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MANAGEMENT OF RISKS OF ADVERSE DRUG REACTIONS ACCORDING TO ADR REPORT FORM DATA FROM LVIV REGION HEALTHCARE FACILITIES IN 2022.

The study aimed to analyse the adverse drug reactions report form data received by the State Expert Center of the Ministry of Health of Ukra … howing the highest incidence rate of adverse reactions. Among cephalosporins, ceftriaxone (46%) and cefixime (15%) were found to take the lead in terms of adverse reaction frequency. The highest proportion among all adverse drug reactions caused by penicillins and cephalosporins was attributed to allergic reactions. To confirm or rule out immediate or dela …

A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.

OBJECTIVES: Novel methods for preserving primary teeth can help to maintain their developmental, esthetic, and functional capabilities. The aim of this study was to assess the success of the repair of bony defects, caused by pre-treatment perforations, with a mixture of three antibiotics combined with simvastatin (3Mixtatin) compared to MTA in hopeless primary molars. STUDY DESIGN: In this randomized clinical trial, 80 teeth from 65 healthy children aged 3-6 years with interradicular or periapical root resorption and/or perforation in primary molars were treated either with 3Mixtatin or MTA b

The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden.

BACKGROUND: Use of third-generation cephalosporins, such as cefotaxime, is associated with an increased risk of selection for antimicrobial … icipants who were showing improvement could be given an oral antibiotic (ciprofloxacin, ceftibuten, cefixime, or co-trimoxazole). Patients not showing improvement were regarded as having treatment failures. Rectal swabs were collected at three timepoints: at baseline (before the first dose), after the last dose of study drug, and 7-10 days after treatment …

Update in women's health.

INTRODUCTION: The aim of this clinical update is to summarize articles and guidelines published in the last year with the potential to chang … uncomplicated infections, treatment of gonorrhea should be initiated with ceftriaxone 125 mg IM or cefixime 400 mg PO and co-treatment for chlamydia infection (unless ruled out with testing). Recent estimates demonstrate that almost 50% of persons with gonorrhea have concomitant chlamydia infection21. STD = sexually transmitted disease, NIH = National Ins …

Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy.

UNLABELLED: Antimicrobial resistance (AMR) in Salmonella Typhi (S. Typhi) is a serious health issue that can complicate typhoid fever treatm … hibitors (BL/BLI) demonstrated good outcomes, with low MICs (<0.5 µg/mL) of ceftazidime/tazobactam, cefixime/tazobactam, and ceftriaxone/tazobactam effective against highly resistant S. Typhi. The emergence of MDR-XDR S. Typhi, attributed to mutations in gyrA, parC, and the H58 lineage, highlights widespread resistance. According to our research, a potenti …

Methods for the detection and isolation of Shiga toxin-producing Escherichia coli.

Shiga toxin-producing Escherichia coli (STEC) are an important cause of haemorrhagic colitis and the diarrhoea-associated form of the haemol … f typical sorbitol-non-fermenting strains of STEC of serogroup O157 is sorbitol MacConkey agar with cefixime and tellurite (CT-SMAC). As some STEC strains are sensitive for tellurite and/or are sorbitol-fermenting, the use of a second isolation medium, such as one of the newer chromogenic media, is recommended. Immunomagnetic separation (IMS) following sel …

[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (1997). I. Susceptibility distribution].

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 560 bacterial strains isolated from patients … nd MINO showed high activities against P. mirabilis. CMX, ceftazidime (CAZ), latamoxef (LMOX), CPR, cefixime (CFIX), cefpodoxime (CPDX) and CRMN showed the highest activities against P. mirabilis. The MICs of them for all strains were equal to or lower than 0.125 microgram/ml. CPFX and TFLX were also active with the MIC90s of 0.125 microgram/ml or below. 7 …

[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (1995). I. Susceptibility distribution].

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 704 bacterial strains isolated from patients … . 9. Proteus mirabilis P. mirabilis was susceptible to a majority of drugs. CMX, ceftazidime (CAZ), cefixime (CFIX), and CRMN showed the highest activities against P. mirabilis isolated from patients with UTIs. MICs of CRMN for all

Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.

The adequate management of central nervous system (CNS) infections requires that antimicrobial agents penetrate the blood-brain barrier (BBB … slower sterilization of the CSF than third-generation agents. Ceftriaxone, cefotaxime, ceftazidime, cefixime and cefepime have been studied in children and are all able to adequately penetrate the CSF. As with penicillins, concentrations are greatest in the presence of meningeal inflammation. Meropenem and imipenem are the only carbapenems with pediatric d …

Wedge urethral meatotomy in meatal stenosis secondary to web formation.

INTRODUCTION: Meatal stenosis is a common acquired urological problem facing pediatric surgeons and urologists. It can affect both the circu … f the meatus three times daily for ten days, together with applying Fucidin cream locally with oral cefixime and paracetamol. RESULTS: The age of the 60 patients ranged between 6 months and 10 years old (median age 38 months) (Fig. 4). Two (3%) patients developed mild meatal stricture, which did not require further intervention as their urine stream remai …

Дело о амеланотической плазмоцитоидной меланоме с сильным CD138, имитируя многократную миелому - доклад о деле.

Фон и объектив Melanomas имеют различные патологические особенности, которые имитируют другие опухоли, такие, как лимфома, саркома и даже слабо различимая карцинома. Самый недавно выявленный вариант — вариант плазмоцитоида — является необычным вариантом, который может выглядеть как одиночная опухоль или метастатическое заболевание. Из-за его редкости эпидемиологический профиль этого варианта не является достаточно точным. Этот случай иллюстрирует диагностический вызов плазмоцитоидного имитатора клеток, который редко встречается в повседневной практике. 49-year-old Человек подавал многочисленны

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… Other prescriptions were cefixime 1x200 mg, meloxicam 1x15 mg, and ranitidine 2x150 mg orally. However, the patient unfortunately passed away before any follow-up was able to be conducted. …

Pharmacists' knowledge of the safety of antibiotics for systemic use.

BACKGROUND: Patients decide to take antibiotics themselves in 21% of cases of acute respiratory viral infections, influenza and acute respir … on of correct answers ranged from 6,0% for the combination amoxicillin+clavulanic acid to 43,4% for cefixime and doxycycline. The relationship between knowledge of respondents and frequency of recommendations of the same group of drugs could not be determined.Pharmacists assume that the safest antibiotics are macrolides (average rank place of 2,99 ± 0,15 o …

Treatment of urinary tract infections among febrile young children with daily intravenous antibiotic therapy at a day treatment center.

OBJECTIVE: Urinary tract infections (UTIs) are common among infants and toddlers. Children can be treated effectively with short courses (2- … ebrile within 24 hours after treatment initiation with IV gentamicin; he was then treated with oral cefixime. A second patient was treated with IV ceftriaxone, administered at the DTC once culture results were available, and remained febrile for <72 hours. The last 2 patients were hospitalized; one, who was also allergic to cephalosporins, had been febrile …

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management.

Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous adverse reaction mainly attributed to drugs, although other triggers, including infections, vaccinations, ingestion of various substances, and spider bites, have also been described. AGEP is characterized by the development of edema and erythema followed by the eruption of multiple punctate, non-follicular, sterile pustules and subsequent desquamation. AGEP typically has a rapid onset and prompt resolution within a few weeks. The differential diagnoses for AGEP are broad and include infectious, inflammatory, a

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… Cephalosporins implicated in AGEP include cefixime, ceftriaxone, cefepime, and cefotaxime [ 31 – 37 ]. Azithromycin has been reported of the macrolide class [ 38 ]. Fluoroquinolones, including ciprofloxacin and tosufloxacin, have also been reported as associated with AGEP [ 39 , 40 ]. … Cefixime-associated acute generalized exanthematous pustulosis: Rare cases in India. Indian J Pharmacol. 2018;50(4):204–207. doi: 10.4103/ijp.IJP_673_17. 35. Lei H, Deng H, Liu X, Li Z, Wang C. …

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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Pentoxifylline and Tocopherol for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Retrospective Clinical Audit.

Background/Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a challenging complication in patients receiving antiresorptive therapy. Management strategies range from conservative pharmacological approaches to extensive surgical resection of necrotic bone. This clinical audit retrospectively evaluated the clinical outcomes of patients undergoing sequestrectomy for MRONJ, comparing those treated with antibiotics alone with those receiving antibiotics in combination with the pentoxifylline-tocopherol (PENTO) protocol. The PENTO protocol was introduced at our institution in 2021

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… Of the 86 patients included in the cohort, 62 (72.1%) received the combined PENTO protocol with antibiotic therapy (e.g., amoxicillin, amoxicillin/clavulanic acid, metronidazole, cefixime); of them, 56 were treated after 2021, while 6 in 2019–2020. …

Infectious Complications of Cancer Therapy

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… Oral administration of cefixime to lower risk febrile neutropenic children with cancer. Cancer. 2000;88:2848–2852. doi: 10.1002/1097-0142(20000615)88:12<2848::aid-cncr27>3.0.co;2-2. 286. Paganini H., Rodriguez-Brieshcke T., Zubizarreta P., et al. … Oral cefixime is similar to continued intravenous antibiotics in the empirical treatment of febrile neutropenic children with cancer. Clin Infect Dis. 2001;32:36–43. doi: 10.1086/317552. 289. Mullen C.A., Petropoulos D., Roberts W.M., et al. …

Расследование результатов и лечение длинных коронавирусных заболеваний 2019 года у пациентов с множественным склерозом, обработанных ритуксимаб: тематическое исследование.

Множественный склероз (MS) — хроническое аутоиммунное заболевание, затрагивающее центральную нервную систему, характеризующееся разрушением миелинской ножки нервов. Пациенты MS, которые лечились ритуксимабом, иммунодепрессивным препаратом, страдают от снижения уровня иммуноглобулина, что повышает их риск различных инфекций, включая коронавирусную болезнь 2019 года (COVID-19). Во время пандемии COVID-19 у многих из этих пациентов появились долгосрочные симптомы после инфицирования. Эти хронические симптомы привели к значительным осложнениям, а в некоторых случаях к росту смертности. В ходе этог

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… Prior to admission, she had received treatment with cefixime, azithromycin, clindamycin, levofloxacin, and ceftriaxone, which yielded no improvement. The patient reported no comorbidities other than MS and denied tobacco, alcohol, or illicit drug use. …

Infectious Diseases

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… Cefoxitin 1–2 g IV q6–8 h Bactericidal, cell wall synthesis inhibition and lysis +++ +++ ++ Yes (interval) Cefotaxime 1–2 g IV q6–8 h +++ +++ Yes (interval) Ceftriaxone 1–2 g IV q24h +++ +++ No Ceftazidime 1 g IV q8–12 h +++ +++Pseudo Yes (interval) Cefepime 1–2 g IV q12h + +++Pseudo Yes (interval) Cefixime … and lysis | +++ | +++ | ++ | | Yes (interval) Cefotaxime 1–2 g IV q6–8 h | | +++ | +++ | | | Yes (interval) Ceftriaxone 1–2 g IV q24h | | +++ | +++ | | | No Ceftazidime 1 g IV q8–12 h | | +++ | +++Pseudo | | | Yes (interval) Cefepime 1–2 g IV q12h | | + | +++Pseudo | | | Yes (interval) Cefixime …

Antibacterial prophylaxis and antimicrobial stewardship in the era of innovative therapies for haematological malignancies: transplantation, cellular therapies and new drugs.

Antibacterial prophylaxis has long been a cornerstone of supportive care in patients with haematological malignancies undergoing intensive chemotherapy and haematopoietic stem cell transplantation (HSCT), particularly in the setting of prolonged and profound neutropenia. However, the widespread use of fluoroquinolone (FQ) prophylaxis has increasingly raised concerns related to antimicrobial resistance, microbiota disruption, drug-related toxicity, and Clostridioides difficile infection, challenging its universal application. At the same time, the therapeutic landscape of haematology is rapidly

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… Among non-FQ regimens, oral third-generation cephalosporins (OTGCs), such as cefpodoxime, cefixime, and cefdinir, represent the most frequently evaluated alternatives. 70 Data from leukaemia and HSCT cohorts show comparable rates of FN, Gram-negative BSI, and infection related mortality relative to levofloxacin …