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Репродуктивная автономия женщин, живущих с множественной миеломой, участвующих в программе профилактики беременности.

Множественная миелома — неизлечимый гематологический рак, который в первую очередь затрагивает пожилых людей. Женщины, имеющие фертильный потенциал, составляют небольшую, но уникальную долю населения, страдающего от многочисленных миелом. Иммуноводные агенты (талидомид, линалидомид и помалидомид) являются высокоэффективными средствами лечения для улучшения длительных периодов глубокой ремиссии и долгосрочного выживания в Множестве миеломы, которые осуществляются в рамках программ контролируемого распределения, требующих наблюдения за беременностью для женщин с потенциалом деторождения, с тем ч

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… Some were not provided advance or sufficient notice about the CDP requirement to have two forms of contraception in place before initiating IMiD treatment, leaving them insufficient time to access certain options (e.g., vasectomy for partner or tubal ligation), and ultimately contributing to unnecessary … delays in treatment onset: If I had known this like six months ago, my husband probably would have just got a vasectomy. …

Deep Phenotyping the Anterior Urethral Stricture: Characterizing the Relationship Between Inflammation, Fibrosis, Patient History, and Disease Pathophysiology.

PURPOSE: Anterior urethral stricture disease (aUSD) is a complex, heterogeneous condition that is idiopathic in origin for most men. This ga … levels of systemic inflammatory and fibrotic cytokines. Two controls groups provided serum (normal vasectomy patients) and urethral tissue (autopsy patients). Cohorts were based on the presence/absence of stricture, by presumed stricture etiology (idiopathic, traumatic/iatrogenic, lichen sclerosus [LS]), and by the presence/absence of stricture inflammatio …

Гинекологическое здоровье женщин с множественным склерозом: обзор текущего состояния и результатов тестов Папаниколау в условиях низких доходов.

КОЛИЧЕСТВО: Женщины, имеющие MS (wMS), в частности женщины, находящиеся в условиях с низким уровнем дохода и подверженные воздействию гинекологической терапии (DMT), могут иметь особые проблемы, связанные с гинекологическим здоровьем. AIM: Оказание помощи в разработке политики и проведении дальнейших исследований путем описания нынешнего состояния гинекологического здоровья и результатов тестов Папаниколау в системе WwMS. МЕТОДЫ: Межсекциональное исследование wwMS, проживающее в Исфахане, Иран. Участники были обследованы и направлены для проведения теста Папаниколау, результаты которого были с

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… As noted, most participants reported having sexual activity more than once per week in the past year, with calendar-based methods, male condoms, and partner vasectomy being the first, second, and third most common reported methods used for contraception, respectively. … fertile 10 (5.1) - peri/postmenopausal 7 (3.5) Method used for contraception (n, %) - None 99 (50.2) - Calendar-based 40 (20.3) - Male condoms 31 (15.7) - Female condoms 1 (0.5) - Oral contraceptive pills 3 (1.6) - Medroxyprogesterone acetate injection 1 (0.5) - Intrauterine device 6 (3) - Partner vasectomy …

V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy.

Various mechanisms exist to prevent a potentially deleterious maternal immune response that results in compromising survival of semiallogeneic fetus. In pregnancy, there is a necessary early preimplantation inflammatory stage followed by a postimplantation anti-inflammatory stage. Thus, there is a biphasic 'immune response' observed during the course of pregnancy. We provide the evidence that capacitation of sperm induced the expression of a2 isoform of V-ATPase (ATP6V0A2 referred to as a2V), leukemia inhibitory factor (Lif), Il1b, and Tnf in the sperm. Capacitated sperm also released cleaved

Research prioritization of men's health and urologic diseases.

OBJECTIVES: We sought to determine whether disease representation in the Cochrane Database of Systematic Reviews (CDSR) reflects disease burden, measured by the Global Burden of Disease (GBD) Study as disability-adjusted life-years (DALYs). MATERIALS AND METHODS: Two investigators performed independent assessment of ten men's health and urologic diseases (MHUDs) in CDSR for systematic review and protocol representation, which were compared with percentage of total 2010 DALYs for the ten conditions. Data were analyzed for correlation using Spearman rank analysis. RESULTS: Nine of ten MHUDs we

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… fertilisation in couples with non-male subfertility (R) Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis (R) Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis (R) Intrauterine insemination versus fallopian tube sperm perfusion for non-tubal infertility (R) Vasectomy … with non-male subfertility (R) | Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis (R) | Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis (R) | Intrauterine insemination versus fallopian tube sperm perfusion for non-tubal infertility (R) | Vasectomy …

Successful Treatment with High-Dose Chemotherapy Followed by Autologous Stem-Cell Transplantation in a Patient with Metastatic Germ Cell Tumor.

Although testicular germ cell tumors (GCTs) are known to curable disease even in cases with metastatic disease, patients in intermediate or poor-risk group may experience disease progression or refractory to the initial chemotherapy and needed second-line therapy. Long-term disease-free survival was unsatisfactory in relapsed/refractory patients with poor-risk factors and clinical trials for those patients are still insufficient. High-dose chemotherapy (HDCT) with stem-cell rescue may be an effective alternative for conventional chemotherapy-resistant patients who are eligible for transplantat

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… After 4 cycles of TIP regimen as a second-line therapy, partial responses were identified and he underwent right radical orchiectomy with vasectomy in May 2019. …

Testicular immune cells and vasculature in Klinefelter syndrome from childhood up to adulthood.

STUDY QUESTION: Is the distribution of immune cells and the testicular vasculature altered in testicular biopsies from patients with Klinefe … REASONS FOR CAUTION: As controls for this study, testicular tissue biopsies of men who underwent a vasectomy reversal or orchiectomy were used, but these men may not represent fertile controls. In addition, a high variability in immune cell numbers, secretory products expression and number of blood vessels could be observed amongst all patient samples. WI …

Risk and response adapted therapy following autologous stem cell transplant in patients with newly diagnosed multiple myeloma (RADAR (UK-MRA Myeloma XV Trial): study protocol for a phase II/III randomised controlled trial.

IntroductionMultiple myeloma is a plasma cell malignancy that accounts for 1%-2% of newly diagnosed cancers.At diagnosis, approximately 20% of patients can be identified, using cytogenetics, to have inferior survival (high-risk). Additionally, standard-risk patients, with detectable disease (minimal residual disease (MRD)-positive) postautologus stem cell transplant (ASCT), fare worse compared with those who do not (MRD-negative). Research is required to determine whether a risk-adapted approach post-ASCT could further improve patient outcomes.MethodsRADAR is a UK, multicentre, risk-adapted, r

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… Male participants, even if surgically sterilised (ie, status post-vasectomy), must agree to one of the following: Agree to practise effective barrier contraception during the entire study treatment period and until 6 months after the last dose of cyclophosphamide or 5 months after the last dose of study … Male participants, even if surgically sterilised (ie, status post-vasectomy), must agree to one of the following: Agree to practise effective barrier contraception during the entire study treatment period and until 6 months after the last dose of cyclophosphamide or 5 months after the last dose of study …

Testicular function in a birth cohort of young men.

STUDY QUESTION: By investigating a birth cohort with a high ongoing participation rate to derive an unbiased population, what are the parame … selected volunteer sperm donors for research or artificial insemination or once-fertile men seeking vasectomy. It is well known that studies requiring semen analysis have low recruitment rates which consequently question their validity. However, there has been some concern that a surprisingly high proportion of young men may have semen variables that do not …

Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial.

CD38-targeting immunotherapy is approved in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma (NDMM) that are transplant ineligible (TI) and is considered the best standard of care (SOC). To improve current SOC, we evaluated the added value of weekly bortezomib (V) to isatuximab plus lenalidomide and dexamethasone (IsaRd versus Isa-VRd). This Intergroupe Francophone of Myeloma phase 3 study randomized 270 patients with NDMM that were TI, aged 65-79 years, to IsaRd versus Isa-VRd arms. The primary endpoint was a minimal residual disease (MRD) nega

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… who is sexually active with a pregnant woman or a woman of childbearing potential must agree to use a barrier method of birth control, for example a condom with spermicidal foam/gel/film/cream/suppository during the study and for at least 5 months after the last dose of treatment, even he has had a vasectomy …

Ixazomib, pomalidomide and dexamethasone in triple-class exposed multiple myeloma patients - a phase II study.

Multi-class upfront regimens for multiple myeloma (MM) have improved outcomes, yet many patients become either triple-class exposed (TCE) or refractory (TCR) early in their disease course. This is a phase II, investigator initiated, open-label, single-arm, prospective, multicenter study evaluating all-oral Ixazomib-pomalidomide- dexamethasone (IPd) regimen for TCE RRMM patients. Sixty-one patients were enrolled between March 1st 2021 and March 17th 2024. The median age was 74 (range: 53-89) years; 25 (41%) were ≥75 years old. Fiftyseven percent had high-risk cytogenetics (t(4;14), t(14;16), +1

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… Male patients, even if surgically sterilized (i.e., status postvasectomy), who: • Agree to completely abstain from heterosexual intercourse, OR • Agree to practice effective barrier contraception (i.e., latex condom) during sexual contact with a FCBP, even if they have had a successful vasectomy …

Male infertility and risk of cardiometabolic conditions: a population-based cohort study.

STUDY QUESTION: Is male infertility independently associated with an increased risk of incident hypertension, ischemic and non-ischemic hear … r index date. The index date was the later of the date of the child's conception or the date of the vasectomy for fertile men or the date of diagnosis of infertility for infertile men, i.e. the time when the exposure status was determined. From the index date, we followed participants for 5 years up until the latest available date of September 2021. PARTIC …