Результаты поиска

HIV and Leishmania coinfection: a review of 91 cases with focus on atypical locations of Leishmania.

A retrospective study was conducted in France in 1998 to determine the clinical features of visceral leishmaniasis (VL) in 91 patients infected cocomitantly with human immunodeficiency virus. Our data suggest that the clinical manifestations of VL may be influenced by the immunological status, with atypical locations of Leishmania amastigotes more frequently found in severely immunocompromised patients. In such patients, the involvement of atypical locations may lead to the discovery of VL.

Infection of sand flies by humans coinfected with Leishmania infantum and human immunodeficiency virus.

To determine the role that Leishmania infantum/human immunodeficiency virus (HIV) coinfected patients could play in the epidemiology of visc … urope, a new natural anthroponotic cycle could be considered in the epidemiology of L. infantum/HIV coinfection. The design of leishmaniasis control programs and the management of coinfected individuals should take these findings into account.

[Significance of coinfection with hepatitis G virus for chronic hepatitis C--a review of the literature].

BACKGROUND: The clinical significance of the recently discovered hepatitis C virus (HGV/GB virus C (GBV-C) is not conclusively clarified. The aim of this analysis was to evaluate the frequency of HGV/GBV-C coinfection at existing hepatitis C infection, the significance for the course of the liver disease, and its response to antiviral therapy. METHODS: The literature available by medline and the PubMed Retrieval System as well as abstracts of recent German, European, and American conferences on liver diseases (GASL, EASL, ASSLU) concerning HCV/GBV-C-coinfection were analyzed. RESULTS: We ide…

Immunohistochemical evaluation of lymphocyte subpopulations in sheep pneumonia caused by RSV, PIV3, and their coinfections.

Respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV‑3) are important pathogens causing respiratory infections in humans and animals worldwide. This study aimed to investigate the presence of RSV and PIV‑3 in lambs with pneumonia, including single and mixed infections, and to evaluate the role of different lymphocyte types in immunopathogenesis. The material consisted of lung samples from 100 lambs (aged 4-12 months) with pneumonia, collected between July and November 2024. PCR and immunohistochemistry (IHC) were used to detect viral presence, while hematoxylin-eosin (HE) stai

Coinfection with Different Feline Papillomaviruses in a Cat with Multicentric Squamous Cell Carcinoma In Situ.

A 14-year-old neutered male domestic shorthair cat was evaluated for long-standing, non-pruritic, crusty skin lesions on the pinnae, neck, and ventral abdomen that had persisted for at least 4 years. The histopathological examination of biopsies from the neck and abdomen revealed multicentric squamous cell carcinoma in situ confined to the epidermis. Papillomavirus diagnostics on ear crusts using PCR, rolling circle amplification (RCA), and next-generation sequencing (NGS) identified coinfection with Felis catus papillomavirus type 7 (FcPV7) and a putative novel feline papillomavirus type. Thi…

Geographic variation in risk of blacklegged tick-borne coinfections in the eastern United States.

Blacklegged tick (Ixodes scapularis)-associated diseases are increasing in incidence and geographic range in the United States. Pathogen range expansion may increase the risk of coinfections, which could complicate accurate diagnosis and treatment of tick-borne diseases. To identify regions of coinfection risk across the eastern United States, we used a national database of tick-borne pathogen occurrence to identify areas of co-occurrence between four I. scapularis-borne human pathogens: Anaplasma phagocytophilum human-active variant (Apha; anaplasmosis), Babesia microti (Bam; babesiosis), Bor…

The changing spectrum of cutaneous leishmaniasis and HIV coinfection in Bolivian Amazonia: a case report.

CASE REPORT: A 34-year-old man with advanced HIV infection presented with localized cutaneous leishmaniasis, after unsuccessful trestment with pentavalent antimonials, progressive dissemination ocurred . On re-evaluation, he exhibited numerous widespread ulcerated papules and nodules , accompanied by systemic symptoms and significant weight loss. Skin smears and histopathology demonstrated intracellular amastigotes. A diagnosis of intermediate cutaneous leishmaniasis with HIV coinfection was established. Treatment with liposomal amphotericin B followed by oral miltefosine led only to transitor…

The Coinfection of Bartonella spp. and Hantavirus in Wild Rodent and Shrew Species in Eastern China.

BACKGROUND: Bartonella spp. are Gram-negative bacteria that cause diseases including endocarditis, lymphadenopathy, and neuroretinitis. Hantavirus (HV), belonging to the family Hantaviridae, induces illnesses such as hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Both pathogens exhibit host specificity-defined as a preference or restriction to specific host species or ranges. Rodents and shrews are primary hosts for these pathogens, and their high coinfection rates often indicate elevated risk of human exposure. To our knowledge, however, data on Bartonella spp.-HV co…

Comparing viral, bacterial, and coinfections in community-acquired pneumonia, a retrospective cohort study.

OBJECTIVES: Despite the substantial rates of viral etiology in community-acquired pneumonia (CAP), empirical antibiotic therapy is regularly … ed into four groups based on the detection of bacterial pathogens, viral pathogens, bacterial/viral coinfection, and no pathogen detected. Differences were analyzed using multivariate linear regression. RESULTS: Patients with bacterial CAP were significantly younger (median age 60 years; adjusted odds ratio [aOR] 0.96 [0.94-0.98]) and reported less smoking ( …

A Rare Case of Coinfection of Rhodococcus equi and Nocardia abscessus in an Immunocompetent Human Host.

BACKGROUND: Rhodococcus and Nocardia spp. are aerobic, gram-positive bacteria distributed extensively in the sediment of various environments globally. They usually manifest as opportunistic infections in immunocompromised hosts. Here, we report a coinfection case of Rhodococcus and Nocardia spp. in a patient with normal immune system. CASE PRESENTATION: We present a case of a 52-year-old healthy man who sustained right hand injury at work. The patient exhibited post-traumatic infection. The skin of the right palm was swollen with acute pain, and active flexion and extension of his fingers we…

On the Dynamics of HIV-Tuberculosis Coinfection Model with Temporal Recovery from Tuberculosis: An Analysis.

The current study is an attempt to frame a deterministic compartmental model for HIV-TB coinfection, considering temporary recovery from Tuberculosis (TB) after treatment (the possibility of reinfection with TB even after recovery). The proposed HIV-TB coinfection model is a composite of an susceptible-infected (SI) type HIV/AIDS model and a susceptible-exposed-infected-recovered type TB model. In the beginning, the HIV-TB model is constructed, followed by the qualitative investigation of the model. The equilibrium points of the model are obtained and have been examined in detail. Further, the…

Coinfections and comorbidities observed in COVID-19 during the influenza season in the pediatric patient.

OBJECTIVE: To evaluate if the comorbidity and coinfections presented by SARS-CoV-2 infection vs. COVID-19 impact our Mexican children. METHOD: Prospective and observational study that included the 2020-2021 peak influenza season. All patients with a diagnosis of infection by SARS-CoV-2 vs. COVID-19 who were admitted to the Hospital Infantil de Mexico were analyzed. Real-time RT-PCR for SARS-CoV-2 was performed in all patients, determining E, RdRp and RP genes and protein N, as well as RT-PCR for detection of respiratory viruses. RESULTS: The inclusion criteria were met by 163 patients. The g…

Molecular Epidemiology and Clinical Characteristics of an Outbreak on Respiratory Virus Coinfection in Gansu, China.

This study aims to analyze the epidemiological and pathogenic characteristics of an outbreak primarily caused by respiratory syncytial virus … 3%), and two cases of positive respiratory syncytial virus (13.33%). Among them, six samples showed coinfections of HMPV and HRV, and one had coinfections of HMPV and RSV, resulting in a coinfection rate of 46.67%. Genetic sequencing indicated that the HMPV genotype in this outbreak was A2c, and the HRV genotype was type A, resulting in a coinfection outbreak …

Coinfections with additional oncoviruses in HPV+ individuals: Status, function and potential clinical implications.

Oncovirus infections account for an estimated 12%-20% of human cancers worldwide. High-risk human papillomavirus (HPV) infection is the etiological agent of some malignancies such as cervical, oropharyngeal, anal, penile, vaginal, and vulvar cancers. However, HPV infection is not the only cause of these cancers or may not be sufficient to initiate cancer development. Actually, certain other risk factors including additional oncoviruses coinfections have been reported to increase the risk of patients exposed to HPV for developing different HPV-related cancers. In the current review, we summariz…

ХЛА-Г выражение печени у хронически инфицированных ВИЧ/гепатитом С.

ВВЕДЕНИЕ И ЦЕЛИ: Болезнь печени, вызванная гепатитом С, представляет собой серьезную угрозу для выживания людей, живущих с ВИЧ. Инфицированные ВИЧ/ГХВ лица имеют более быструю тенденцию к циррозу и его осложнениям, чем больные, инфицированные ВИЧ-инфекцией. Хотя основные механизмы остаются неясными, HLA-G, неклассическая молекула I HLA, обладает широко признанным свойством для снижения иммунной реакции на вирусы и может способствовать развитию хронического гепатита С.МАТЕРИАЛЫ И МЕТОДЫ: Мы проанализировали выражение HLA-G в 59 образцах печени пациентов с хроническим ВИЧ-инфекцией и ВИЧ-инфекци

Совпадение в аннотации оригинала
INTRODUCTION AND OBJECTIVES: Hepatitis C-induced liver disease represents a significant threat to the survival of people living with HIV. HI … THODS: We analyzed HLA-G expression in 59 liver specimens of patients harboring chronic HCV and HIV coinfection and stratified the findings according to clinical and histopathological features. RESULTS: Genotype 1 was the most prevalent (88%); the HLA-G expression was observed in 38 (64%) liver specimens, and it was more frequent in more severe stages than i …

Prolonged, Atypical, and Fulminant Mpox in a HIV/HBV-Coinfected Patient: A Case Report.

Mpox (monkeypox) is a zoonotic disease that has been endemic in African countries for decades, with a recent global outbreak in countries around the world. A 39-year-old male with human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection and poor adherence to antiretroviral treatment, who was severely immunocompromised and had a concurrent diagnosis of Mpox, presented to our hospital with disseminated skin lesions (over 350 lesions), perianal ulcers, odynophagia, oral intolerance, diarrhea, and soft-tissue bacterial superinfection of the lower extremities. Laboratory results were …

Trends of coinfections among healthy blood donors: COVID-19 pandemic repercussion.

BACKGROUND: Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) coinfection has emerged as a leading cause of morbidity throughout the world in the last two decades. The coronavirus disease 2019 (COVID-19) pandemic has escalated the disease burden further by increasing the number of intravenous (IV) drug abusers and unemployment. AIM: The present study was done to analyse the impact of COVID-19 on seroprevalence as well as trends during pre, post and pandemic years of coinfection and mono-infections in the Malwa region of Punjab. SETTING AND DESIGN: This …

Multiple coinfections and Guillain Barré syndrome following outdoor travel to the American Northeast.

A 66-year-old immunocompetent man with preceding travel through the Northeastern United States developed Guillain-Barré syndrome. A broad se … case also highlights the importance, in the setting of endemic exposure, of screening for multiple coinfections that can be transmitted by the same arthropod vector.