Результаты поиска

Immunosenescence and cancer predisposition in pediatric transplant recipients: An emerging paradigm.

Pediatric solid organ and hematopoietic stem cell transplant recipients paradoxically experience accelerated immune aging despite chronological youth, establishing a paradigm with profound implications for cancer risk and long-term outcomes. This comprehensive review synthesizes current evidence demonstrating how transplantation-related factors, anti-thymocyte globulin-mediated T cell depletion, cytomegalovirus reactivation, chronic immunosuppression, and thymic dysfunction, induce premature immunosenescent phenotypes. These processes converge to generate T cell populations exhibiting CD28 los

CHARM is prognostic of geriatric morbidity and toxicity after allogeneic transplant for older adults: BMT CTN 1704 study.

AbstractDespite concerns about the toxicity of allogeneic hematopoietic cell transplantation (alloHCT) in older patients, prospective data characterizing prevalence or risk stratification for geriatric morbidity such as disability or frailty are limited. We prospectively assessed the prognostic impact of the novel composite health assessment risk model (CHARM), a score established to predict 1-year nonrelapse mortality (NRM), among 1105 patients aged ≥60 years enrolled on the Bone Marrow Transplant Clinical Trials Network Study 1704. Secondary end points were assessed post-alloHCT at day 100 (

Совпадение в полном тексте источника
… Geroscience. 2018;40(4):361–364. doi: 10.1007/s11357-018-0036-9. 20. Muffly LS, Boulukos M, Swanson K, et al. Pilot study of comprehensive geriatric assessment (CGA) in allogeneic transplant: CGA captures a high prevalence of vulnerabilities in older transplant recipients. …

Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk.

Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely that many true risk loci are missed. Functional annotation of GWAS polymorphisms is a proven strategy to identify additional risk loci. We aimed to investigate single-nucleotide polymorphisms (SNP) in regulatory regions [transcription factor binding sites (TFBSs) and enhancers] that could change the expre

Совпадение в полном тексте источника
… Geroscience. 2022;44(2):997–1009. doi: 10.1007/s11357-021-00398-y. 48. Zhang JJ, Zhu Y, Xie KL, et al. Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. …

Advances in the Study of Denosumab Treatment for Osteoporosis and Sarcopenia in the Chinese Middle-Aged and Elderly Population.

Osteosarcopenia (OS) is a geriatric syndrome characterized by the concurrent presence of osteoporosis and sarcopenia, predominantly affecting the elderly population. Osteoporosis (OP) is a systemic skeletal disorder characterized by decreased bone mass, compromised bone microarchitecture, and heightened bone fragility, substantially elevating fracture risk. Sarcopenia (SP) is defined by decreased muscle mass, strength, and/or functional capacity. Both conditions are age-related degenerative diseases with overlapping pathophysiological mechanisms, commonly co-occurring in elderly individuals an

Совпадение в полном тексте источника
… Osteosarcopenia: a case of geroscience . Aging Med . 2019 ; 2 ( 3 ): 147 – 156 . doi: 10.1002/agm2.12080 PMC6880711 31942528 41. Kirk B , Zanker J , Duq G. Osteosarcopenia: epidemiology, diagnosis, and treatment—facts and numbers . …

Biological Age, Aging Clocks, and the Interplay with Lymphoid Neoplasms: Mechanisms and Clinical Frontiers.

Lymphoid neoplasms (LN), a diverse group of malignancies arising from lymphocytes, exhibit a striking increase in incidence with chronological age, suggesting a deep connection with the aging process. While chronological age remains a primary risk factor, the concept of biological age, reflecting an individual's physiological state and susceptibility to age-related diseases, offers a more nuanced understanding of this relationship. Aging clocks, particularly epigenetic clocks based on DNA methylation, provide quantitative measures of biological age and have revealed associations between accele

Совпадение в полном тексте источника
… GeroScience 2024 , 47 , 703 – 720 . 39405013 10.1007/s11357-024-01374-y PMC11872960 64. Parker D ; Bartlett BN ; Cohen HJ ; Fillenbaum G ; Huebner JL ; Kraus VB ; Pieper C ; Belsky DW Association of blood chemistry quantifications of biological aging with disability and mortality in older adults . …

Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy.

PurposeStudy purposes were to evaluate for inter-individual variability in the trajectories of three objective measures of physical function (PF) in older patients receiving chemotherapy (n = 112) and determine which characteristics were associated with worse PF.MethodsBalance, gait speed, and chair-stand test were evaluated at initiation and 1, 3, 6, 9, and 12 months following chemotherapy. Hierarchical linear modeling was used to assess inter-individual variability in the trajectories of the three tests. Demographic, clinical, and symptom characteristics, and levels of cognitive function ass

Совпадение в полном тексте источника
… Ferrucci L Cooper R Shardell M Simonsick EM Schrack JA Kuh D Age-related change in mobility: perspectives from life course epidemiology and geroscience J Gerontol A 2016 71 9 1184 1194 10.1093/gerona/glw043 PMC4978365 26975983 41. …

Питание N-6 Полиненасыщенное содержание жира в кислоте и здоровье мозга у взрослых людей среднего и старшего возраста.

ПАФА играет важную роль в возникновении и развитии нейродегенеративных заболеваний. С тех пор, как нейрозащитные эффекты n-3 ПУФА получил широкую поддержку, роль n-6 ПУФА по-прежнему обсуждается, а их основополагающие механизмы до сих пор не в полной мере понятны. В этом исследовании 169,295 Участники из Биобанка Соединенного Королевства были включены для анализа связей между питанием n-6 Поступление ПУФА и нейродегенеративные заболевания с использованием моделей коксовой регрессии с полной корректировкой для потенциальных сомнителей. Кроме того, для оценки воздействия различных моделей линейн

Совпадение в полном тексте источника
… Circulating polyunsaturated fatty acids, fish oil supplementation, and risk of incident dementia: A prospective cohort study of 440,750 participants Geroscience 2023 45 1997 2009 10.1007/s11357-023-00778-6 37046127 PMC10400523 34. Aristotelous P. Stefanakis M. Pantzaris M. Pattichis C.S. …

Sjögren Disease-B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell-Targeted Therapies.

Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)-approved disease-modifying therapies for SjD. In this review, we explore the expanding field of SjD endotyping as a tool to enhance patient stratification, prognostication, and clinical decision-making. SjD endotypes driven by heightened B cell activity are linked to increased lymphoma risk. B cells play a ce

Совпадение в полном тексте источника
… Geroscience 2024 ; 46 ( 6 ): 6085 – 6099 . 38656650 10.1007/s11357-024-01159-3 PMC11493885 28 Cancro MP . Age‐associated B cells . Annu Rev Immunol 2020 ; 38 : 315 – 340 . 31986068 10.1146/annurev-immunol-092419-031130 29 Xu T , Zhu HX , You X , et al. …

Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and colocalization analysis.

BackgroundThe proteome is a crucial reservoir of targets for cancer treatment. While some targeted therapies have been developed, there are still significant challenges in early diagnosis and treatment, highlighting the need to identify new biomarkers and therapeutic targets for breast cancer. Therefore, we conducted a comprehensive proteome-wide Mendelian randomization (MR) study to identify novel biomarkers and potential therapeutic targets for breast cancer.MethodsProtein quantitative trait locus (pQTL) data were extracted from two published plasma proteome-wide association studies. Genetic

Совпадение в полном тексте источника
… GeroScience . ( 2022 ) 44 : 2259–70 . doi: 10.1007/s11357-022-00602-7 PMC9616983 35689786 24 Burgess S Davey Smith G Davies NM Dudbridge F Gill D Glymour MM . Guidelines for performing Mendelian randomization investigations: update for summer 2023 . …

Prescription and use of psychoactive medications among cancer patients and associated factors in lower and upper middle-income countries: systematic review.

PURPOSE: To describe the prescription and use of psychoactive medications among cancer patients in low- and middle-income countries (LMICs) and explore the factors influencing their prescription and use. METHODS: This systematic review was conducted following the PRISMA guidelines. Six electronic databases were searched. We included observational studies that investigated the prescription and use of psychoactive medications among adult cancer patients in low- and middle-income countries (LMICs) according to the 2024 World Bank's classification. Eligible studies specifically focused on the use

Совпадение в полном тексте источника
… GeroScience. Available from: 10.1007/s11357-025-01676-9. Accessed 22 Sep 2025 9. Depression symptoms (2024) How to manage depression. Available from: https://www.cancer.org/cancer/managing-cancer/side-effects/emotional-mood-changes/depression.html . Accessed 24 Oct 2024 10. …

Inflammaging in periodontal, periapical, and malignancy-associated disease: drivers of alveolar bone loss and repair.

BACKGROUND: Aging significantly impacts bone metabolism through altered osteoblast/osteoclast dynamics, reduced stem cell regeneration, and chronic inflammaging. This narrative review explores how these age-related changes influence alveolar bone loss and regeneration in the oral cavity. METHODS: The review investigates key mechanisms-including immunosenescence and inflammasome activation-across three specific pathological contexts: (1) periodontitis, (2) periapical bone resorption, and (3) malignancy-associated osteolysis. Preclinical and clinical evidence were integrated to analyze the bone

Совпадение в полном тексте источника
… Khalaf F, Barayan D, Saldanha S, Jeschke MG (2025) Metabolaging: a new geroscience perspective linking aging pathologies and metabolic dysfunction. Metabolism 166:156158. 10.1016/j.metabol.2025.156158 13. Infante A, Rodríguez CI (2018) Osteogenesis and aging: lessons from mesenchymal stem cells. …

Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study.

Recent observational studies revealed an association between gut microbiota and aging, but whether gut microbiota are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate the causal association between gut microbiota and biological age acceleration using the largest available gut microbiota GWAS summary data from the MiBioGen consortium and GWAS data on biological age acceleration. We further conducted sensitivity analysis using MR-PRESSO, MR-Egger regression, Cochran Q test, and reverse MR analysis. Streptococcus (IVW

Совпадение в полном тексте источника
… Gastro-intestinal and oral microbiome signatures associated with healthy aging Geroscience 2019 41 907 921 10.1007/s11357-019-00098-8 31620923 PMC6925087 58. Zhang S. Zeng B. Chen Y. Yang M. Kong F. Wei L. Li F. Zhao J. Li Y. …

Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies.

Cellular senescence is characterized by the permanent arrest of cell proliferation and is a response to endogenous and exogenous stress. The continuous accumulation of senescent cells (SnCs) in the body leads to the development of aging and age-related diseases (such as neurodegenerative diseases, cancer, metabolic diseases, cardiovascular diseases, and osteoarthritis). In the face of the growing challenge of aging and age-related diseases, several compounds have received widespread attention for their potential to target SnCs. As a result, senolytics (compounds that selectively eliminate SnCs

Long-term health outcomes in older recipients of blood or marrow transplantation: a report from the BMTSS.

AbstractLittle is known about the long-term health and well-being of older (≥60 years) patients who received blood or marrow transplant (BMT), a growing population at risk for late-occurring morbidity and mortality. This study included ≥2-year survivors (N=1581) who underwent BMT between 1990 and 2014 at age ≥60 years. Severe/life-threatening and fatal chronic health conditions were identified using Common Terminology Criteria for Adverse Events. Multivariable regression analysis compared the risk of severe/life-threatening health conditions and health status between survivors and 594 age-matc

Совпадение в полном тексте источника
… the mean of a Poisson distribution: a review Biometrical J 35 7 1993 857 867 27 Lin RJ Artz AS Allogeneic hematopoietic cell transplantation for older patients Hematol Am Soc Hematol Educ Program 2021 1 2021 254 263 10.1182/hematology.2021000257 PMC8791130 34889392 28 Kennedy BK Berger SL Brunet A Geroscience …

Common Neurologic Diseases in Geriatric Dogs.

The increase in the canine geriatric population means that veterinarians are more often confronted with diseases that are more prevalent in patients in this age group. As in other organ systems, degenerative, neoplastic, and vascular diseases are the most prevalent neurologic disorders in older dogs. A neurological disease in an older dog poses a challenge for the clinician due to the presence of concomitant diseases and age-related changes that make it difficult to interpret the neurological examination. In addition, given the age of the patients, some owners do not allow advanced imaging tes

Совпадение в полном тексте источника
… Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience. Front. Vet. Sci. 2022;9:853743. doi: 10.3389/fvets.2022.853743. 3. Bagley R.S. Common Neurologic Diseases of Older Animals. Vet. Clin. N. Am. Small Anim. …

Anti-PEG Antibodies and Their Biological Impact on PEGylated Drugs: Challenges and Strategies for Optimization.

Polyethylene glycol (PEG) has been widely utilized in optimizing therapeutics due to its excellent biocompatibility and chemical stability. However, multiple dosing of PEGylated drugs may result in toxicity due to PEG accumulation in tissues, leading to the formation of anti-PEG antibodies (APAs), which can accelerate drug clearance, reduce efficacy, and alongside enhanced side effects, such as allergic reactions. Notably, pre-existing APAs have also been detected in individuals with no prior exposure to PEGylated drugs, raising additional clinical concerns. This review summarizes the mechanis

Совпадение в полном тексте источника
… A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: Complement activation as a possible contributing factor Geroscience 2022 44 597 618 10.1007/s11357-021-00495-y 35146583 PMC8831099 45. Richter A.W. …

Clinical characteristics of older patients with COVID-19: a systematic review of case reports.

In the context of the current COVID-19 pandemic, higher morbidity and mortality have been reported in older adults. This age group presents physiological changes and its own clinical conditions such as frailty, dementia, among others.ObjectiveTo describe the characteristics of COVID-19 patients, both over and under 80 years old, by conducting a systematic review of the literature describing case reports, and to summarize and critically assess these characteristics.MethodsSystematic review. The study was registered on the Registry of Health Research Projects (PRISA) of the Peruvian National Ins

Совпадение в полном тексте источника
… GeroScience. 2020;42(2):505–514. doi: 10.1007/s11357-020-00186-0. 26. Carrillo-Vega MF, Salinas-Escudero G, García-Peña C, Gutiérrez-Robledo LM, Parra-Rodríguez L. Early estimation of the risk factors for hospitalisation and mortality by COVID-19 in Mexico. [[accessed on Jun 8, 2020]]. …

Слежка за глазами для оценки легкого когнитивного расстройства: систематический обзор.

Легкое когнитивное расстройство (MCI), представляющее собой «переходную зону» между нормальным когнитивом и слабоумием, стало новой темой в клинических исследованиях. Хотя раннее обнаружение имеет решающее значение, в то же время оно по-прежнему сопряжено с материально-техническими трудностями. В то время как традиционные тесты с использованием перчаток и бумаги требуют углубленной подготовки для обеспечения стандартного управления и точного толкования результатов, значительные технологические достижения ведут к разработке процедур раннего обнаружения болезни Альцгеймера (АЗ) и облегчают диагн

Obesity and Cancer: Mechanisms, Epidemiological Evidence, and Potential Risk Reduction.

Obesity promotes carcinogenesis through interlocking metabolic, inflammatory, immune, and hormonal pathways. We narratively synthesize recent meta-analyses and selected cohort studies that examine adiposity-principally body mass index (BMI) and waist circumference-in relation to cancer incidence. Across the 13 cancers designated by the U.S. National Cancer Institute as obesity-associated, risk elevations are generally consistent, though magnitudes vary by histology (e.g., esophageal adenocarcinoma vs. squamous cell carcinoma), anatomic subsite (gastric cardia vs. non-cardia), sex or menopausal

Совпадение в полном тексте источника
… cohort study Lancet Reg Health Eur 45 101034 10.1016/j.lanepe.2024.101034 39253735 PMC11381908 21 Ungvari Z Fekete M Varga P Lehoczki A Fekete JT Ungvari A 2025 Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk Geroscience …

Oxidative Stress in Multiple Myeloma: Pathogenic Mechanisms, Biomarkers, and Redox-Targeted Therapeutic Strategies.

Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by high metabolic activity, chronic endoplasmic reticulum stress, and persistent redox imbalance. Excessive immunoglobulin synthesis and adaptation to the hypoxic bone marrow microenvironment lead to sustained production of reactive oxygen species (ROS). Their excessive accumulation promotes genomic instability, disease progression, osteolytic bone disease, and resistance to therapy. Paradoxically, MM cells adapt to oxidative stress by activating antioxidant and metabolic defense mechanisms, including Nuclear factor ery

Совпадение в полном тексте источника
… Genomic Instability and Genetic Heterogeneity in Aging: Insights from Clonal Hematopoiesis (CHIP), Monoclonal Gammopathy (MGUS), and Monoclonal B-Cell Lymphocytosis (MBL) GeroScience 2024 47 703 720 10.1007/s11357-024-01374-y 39405013 PMC11872960 35. Picou F. Vignon C. Debeissat C. Lachot S. …