Результаты поиска

DNA Damaging Drugs

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… The agent also interferes with oogenesis and spermatogenesis. It may cause sterility in both sexes. Chemotherapy with cyclophosphamide, given to boys before or during puberty, results in a high rate of gonadal dysfunction. …

Epigenetics-targeted drugs: current paradigms and future challenges.

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone modification, RNA modification, chromatin remodeling, and non-coding RNA regulation. These mechanisms and their associated enzymes convey genetic information independently of DNA base sequences, playing essential roles in organismal development and homeostasis. Conversely, disruptions in epigenetic landscapes critically influence the pathogenesis of various human diseases. This understanding has laid a robust theoretical groundwork for developing drugs that target epigenetics-modifyin

Esid 2014 oral presentations.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster critical for oogenesis and ER reorganization. JAGN1 -mutant human granulocytes showed enlarged ER structures and paucity of secretory vesicles. …

Резюме докладов 53rd Конференция Европейского общества генетики человека: интерактивные электронные постеры.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.