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Case report: the clinical toxicity of dimethylamine borane.

CONTEXT: Dimethylamine borane (DMAB) is a reducing agent used in nonelectric plating of semiconductors. Exposures are usually through occupa … al neuropathy. RELEVANCE: Further investigation of the toxic mechanism of DMAB is warranted. Early decontamination with copious water is the best current treatment for exposure to DMAB.

Binding and degradation of 3,5,3'-triiodothyronine and thyroxine by rat intestinal bacteria.

Intestinal bacteria hydrolyze conjugates of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) secreted in bile, but it is not clear whether they have any other role in metabolism, storage, transport, or action of thyroid hormone in the intestines. We have examined aspects of T3 and T4 binding and degradation processes in fresh feces and cecum contents, obtained from normal control rats and from rats partially decontaminated by treatment with oral antibiotics for 2-3 wk. Samples were homogenized in phosphate buffer, fractionated, and subjected to various test conditions and incubated at 37 degree

(Un)targeted hair metabolomics: first considerations and systematic evaluation on the impact of sample preparation.

The interest in metabolomic studies has rapidly increased over the past few years. Changes of endogenous compounds are typically detected in plasma or urine. However, the use of hair allows for long-term monitoring of metabolomic changes and has recently started being applied to metabolomic studies. Within the proposed study, we aimed for a systematical investigation of different pre-analytical parameters on detected metabolites from different chemical classes in hair. For this purpose, three different parameters were varied: (1) multi-step decontamination (dichloromethane (DCM), acetone, H2O,…

Boost piezocatalytic activity of BaSO4 by coupling it with BaTiO3, Cu:BaTiO3, Fe:BaTiO3, S:BaTiO3 and modify them by sucrose for water purification.

The purpose of this study is to improve the efficiency of decontamination using BaSO4 as a piezocatalyst. Three techniques are employed in this study to enhance the piezocatalytic activity of BaSO4. The first method involves coupling BaSO4 with BaTiO3. The acid red 151 and acid blue 113 decontamination rates improved from 56.7% and 60.9% to 61.3% and 64.4%, respectively, as a result of this strategy. Additionally, the composite of BaSO4 and BaTiO3 was doped with copper, iron, sulfur, and nitrogen. By doping BaTiO3, acid red 151 and acid blue 113 achieved 86.7% and 89.2% efficiency, respectivel…

Bioterrorism: processing contaminated evidence, the effects of formaldehyde gas on the recovery of latent fingermarks.

In the present age of heightened emphasis on counter terrorism, law enforcement and forensic science are constantly evolving and adapting to … ubjected to a standard formulation of formaldehyde gas. Latent fingermarks were then recovered post decontamination using a range of methods. Standard fumigation, while effective at destroying viable spores, contributed to the degradation of amino acids leading to loss of ridge detail. A new protocol for formaldehyde gas decontamination was developed which allows …

Contaminated dental instruments.

There is current concern in the UK over the possible transmission of prions via contaminated surgical instruments. Some dental instruments (endodontic files) raise particular concerns by virtue of their intimate contact with terminal branches of the trigeminal nerve. A visual assessment using a dissecting light microscope and scanning electron microscopy of endodontic files after clinical use and subsequent decontamination was performed. The instruments examined were collected from general dental practices and from a dental hospital. Seventy-six per cent (22/29) of the files retrieved from gen…

Углеродные бриллиантовые покрытия для хирургических инструментов сокращают количество белков и прионово-амилоидных биообращений и улучшают последующую очистку.

Углеродные углеродные покрытия (DLC) могут быть противообрастающими поверхностями против микробных и белковых соединений. В частности, хирургические инструменты из нержавеющей стали подвергаются воздействию тканевого белка и стойкого прионного белка, что делает неэффективными методы обеззараживания, используемые в стерильных отделениях обслуживания, что потенциально повышает риск ятрогенического креуцфельда-Якоба во время хирургических операций. В ходе этого исследования были проанализированы адсорбция белков и амилоидов, связанных с прионом, на поверхностях ДКН и эффективность коммерческих чи

Совпадение в аннотации оригинала
Doped diamond-like carbon (DLC) coatings offer potential antifouling surfaces against microbial and protein attachment. In particular, stainless steel surgical instruments are subject to tissue protein and resilient prion protein attachment, making decontamination methods used in sterile service departments ineffective, potentially increasing the risk of iat…

Furcation lesion in a mandibular canine.

Morphological changes can complicate dental treatment. This report presents a rare case of a furcation lesion in a mandibular canine with tw … n an atypical location, the site of periodontal furcation received conventional therapy for initial decontamination, including tissue debridement and a combination of polyvinylpyrrolidone irrigation and antibiotics. To improve access, the decontamination was completed with surgical techniques and scaling and root planing. Early diagnosis of this rare morphologica …

New prion inactivation treatment presented.

Information on breakthroughs in prion decontamination and detection were presented by Dr Graham Jackson, head of molecular diagnostics at the Medical Research Council, to a Central Sterilising Club meeting held in Manchester earlier this year.

The double-edged sword of metabolic and bariatric surgery: extending the biliary limb can trigger bacterial translocation, sepsis, and liver inflammation - an experimental study.

BACKGROUND: Metabolic and bariatric surgery (MBS) procedures with extended biliary limb length are gaining popularity to expedite weight los … olic and liver health, bacterial translocation, inflammation, and biliary and fecal microbiome. Gut decontamination with oral antibiotics (amoxicillin, vancomycin, neomycin, and metronidazole) was performed in a subset of Ω 3 mice. Liver histology from mice with different biliary limb lengths was compared to samples from human patients who developed liver failure …

Is systematic fecal carriage screening of extended-spectrum beta-lactamase-producing Enterobacteriaceae still useful in intensive care unit: a systematic review.

BACKGROUND: Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are disseminating worldwide leading to increased hospital … e consumption of carbapenems among ESBL-E carriers without any clinical benefit. Finally, selective decontamination among ESBL-E fecal carriers is evoked to decrease the risk for subsequent ESBL-E infection, but its efficacy remains debated. We propose to systematically review the evidence to recommend or not such systematic ESBL-E fecal carriage screening in adu …

Fulminant Postoperative Peritonitis Following Cocaine Packet Rupture in a Body Packer.

Body packing carries a well-documented risk of life-threatening complications, particularly in packet rupture. Postoperative peritonitis fol … eved, and one was found ruptured, with no bowel perforation or ischaemia. Despite complete surgical decontamination, the patient developed fulminant postoperative peritonitis with disseminated intravascular coagulation and multiorgan failure. He died on postoperative day 2. Intraperitoneal cocaine contamination may lead to a rapidly progressive and potentially fa …

Development of a Procedure for Prion Surveillance in the Laboratory Setting.

Infectious prions readily adhere to common surfaces, retain infectivity, and are highly resistant to conventional decontamination, posing significant biosafety challenges in the medical and research environments. Recent occupational exposures underscore the urgency of improving safety measures. Here, we describe an approach combining foam-swab surface sampling and protein misfolding cyclic amplification to enhance prion surveillance. Our results demonstrate the ability to detect prions most relevant to human health directly from contaminated surfaces, even at 100 million-fold dilutions of the …

Diagnosis and management of the poisoned child.

Pediatric toxic ingestions are treated commonly by pediatricians and emergency physicians. Significant injury after these ingestions is infrequent, but identifying the dangerous ingestion is sometimes a difficult task. By performing a detailed history, focused physical examination, and directed laboratory evaluation, an estimation of risk can be developed. This article introduced the term "toxic triage" to describe this process. The toxic triage estimation allows the clinician to make thoughtful decontamination and treatment decisions. Familiarity with the literature supporting or refuting eac…

Enhanced topical delivery of non-complexed molecular iodine for Methicillin-resistant Staphylococcus aureus decolonization.

Staphylococcus aureus, a leading cause of serious human infections in both healthcare and community settings, is increasingly difficult to c … l priority. With rising resistance to mupirocin, the most common antibiotic utilized for nasal MRSA decontamination, we are examining the use of pure molecular iodine (I2)-based formulations for this indication. Recently, an iodophor formulation of povidone-iodine (PVP-I) has shown significant promise for nasal MRSA decontamination by swabbing the anterior nares …

Sanitation of tomatoes based on a combined approach of washing process and pulsed light in conjunction with selected disinfectants.

In this study, we evaluated the performance of a large-scale decontamination system based on a washing process in combination with pulsed light (PL) exposure and H2O2/chlorine. In order to identify optimum processing condition, we first evaluated the effect of single and combined PL treatments on the inactivation of Salmonella on grape tomatoes using a small sample size of 50 g. Two inoculation methods, spot and dip, were used to simulate different contamination scenarios and two wash water quality, clear tap water and turbid tap water with extremely high levels of organic load and soil, were …

Acute, unintentional pediatric brodifacoum ingestions.

BACKGROUND: Brodifacoum is the major rodenticide used in the United States today. It is similar to warfarin but has more potent and prolonge … 5404 (50.2 %) cases. Approximately half of all the children received some form of gastrointestinal decontamination. Decontamination had no effect on the distribution of outcomes. Adverse effects from decontamination therapy were reported in 42 patients. CONCLUSION: Acute pediatric ingestions of brodifacoum rarely caused clinical effects and were not associated …

Experience and Reflection on the Treatment of Calcium Channel Blockers Poisoning: Two Case Reports of Elderly Patients.

Calcium channel blockers (CCBs) poisoning presents an extremely dangerous condition, with a particularly poor prognosis in elderly patients. Early identification, aggressive decontamination, and individualized hemodynamic and blood purification strategies significantly improve outcomes in elderly patients with CCBs poisoning.

Pulsed light causes structural damage and proteomic alterations in Aspergillus brasiliensis conidia.

Aspergillus brasiliensis conidia are highly resistant fungal contaminants relevant to food-processing environments. Pulsed light (PL) is a non-thermal technology used for surface decontamination; however, its intracellular effects on fungal spores remain poorly understood. In this study, scanning electron microscopy (SEM) combined with shotgun proteomics was used to investigate the impact of a 1.24 J cm-2 PL treatment on A. brasiliensis DSM 1988 conidia. SEM revealed marked structural damage to the surface of conidia exposed to PL, including surface perforations and extracellular material sugg…

Coupling flexible stripping with efficient impurity removal for high-quality regeneration of spent LiFePO4 materials.

Lithium iron phosphate (LiFePO4) batteries are widely used in electric vehicles and energy storage systems due to their superior safety and cycling stability. However, their limited lifespan results in substantial spent battery accumulation. Current recycling methods face challenges including high costs, inefficient cathode detachment, and inadequate removal of metallic impurities. This study proposes a flexible stripping combined with efficient decontamination to achieve regeneration of spent LiFePO4. The physical stripping method achieves >99 % cathode detachment efficiency without structura…