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Insight into the number of pre-malignancies and malignancies of the skin in a hospital population in the Netherlands.

BACKGROUND: Skin cancer incidence is rising, placing a burden on healthcare systems worldwide. This problem may even be more extensive than expected, since registration of (pre)malignancies of the skin is poor. OBJECTIVE: To provide insight into the numbers of (pre)malignancies in patients with actinic keratosis (AK) or basal cell carcinoma (BCC) in 2 university and 2 general hospitals. METHODS: The types and numbers of previous tumours and of tumours during a two-year follow-up were collected from 574 patients. RESULTS: Mean time between the first diagnosed (pre)malignancy and time of incl

Pregnancy outcomes in women with heart disease: Experience of a tertiary center in the Netherlands.

OBJECTIVES: Clinical data of pregnant women with heart disease were obtained with the intention to provide input for local counseling and management guidelines. STUDY DESIGN: Retrospective data from all pregnant women with congenital or acquired heart disease between 2000 and 2011 in the VU University Medical Centre Amsterdam. MAIN OUTCOME MEASURES: Maternal and neonatal outcomes were evaluated. RESULTS: Data of 122 women with 160 pregnancies were obtained. The most common heart diseases were congenital heart disease (n=65, 53.3%) and arrhythmia (n = 20, 16.4%). Based on the functional crit

Exploring the trend of increased cervical intraepithelial neoplasia detection rates in the Netherlands.

OBJECTIVE: Over the last decade, cervical intraepithelial neoplasia (CIN) detection has increased in the Netherlands. We investigated the underlying mechanism by quantifying the increase, and analyzing patterns of CIN and cervical cancer detection over time. METHODS: We observed annual CIN and cervical cancer detection rates (DRs) per 10,000 primary smears within the Dutch screening programme for 2000-2011. Joinpoint analyses were performed to determine changes in time trends, logistic regression analyses to assess the relative risk of calendar time on histological outcomes, adjusted for demo…

Overdiagnosis by mammographic screening for breast cancer studied in birth cohorts in The Netherlands.

A drawback of early detection of breast cancer through mammographic screening is the diagnosis of breast cancers that would never have becom … screening. Data on the female population and breast cancer incidence were obtained from Statistics Netherlands, "Stichting Medische registratie" and the Dutch Cancer Registry for women aged 0-99 years. Data on screening participation was obtained from the five regional screening organizations. Overdiagnosis was calculated from the excess breast cancer incide …

Need for Optimisation of Immunisation Strategies Targeting Invasive Meningococcal Disease in the Netherlands.

Invasive meningococcal disease (IMD) is a severe bacterial infectious disease with high mortality and morbidity rates worldwide. In recent years, industrialised countries have implemented vaccines targeting IMD in their National Immunisation Programmes (NIPs). In 2002, the Netherlands successfully implemented a single dose of meningococcal serogroup C conjugate vaccine at the age of 14 months and performed a single catch-up for children ≤18 years of age. Since then the disease disappeared in vaccinated individuals. Furthermore, herd protection was induced, leading to a significant IMD reductio…

Determinants of plasma 25-hydroxyvitamin D levels in healthy adults in the Netherlands.

BACKGROUND: Vitamin D plays a key role in maintaining skeletal health, but is also related to various non-skeletal health issues. Several de … with 25(OH)D in a group of 539 adults, who were healthy control subjects in the NESDA study in the Netherlands (latitude 52 °N). RESULTS: Mean 25(OH)D levels were 68.0 (± 27.2) nmol/l. Levels under 50 nmol/l occurred in 27% of the population; 40% reached levels above 75 nmol/l. Women had higher levels than men, and the use of oral contraceptives showed a si …

Injuries in professional male soccer players in the Netherlands: a prospective cohort study.

CONTEXT: Injuries are a major adverse event in a soccer player's career. Reducing injury incidence requires a thorough knowledge of the epidemiology of soccer injuries. OBJECTIVE: To investigate the incidence and characteristics of injuries in the Dutch premier soccer league. DESIGN: Cohort study. SETTING: The Dutch premier soccer league. PATIENTS OR OTHER PARTICIPANTS: During the 2009-2010 soccer season, a total of 217 professional soccer players from 8 teams were prospectively followed. MAIN OUTCOME MEASURE(S): The medical staff recorded time-loss injuries, including information on inju

Umbilical cord prolapse in primary midwifery care in the Netherlands; a case series.

We aimed to gain insight into umbilical cord prolapse (UCP) reported by primary care midwives in the Netherlands. Cases of UCP were reported by midwives who participated in a postgraduate training programme developed for community-based midwives. Cases were analysed using midwifery charts, ambulance report forms and discharge letters. Procedures to alleviate cord pressure, ambulance timing, mode of birth and neonatal outcomes were inventoried. Diagnosis to delivery interval (DDI) and risk factors were identified. Eight cases of UCP in primary midwifery care were reported of which six occurred …

Vaccination coverage for measles, mumps and rubella in anthroposophical schools in Gelderland, The Netherlands.

BACKGROUND: Social clustering of unvaccinated children in anthroposophical schools occurs, as inferred from various measles outbreaks that can be traced to these schools. However, accurate vaccination coverage data of anthroposophical schools are not widely available. METHODS: In 2012, we performed a survey to estimate the vaccination coverage in three different grades of 11 anthroposophical schools in Gelderland, The Netherlands. We also gauged the opinion on childhood vaccination of the parents and compared these with the results of a national survey. In 2014, we were also able to obtain th…

В Нидерландах подозревается в болезни вицертропика, связанной с желтой лихорадкой.

Желтая лихорадка (YF) 17D вакцина является одной из самых успешных вакцин, когда-либо разработанных. С 2001 года в рецензируемой литературе было опубликовано 56 случаев заболевания вицертропиком желтой лихорадки (YEL-AVD). В этой связи мы сообщаем о новом деле, подозреваемом в совершении преступления ЙЕЛ-АВД в Нидерландах. Необходимо провести дополнительные исследования для определения реальной распространенности ЕИЖ-АВД и уточнения факторов, связанных с носителями и вакцинами, в патогенезе ЙЕЛ-АВД. В связи с возможными неблагоприятными явлениями медицинские работники должны тщательно рассматр

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Yellow fever (YF) 17D vaccine is one of the most successful vaccines ever developed. Since 2001, 56 cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) have been published in the peer-reviewed literature. Here, we report a new case suspected for YEL-AVD in the Netherlands. Further research is needed to determine the true incidence of YEL…

Coxiella burnetii seroprevalence and risk factors on commercial sheep farms in The Netherlands.

Coxiella burnetii seroprevalence was assessed on Dutch dairy and non-dairy sheep farms using ELISA. Risk factors for seropositivity on non-dairy sheep farms were identified at farm and sheep level by univariate and multivariate multilevel analyses. Based on 953 dairy and 5671 non-dairy serum samples, sheep seroprevalences were 18.7 per cent and 2.0 per cent, respectively, and 78.6 per cent and 30.5 per cent at farm level. Significant risk factors for non-dairy sheep farms were farm location in the south of the country, sheep kept on marginal grounds, one or several supply addresses for ewes du

Cost-of-illness and disease burden of food-related pathogens in the Netherlands, 2011.

To inform risk management decisions on control and prevention of food-related disease, both the disease burden expressed in Disability Adjusted Life Years (DALY) and the cost-of-illness of food-related pathogens are estimated and presented. Disease burden of fourteen pathogens that can be transmitted by food, the environment, animals and humans was previously estimated by Havelaar et al. (2012). In this paper we complement these by cost-of-illness estimates. Together, these present a complete picture of the societal burden of food-related diseases. Using incidence estimates for 2011, community

Imported Armillifer pentastomiasis: report of a symptomatic infection in The Netherlands and mini-review.

We report a case of symptomatic visceral Armillifer pentastomiasis in a 23-year-old female Liberian immigrant to The Netherlands. The patient was referred to the gynecologist because of lower abdominal pain. During laparotomy, multiple adhesions were seen in the lower pelvis and a hydrosalpinx with an encapsulated Armillifer nymph, most likely Armillifer armillatus, was found. Key features of the parasite's cuticle which facilitate the diagnosis of pentastomiasis, are presented. Symptomatic pentastomiasis is uncommon, and most cases are diagnosed incidentally during surgery for other reasons, …

The absence of zoonotic agents in invasive bullfrogs (Lithobates catesbeianus) in Belgium and The Netherlands.

Exotic invasive bullfrogs (Lithobates catesbeianus) are considered to exert a considerable negative impact on native amphibian communities. … eta-lactamase producing Escherichia coli in 164 bullfrogs from three populations in Belgium and The Netherlands. Although B. dendrobatidis was present at a high prevalence of 63%, mean infection loads were low with an average of 10.9 genomic equivalents (SD 35.5), confirming the role of bullfrogs as B. dendrobatidis carriers, but questioning their role as pri …

Keeping venomous snakes in the Netherlands: a harmless hobby or a public health threat?

OBJECTIVE: To describe the incidence of venomous snakebites and the hospital treatment thereof (if any) amongst private individuals who keep venomous snakes as a hobby. STRUCTURE: Descriptive study. METHOD: Private keepers of venomous snakes were invited via the social media Facebook, Hyves, Twitter, Google Plus, Linked In and two large discussion forums to fill in an online questionnaire on a purely voluntary and anonymous basis. RESULTS: In the period from 1 September 2012 to 31 December 2012, 86 questionnaires were completed by individuals who keep venomous snakes as a hobby. One-third o

Perioperative prophylactic antithrombotic strategies in vascular surgery: current practice in the Netherlands.

AIM: The aim of this study was to evaluate the current practice of the use of perioperative antithrombotic drugs to prevent arterial thrombo-embolic complications during arterial vascular surgery by Dutch vascular surgeons. Aim was also to compare the results with the literature and to evaluate the effect of guidelines. METHODS: A comprehensive questionnaire was sent to all Dutch vascular surgeons performing arterial reconstructive surgery. RESULTS: The response rate was 84%. Acetylsalicylic acid (ASA) was continued perioperatively by most surgeons (91%). Clopidogrel was discontinued by the

Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands.

INTRODUCTION: A worldwide increasing incidence is seen for oesophageal adenocarcinoma, but not for oesophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma. Purposes of the current study were to evaluate the changing incidence rates of oesophageal and gastric cardia cancer, and to assess survival trends. PATIENTS AND METHODS: Patients diagnosed with oesophageal adenocarcinoma (N=12,195) or SCC (N=9046), or gastric cardia adenocarcinoma (N=9900) between 1989 and 2008 in the Netherlands were included. Changes in European Standard Population (ESP) and relative survival over ti…

A lifetime of professional singing: Voice parameters and age in the Netherlands Radio Choir.

In professional choirs one would like to identify the incidence and severity of vocal problems due to ageing, and know how to influence them. The aim of the current study was to investigate to what extent easily obtainable voice parameters were age-related. From 47 singers of the Netherlands Radio Choir the Voice Range Profile parameters and the vibrato characteristics were measured. Dysphonia Severity Index (DSI) was calculated. We found that the age of male and female singers correlated negatively to the highest fundamental frequency and the Dysphonia Severity Index. No signs of slower and w…

Severe maternal morbidity and mortality from amniotic fluid embolism in the Netherlands.

We have assessed the incidence, symptoms and risk factors of amniotic fluid embolism in the Netherlands. Data were retrieved from two nationwide registration systems. From 1983 to 2005 the maternal mortality ratio of amniotic fluid embolism increased from 0.11 to 0.63 (odds ratio (OR) 5.8, 95% confidence interval (CI) 1.3-25.3). The most common signs and symptoms of amniotic fluid embolism were dyspnea and massive obstetric hemorrhage. In the majority of women, onset of symptoms was intrapartum or immediately postpartum. Potential risk factors of developing amniotic fluid embolism were materna…