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Exosomes for angiogenesis induction in ischemic disorders.

Ischaemic disorders are leading causes of morbidity and mortality worldwide. While the current therapeutic approaches have improved life expectancy and quality of life, they are unable to "cure" ischemic diseases and instate regeneration of damaged tissues. Exosomes are a class of extracellular vesicles with an average size of 100-150 nm, secreted by many cell types and considered a potent factor of cells for paracrine effects. Since exosomes contain multiple bioactive components such as growth factors, molecular intermediates of different intracellular pathways, microRNAs and nucleic acids, t

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… Extracellular vesicles derived from human embryonic stem cell‐MSCs ameliorate cirrhosis in thioacetamide‐induced chronic liver injury. J Cell Physiol. 2018;233:9330‐9344. 18. Moeinabadi‐Bidgoli K, Rezaee M, Rismanchi H, Mohammadi MM, Babajani A. …

Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis.

Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the presence of harmful microorganisms in blood which could cause mortality. Complications associated with sepsis involve multiple organ dysfunction. The pathogenesis of sepsis remains intricate, with limited treatment options and high mortality rates. Traditional Chinese medicine (TCM) has consistently demonstrated to have a potential on various disease management. Its complements include reduction of oxidative stress, inhibiting inflammatory pathways, regulating immune responses, and improving microcirculation. Tra

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… Nephroprotective effect of cilostazol and verapamil against thioacetamide-induced toxicity in rats may involve Nrf2/HO-1/NQO-1 signaling pathway . Toxicol. Mech. Methods 29 , 146 – 152 . 10.1080/15376516.2018.1528648 30295103 Han H. Wu W. ( 2010 ). …

Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies.

Methotrexate (MTX) is a folic acid reductase inhibitor that manages various malignancies as well as immune-mediated inflammatory chronic diseases. Despite being frequently prescribed, MTX's severe multiple toxicities can occasionally limit its therapeutic potential. Intestinal toxicity is a severe adverse effect associated with the administration of MTX, and patients are significantly burdened by MTX-provoked intestinal mucositis. However, the mechanism of such intestinal toxicity is not entirely understood, mechanistic studies demonstrated oxidative stress and inflammatory reactions as key fa

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… Previous research demonstrated that NIF inhibited NF-κB signaling in liver failure induced by thioacetamide in rats (Khodir and Said 2020 ) and acetic acid-induced ulcerative colitis (Yousra et al. 2020 ). …

Targeting fibrosis, mechanisms and cilinical trials.

Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response. Multiple organs can develop fibrosis, including the liver, kidney, heart, and lung. Fibrosis such as liver cirrhosis, idiopathic pulmonary fibrosis, and cystic fibrosis caused substantial disease burden. Persistent abnormal activation of myofibroblasts mediated by various signals, such as transforming growth factor, platelet-derived growth factor, and fibroblast growh factor, has been recongized as a major event in the occurrence and progression of fibrosi

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… Treatment with PPARα ligands attenuated liver fibrosis in rat thioacetamide models of liver cirrhosis 222 . …

Plants as a Source of Anticancer Agents: From Bench to Bedside.

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in

Piperine: From Green Extraction to Clinical Translation-A Review.

BACKGROUND: Piperine has diverse pharmacological and bioenhancing activities, but poor aqueous solubility, variable exposure, interaction liability, and discontinuity across production, formulation, and clinical evaluation limit translation. This review integrates these frequently separated stages. METHODS: A structured narrative PubMed search covered English-language studies published from 1 January 2021 to 27 April 2026, supplemented by ClinicalTrials.gov records checked through 13 June 2026, backward citation searching, and selected earlier seminal studies. Evidence was synthesized by expe

Invited Lectures : Overviews Purinergic signalling: past, present and future.

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Natural anti-cancer products: insights from herbal medicine.

Herbal medicine exhibits a broad spectrum of potent anti-cancer properties, including the enhancement of tumor immune responses, reversal of multidrug resistance, regulation of autophagy and ferroptosis, as well as anti-proliferative, pro-apoptotic, and anti-metastatic effects. This review systematically explores recent advances (primarily documented since 2019) in research on key anti-cancer compounds derived from herbal medicine, such as apigenin, artemisinin, berberine, curcumin, emodin, epigallocatechin gallate (EGCG), ginsenosides, icariin, resveratrol, silibinin, triptolide, and ursolic

Устные бесплатные бумажные сессии.

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UEG Week 2015 Poster Presentations

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… Liver cirrhosis was induced in rats by injection of thioacetamide (TAA) introperitoneally. Expressions of SSTR2, Cyclooxygenase -2 (COX-2) were assessed by western blot and real-time PCR. DNA methylation level of SSTR2 was investigated by bisulfite sequencing. …

62nd Annual Conference of the Indian Society of Gastroenterology, February 10th - 13th, 2022, Pune.

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… Moreover, peak injury was achieved by a combination of alcohol and thioacetamide-(TAA), which resulted in more severe liver damage. Fecal microbiota was assessed using 16s rRNA. Proteome linked to liver steatosis, injury and intestinal barrier integrity were evaluated by LC-MS. …

ISEV2019 Abstract Book

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Резюме ЭСП 2013.

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ISEV2018 абстрактная книга

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Abstract

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Неделя ГЭЭ 2017 Презентации на плакате

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… MONDAY, OCTOBER 30, 201709:00-17:00 LIVER AND BILIARY I - HALL 7___________ P0001 ALTERATIONS OF THE NO-CGMP PATHWAY IN THIOACETAMIDE-INDUCED LIVER FIBROSIS/CIRRHOSIS IN RATS D. Schaffner 1 , A. Lazaro 1 , I. Merfort 2 , P. Hasselblatt 1 , P. Deibert 1 , W. … Aims & Methods: The rat model of thioacetamide (TAA) was used to induce liver fibrosis/cirrhosis and alterations of the NO-cGMP pathway and subsequent liver damage were assessed. 25 male Wistar rats were studied (11 untreated controls and 14 TAA treated animals [0.03 g TAA/100 ml drinking water for 16 …

Неделя ГЭЭ 2018 Презентации на плакате

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… In vivo study, peritoneal injection of thioacetamide (TAA) was employed to induce liver cirrhosis for 16 weeks. 36 male Sprague-Dawley rats were randomly assigned to the control, TAA, and TAA+celecoxib groups. TAA-cirrhotic rats received celecoxib or its vehicle by gastric gavage for last 8 weeks. …