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Public Omics Explorer (POE): Создание возможностей для комплексного семантического поиска по наборам данных GEO omics на основе публикаций PubMed.

Экспоненциальный рост общедоступных массивов данных об омиках и биомедицинской литературы создает как возможности, так и проблемы для открытия данных в области биологических наук. В то время как " Gene Express Omnibus " (GEO) содержит миллионы высокопроизводительных экспериментальных наборов данных, Европейский архив нуклеотидов (ENA) хранит соответствующие исходные данные о последовательности, а " PubMed " содержит большой объем соответствующих научных публикаций, комплексное исследование этих ресурсов по-прежнему носит ограниченный характер. Мы представляем "Public Omics

Олептические рецепторы в нейронной регенерации в центральной нервной системе.

Олептические рецепторы имеют решающее значение для обнаружения запахов и играют жизненно важную роль в нашем чувстве запаха, оказывая влияние на поведение, начиная от выбора пищи и кончая эмоциональными воспоминаниями. Эти рецепторы также способствуют нашему восприятию вкуса и могут применяться в медицинской диагностике и экологическом мониторинге. Способность обонятельной системы регенерировать свои сенсорные нейроны обеспечивает уникальную модель для изучения нейронной регенерации — явления, которое в основном отсутствует в центральной нервной системе. Понимание, полученное благодаря тому, к

Отчет о ДИД 1st Ежегодный Всемирный конгресс биомедицинской инженерии, проводимый в Сиане, Китай, 9-11 ноябрь 2017.

Мы рады представить на этом заседании резюме доклада "ДИД" 1st Всемирный конгресс биомедицинской инженерии 2017которая была проведена в Сиане в Китае [...].

Abstracts for the Eighth Congress of the European Association for Neuro-Oncology (EANO) : September 12–14, 2008 Barcelona, Spain

Background: Standard treatment consisting of surgery, irradiation plus concomitant and following T is established in GBM with median survival of 15.6 months, indicating the need for further effective treatment. In several phase II studies B plus I showed impressive objective response rates (>50%) in pre-treated GBM pts with low toxicity rate, duration of response, however, was moderate. Therefore, B plus I might be an effective induction regimen for T resistant GBM patients as basis for further treatments. In colo-rectal cancer a lower dose of B plus I was effective, therefore B and I dose was

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside.

Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedside. Moreover, the overall concept of precision medicine is not widely recognized in routine medical practice and the reductionist approach remains predominant in treating patients affected by major diseases such as cancer and cardiovascular diseases. By its' very nature, epigenetics is integrative of genetic networks. The study of epigenetic biomarkers has led to the identification of num

Emerging predictive biomarkers for novel therapeutics in peripheral T-cell and natural killer/T-cell lymphoma.

Peripheral T-cell lymphoma (PTCL) and natural killer/T-cell lymphoma (NKTCL) are rare subtypes of non-Hodgkin's lymphoma that are typically associated with poor treatment outcomes. Contemporary first-line treatment strategies generally involve the use of combination chemoimmunotherapy, radiation and/or stem cell transplant. Salvage options incorporate a number of novel agents including epigenetic therapies (e.g. HDAC inhibitors, DNMT inhibitors) as well as immune checkpoint inhibitors. However, validated biomarkers to select patients for individualized precision therapy are presently lacking,

Генетические данные о оси печени и мозга: риск липидного метаболизма и нейродегенеративного заболевания.

Ось печени - мозга имеет критическое значение для нейродегенеративных заболеваний (ND), при этом липидный метаболизм влияет на нейроинфламму и микроглиальную функцию. Систематическое исследование генетической связи между липидными метаболическими аномалиями и ND, а именно болезнью Альцгеймера (AD), болезнью Паркинсона (PD), множественным склерозом (MS) и амиотропическим боковым склерозом (ALS), отсутствует. Для оценки потенциальных причинно-следственных связей между ND и шестью липидными параметрами использовалась двухвыборная мендельская случайность (MR). МЕТОДЫ: Для параметров липидов и ND (

Emerging role of low-frequency somatic mutations in cancer relapse: from early detection to precision oncology.

Somatic mutations with low variant allele frequencies offer a highly sensitive lens for detecting cancer relapse driven by diverse causes, including clonal evolution and therapy resistance. Advances in next-generation sequencing have enabled robust subclonal variant identification that typically fall below conventional detection limits, supporting a comprehensive understanding of individual molecular profiles that can lead to relapse. These low-level alterations frequently emerge before clinical or radiological relapse and can inform response-adaptive treatment decisions. This review integrate

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… With completion of the Human Genome Project, the need for fast and scalable sequencing has become evident ( 60 , 61 ). This demand has driven the emergence of NGS, which has enabled parallel sequencing of massive amounts of data and improved the efficiency of genome analysis ( 62 ). … The human genome project: big science transforms biology and medicine . Genome Med . ( 2013 ) 5 : 79 . doi: 10.1186/gm483 , PMID: 24040834 PMC4066586 62 Satam H Joshi K Mangrolia U Waghoo S Zaidi G Rawool S . Next-generation sequencing technology: current trends and advancements . …

Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology.

Technological advancements in cell-free DNA (cfDNA) liquid biopsy have triggered exponential growth in numerous clinical applications. While cfDNA-based liquid biopsy has made significant strides in personalizing cancer treatment, the exploration and translation of epigenetics in liquid biopsy to clinical practice is still nascent. This comprehensive review seeks to provide a broad yet in-depth narrative of the present status of epigenetics in cfDNA liquid biopsy and its associated challenges. It highlights the potential of epigenetics in cfDNA liquid biopsy technologies with the hopes of enha

NEAT1 lncRNA overexpression results in short-term progression and poor treatment outcome in childhood B-ALL.

Childhood acute lymphoblastic leukaemia (chALL) remains the most prevalent malignancy in children and adolescents. Improving risk stratification and providing personalized prognosis and treatment remain major clinical challenges. Herein, we analysed the clinical utility of NEAT1 lncRNA for the prognosis and prediction of treatment outcome of childhood B-cell precursor ALL (chB-ALL). NEAT1_1 isoform was quantified in bone marrow samples of chB-ALL patients at diagnosis (n = 160) and at the end of induction (n = 108) of ALL-BFM protocol, and in age-matched healthy children (n = 68). Relapse and

Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio-Oncology, and the ESC Working Group on Cellular Biology of the Heart.

New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the implementation of effective treatments. Therefore, there is a crucial need for appropriate preclinical models to understand the biological basis of their cardiotoxicity. This scientific statement summarizes the preclinical models hitherto used, from in

From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine.

Cancer drug discovery is an inefficient process, with more than 90% of newly-discovered therapies failing to gain regulatory approval. Patient-derived models of cancer offer a promising new approach to identify new treatments; however, for rare cancers, such as sarcomas, access to patient samples is limited, which precludes development of patient-derived models. To address the limited access to patient samples, we have turned to pet dogs with naturally-occurring sarcomas. Although sarcomas make up <1% of all human cancers, sarcomas represent 15% of cancers in dogs. Because dogs have similar im

The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and Therapy.

(1) Background: Small ubiquitin-like modifiers (SUMOs) are pivotal in post-translational modifications, influencing various cellular processes, such as protein localization, stability, and genome integrity. (2) Methods: This review explores the SUMO family, including its isoforms and catalytic cycle, highlighting their significance in regulating key biological functions in thyroid cancer. We discuss the multifaceted roles of SUMOylation in DNA repair mechanisms, protein stability, and the modulation of receptor activities, particularly in the context of thyroid cancer. (3) Results: The aberran

Inhibition of EIF2α Dephosphorylation Decreases Cell Viability and Synergizes with Standard-of-Care Chemotherapeutics in Head and Neck Squamous Cell Carcinoma.

Drug resistance is a common cause of therapy failure in head and neck squamous cell carcinoma (HNSCC). One approach to tackling it is by targeting fundamental cellular processes, such as translation. The eukaryotic translation initiation factor 2α (EIF2α) is a key player in canonical translation initiation and integrates diverse stress signals; when phosphorylated, it curbs global protein synthesis. This study evaluates EIF2α expression and phosphorylation in HNSCC. A small-molecule inhibitor of EIF2α dephosphorylation, salubrinal, was tested in vitro, followed by viability assays, flow cytome

New clinical research strategies in thoracic oncology: clinical trial design, adaptive, basket and umbrella trials, new end-points and new evaluations of response.

In the genomics era, our main goal should be to identify large and meaningful differences in small, molecularly selected groups of patients. Classical phase I, II and III models for drug development require large resources, limiting the number of experimental agents that can be tested and making the evaluation of targeted agents inefficient. There is an urgent need to streamline the development of new compounds, with the aim of identifying "trials designed to learn", which could lead to subsequent "trials designed to conclude". Basket trials are often viewed as parallel phase II trials within

HIV-Associated Lymphomas: Updates from Pathogenesis to Treatment Strategies.

HIV-associated lymphoma (HAL) is an aggressive malignancy directly linked to HIV infection and accounts for more than 30% of cancer-related deaths in people living with HIV (PLWH). HAL subtypes, including diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), primary effusion lymphoma (PEL), and plasmablastic lymphoma (PBL), exhibit five to ten times higher incidence rates and distinct molecular profiles compared to HIV-negative lymphomas. Pathogenesis involves HIV-driven CD4+ T-cell depletion, chronic B-cell activation, and oncogenic viral coinfection. First-line therapy combines antir

Peripheral inflammatory T cell subsets are effective predictive factors in the development of heterotopic ossification after posttraumatic elbow surgery.

Heterotopic ossification refers to the pathological formation of extra-skeletal bone. It is a common complication of trauma or surgery that can cause disability and has no definitive cure. Furthermore, the mechanisms underlying chronic inflammation during ossification remain unclear. Therefore, this study aimed to elucidate the systemic immune microenvironment status of heterotopic ossification and identify biomarkers of therapeutic efficacy and recurrence. A combination of stereoarthrolysis with prophylactic radiotherapy and non-steroidal anti-inflammatory drugs was used to treat patients wit

Микробиота грибкового кишечника в педиатрии с множественным склерозом.

По имеющимся данным, кишечный микробиом может играть определенную роль в множестве склероза (MS). Однако в большинстве исследований основное внимание уделяется кишечным бактериальным сообществам; ни одно из них не изучало грибковую микробиоту (mycobiota) у лиц с педиатрическим множественным склерозом (POMS). Мы изучили кишечник микобиота у людей с ПОМС и без нее посредством перекрестного обследования кишечника микобиота из 46 Образцы стульев участниковthree группы: 18 ПОМЫ, 13 приобретенные монофазные демиелинизирующие синдромы [моноАДС], и 15 Не связанные с этим меры контроля). Использование

Histone modifications across cancers: mechanisms, therapy and clinical translation.

Cancer continues to be a major cause of death across the globe, and epigenetic dysregulation, including histone modifications, has been recognized as a major hallmark of cancer development, heterogeneity, and drug resistance. This review seeks to offer an overview of histone modifications in cancer, including the more studied histone modifications such as acetylation and methylation, as well as the less explored histone modifications such as phosphorylation, ubiquitination, and glycosylation. It also examines the role of histone modifications in the dysregulation of the three categories of enz

Лекарства, модифицирующие течение болезни, связаны с улучшением обонятельной функции через взаимодействие клеток NK и микробиоты при множественной склерозе.

ЦЕЛЬ: изучение связей носовой микробиоты с терапией, изменяющей заболевания (ДМТ), подмножеством лимфоцитов и функцией обоняния в множестве склерозов (МС). МЕТОДЫ: Thirty больные с синдромом MS и 30 Были приняты меры по контролю за здоровым здоровьем (ЗП) в разбивке по возрасту и полу. Пациенты были отнесены к категории пациентов, проходящих лечение по линии ДМТ (MS[DMT+]), или к категории пациентов, не прошедших лечение (MS[DMT-). Оличественная функция оценивалась с помощью теста на идентификацию запаха Пенсильванского университета (UPSIT). Подмножества лимфоцитов измерялись с помощью цитомет