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Administrative claims analysis of the relationship between warfarin use and risk of hemorrhage including drug-drug and drug-disease interactions.

BACKGROUND: Despite the risk of hemorrhage, warfarin is the most commonly used oral anticoagulant today, both as monotherapy and when taken … omitant use of warfarin and NSAIDs/COX-2 inhibitors, amiodarone, or fibric acid derivatives such as fenofibrate was not greater than for warfarin alone. Liver disease or HF in warfarin users was associated with a significant increase in the likelihood of hemorrhage.

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE.

OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Director … ccident EL = evidence level FH = familial hypercholesterolemia FIELD = Secondary Endpoints from the Fenofibrate Intervention and Event Lowering in Diabetes trial FOURIER = Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects With Elevated Risk trial HATS = HDL-Atherosclerosis Treatment Study HDL-C = high-density lipoprotein cholesterol H …

Work in Progress: Drugs in Development.

Primary biliary cholangitis is an archetypal autoimmune disease that causes cholestasis, fibrosis, and liver failure. Ursodeoxycholic acid and obeticholic acid are approved for its treatment. Not all patients respond, some are intolerant, many have ongoing symptoms, and new therapies are required. Herein we describe drugs in development and potential future biological targets. We consider compounds acting on the farnesoid X receptor/fibroblast growth factor 19 pathway, fibrates and other agonists of the peroxisome proliferator-activated receptor family, transmembrane-G-protein-receptor-5 agoni

Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis.

Classic tumor therapy, consisting of cytotoxic agents and/or targeted therapy, has not overcome therapeutic limitations like poor risk genetic parameters, genetic heterogeneity at different metastatic sites or the problem of undruggable targets. Here we summarize data and trials principally following a completely different treatment concept tackling systems biologic processes: the principle of communicative reprogramming of tumor tissues, i.e., anakoinosis (ancient greek for communication), aims at establishing novel communicative behavior of tumor tissue, the hosting organ and organism via re

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… Fenofibrate, retinoic acid, and vitamin D combined with metronomic chemotherapy induced in pediatric patients with refractory tumors of quite different histology complete remissions (15%) (Zapletalova et al., 2012 ). … Bexarotene, fenofibrate plus vorinostat may induce complete remission in tumor-stage mycosis fungoides (Steinhoff et al., 2008 ). …

[Prevention of diabetic foot].

Diabetic foot (DF) is the most common chronic complication, which depends mostly on the duration and successful treatment of diabetes mellit … f body weight, quit smoking, and appropriate treatment of glycemia, lipid disorders (treatment with fenofibrate reduces the incidence of DF amputations (EBM-Ib/A), hypertension, hyperuricemia, neuropathy, and angiopathy (surgical reconstructive bypass) or endovascular (percutaneous transluminar angioplasty). In the low-risk group of PwDM, no particular result …

A Randomized Controlled Pilot Study Evaluating the Safety and Efficacy of Nifuroxazide in Patients with Ulcerative Colitis.

BACKGROUND: The therapeutic potential of nifuroxazide in colitis has been explored in several experimental studies of ulcerative colitis (UC). AIM: To evaluate the efficacy of nifuroxazide in patients with UC. METHODS: Fifty patients with mild to moderate UC were randomly assigned into two groups (n = 25 each). The placebo group received a placebo alongside mesalamine (1 g three times daily [t.i.d.]) for six months. The nifuroxazide group received nifuroxazide (200 mg twice daily) in combination with mesalamine (1 g t.i.d). A gastroenterologist assessed disease severity using the partial May

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… Studies have demonstrated that atorvastatin, pentoxifylline, fenofibrate, and metformin exert a protective effect on the colon and enhance the therapeutic efficacy of mesalamine. 9 , 39 , 43 , 44 These findings help highlight the potential benefits of nifuroxazide in reducing the PMS, lowering bleeding … Fenofibrate as an adjunct therapy for ulcerative colitis: targeting inflammation via SIRT1, NLRP3, and AMPK pathways: a randomized controlled pilot study. Drug Des Devel Ther . 2024;Volume 18:5239–5253. doi: 10.2147/DDDT.S490772 40. Nazmy EA, Helal MG, Said E. …

Hypercalcemia of malignancy in metastatic esophageal squamous cell carcinoma with simultaneous PTHrP and calcitriol overproduction: A case report with literature review.

INTRODUCTION AND IMPORTANCE: hypercalcemia of malignancy is a severe complication of malignancy and associated with poor prognosis. Four mechanisms are implicated in this metabolic disorder, including excess parathyroid-related peptide secretion, focal osteolysis secondary to bone metastasis or multiple myeloma, excess calcitriol production, and ectopic parathyroid hormone production. Humoral hypercalcemia of malignancy secondary to isolated PTHrP or calcitriol overproduction is known; however, hypercalcemia of malignancy due to simultaneous PTHrP and calcitriol overproduction is less well kno

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… Home medications included atorvastatin, fenofibrate, morphine sulfate ER, oxycodone/acetaminophen, and docusate sodium. The serum calcium was 9.4 mg/dL at the time of diagnosis of esophageal cancer 9 months prior to admission, and was between 9.1 and 10.4 mg/dL until this admission. …

Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio.

To meet the anabolic demands of the proliferative potential of tumor cells, malignant cells tend to rewire their metabolic pathways. Although different types of malignant cells share this phenomenon, there is a large intracellular variability how these metabolic patterns are altered. Fortunately, differences in metabolic patterns between normal tissue and malignant cells can be exploited to increase the therapeutic ratio. Modulation of cellular metabolism to improve treatment outcome is an emerging field proposing a variety of promising strategies in primary tumor and metastatic lesion treatme

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… Fenofibrate (FEN), a PPARα agonist, reverses metabolic reprogramming of cancer cells leading to enhanced radiosensitivity in vitro and in vivo under hypoxic conditions ( 69 , 70 ) and also reduces metastasis formation of melanomas ( 362 ). … Enhancement of radiosensitivity in human esophageal carcinoma cells by fenofibrate and its potential mechanism. Tumori (2015) 101(1):123–30. 10.5301/tj.5000228 71. Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, et al. …

Pregabalin-associated myoclonic encephalopathy without evidence of drug accumulation in a patient with acute renal failure.

Pregabalin, used for treating partial epilepsy and neuropathic pain, is usually well tolerated. Patients with impaired renal function are at risk to develop more serious adverse events. A 64-year-old woman was admitted in the Emergency Department for altered consciousness and abnormal movements. She recently started to take pregabalin (150 mg/day) for neuropathic pain. The drug was withdrawn 36 h before hospitalization following worsening of neurological symptoms. At physical examination, myoclonus was noted as main finding in the limbs and head, with encephalopathy. Laboratory investigations

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… Her current medications included clonazepam, amlodipine, L-thyroxin, metformin, repaglinide, spironolactone, furosemide, minoxidil, irbesartan, hydrochlorothiazide, acyclovir, pantoprazole, and fenofibrate. …

Доклад по делу Ига-Ига-И типа Мильомы, совпадающей с Гиперлипидемией.

В большинстве случаев у пациентов с множественной миеломой (ММ) обычно наблюдаются нормальные или пониженные уровни липидов крови. Однако небольшое число случаев свидетельствует о значительной роли белка M в повышенных липидовых уровнях, особенно в тесной связи между типом IgA MM и гипертриглицеридемией и гиперхлестеролемией. Здесь мы сообщаем о случае MM типа Ига-Ига с одновременно гиперлипидемией, когда пациент с повышенным уровнем липидов при поступлении: полный холестерин 10.44 mmol/L (обычный диапазон: 2.8-5.6 mmol/L) и триглицериды 28.45 mmol/L (обычный диапазон: 0.45-1.70 mmol/L) Пациен

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… Given the elevated triglycerides, treatment included fenofibrate, elotuzumab, and plasma exchange therapy. …

Возможная роль метаформы и фибробластного роста Factor-21 В Multical Sclerosis Neuropathology: Birds of a Feather Flock Common.

Множественный склероз (MS) — прогрессивное демиелинизирующее заболевание CNS, характеризующееся воспалением, образованием CNS-клеров и повреждением нейронной миелинской оболочки (graphical abstract). Фактор роста фибробласта 21 (FGF21) занимается различными метаболическими расстройствами и нейродегенеративными заболеваниями. FFF21 и его корецептор β-Kloth имеют существенно важное значение для процесса ремиелиции MS. Метформин, инсулин-сенсибилизирующее лекарство, которое является первой линией лечения для типа 2 Мэлитус диабета (T2DM) может оказывать потенциальное нейрозащитное воздействие, ре

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… For instance, fenofibrate, a PPARα agonist, attenuates LPS‐induced expression and the release of pro‐inflammatory cytokines from activated astrocytes in EAE (Xu et al.  2007 ). Fenofibrate achieves this by inhibiting MyD88‐mediated TLR4 signaling and the expression of IL‐12 (Xu et al.  2007 ). …

Targeted Therapies in Adult B-Cell Malignancies.

B-lymphocytes are programmed for the production of immunoglobulin (Ig) after antigen presentation, in the context of T-lymphocyte control within lymphoid organs. During this differentiation/activation process, B-lymphocytes exhibit different restricted or common surface markers, activation of cellular pathways that regulate cell cycle, metabolism, proteasome activity, and protein synthesis. All molecules involved in these different cellular mechanisms are potent therapeutic targets. Nowadays, due to the progress of the biology, more and more targeted drugs are identified, a situation that is c

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… Fenofibrate, a PPAR- α agonist, has been shown to induce apoptosis on certain cancer cells via activation of NF- κ B pathway [ 84 ]. Inhibitors for PPAR- γ may enhance the activity of radiation therapy in cancer [ 85 ]. There are several compounds that modulate glycolytic metabolism. … Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF- κ B pathway BMC Cancer 2014 14, article 96 10.1186/1471-2407-14-96 2-s2.0-84898600914 PMC4015735 24529079 85 An Z. Muthusami S. Yu J. Park W. …

Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes.

The use of targeted cancer therapies in combination with conventional chemotherapeutic agents and/or radiation treatment has increased overall survival of cancer patients. However, longer survival is accompanied by increased incidence of comorbidities due, in part, to drug side effects and toxicities. It is well accepted that inflammation and tumorigenesis are linked. Because peroxisome proliferator-activated receptor (PPAR)-gamma agonists are potent mediators of anti-inflammatory responses, it was a logical extension to examine the role of PPARgamma agonists in the treatment and prevention of

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… agonists and the metabolic syndrome Therapie 2007 62 4 319 326 17983557 10.2515/therapie:2007051 10 Jay MA Ren J Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus Current Diabetes Reviews 2007 3 1 33 39 18220654 10.2174/157339907779802067 11 Rosenson RS Fenofibrate … Dong Y-W Wang X-P Wu K Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor γ involves angiogenesis inhibition World Journal of Gastroenterology 2009 15 4 441 448 19152448 10.3748/wjg.15.441 PMC2653365 33 Panigrahy D Kaipainen A Huang S PPAR α agonist fenofibrate …

45th International Symposium on Intensive Care & Emergency Medicine.

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HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies.

The hypoxic microenvironment is an essential characteristic of most malignant tumors. Notably, hypoxia-inducible factor-1 alpha (HIF-1α) is a key regulatory factor of cellular adaptation to hypoxia, and many critical pathways are correlated with the biological activity of organisms via HIF-1α. In the intra-tumoral hypoxic environment, HIF-1α is highly expressed and contributes to the malignant progression of tumors, which in turn results in a poor prognosis in patients. Recently, it has been indicated that HIF-1α involves in various critical processes of life events and tumor development via r

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… Another recent study found that HIF-1α prevents tumor cells from being subjected to immune surveillance with enhanced levels of carbonic anhydrase IX (CA9) expression. 75 More importantly, it is apparent that fenofibrate, a PPAR alpha (PPAR-α)-specific agonist, further represses the expression of hypoxia-induced … Fenofibrate inhibits hypoxia-inducible factor-1 alpha and carbonic anhydrase expression through activation of AMP-activated protein kinase/HO-1/Sirt1 pathway in glioblastoma cells Environ Toxicol 36 12 2021 2551 2561 34520103 10.1002/tox.23369 76 Osada-Oka M. Kuwamura H. Imamiya R. …

Chronic Kidney Disease: Strategies to Retard Progression.

Chronic kidney disease (CKD), defined as the presence of irreversible structural or functional kidney damages, increases the risk of poor outcomes due to its association with multiple complications, including altered mineral metabolism, anemia, metabolic acidosis, and increased cardiovascular events. The mainstay of treatments for CKD lies in the prevention of the development and progression of CKD as well as its complications. Due to the heterogeneous origins and the uncertainty in the pathogenesis of CKD, efficacious therapies for CKD remain challenging. In this review, we focus on the follo

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… Although most statins exhibit minimal renoprotective effects [ 58 , 59 , 60 ], fenofibrate, a peroxisome proliferator-activated receptor (PPAR) α-agonist, has been shown to have an antiproteinuric effect in DKD [ 61 ]. … Ansquer J.C., Foucher C., Rattier S., Taskinen M.R., Steiner G., DAIS Investigators Fenofibrate reduces progression to microalbu-minuria over 3 years in a placebo-controlled study in type 2 diabetes: Results from the Diabetes Atherosclerosis Intervention Study (DAIS) Am. J. …

Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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Cancer vaccines: an update on recent achievements and prospects for cancer therapy.

Decades of basic and translational research have led to a momentum shift in dissecting the relationship between immune cells and cancer. This culminated in the emergence of breakthrough immunotherapies that paved the way for oncologists to manage certain hard-to-treat cancers. The application of high-throughput techniques of genomics, transcriptomics, and proteomics was conclusive in making and expediting the manufacturing process of cancer vaccines. Using the latest research technologies has also enabled scientists to interpret complex and multiomics data of the tumour mutanome, thus identify

Treatment of Established Chemotherapy-Induced Neuropathy with N-Palmitoylethanolamide: A Randomized, Double-Blind Phase II Pilot Study.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) from oxaliplatin and taxane drugs is a bothersome toxicity. Palmitoylethanolamide (PEA) has been reported to improve myelinated nerve fiber function in patients experiencing painful CIPN. We conducted a double-blind, placebo-controlled, randomized trial of PEA in patients with established CIPN. Methods: Eligible patients were adults who had pain, numbness, tingling, or other symptoms of CIPN for at least three months following completion of paclitaxel, oxaliplatin, or cisplatin-based chemotherapy. Study patients were randomized to o

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… Profound Modification of Fatty Acid Profile and Endocannabinoid-Related Mediators in PPARalpha Agonist Fenofibrate-Treated Mice Int. J. Mol. Sci. 2022 24 709 10.3390/ijms24010709 36614161 PMC9821630 20. Zhou G. Fu X. Wang L. Cao Y. Zhuang J. Hu J. Li Y. Xu C. Gao S. Shao A. …

The sirtuin family in health and disease.

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a