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Possibilities of Using Medicinal Plant Extracts and Salt-Containing Raw Materials from the Aral Region for Cosmetic Purposes.

The aim of this work was to study the possibility of using medicinal plants in combination with salt-containing raw materials from the Aral … temisia cipa O. Vegd., Thymus vulgaris L., Morus alba L., Salvia pratensis L., Glycyrhizaglabra L., Tanacetum vulgare L., Polygonumaviculare L., Alhagipseudoalhagi Gagnebin and Peganumharmala L., chosen on the basis of their herbal components for future cosmetic products, was determined. In total, 187 different volatile compounds were found in the endemic p …

Parthenolide alleviates peritoneal fibrosis by inhibiting inflammation via the NF-κB/ TGF-β/Smad signaling axis.

Peritoneal fibrosis is a common complication of peritoneal dialysis (PD) with a complicated pathogenesis and limited treatments. Parthenolide (PTL), a recognized nuclear factor-κB (NF-κB) inhibitor extracted from Tanacetum balsamita, has been widely used to treat various inflammatory diseases and has been proven to improve peritoneal fibrosis in PD mice by selectively inhibiting the phosphorylation of Smad2/3. Transforming growth factor-β1 (TGF-β1), via Smad-dependent signaling, has a pivotal role in promoting pathogenic of fibrosis. To investigate whether PTL can inhibit peritoneal fibrosis, …

Bioinformatics-Guided Discovery of miRNAs Involved in Apoptosis Modulated by Parthenolide Combined with Vincristine in The NALM6 Cell Line.

ObjectiveAcute lymphoblastic leukemia (ALL) is a highly heterogeneous leukemia. Despite the current improvement in conventional chemotherapy and high survival rates, the outcomes remain challenging. Sesquiterpen extracted from the Tanacetum parthenium, parthenolide, is a potential anticancer agent that can modulate the expression of miRNAs and induce apoptosis. The objective of this study was to investigate the effect of parthenolide in combination with vincristine and alone on the apoptosis rate and expression of miR-125b-5p, miR-181b-5p, and miR-17-5p in the NALM6 cell line.Materials and met…

Immunological response to Parthenium hysterophorus in Indian Patients with Parthenium sensitive atopic dermatitis.

Parthenium hysterophorus is the leading cause of airborne contact dermatitis, a type IV hypersensitivity reaction in India. Though there are reports of it causing type-I hypersensitivity in atopic individuals in the form of allergic rhinitis and asthma, there is very little information on its role in pathogenesis of atopic dermatitis (AD), another predominately type I hypersensitivity. In the present study, we evaluated the presence of immediate hypersensitivity to P. hysterophorus in patients with AD and evaluated the in vitro immunological response of P. hysterophorus SPT positive AD patient

In vitro anti-inflammatory properties of twelve Norwegian medicinal plants.

ETHNOPHARMACOLOGICAL RELEVANCE: Today, inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease represent a major h … igh bioactivity, namely Matricaria discoidea, Alnus incana, Geranium sylvaticum, Antennaria dioica, Tanacetum vulgare and Malva moschata. A stronger effect was observed among the dichloromethane extracts in NO and TNF-α inhibition, while the 80 % ethanol extracts showed greater protection of the barrier integrity. M. discoidea, A. incana and G. sylvaticum a …

A reproductive screening test of feverfew: is a full reproductive study warranted?

Feverfew is currently used in the treatment of migraine and arthritis. It is traditionally contraindicated in pregnancy but there are no studies confirming this warning. An in vivo and in vitro preliminary screen was performed using a rat model: five female rats were orally dosed with 839 mg/kg feverfew daily on either gestation days (GD) 1-8 or 8-15. On GD20, rats were sacrificed and fetuses, placentae and ovaries were collected. The fetuses were weighed and examined for malformations. While maternal weight gain appeared to be reduced, ANCOVA analysis suggested that the difference was due to

[Compositae dermatitis].

INTRODUCTION: Compositae dermatitis is an allergic contact dermatitis caused by plant species of the Compositae family. The first report of … dive Cichorium endivia (20-30%), and wild-growing feverfew--Tanace--tum parthenium (70-90%), tansy--Tanacetum vulgare (54%), and dandelion--Taraxacum officinale (65%). Sesquiterpene lactones are the main sensitizers of the Compositae family. Other components, thiophenes and acetylenes are said to elicit only phytophotodermatitis, but recent studies have dem …

A metabolomics approach reveals metabolic disturbance of human cholangiocarcinoma cells after parthenolide treatment.

ETHNOPHARMACOLOGICAL RELEVANCE: Tanacetum parthenium (L.) Schultz-Bip, commonly known as feverfew, has been traditionally used to treat fever, migraines, rheumatoid arthritis, and cancer. Parthenolide (PTL), the main bioactive ingredient isolated from the shoots of feverfew, is a sesquiterpene lactone with anti-inflammatory and antitumor properties. Previous studies showed that PTL exerts anticancer activity in various cancers, including hepatoma, cholangiocarcinoma, acute myeloid leukemia, breast, prostate, and colorectal cancer. However, the metabolic mechanism underlying the anticancer effe…

Fractional composition of Cd, Pb, and Zn in medicinal plants at the impact territories of a coal-fired power station.

Industrial emissions are a major source of heavy metal (HM) contamination, posing risks to medicinal plants collected for therapeutic use. A … chamomilla L., Plantago major L., Chelidonium majus L., Urtica dioica L., Taraxacum officinale, and Tanacetum vulgare L. were analyzed for metal fractionation using a stepwise extraction scheme to differentiate between bioavailable and strongly bound metal forms: (I) water-soluble, (II) aqueous-alcoholic, (III) hydrochloric acid, (IV) acid-soluble, and (V) …

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… Parthenolide Parthenolide is an important naturally occurring metabolite in the Asterceae family of medicinal plants [ 198 ], especially in Tanacetum parthenium (feverfew) [ 199 ]; however, it can be found in other species, including Tanacetum vulgare (tansy) and Tanacetum larvatum [ 200 ]. … Additionally, studies revealed that the content of parthenolide in different parts of Tanacetum parthenium decreased during 18 months of storage [ 210 ]. …

Biosynthesis of anticancer phytochemical compounds and their chemistry.

Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, and metastatic malignancies have increased. Plant-derived phytochemical compounds target different oncogenes, tumor suppressor genes, protein channels, immune cells, protein channels, and pumps, which have attracted much attention for treating cancer in preclinical studies. Despite the anticancer capabilities of these phytochemical compounds, systemic toxicity, medication resistance, and limited absorption re

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… Diindoylmenthane | Cauliflower, Cabbage, Mustard, Radish, Broccol, Brussels sprouts | Phase II clinical trial for prostate cancer | • Activation Nrf2 signaling pathway | Wang et al. (2022) • Suppresses TGF-ß, Smad2/Smad3 signaling, and Ap-1 transcription factor 5 | Parthenolide and its analogs | Leaves of Tanacetum … Parthenolide and its analogs Parthenolide is found in aerial parts, mainly in leaves of Tanacetum parthenium and Chrysanthemum parthenium . …

Is Camphor the Future in Supporting Therapy for Skin Infections?

The aim of this review is to present the potential application of camphor-a bicyclic monoterpene ketone-in the prevention of skin infections. Skin diseases represent a heterogeneous group of disorders characterized by prolonged symptoms that significantly diminish the quality of life. They affect the dermis, the epidermis, and even subcutaneous tissue. They very often have a bacterial or fungal background. Therapy for dermatological skin disorders is difficult and long-term. Therefore, it is important to find a compound, preferably of natural origin, that (i) prevents the initiation of this in

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… Antibacterial Efficiency of Tanacetum Vulgare Essential Oil against ESKAPE Pathogens and Synergisms with Antibiotics. Antibiotics. 2023;12:1635. doi: 10.3390/antibiotics12111635. 30. … Chemical Composition and Antimicrobial Activity of Feverfew (Tanacetum parthenium) Essential Oil. Int. J. Agric. Biol. 2010;12:759–763. 64. Zouari N., Ayadi I., Fakhfakh N., Rebai A., Zouari S. …

Parthenolide: pioneering new frontiers in hematological malignancies.

Hematological malignancies are the fifth most prevalent cancer category in developed countries, presenting significant treatment challenges. The side effects of chemotherapy and its non-selective nature have led researchers to explore combination therapies to enhance efficacy and improve patient outcomes. Parthenolide (PTL) emerges as a promising candidate, being the first small molecule identified for its selective action against leukemic stem cells. This article provides an overview of PTL's effects and its potential as a complementary treatment for hematological malignancies. A systematic s

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… Parthenolide is a sesquiterpene lactone extracted from the leaves of the medicinal herb Tanacetum parthenium. … Widespread pain reliever profile of a flower extract of Tanacetum parthenium . Phytomedicine 22 ( 7-8 ), 752 – 758 . 10.1016/j.phymed.2015.05.006 26141762 Marin G. H. Mansilla E. ( 2006 ). Parthenolide has apoptotic and cytotoxic selective effect on B-chronic lymphocytic leukemia cells . J. Appl. …

Synergy between parthenolide and arsenic trioxide in adult T-cell leukemia/lymphoma cells in vitro.

ObjectivesAdult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoid malignancy with low survival rate and distinct geographical distribution. In search for novel chemotherapeutics against ATLL, we investigated the combinatorial effects of parthenolide, a sesquiterpene lactone with valuable pharmaceutical activities, and arsenic trioxide (ATO) in vitro.Materials and methodsMT2 cells, an ATLL cell line, were treated with increasing concentrations of parthenolide (1.25, 2.5, and 5 μg/ml) and ATO (2, 4, 8, and 16 µM) to determine their IC50. Then, cells were treated with a combination of sub

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… Parthenolide, first isolated from medicinal plant Tanacetum parthenium, is a sesquiterpene lactone of the germacranolide class with a wide range of pharmaceutical activities such as anti-inflammatory and anti-cancer effects ( 8 , 9 ). …

Nature-Inspired Strategies in Cancer Management: The Potential of Plant Extracts in Modulating Tumour Biology.

Cancer is a serious group of diseases that is a huge problem on a global scale and is the second most common cause of death. Commonly used therapies do not always lead to the complete elimination of diseased cells or tissues and are also burdened with side effects that reduce the quality of life of patients. Due to these difficulties, new therapeutic approaches are still being sought. In recent years, there has been a return to interest in natural methods of treating various diseases, among which phytochemicals are particularly interesting. This article reviews plant extracts with anticancer p

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… A sesquiterpene lactone obtained from Tanacetum parthenium inhibits the growth of non-small cell lung cancer (NSCLC) cells by suppressing the B-Raf/MAPK/ERK pathway. Parthenolide suppresses non-small cell lung cancer GLC-82 cell growth via the B-Raf/MAPK/Erk pathway [ 74 ]. … cordifolia | Indian Madder | Reducing the side effects: inhibitory effect on kidney damage caused by cisplatin | [ 112 ] Rumex hydrolapathum | Water Dock | Antiangiogenic: angiogenesis inhibition—affecting the level of angiogenic/angiostatic mediators: PDGF, HGF, IL-8, IL-6, TIMP-1, and MMP-9 | [ 90 ] Tanacetum …

Application of High Throughput Technologies in the Development of Acute Myeloid Leukemia Therapy: Challenges and Progress.

Acute myeloid leukemia (AML) is a complex hematological malignancy characterized by extensive heterogeneity in genetics, response to therapy and long-term outcomes, making it a prototype example of development for personalized medicine. Given the accessibility to hematologic malignancy patient samples and recent advances in high-throughput technologies, large amounts of biological data that are clinically relevant for diagnosis, risk stratification and targeted drug development have been generated. Recent studies highlight the potential of implementing genomic-based and phenotypic-based screen

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… Focusing on a library of natural products, Sweeney et al. identified a synergistic combination of dimethylaminoparthenolide, a sesquiterpene lactone extracted from Tanacetum parthenium , and shikonin, a naphthoquinone found in the root of Lithospermum erythrorhizon , in pediatric precursor-B cell acute …

Comprehensive Review of Cyclamen: Development, Bioactive Properties, and Therapeutic Applications.

Plants are being researched as potential sources of novel drugs, which has led to a recent acceleration in the discovery of new bioactive compounds. Research on tissue culture technology for the synthesis and processing of plant compounds has skyrocketed, surpassing all expectations. These plants can be bought either raw or as extracts, where some of the chemicals are extracted by mashing the plant in water, alcohol, or another solvent. The use of herbal medicine may open new chances for reducing the onset of infections and treating different diseases including cancer. A perennial plant that b

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… Antioxidant Constituents in Feverfew (Tanacetum parthenium) Extract and Their Chromatographic Quantification. Food Chem. 2006;96:220–227. doi: 10.1016/j.foodchem.2005.02.024. 60. Turan M., Mammadov R. …

Plants as a Source of Anticancer Agents: From Bench to Bedside.

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in

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… It is extracted from leaves of the medicinal plant feverfew ( Tanacetum parthenium ) [ 299 , 300 ]. Basically, PTL contains an α-methylene-γ-lactone ring and epoxide group, which contribute to its ability to interact with nucleophilic sites of biological molecules [ 298 , 299 , 300 ]. …

Towards Drug Repurposing in Cancer Cachexia: Potential Targets and Candidates.

As a multifactorial and multiorgan syndrome, cancer cachexia is associated with decreased tolerance to antitumor treatments and increased morbidity and mortality rates. The current approaches for the treatment of this syndrome are not always effective and well established. Drug repurposing or repositioning consists of the investigation of pharmacological components that are already available or in clinical trials for certain diseases and explores if they can be used for new indications. Its advantages comparing to de novo drugs development are the reduced amount of time spent and costs. In thi

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… Parthenolide Parthenolide is a sesquiterpene lactone present in the flowers and leaves of the plant feverfew ( Tanacetum parthenium L.). Parthenolide has been used in clinical trials for the diagnostic of Allergic Contact Dermatitis [ 69 ]. …

Acquired platelet disorders.

Platelets are essential to primary hemostasis, and defects in their number or function can lead to clinically significant bleeding or thrombosis. Acquired platelet disorders are far more common than the inherited forms and arise in a wide range of settings, including drug exposure, autoimmune, systemic, and critical illnesses. This review examines current understanding of the mechanisms driving acquired platelet dysfunction and outlines the diagnostic and therapeutic approaches that are shaping contemporary standards of care. Drug-related and immune-mediated platelet defects remain the most re

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… Green tea ¶ | Reduced platelet aggregation ( 13 , 141 ) Cinnamomum cassia | Reduced platelet aggregation ( 142 ) ‡ Dong Quai (Angelica sinensis) | Contains coumarin derivatives that reduce rate of platelet aggregation, thrombin-induced platelet activation, and TXB 2 * production ( 143 ) Feverfew ( Tanacetum …