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Differing normative reference ranges for body composition and physical performance measures in Hong Kong Chinese and Canadian older adults: the Hong Kong Os study and the Canadian Longitudinal Study on Aging.

Normal reference values for body composition and physical performance measures are needed in order to determine cut-off values for suboptimal health such as obesity and related cardiometabolic diseases, and/or sarcopenia. Few studies have provided comparative normative reference ranges across different populations. We compare several body composition and physical performance measures between older Hong Kong Chinese and Canadians to derive and contrast their respective reference values. 17 451 older adults from the Canadian Longitudinal Study on Aging (CLSA) and 4000 from the Hong Kong Mr. and …

В канадском продольном исследовании по проблемам старения было проведено исследование с целью выявления взаимосвязи между неблагоприятным детским опытом и иммунопосредованным воспалительным заболеванием.

ЦЕЛЬ: Неблагоприятный детский опыт (АСЕ) непоследовательно учитывается в качестве факторов риска для иммунных подстрекательских заболеваний (ИМИД). Мы провели оценку того, отличается ли связь между ACE и болезнями между IMID и другими хроническими заболеваниями. DESIGN: Ретроспективное исследование по вопросам контроля за делами. СИТТИНГ: Мы использовали данные Канадского продольного исследования по проблемам старения (CLSA), в котором за период с 2010 по 2015 год были привлечены участники в возрасте от 45 до 85 лет.В число участников входили 12 627 участников КЛСА: 2 102 человека, сообщившие

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OBJECTIVE: Adverse childhood experiences (ACE) have inconsistently been implicated as risk factors for immune-mediated inflammatory diseases … chronic diseases. DESIGN: Nested retrospective case-control study. SETTING: We used data from the Canadian Longitudinal Study on Aging (CLSA), which recruited participants aged 45-85 years between 2010 and 2015. PARTICIPANTS: We included 12 627 CLSA participants: 2 102 who reported diagnoses of IMID (258 multiple sclerosis (MS), 1 692 rheumatoid arthritis (RA) and 160 inflammatory …

The association between diabetes type, age of onset, and age at natural menopause: a retrospective cohort study using the Canadian Longitudinal Study on Aging.

OBJECTIVES: With growing incidence of type 1 diabetes (T1D), type 2 diabetes (T2D), and gestational diabetes, more women are expected to spend a larger proportion of their reproductive years living with a diabetes diagnosis. It is important to understand the long-term implications of premenopausal diabetes type on women's reproductive health including their age at natural menopause (ANM). METHODS: Baseline data from the Comprehensive Cohort of Canadian Longitudinal Study on Aging were used. Females who reported premenopausal diagnosis of diabetes were considered exposed. Kaplan-Meier cumulati…

Situations of Vulnerability, Life Satisfaction, and Social Support of Older Women and Men: Results From the Canadian Longitudinal Study on Aging (CLSA).

Situations of vulnerability are associated with reduced life satisfaction. Although social support moderates the influence of situations of vulnerability, little is known about their associations. This study aimed to document situations of vulnerability and examine their association with life satisfaction among older adults, and the moderating effect of social support. Secondary analyses of cross-sectional data (n = 21,491; 73.4 ± 0.04) from the Canadian Longitudinal Study on Aging, stratified by sex. Confirmatory factor analysis identified a vulnerability variable from physiological, psycholo…

Relation between frailty and hypertension is partially mediated by physical activity among males and females in the Canadian Longitudinal Study on Aging.

Frailty reflects the heterogeneity in aging and may lead to the development of hypertension and heart disease, but the frailty-cardiovascular relationship and whether physical activity modifies this relationship in males and females are unclear. We tested whether higher frailty was positively associated with hypertension and heart disease in males and females and whether habitual movement mediated this relationship. The relationship between baseline frailty with follow-up hypertension and heart disease was investigated using the Canadian Longitudinal Study on Aging at 3-year follow-up data (ma…

Adverse childhood experiences and psychiatric comorbidity in multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis in the Canadian longitudinal study on aging.

OBJECTIVES: Adverse childhood experiences (ACE) are associated with immune-mediated inflammatory diseases (IMID). We evaluated whether: (i) ACE associate with psychiatric comorbidity among individuals with IMID, including rheumatoid arthritis (RA), multiple sclerosis (MS), and inflammatory bowel disease (IBD); (ii) whether psychiatric disorders mediate the relationship between ACE and IMID; and (iii) whether these findings differ from those in individuals with other chronic physical disorders. METHODS: Using data from the Canadian Longitudinal Study on Aging (CLSA) we performed a retrospectiv…

Increased prevalence of loneliness and associated risk factors during the COVID-19 pandemic: findings from the Canadian Longitudinal Study on Aging (CLSA).

BACKGROUND: Older adults have been disproportionately impacted by COVID-19 and related preventative measures undertaken during the pandemic. … d between Sept 29-Dec 29, 2020 (n = 24,114) from community-living older adults participating in the Canadian Longitudinal Study on Aging. Loneliness was measured using the 3-item UCLA Loneliness Scale. Weighted generalized estimating equations estimated the prevalence of loneliness pre-pandemic and during the pandemic. Lagged logistic regression models examined individual-level facto …

Depressive symptoms in adults in rural and urban regions of Canada: a cross-sectional analysis of the Canadian Longitudinal Study on Aging.

OBJECTIVES: Previous studies on depression in rural areas have yielded conflicting results. Features of rural areas may be conducive or detrimental to mental health. Our objective for this study was to determine if there are rural-urban disparities in depressive symptoms between those living in rural and urban areas of Canada. DESIGN: We conducted a cross-sectional analysis of a prospective cohort study, which is as representative as possible of the Canadian population-the Tracking Cohort of the Canadian Longitudinal Study on Aging. For this cohort, data were collected from 2010 to 2014. Data…

Race/ethnic differences in the prevalence of osteoporosis, falls and fractures: a cross-sectional analysis of the Canadian Longitudinal Study on Aging.

UNLABELLED: Most of the published epidemiology on osteoporosis is derived from White populations; still many countries have increasing ethno … adians by their racial/ethnic backgrounds. METHODS: For this cross-sectional analysis, we used the Canadian Longitudinal Study on Aging baseline data (2011-2015) of 22,091 randomly selected participants of Black, East Asian, South or Southeast Asian (SSEA) and White race/ethnic backgrounds, aged 45-85 years with available information on the presence or absence of self-reported preva …

Long-term cognitive impairment following single mild traumatic brain injury with loss of consciousness: Findings from the Canadian Longitudinal Study on Aging.

Objective: We examined the extent to which loss of consciousness (LOC) following mild traumatic brain injury (mTBI) may be associated with impairments in executive functions and declarative memory more than a year after brain injury.Method: Analyses were run on 548 participants who had self-reported LOC of <1 min, 441 with LOC of 1-20 min, and 13,609 no brain injury comparison participants, taken from the Canadian Longitudinal Study on Aging (CLSA), a nationwide study on health and aging.Results: Those that had mTBI with LOC of 1-20 min were more likely than no head injury comparisons to be im…

The association of pre-COVID-19 social isolation and functional social support with loneliness during COVID-19: a longitudinal analysis of the Canadian Longitudinal Study on Aging.

OBJECTIVES: We evaluated the association between two measures of social connection prior to COVID-19-social isolation and functional social support-and loneliness during the pandemic. METHOD: The study was a retrospective longitudinal analysis of 20,129 middle-aged and older adults enrolled in the Canadian Longitudinal Study on Aging (CLSA). We drew upon two waves of CLSA data spanning three years and the supplemental COVID-19 Questionnaire Study of eight months to conduct our analysis. RESULTS: Social isolation prior to COVID-19 was associated with loneliness during COVID-19 only among pers…

Prevalence and risk factors for refractory and untreated chronic cough in the Canadian Longitudinal Study of Aging.

BACKGROUND: Chronic cough, defined as a persistent cough lasting >8 weeks, affects 16% of Canadian adults in the community. Chronic cough can be classified as refractory chronic cough when cough persists despite treatment of any identifiable underlying condition. The prevalence of refractory chronic cough is unclear, as is the number of patients who remain untreated despite having a persistent cough. METHODS: This prospective cohort study included 26 606 adults of 45-85 years old from the Canadian Longitudinal Study of Aging (CLSA) with available chronic cough data at baseline and first follo

Prevalence, Incidence, and Predictors of Self-reported Swallowing Difficulties in Community-Dwelling Adults: A Population-Based Study from the Canadian Longitudinal Study on Aging (CLSA).

There is a paucity of evidence from population-based studies identifying prevalence and incidence of dysphagia, as well as health and sociodemographic risk factors that may contribute to its development. As such, the current study aimed to determine prevalence, incidence, and associated predictors of dysphagia in adults. The Canadian Longitudinal Study on Aging is a nationally representative population study that follows 51,338 Canadians over 45 years of age. Biological, medical, psychological, social, lifestyle and economic data are collected. A secondary analysis of the data was conducted to…

Association of Novel Loci With Keratoconus Susceptibility in a Multitrait Genome-Wide Association Study of the UK Biobank Database and Canadian Longitudinal Study on Aging.

IMPORTANCE: Keratoconus can be a debilitating corneal ectasia in which the cornea thins, bulges, and steepens into a conical shape. Early fe … S: This multitrait GWAS used European ancestry CRF data from UK Biobank (UKB) (n = 105 427) and the Canadian Longitudinal Study on Aging (CLSA) (n = 18 307) and European ancestry CCT data from the International Glaucoma Genetics Consortium (IGGC) (n = 17 803). The CRF and CCT variants in published keratoconus data sets (4669 cases and 116 547 controls) were compared. The data set fro …

Mobility screening for fall prediction in the Canadian Longitudinal Study on Aging (CLSA): implications for fall prevention in the decade of healthy ageing.

BACKGROUND: Guidelines for fall prevention in older adults recommend mobility screening for fall risk assessment; however, there is no consensus on which test to use and at what cutoff. This study aimed to determine the accuracy and optimal cut-off values of commonly used mobility tests for predicting falls in the Canadian Longitudinal Study on Aging (CLSA). METHODS: Mobility tests at baseline included the Timed Up and Go (TUG), Single Leg Stance (SLS), chair-rise and gait speed. Inclusion criteria were: age ≥ 65 years and meeting first-level fall screening criteria (i.e. history of a fall or…

Prevalence of adverse childhood experiences among individuals aged 45 to 85 years: a cross-sectional analysis of the Canadian Longitudinal Study on Aging.

BACKGROUND: Population-level prevalence estimates for a broad range of adverse childhood experiences (ACEs), which are known to affect health across the lifespan, are currently unavailable in Canada. The purpose of this study was to estimate the prevalence of individual ACEs by sociodemographic factors among middle-aged and older adults. METHODS: Data for this cross-sectional analysis were obtained from the first follow-up (2015-2018) of the Canadian Longitudinal Study on Aging (baseline recruitment from 2011 to 2015). Participants included individuals aged 45-85 years and residing in the com…

The Association Between Self-Reported and Performance-Based Physical Function With Activities of Daily Living Disability in the Canadian Longitudinal Study on Aging.

BACKGROUND: Physical function limitations precede disability and are a target to prevent or delay disability in aging adults. The objective of this article was to assess the relationship between self-report and performance-based measures of physical function with disability. METHODS: Baseline data (2012-2015) from the Canadian Longitudinal Study on Aging (n = 51,338) was used. Disability was defined as having a limitation for at least one of 14 activities of daily living. Physical function was measured using 14 questions across three domains (upper body, lower body, and dexterity) and five pe…

Response to the correspondence regarding "Association between anticholinergic and sedative medications and physical functioning: data from the Canadian Longitudinal Study on Aging (CLSA)".

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Associations of Adverse Childhood Experiences with Frailty in Older Adults: A Cross-Sectional Analysis of Data from the Canadian Longitudinal Study on Aging.

INTRODUCTION: Frailty in older adults, characterized by a decline in multiple physiological systems and increasing vulnerability to loss of … sectional analysis of data for a population-based sample of 27,748 adults aged 45-85 years from the Canadian Longitudinal Study on Aging. The frailty index (FI) was computed with 76 health-related characteristics of physical and cognitive performance, self-rated health, chronic conditions, visual and hearing ability, activities of daily living, and well-being. Self-reported exposure …

Depressive Symptoms and Physical Activity Mediate the Adverse Effect of Pain on Functional Dependence in Patients With Arthritis: Evidence From the Canadian Longitudinal Study on Aging.

IMPORTANCE: Arthritis is a chronic condition affecting hundreds of millions of people worldwide, often leading to pain and functional limitations. OBJECTIVE: This study aimed to investigate the direct and indirect effects of pain on functional dependence in individuals with arthritis. Depressive symptoms and physical activity were examined as potential mediators of this relationship. DESIGN: This study was a longitudinal cohort study. SETTING: The study setting included community-dwelling adults participating in the Canadian Longitudinal Study on Aging. PARTICIPANTS: This study sample cons…