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Bleeding risk after kidney biopsy with platelet inhibition.

BACKGROUND AND HYPOTHESIS: Platelet inhibitor therapy is a relative contraindication to percutaneous kidney biopsies due to concerns about bleeding risk. Here we present an analysis of a prospective observational study on the risk of complications after native and transplant kidney biopsy with and without platelet inhibition. METHODS: 1103 consecutive biopsies between 2020 and 2025 at a single tertiary academic care center were included (26.0% in transplanted kidneys). Complications after biopsy were assessed and recorded before discharge, which was the day after the biopsy unless complicatio

Glanzmann's Thrombasthenia: How Listening to the Patient Is Sometimes the Simple Key to Good Medicine!

Introduction. Glanzmann's thrombasthenia is a rare clotting disorder caused by impaired platelet function. Lack of awareness of the appropri … n presentation to the emergency department (ED). In the ED, the patient requested administration of platelet transfusion but was refused due to a normal platelet count. During the course of his hospital stay, he complained of epistaxis and was noted to have a downtrending hemoglobin from 11.0 g/dl to 9.0 g/dl. The patient and his family were not comfortable when the d …

Outcomes of recombinant activated factor VIIa (NovoSeven) therapy in glanzmann thrombasthenia: two case reports.

Glanzmann thrombasthenia (GT) is a rare autosomal recessive platelet function disorder resulting from qualitative or quantitative defects in the GPIIb/IIIa (integrin αIIbβ3) complex. Patients typically present with mucocutaneous bleeding. Standard treatment involves antifibrinolytic agents and platelet transfusions; however, repeated transfusions may lead to alloimmunization and platelet refractoriness. Recombinant activated factor VIIa (rFVIIa; NovoSeven) offers an alternative hemostatic approach. We present two pediatric cases of GT managed with rFVIIa. The first case involves a 12-year-old …

Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient.

Bleeding related to thrombocytopenia is common in hematology-oncology patients. Platelets stored at room temperature (RTPs) are the current … logistical advantages of CSPs would improve outcomes for many patients who currently cannot access platelet transfusions.

Preoperative Thrombocytopenia Increases In-Hospital Burden but Not Postoperative Adverse Events After Total Knee Arthroplasty.

Background/Objectives: Thrombocytopenia increases bleeding tendency and may complicate perioperative management in total knee arthroplasty (TKA), yet data on both in-hospital burden and post-discharge adverse events are limited. This study evaluated the association between preoperative platelet count and outcomes after primary TKA. Methods: In total, 3474 primary TKAs performed for osteoarthritis at a single institution (2008-2023) were retrospectively reviewed. Patients were classified as Normal, Mild, Moderate, or Severe by preoperative platelet count; the Severe group (N = 6) was excluded f

Carbon dioxide alleviates platelet storage lesions via stimulating fatty acid metabolism and reducing platelet glucose consumption.

BACKGROUND: The timely administration of platelet transfusions is critical for patient survival, and the clinical demand for platelet transfusions has been steadily increasing. However, platelet storage lesions (PSLs) that develop during in vitro preservation exacerbate these shortages. The PSL is significantly influenced by various factors, including temperature, gas composition, and buffering systems. Strategies to mitigate PSLs and improve platelet storage have been actively explored in recent years. OBJECTIVES: This study aimed to investigate whether elevated carbon dioxide (CO2) levels i…

Effect of intraoperative cell rescue on bleeding related indexes after cesarean section.

BACKGROUND: Obstetric hemorrhage is the leading cause of maternal mortality globally, especially in China. The key to a successful rescue is immediate and rapid blood transfusion. Autotransfusion has become an integral part of clinical blood transfusion, with intraoperative cell salvage (IOCS) being the most widely used. AIM: To investigate the application of IOCS in cesarean section. METHODS: A total of 87 patients who underwent cesarean section and blood transfusion in our hospital from March 2015 to June 2020 were included in this prospective controlled study. They were divided into the o

Glanzmann's thrombasthenia proposed optimal management during surgery and delivery.

Glanzmann's thrombasthenia (GT) is an autosomal recessive disorder of platelet function. Conventional management is by platelet transfusion, given before invasive interventions. Alloimmunization resulting in platelet refractoriness and an unpredictable response to platelet infusion have provided particular management difficulties in the past. More recently recombinant (r)VIIa (Novoseven) has a valuable role in the treatment of platelet function disorders. Treatment of a patient with GT during two pregnancies and spinal surgery is reported. An algorithm is presented to provide a structured and …

LncRNAs as potential biomarkers for platelet storage lesion.

Platelet transfusion is indispensable in clinical care for hemostatic disorders. During storage, platelets undergo progressive physiological and biochemical deterioration known as platelet storage lesions (PSL), which compromise quality, shelf life, and transfusion effectiveness. This study aimed to profile long noncoding RNA (lncRNA) expression in stored platelets and evaluate their associations with storage duration, donor gender, blood type, and lifetime apheresis donation frequency, to identify candidate biomarkers for PSL. We examined expression of GAS5, LIPCAR, MALAT1, and SNHG9 and thei…

Plasma thrombopoietin levels in marrow transplant patients with veno-occlusive disease of the liver.

Platelet transfusion requirements are higher among patients with veno-occlusive disease (VOD), compared to patients without VOD. One possible explanation is inadequate production of thrombopoietin (TPO), a protein synthesized in the liver. We prospectively studied 28 patients to test the hypothesis that plasma TPO levels were decreased in patients who developed VOD. Plasma TPO levels to day +30 were measured by ELISA (normal, 0.36+/-0.15 fmol/ml). VOD developed in 18/28 patients. Platelet transfusion requirements were significantly different in patients with and without VOD (97+/-46.1 units vs…

A novel in vivo ovine model of transfusion-related acute lung injury (TRALI).

BACKGROUND AND OBJECTIVES: Even with the introduction of specific risk-reduction strategies, transfusion-related acute lung injury (TRALI) continues to be a leading cause of transfusion-related morbidity and mortality. Existing small animal models have not yet investigated TRALI resulting from the infusion of heat-treated supernatant from whole blood platelet concentrates. In this study, our objective was the development of a novel in vivo two-event model of TRALI in sheep. MATERIALS AND METHODS: Lipopolysaccharide (LPS; 15 μg/kg) as a first event, modelled clinical infection. Transfusion (es

Скрытые расходы PEG-rhG-CSF на аутлогическую трансплантацию стволовых клеток для недавно диагностированной множественной миеломы.

Оценить клиническую ценность полиэтилен-гликолизированного рекомбинированного человеческого гранулоцита-стимулирующего фактора (PEG-rhG-CSF) для гематопоэтического восстановления после аутологической трансплантации стволовых клеток (ASCT) у недавно диагностированных пациентов с множественными миеломами (NDMM). В настоящем исследовании анализируются данные, полученные от 70 Пациенты NDMM, проходящие ACCT, с 33 получение PEG-rhG-CSF и 37 Принимаю RG-CSF. Среднее время нейтрофильного и тромбоцитного оплодотворения, медианное переливание продуктов крови, неблагоприятные реакции, связанные с лечени

Совпадение в аннотации оригинала
To evaluate the clinical value of polyethylene glycolized recombinant human granulocyte-stimulating factor (PEG-rhG-CSF) for hematopoietic r … ment, but PEG-rhG-CSF resulted in slower platelet engraftment (13.7 vs. 11.4 days, p < 0.001), more platelet transfusions (2.9 vs. 1.6 units, p < 0.001), higher incidence of grade ≥ 3 diarrhea (60.6 vs. 29.7%, p = 0.006), longer diarrhea duration (9.0 vs. 5.5 days, p = 0.004), and higher costs (RMB 77,126 vs. RMB 68,361, p = 0.027). PEG-rhG-CSF support post-ASCT in ND …

The relative safety of pooled whole-blood-derived platelets prepared by the buffy-coat method versus single-donor (apheresis) platelets.

Conversion to a single-donor (apheresis) platelet inventory in Western Europe and other countries that provide similar health care to the US but rely on buffy-coat pooled whole-blood-derived platelets will confer the benefit of a > or = 2-fold reduction in the risk of all emerging transfusion-transmitted infections (TTIs). In Europe, this benefit will include a > or = 2-fold reduction in the risk of acquiring variant Creutzfeldt-Jakob disease (vCJD) from platelet transfusion. In countries that use buffy coats from first-time donors to produce platelet pools, there will also be a > or = 2-fold …

Successful surgery using recombinant factor VIIa for recurrent, idiopathic nonulcer duodenal bleeding in a patient with Glanzmann's thrombasthenia.

A 68-year-old man with Glanzmann's thrombasthenia suffered from recurrent cryptogenic bleeding originating in the upper duodenal flexure. Extensive endoscopic procedures and medical treatments were unsuccessful and proximal duodenectomy was proposed. In preceding years platelet transfusions had often had a suboptimal result and were complicated by allergic reactions. Surgery was carried out while he was being treated with recombinant Factor VIIa. Neither major blood loss nor other complications occurred. Histological examination of the bleeding site failed to show abnormalities and the nature …

Platelet-inspired nanomedicine in hemostasis thrombosis and thromboinflammation.

Platelets are anucleate cell-fragments derived predominantly from megakaryocytes in the bone marrow and released in the blood circulation, w … eatment for such complications involve prophylactic or emergency transfusion of platelets. However, platelet transfusion logistics constantly suffer from limited donor availability, challenges in portability and storage, high bacterial contamination risks, and very short shelf life (~5 days). To address these issues, an exciting area of research is focusing on the dev …

Allogeneic blood transfusion in bilateral lung transplantation: impact on early function and mortality.

OBJECTIVES: Blood transfusion is associated with higher morbidity and mortality after general cardiothoracic surgery but its impact within the transplant population is unclear. We investigated the profile of blood product transfusion in the bilateral lung transplant population and its impact on function and mortality. METHODS: Three hundred and eleven adult patients who underwent bilateral lung transplant between 2003 and 2013 were retrospectively reviewed. Patients were stratified according to pretransplant diagnoses and amount of blood products transfused within 24 h of transplant. All-caus

[The Clinical Characteristics and Influential Factors of Adverse Transfusion Reactions].

OBJECTIVE: To provide evidence for early prevention and ensure the safety of blood transfusion by analyzing the clinical characteristics and influential factors of patients with adverse transfusion reactions in our hospital. METHODS: The information of patients with adverse transfusion reactions among all inpatients receiving blood transfusion from July 2021 to July 2023 in our hospital were collected. The types of adverse transfusion reactions, patients' characteristics, the time of transfusion reactions, the time of blood component leaving the blood bank were analyzed. RESULTS: From July 2

Burn injury and blood transfusion.

PURPOSE OF REVIEW: Blood transfusion is ubiquitous in major burn injury. The present article describes recent research findings directly impacting blood transfusion strategies in major burn injury both in the operating room and the ICU. RECENT FINDINGS: Transfusion strategies have been the focus of recent burn investigations. First, a randomized prospective trial encompassing both the ICU and operating room reported that a restrictive red blood cell transfusion threshold (7 g/dl) had equivalent outcomes to a traditional threshold (10 g/dl) for burns more than 20% in terms of mortality, infect

Platelet Dysfunction in Liver and Kidney Disease.

Patients with liver or kidney disease exhibit complex hemostatic changes, including abnormalities in platelet count and function. Although patients frequently bleed, bleeding is often unrelated to and not predicted by platelet abnormalities. Likewise, routine platelet transfusion to correct platelet abnormalities does not appear to prevent bleeding. Patients also exhibit prohemostatic abnormalities such as increased von Willebrand factor levels and platelet activation, which may compensate for antihemostatic changes. Notably, thrombosis is a frequent complication in these patients. Here, we na…

Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome.

IMPORTANCE: Recent case reports suggest that B antigen-containing blood products may be associated with anaphylactic transfusion reactions in recipients with preformed immunoglobulin E to galactose-α-1,3-galactose (alpha-gal). OBJECTIVE: To test the association of local alpha-gal syndrome (AGS) prevalence and allergic transfusion reaction (ATR) in patients with blood type O. DESIGN, SETTING, AND PARTICIPANTS: In this international, multicenter, retrospective cohort study at academic medical centers, sites were assigned to AGS high- or low-prevalence clusters based on the known geographic dis