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When selecting an HLA mismatched stem cell donor consider donor immune status.

Until now, hematopoietic stem cell (HSC) donor selection has been almost exclusively based on selecting a (near) HLA identical donor but many patients fail to find a suitable donor. However all donors have been exposed during fetal life and by breastfeeding to microchimeric maternal cells and molecules, which may induce long lasting T regulator cells. Likewise fetal cells invade the maternal circulation and one-third of the mothers are immunized to the paternal antigens of the child, while part of the mothers become tolerant to them. By taking the alloimmune status of the HSC donor into accoun…

Donor selection for patients with HLA-homozygous haplotypes in allogeneic hematopoietic stem cell transplantation.

HighlightsRegistry analysis of first allogeneic transplant in HLA-homozygous recipients.Overall survival did not significantly differ with related donor hetero-to-homo or cord blood hetero-to-homo transplantation.Cord blood homo-to-homo transplantation was associated with inferior survival in the primary analysis.

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… However, donor selection remains unclear when no suitable related donor is available. … Kanda J, Fuji S, Kato S et al (2014) Decision analysis for donor selection in stem cell transplantation-HLA-8/8 allele-matched unrelated donor vs HLA-1 AG mismatched related donor. Blood Cancer J 4:e263 3. …

Impact of germline predisposition genes to hematologic malignancies on transplant outcomes and donor selection.

INTRODUCTION: Germline predisposition gene mutations may influence outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT). METHODS: This retrospective study of 558 patients undergoing HSCT (allo-HSCT in 557 cases, auto-HSCT in 1 case) evaluated the impact of germline predisposition gene mutations on outcomes. RESULTS: Enrichment of HAVCR2 mutations in B-NHL and UNC13D mutations in MDS was associated with poorer prognosis. While homozygous mutation carriers (7.5%) overall did not have reduced survival, their outcomes were significantly better with unrelated versus rela

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… Insufficient data were available to demonstrate a significant impact of donor selection or HAVCR2 donor genotype on prognosis ( Supplementary Figures 2B, C ). … For patients harboring high-risk mutations, such as homozygous IEI-related variants or IACHI-associated mutations, appropriate donor selection may contribute to improved prognosis. …

Predicting Donor Selection and Multi-Organ Transplantation within Organ Procurement Organizations Using Machine Learning.

Organ procurement organizations (OPOs) play a crucial role in the field of organ transplantation, serving as key intermediaries in the process of organ donation. However, despite their vital function, there exists a pressing issue of transparency within the organ allocation process. This opacity not only impedes the overall effectiveness of OPOs but also raises ethical and societal concerns regarding organ distribution. This study utilizes the recently published ORCHID dataset, containing 133,101 records of organ donor referrals, to understand organ procurement and donor selection strategies i…

Consideration of noninherited maternal Ags as permissible HLA mismatches in cord blood donor selection.

In cord blood (CB) transplantation, virtual 6/6 HLA matches, whereby the donor-recipient mismatch is identical to the CB noninherited matern … B with defined NIMA and yielded comparable increases. Considering NIMA as permissible mismatches in donor selection therefore increased the availability of a 6/6 match in this cohort.

Hepatitis-associated with markers in the American Red Cross volunteer blood donor population. III. Influence of donor selection practice upon HBsAg prevalence.

The American Red Cross collects blood from a number of defined subsets of the donor population and teh proportion of blood collected from each subset varies widely from center to center. A large part of the variation in prevalence of HBsAg may be related to variations in the proportion of blood collected from plants and factories, military units and schools or colleges. We have derived a regression equation, significant at the p less than 0.001 level, which links HBsAg prevalence with these collection parameters. Using this equation, we were able to predict the prevelance of HBsAg among first-

Application of Raman Spectroscopy for Selecting Seminal Plasma Donors.

The composition of seminal plasma from men with varying ejaculate parameters was analyzed using Raman spectroscopy. Distinct differences wer … e use of Raman spectral signatures for the selection of seminal plasma donors and the refinement of donor selection criteria.

Evidence-based selection criteria to protect blood donors.

A safe and adequate blood supply depends on healthy, volunteer blood donors. Blood centers have instituted various screening procedures in an effort to determine that donors are free of diseases that can be transmitted to patients by blood transfusion and are able to tolerate the collection procedure without experiencing significant complications. This review focuses on selection criteria intended to minimize the risk to the blood donor. Defining a rational, evidence-based approach to donor selection is crucial not only to take reasonable precautions to protect the donors' health but also to e…

[Conditions of selection and matching of bone marrow donors for transplantation].

Number of bone marrow transplantations increases rapidly during last years. Our work presents the immunogenetics and organisation rules of unrelated bone marrow donor selection for Polish patients. Actual possibilities of the transplantation of matched unrelated bone marrow donor in Poland are also presented.

Selection criteria for the evaluation of living related renal donors.

The documented long-term health of the living related renal donor is a tribute to careful preoperative selection and surgical technique. At … hrectomy. The minimal morbidity sustained by these patients re-emphasizes the importance of careful donor selection.

Prevalence of Babesia antibody in a selected blood donor population.

Human babesiosis, a parasitic disease transmitted by the tick, Ixodes dammini, was confined previously to limited areas of the northeastern United States. It is a rare but potentially life-threatening complication of transfusion. Red cells and platelets prepared from asymptomatic donors have been implicated in transfusion-transmitted cases. More cases of babesiosis are being reported as the range of the vector expands in the United States. Blood donors from an endemic area were tested for antibody to Babesia microti during the summer. Only 3.7 percent of the 779 donors were seropositive, compa

Use of in vitro assays in selection of compatible platelet donors.

Although HLA-matched platelet transfusions are of value in the support of some alloimmunized thrombocytopenic patients, poor posttransfusion increments can be observed following HLA-matched platelet transfusions and conversely good posttransfusion increments may result after HLA-mismatched platelet transfusions. We have explored the possibility that in vitro assays in addition to HLA typing might better select compatible donors for refractory recipients. Our studies suggested that a platelet migration inhibition assay is predictive of platelet transfusion responses in HLA-compatible and incomp

Measured GFR in Donor Selection, to Do or Not to Do? That is the Question.

INTRODUCTION: The accurate assessment of the pre-donation glomerular filtration rate (GFR) is a crucial step in donor selection. We conducted a prospective cross-sectional study to identify the best equation to estimate GFR and the necessity of a radio-nuclear scan in GFR evaluation. METHODS: In this study, 154 potential donors were enrolled, and GFR equations (the MDRD study, the CKD-EPI study, and the full age spectrum [FAS]), and creatinine clearance were compared with measured GFR (mGFR) by the radio-nuclear method. RESULTS: The study results indicate that Potential donors had an mGFR of…

[Selection of live donors for segmental liver transplantation in children].

OBJECTIVE: To analyse selection criteria and complications in living related donors of liver segments with a view to introducing standardised guidelines for the selection of such donors. PATIENTS AND METHODS: Forty-two mothers and 31 fathers (median age 31 [19-50] years) were tested between October 1991 and July 1994 for their suitability as donors of a liver segment. RESULTS: 24 of the potential donors (33%) were found not to be suitable. Reasons for this were: poor immunological match of the donor liver as transplant (13), risk factors for thromboembolism (5), and psychological or socioeco

Selective Recruitment of Large Lower Lobe Atelectasis on Donor Back Table in Rejected Donor Lungs.

BACKGROUND: Large atelectatic areas in donor lungs are frequently resistant to standard recruitment maneuvers, producing a tenaciously low PO2/FiO2 ratio. The aim of this study is to investigate the optimal protocol for the recruitment of large atelectatic areas in the context of ex vivo lung perfusion (EVLP). METHODS: Seventeen rejected lungs with large lower lobe atelectasis (≥40%) were divided into 2 groups: manual resuscitation (n = 5) and selective recruitment (n = 12). Transplant suitability was then evaluated in cellular EVLP. In the manual resuscitation group, following bronchoscopy,

Molecular tetrominoes: selective masking of the donor π-face to control the configuration of donor-acceptor complexes.

Understanding the doping mechanism in organic semiconductors and generating molecular design rules to control the doping process are crucial for improving the performance of organic electronics. Even though controlling the location and orientation of the dopant along the semiconductor backbone is an important step in the doping mechanism, studies in this direction are scarce as it is a challenging task. To address this, herein, we incorporated π-face masked (strapped) units in 1,4-bis(phenylethynylene)benzene (donor) to control the acceptor (dopant) location along the trimer, donor-acceptor bi

Selection and Short-Term Outcomes of Living Kidney Donors in Singapore - An Analysis of the Donor Care Registry.

INTRODUCTION: Transplant rates in Singapore have been falling and there is limited information on baseline characteristics and clinical outc … -nephrectomy eGFR of less than 60 mL/kg/1.73 m2. CONCLUSION: Kidney donation is safe in Singapore. Donor selection is in keeping with international guidelines and short-term outcomes are comparable to other cohorts.