wide range of target genes in response to endogenous and exogenous ligands, including steroid hormones, thyroid hormone, vitamin D, retinoic acid, fatty acids, and oxidative steroids. Upon ligand binding, nuclear receptors form dimer complexes with transcriptional cofactors, which interact with specific DNA sequences in the promoter or enhancer regions of target genes to modulate gene expression. This process plays a crucial role in many physiological processes such as reprodu

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… platelets, a process dependent on cyclophilin D activity. 212 FXR ligands also increased cGMP levels, which increased PKG activity and VASP S239 phosphorylation, further suppressing platelet activation. 189 Other studies have identified PPARα as a key mediator of the antiplatelet effects of statins and fenofibrate … . 213 Treating platelets with PPARα ligands, such as fenofibrate or statins (e.g., simvastatin), inhibited ADP-stimulated platelet activation by increasing intracellular cAMP levels through a PPARα-dependent mechanism. 214 This role of PPARα was further confirmed by experiments showing that fenofibrate-induced …

[Noninvasive analysis of retinal microstructure and function: challenges and a promising future].

Challenges in the evaluation of the retinal microstructure. To facilitate evaluation of the retinal microstructure we participated in the de … ression in the HRMECs. In ex vivo studies, we found that simvastatin, pioglitazone, resveratrol and fenofibrate dilated isolated porcine retinal arterioles, suggesting that systemic administration of these drugs may have the therapeutic potential to improve the impaired RBF in patients with type 2 diabetes mellitus. 3. Challenges to the development of a telem …