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A rare coincidence of different types of driver mutations among uterine leiomyomas (UL).

BACKGROUND: Alcohol is a major risk factor for preventable illness, with huge cost to healthcare economies. There is a role for alcohol-specific digital health interventions (DHI), but there have been few randomised controlled trials (RCT) comparing DHI with face-to-face treatment. Such trials are complex and face obstacles in recruitment and retention. METHODS: Mixed-methods feasibility RCT of an alcohol DHI, testing recruitment, online data-collection and randomisation processes, with an embedded process evaluation. Recruitment ran from October 2014 for 9 months. Participants were adults dr

Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care.

IntroductionInfection is an important complication in cancer patients, which frequently leads to or prolongs hospitalization, and can also lead to acute organ dysfunction (severe sepsis) and eventually death. While cancer patients are known to be at higher risk for infection and subsequent complications, there is no national estimate of the magnitude of this problem. Our objective was to identify cancer patients with severe sepsis and to project these numbers to national levels.MethodsData for all 1999 hospitalizations from six states (Florida, Massachusetts, New Jersey, New York, Virginia, an

Balancing Innovation and Access: Insights from AIM's Fair Pricing Model and Its Current and Future Applications.

OBJECTIVE: Access to affordable medicines is a cornerstone of equitable healthcare, yet escalating drug prices increasingly strain national healthcare systems. Cost-based pricing can be a useful complement to value-based pricing, provided that relevant variables are considered. METHODS: We applied the International Association of Mutual Benefit Societies (AIM) Fair Pricing Model to ten market-protected medicines authorized by the European Medicines Agency between 2015 and 2018, covering oncology, rare diseases, and chronic conditions. Analyses were conducted across six European countries-Belg

Unlocking artificial intelligence, machine learning and deep learning to combat therapeutic resistance in metastatic castration-resistant prostate cancer: a comprehensive review.

Metastatic castration-resistant prostate cancer (mCRPC) remains a formidable clinical challenge despite advancements in therapy. This narrative review explores the role of artificial intelligence (AI), machine learning and deep learning in addressing therapeutic resistance in mCRPC. AI-driven approaches leverage integrated datasets encompassing genomics, proteomics and clinical parameters to uncover molecular mechanisms, predict treatment responses and identify biomarkers of resistance. These methodologies promise personalised treatment strategies tailored to individual patient profiles. Howev

Применение цифровой технологии в области управления качеством медицинских сестер: обзор аналитического исследования.

Справочная технология включает в себя такие информационно-коммуникационные средства, как электронные медицинские записи, износимые устройства и искусственный интеллект, которые стали важной движущей силой оптимизации управления качеством медицинских сестер. Вместе с тем существующие исследования по применению цифровых технологий в области управления качеством ухода за больными носят фрагментарный характер с нечеткими концептуальными границами и отсутствием систематического картирования фактических данных. Цель этого аналитического обзора состоит в том, чтобы систематически картировать прикладн

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… Fourth, the included studies predominantly originated from high-income countries (Germany, USA, UK) and urban tertiary hospitals in China, potentially limiting applicability to low-resource settings, primary care environments, or different healthcare financing systems. …

The work of managing multiple myeloma and its implications for treatment-related decision making: a qualitative study of patient and caregiver experiences.

BackgroundThe evolving nature of multiple myeloma (MM) therapies, including the introduction of novel oral agents, has produced a shift in the delivery of care from hospital to home. Within this context, patients and their caregivers are becoming increasingly engaged in the work of illness management, however the exact nature of this work as well as the ways in which this work informs treatment preferences and decisions within this population has not been explored. This qualitative study sought to develop an in-depth understanding of patient and caregiver experiences with different MM treatmen

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… Lastly, the findings should be interpreted in the context of a universal healthcare financing system. These findings may not necessarily align with the experiences of those who live in countries with private payer systems. …

Comparison of Access to Novel Drugs for Lymphoma and Chronic Lymphocytic Leukemia Between India and the United States.

This review will compare and contrast the costs and access to novel drugs for treating chronic lymphocytic leukemia (CLL) and lymphoma in the United States and India during the last 5 years. Clinical outcomes for patients with hematologic malignancies have improved significantly since the approval of immunotherapeutic and targeted therapies. These new treatments have had an impact on overall outcomes and have helped determine the design for translational research and future trials. Although most of these novel drugs called "innovators" are initially approved and marketed in the United States,

Return to work experiences of patients treated with stem cell transplantation for a hematologic malignancy.

PurposeThis qualitative study aimed to identify hematopoietic stem cell transplantation (HSCT) survivors' (1) work perceptions; (2) barriers to and facilitators of return to work (RTW); and (3) possible solutions to improve RTW.MethodFifteen patients treated with HSCT 1-5 years ago participated in face-to-face semi-structured interviews. Interviews were analyzed following the steps of thematic content analyses.ResultsRTW was often characterized as a complex and prolonged trajectory, and it was frequently incomplete in working hours, tasks, and/or responsibilities. Work perceptions varied betwe

Is the incidence of early-onset cancers increasing in the northeast of Italy? A 30-year analysis of the regional cancer registration data by age, 1987-2019.

The analysis of cancer incidence trends in adolescents and young adults reveals a concerning increase. This observational study aims to investigate cancer incidence trends among young adults under 50, compared to older age trends, using the population-based Cancer Registry of the Veneto Region (Northeastern Italy) from 1987 to 2019. Yearly age-standardized cancer incidence rates per 100,000 individuals were obtained from the Veneto Tumour Registry for 24 tumor sites and all cancers combined. Temporal trends from 1987 to 2019 were analyzed for each cancer type, stratified by sex and age group a

A comprehensive survey of cancer medicines prices, availability and affordability in Ghana.

IntroductionIn Ghana, prices for cancer medicines are characterized by high retail markups, forex fluctuations and high variation in prices of medicines. Most patients cannot afford the cancer medicines. There is a problem of unaffordability and limited availability of essential cancer medicines which suggests potential inequity in patient access to cancer medicines. The study objective was to assess the prices, availability, and affordability of cancer medicines in Ghana. Prices of cancer medicines are a major contributor to the cost of treatment for cancer patients and the comparison of thes

Stakeholder perspectives and requirements to guide the development of digital technology for palliative cancer services: a multi-country, cross-sectional, qualitative study in Nigeria, Uganda and Zimbabwe.

IntroductionCoverage of palliative care in low and middle-income countries is very limited, and global projections suggest large increases in need. Novel approaches are needed to achieve the palliative care goals of Universal Health Coverage. This study aimed to identify stakeholders' data and information needs and the role of digital technologies to improve access to and delivery of palliative care for people with advanced cancer in Nigeria, Uganda and Zimbabwe.MethodsWe conducted a multi-country cross-sectional qualitative study in sub-Saharan Africa. In-depth qualitative stakeholder intervi

Создание барьеров и возможностей для осуществления программ самостоятельной терапии для пациентов с миломой: протокол качественного декриптационного исследования.

Множественная миелома (ММ) связана с наибольшим симптомным бременем всех гематологовых раковых заболеваний и, несмотря на значительное улучшение методов лечения с высокими показателями реагирования и выживаемости, все еще считается неизлечимой, причем пациенты в течение многих лет проходят многочисленные циклы лечения. Инъекции по подкожному методу (СК) являются распространенным способом доставки для текущей и будущей терапии ММ, при этом данные свидетельствуют о том, что программы, наделяющие пациентов или лиц, занимающихся уходом за больными, ответственностью за управление, могут принести по

Evaluation of the SCA instrument for measuring patient satisfaction with cancer care administered via paper or via the Internet.

BackgroundPatients' perspectives provide valuable information on quality of care. This study evaluates the feasibility and validity of Internet administration of Service Satisfaction Scale for Cancer Care (SCA) to assess patient satisfaction with outcome, practitioner manner/skill, information, and waiting/access.Patients and methodsPrimary data collected from November 2007 to April 2008. Patients receiving cancer care within 1 year were recruited from oncology, surgery, and radiation clinics at a tertiary care hospital. An Internet-based version of the 16-item SCA was developed. Participants

Европейский статус карты CAR-T и будущие направления улучшения доступа к клеточной терапии CAR для гематологовых маньяков.

Несмотря на свои большие надежды, осуществление терапии CAR-T является индивидуализированным, технически сложным и дорогостоящим лечением, которое по-прежнему сопряжено с трудностями, что затрудняет доступ пациентов в различных странах и внутри стран. С тех пор 2018, six в Европе (т.е. Европейская экономическая зона; утвержден ЕС) 15 Гематологические признаки злоумышленничества. Чтобы лучше понять доступ пациентов к коммерческой терапии CAR-T, одобренной ЕС, мы провели оценку нынешнего положения дел в целом. 30 Страны, в которых одобрение ЕС действительно, плюс Соединенное Королевство, рассмат

Validation of the Medicare-Enhanced Laboratory and Demographics (MELD™) Dataset: A Comprehensive Psychometric, Epidemiologic, and Predictive-Utility Assessment of a 60-Million-Patient Real-World Evidence Resource.

BackgroundReal-world evidence studies increasingly rely on integrated data resources that combine Medicare fee-for-service claims with electronic medical records (EMRs), laboratory results, and patient-reported outcomes. The Medicare-Enhanced Laboratory and Demographics (MELD™) dataset, developed by Columbia Data Analytics, spans 2020 through 2024 and contains 60 million unique patients, roughly 1 billion visits, and more than 241 000 clinicians. Its data-quality properties must be characterized before regulatory-grade use.ObjectiveTo provide a preregistered, multidomain validation of MELD, qu

Impact of the National Health Insurance Coverage Policy on the Utilisation and Accessibility of Innovative Anti-cancer Medicines in China: An Interrupted Time-Series Study.

Objective: The study aimed to evaluate the impact of the National Health Insurance Coverage (NHIC) policy on the utilisation and accessibility of innovative anti-cancer medicines in Nanjing, China. Methods: We used the adjusted World Health Organisation and Health Action International methodology to calculate the price and availability of 15 innovative anti-cancer medicines included in the National Health Insurance drug list in 20 tertiary hospitals and six secondary hospitals in Nanjing before and after NHIC policy implementation. Interrupted time-series regression was used to analyse the cha

Patient Preferences in Targeted Pharmacotherapy for Cancers: A Systematic Review of Discrete Choice Experiments.

BackgroundTargeted pharmacotherapy has been increasingly applied in cancer treatment due to its breakthroughs. However, the unmet needs of cancer patients are still significant, highlighting the urgency to investigate patient preferences. It is unclear how patients deliberate their choices between different aspects of targeted therapy, including cost, efficacy, and adverse events. Since discrete choice experiments (DCEs) have been widely applied to patient preference elicitation, we reviewed DCEs on targeted therapy for different cancers. We also synthesized evidence on the factors influencing

A latent profile analysis of financial toxicity and its association with anxiety and depression in patients with hematologic malignancies.

OBJECTIVE: To identify latent subgroups of financial toxicity among patients with hematologic malignancies, examine associated sociodemographic and clinical predictors, and explore the relationship between financial toxicity and anxiety-depression symptoms. METHODS: A cross-sectional study was conducted among 486 patients with hematologic malignancies recruited through convenience sampling from provincial-level hospitals in Hunan Province, China. Participants completed the General Information Questionnaire, the Patient-Reported Outcome Financial Toxicity (PRO-FT) Scale, the Patient Health Que

Long-Term Projections of Cancer Incidence and Mortality in Japan and Decomposition Analysis of Changes in Cancer Burden, 2020-2054: An Empirical Validation Approach.

PurposeThe aim of this study was to project new cancer cases/deaths forward to 2054, and decompose changes in cancer cases/deaths to assess the impact of demographic transitions on cancer burden.MethodsWe collected data on cancer cases/deaths up to 2019, empirically validated the projection performance of multiple statistical models, and selected optimal models by applying time series cross-validation.ResultsWe showed an increasing number of new cancer cases but decreasing number of cancer deaths in both genders, with a large burden attributed to population aging. We observed the increasing in

Cancer disparities: an extensive review.

Cancer disparities are persistently a significant public health burden worldwide and disproportionately impact the underserved populations. To effectively combat cancer disparities, a clear understanding of their causes and patterns is essential. Currently, government data and peer-reviewed research journals display a wide range of data to describe the extent of different cancer disparities. However, there are still gaps in understanding the scope and patterns of these disparities and in adopting practical approaches to eliminate them adequately. Accordingly, we examine essential topics that a