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Results of an intervention in an academic Internal Medicine Clinic to continue, step-down, or discontinue proton pump inhibitor therapy related to a tennessee medicaid formulary change.

BACKGROUND: In July 2005, the State of Tennessee Medicaid Program (TennCare) announced formulary changes for proton pump inhibitors (PPIs) to be implemented in August 2005. Prior to these changes, pantoprazole was the only preferred PPI, and there were no restrictions to its use. The revised formulary included 3 preferred PPIs (esomeprazole, lansoprazole, and omeprazole OTC), all of which required prior authorization (PA). In order to obtain an approved PA for a PPI, the patient was required to have either (a) a diagnosis of erosive esophagitis, Barrett's esophagus, Schatzki's ring, a patholog…

Renal failure due to primary amyloidosis: a case report and literature review.

ContextPrimary amyloidosis, also known as AL amyloidosis, is commonly caused by clonal expansion of plasma cells in the bone marrow, thereby segregating light chains of clonal immunoglobulin that settle in tissues in the form of insoluble amyloid fibrils. The aim of this study was to report a case of primary amyloidosis with renal failure, diagnosed in Hospital São João, Porto, Portugal, focusing on the diagnostic difficulties and presenting a literature review.Case reportA 68-year-old Caucasian man was admitted to the Internal Medicine Department of the hospital with a condition of anasarca a

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… He was medicated with lisinopril in association with hydrochlorothiazide, lorazepam, finasteride, lansoprazole and furosemide. While under observation, he seemed to be aware, well-oriented and cooperative in time and space, and was hemodynamically stable. …

Krukenberg's Spindle-Like Corneal Changes in a Patient With Prolonged ICU Admission: A Case Report.

Krukenberg's spindles are vertical, spindle-shaped pigment deposits on the posterior cornea and are primarily associated with pigment dispersion syndrome (PDS). We present a case of Krukenberg's spindle-like corneal changes in a 39-year-old male patient following prolonged ICU management for thyroid storm complicated by infective endocarditis. The patient's complex ICU course included mechanical ventilation, veno-arterial extracorporeal membrane oxygenation (VA-ECMO), and multiple medications. Ophthalmological examination revealed bilateral, brownish, linear changes in the central corneal stro

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… October 24 | Gentamicin sulfate | Topical August 15 | October 16 | Bisoprolol | Patch August 15 | October 31 | Vidarabine | Topical August 18 | November 1 | Acetaminophen | Oral August 19 | November 6 | Lemborexant | Oral August 20 | October 22 | Clostridium butyricum | Oral August 20 | November 6 | Lansoprazole …

Correlation between Constipation Symptoms and Abdominal CT Imaging: A Cross-Sectional Pilot Study.

Evaluation of chronic constipation is important, although it is often difficult to satisfactorily treat due to the complex interplay of factors. This study aimed to determine whether the volume of intraluminal contents and lateral diameter of the colon measured from computed tomography (CT) images were correlated with the symptoms of chronic constipation and stool consistency. Consecutive patients who underwent the Constipation Scoring System (CSS), Bristol Stool Form Scale (BSFS) questionnaires and simple abdominal CT were selected retrospectively. The intestinal tract diameter at each site w

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… A PPI/PCAB user was defined as an individual who used any of the five types of PPI/PCAB (rabeprazole, lansoprazole, omeprazole, esomeprazole or vonoprazan) daily for more than 8 weeks. …

Recurrent severe hypocalcemia following chemotherapy regimen changes in advanced breast cancer: two case reports.

BACKGROUND: As an oncologic emergency related to abnormalities in calcium metabolism, hypercalcemia associated with paraneoplastic syndrome and bone metastases is well known. Meanwhile, the incidence of hypocalcemia is low, except in cases associated with bone-modifying agents used for bone metastases. Hypocalcemia induced by bone-modifying agents typically occurs early after the initial administration, and its incidence can be significantly reduced by preventive administration of calcium and vitamin D3 supplements. CASE REPORT: We report two cases of recurrent severe hypocalcemia occurring d

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… Calcium abnormalities owing to drug interactions were also unlikely, given case 1 involved sodium ferrous citrate and magnesium oxide, and case 2 included levothyroxine sodium hydrate, lansoprazole, and acetaminophen. Additionally, severe and acute hypocalcemia recurred after the regimen changes. …

Acute interstitial nephritis - a reappraisal and update.

Acute interstitial nephritis (AIN) is an under recognized and under diagnosed cause of acute kidney injury (AKI). It is estimated to account for 15 - 20% of cases of AKI; it is the reported diagnosis in 2.8% of all kidney biopsies, and 13.5% of biopsies done specifically for acute renal failure. Considerable evidence implicates antigen initiated cell-mediated injury in the pathogenesis of AIN. Drugs account for 70% of all cases, with over 150 different agents incriminated. The remaining cases are due to infections, autoimmune diseases, and rarely idiopathic. The central component of renal inju

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… rofecoxib Other agents: aceclofenac, indomethacin, diclofenac, diflusinal, flurbiprofen, mefenamate, phenazone, phenylbutazone, noramidopyrine, nimesulide, prioxicam, sulindac, tolmentin, zomepirac Drug-induced: proton-pump inhibitors & H 2 -Antagonists Incidence > 50 cases reported Omeprazole Other PPIs: lansoprazole … Other agents: aceclofenac, indomethacin, diclofenac, diflusinal, flurbiprofen, mefenamate, phenazone, phenylbutazone, noramidopyrine, nimesulide, prioxicam, sulindac, tolmentin, zomepirac Drug-induced: proton-pump inhibitors & H 2 -Antagonists | Incidence > 50 cases reported Omeprazole Other PPIs: lansoprazole …

Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging.

Bile acids are strongly associated with the pathogenesis of functional gastrointestinal diseases. In recent years, blue laser imaging (BLI) endoscopy has emerged as a novel image-enhanced endoscopic method, which illustrates bile as a reddish hue. The present study investigated the factors that affect the area of bile in duodenal bulbs using BLI. For this purpose, patients (356 cases) who underwent upper endoscopy with BLI between April, 2017 and December, 2019, and completed patient background and symptom questionnaires [Constipation Scoring System (CSS), Bristol Stool Form Scale (BSFS) and F

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… Daily use of any of the five types of PPIs/PCABs (rabeprazole, lansoprazole, omeprazole, esomeprazole or vonoprazan) for >8 weeks was regarded as indicating a PPI/PCAB user. Patients taking a normal dose of aspirin or a PPI/PCAB were regarded as users of such therapies. …

Futibatinib, an Irreversible FGFR1-4 Inhibitor for the Treatment of FGFR-Aberrant Tumors.

Fibroblast growth factor receptors (FGFR) are emerging as an important therapeutic target for patients with advanced, refractory cancers. Most selective FGFR inhibitors under investigation show reversible binding, and their activity is limited by acquired drug resistance. This review summarizes the preclinical and clinical development of futibatinib, an irreversible FGFR1-4 inhibitor. Futibatinib stands out among FGFR inhibitors because of its covalent binding mechanism and low susceptibility to acquired resistance. Preclinical data indicated robust activity of futibatinib against acquired res

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… In a food-effect and drug-drug interaction (DDI) study with a proton pump inhibitor (PPI; lansoprazole), consuming a high-fat, high-calorie meal slightly lowered futibatinib oral bioavailability, and delayed time to futibatinib maximum plasma concentration, but the differences were not clinically meaningful … Coadministration of lansoprazole had no clinically relevant effect on futibatinib pharmacokinetics, indicating that futibatinib can be coadministered with PPIs. 64 , 65 Other phase I studies in healthy adult volunteers evaluated the involvement of futibatinib in the common drug metabolizing CYP3A pathway …

The updated landscape of tumor microenvironment and drug repurposing.

Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and response to therapies. Cancer research and treatment have switched from a cancer-centric model to a TME-centric one, considering the increasing significance of TME in cancer biology. Nonetheless, the clinical efficacy of therapeutic strategies targeting TME, especially the specific cells or pathways of TME, remains unsatisfactory. Classifying the chemopathological characteristics of TME and crosstalk among one another can greatly b

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… , pembrolizumab, avelumab, nivolumab, ipilimumab, lenalidomide) | Ovarian cancer, HNSCC, TNBC, solid adult tumor, multiple myeloma | NCT04188119 | Not yet recruiting NCT02659384 ; NCT03245489 ; NCT03728179 ; NCT03428373 | Recruiting Combination immunomodulatory cocktail (Vitamin D, aspirin, CTX and lansoprazole … A recruiting phase II clinical trial (PRIMMO) has shown that aspirin, together with vitamin D, cyclophosphamide, and lansoprazole, forms an immunomodulatory cocktail and can be combined with immunotherapy pembrolizumab and radiotherapy to treat cervical and uterine cancers ( NCT03192059 ) (Table 1 ). …

Pharmacological treatment of children with gastro-oesophageal reflux.

BACKGROUND: Gastro-oesophageal reflux (GOR) is a common disorder, characterised by regurgitation of gastric contents into the oesophagus. GO … ant(®) , but further studies with longer follow-up times are recommended. Studies of omeprazole and lansoprazole in infants with functional GOR have demonstrated variable benefit, probably because of differences in inclusion criteria.No robust RCT evidence has been found regarding treatment of preterm babies with GOR/GORD or children with neurodisabilities. In …

Atypical Femoral Fracture in Patients With Metastatic Bone Tumors: An Analysis Based on the Japanese Adverse Drug Event Reaction Database (JADER).

Objective Denosumab (DEN)-related atypical femoral fracture (AFF) is a rare entity, and hence not feasible to examine with a single institution-based study. In light of this, we performed a retrospective analysis of the clinical characteristics of patients with metastatic bone tumors treated with DEN and developed AFF. Methods The Japanese Adverse Drug Event Report (JADER) database (2023.8 public version) from the second quarter of 2004 to the second quarter of 2023 was used to investigate the backgrounds of patients with metastatic bone tumors who developed AFF while receiving DEN. The time o

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… . ** Omeprazole, lansoprazole, rabeprazole, esomeprazole, and vonoprazan AFF: atypical femoral fracture; CI: confidence interval; PPIs: proton pump inhibitors; ROR: reporting odds ratio Pharmaceutical agent | AFF (n=106), n (%) | Non-AFF (n=1,906), n (%) | Total (n=2,012), n (%) | ROR | 95% CI Zoledronic …

Chemotherapy-induced acute kidney injury: epidemiology, pathophysiology, and therapeutic approaches.

Despite significant advancements in oncology, conventional chemotherapy remains the primary treatment for diverse malignancies. Acute kidney injury (AKI) stands out as one of the most prevalent and severe adverse effects associated with these cytotoxic agents. While platinum compounds are well-known for their nephrotoxic potential, other drugs including antimetabolites, alkylating agents, and antitumor antibiotics are also associated. The onset of AKI poses substantial risks, including heightened morbidity and mortality rates, prolonged hospital stays, treatment interruptions, and the need for

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… Other inhibitors of OCT2, such as Lansoprazole and Imatinib, have also been reported to reduce CIA in animal models ( 52 , 53 ). … Concomitant lansoprazole ameliorates cisplatin-induced nephrotoxicity by inhibiting renal organic cation transporter 2 in rats. Biopharm Drug Dispos. (2020) 41:239–47. doi: 10.1002/bdd.2242 53. Tanihara Y, Masuda S, Katsura T, Inui Ki. …

The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?

Immune checkpoint inhibitors (ICIs) are a novel class of immunotherapy drugs that have improved the treatment of a broad spectrum of cancers as metastatic melanoma, non-small lung cancer or renal cell carcinoma. These humanized monoclonal antibodies target inhibitory receptors (e.g. CTLA-4, PD-1, LAG-3, TIM-3) and ligands (PD-L1) expressed on T lymphocytes, antigen presenting cells and tumor cells and elicit an anti-tumor response by stimulating immune system. Nevertheless, the improved overall survival is complicated by the manifestation of Immune-related Adverse Effects (irAEs). During treat

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… Accordingly, in a patient with NSCLC treated with the anti-PD-1 antibody nivolumab who developed kidney injury, circulating lymphocytes appeared to be effectively stimulated by the PPI lansoprazole ( 78 ). … Strikingly, patient showed rapid improvement in kidney function in 3 days (creatinine decreased from 2.74 to 1.82 mg/dl) upon discontinuation of lansoprazole ( 78 ). In summary, patients with ICIs-induced AKI receiving a concomitant drug (e.g. …

Risk Factors for Mucosal Redness in the Duodenal Bulb as Detected via Linked Color Imaging.

Linked color imaging (LCI) for image-enhanced endoscopy (IEE) highlights mucosal color differences. We investigated risk factors associated with mucosal redness of the duodenal bulb using LCI. Consecutive patients were retrospectively selected after their duodenal bulbs were observed via LCI. A symptom questionnaire (Izumo scale) was completed. The LCI of the duodenal bulb was subjectively evaluated on whether redness was present and objectively evaluated based on L* a* b* color values. The clinical characteristics of the 302 study participants were: male/female, 120/182; mean age, 70.9 years.

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… A PPI/PCAB user was deemed to be someone who used any of five types of PPI/PCAB daily (lansoprazole, rabeprazole, esomeprazole, vonoprazan, or omeprazole) for more than 2 months. …

Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity.

Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two. The deficiency of Nrf2 elevates the expression of NF-κB, leading to increased production of inflammatory factors, while NF-κB can affect the expression of downstream target genes by regulating the transcription and activity of Nrf2. At the same time, many therapeutic drug-induced organ toxicities, including hepatotoxicity, nephrotoxicity, cardiotoxicity, pulmonary toxicity, dermal toxicity, and neurotoxi

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… NF-κB-controlled chemokines and pro-inflammatory cytokines Contrast | Atorvastatin; Infliximab; stanniocalcin-1 | • Activating the Nrf2/Sirt3/SOD2 or Nrf2/HO-1 pathways | Saritemur et al. (2015) , Khaleel et al. (2017) , Yue et al. (2017) , Khaleel et al. (2019) , Zhou Z et al. (2019) , Zhao et al. (2020) Lansoprazole … Lansoprazole Halts Contrast Induced Nephropathy through Activation of Nrf2 Pathway in Rats. Chemico-Biological Interactions 270, 33–40. 10.1016/j.cbi.2017.04.010 Khaleel S. A., Raslan N. A., Alzokaky A. A., Ewees M. G., Ashour A. A., Abdel-Hamied H. E., et al. (2019). …

Combination therapy in combating cancer.

Combination therapy, a treatment modality that combines two or more therapeutic agents, is a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy compared to the mono-therapy approach because it targets key pathways in a characteristically synergistic or an additive manner. This approach potentially reduces drug resistance, while simultaneously providing therapeutic anti-cancer benefits, such as reducing tumour growth and metastatic potential, arresting mitotically active cells, reducing cancer stem cell populations, and inducing apoptosis. The 5-year survival

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… However, in another study, it was postulated that in combination with the proton pump inhibitor lansoprazole it potentiated the effects of melanoma Me30966 cells treated with CAIX specific inhibitor FC9-399A or S4 treatment [ 86 ]. … Lok J Supuran CT Kaanders JH Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model PLoS One 2014 9 e108068 10.1371/journal.pone.0108068 PMC4167542 25225880 86 Federici C Lugini L Marino ML Carta F Iessi E Azzarito T Supuran CT Fais S Lansoprazole …

Кислотная терапия и риск излечения в случае воспламенительной болезни лопатки: сравнительное исследование в целях информирования о личностном лечении в мире.

Предыстория/цели: Известно, что ингибиторы протонных насосов (ИПЦ) изменяют состав кишечника микробиота; однако их связь с курсами заболеваний и результатами у пациентов с воспалительным кишечным заболеванием (ИБД) остается неопределенной. Наши цели заключались в оценке связи между использованием ИЦП и эскалацией лечения, диффицией Клостридиодов и использованием медицинских услуг в ИБД. Методы: Мы провели ретроспективное когортное исследование на платформе TriNetX. Пациенты IBD с ИЦП или histamine-2 Совпадали антагонисты рецептора (H2RA) one- чтобы...one с помощью баллов склонности. Итогом это

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… Patients were required to have a documented diagnosis of IBD, including ulcerative colitis (UC, ICD-10 code K51) or Crohn’s disease (CD, ICD-10 code K50), and subsequent exposure to either PPI (omeprazole, pantoprazole, esomeprazole, lansoprazole, or rabeprazole) or H2RAs (cimetidine, famotidine, nizatidine …

Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies.

With the increasing use of targeted anticancer drugs and immunotherapies, there have been a substantial number of reports concerning life-threatening severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms, drug-induced hypersensitivity syndrome, and acute generalized exanthematous pustulosis. Although the potential risks and characteristics for targeted anticancer agent- and immunotherapy-induced SCAR were not well understood, these serious adverse reactions usually result in morb

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… 303 304 12707720 10.1007/s00277-003-0643-z 121 Hsieh HJ Chan AL Lin SJ Stevens-Johnson syndrome induced by combination of imatinib and allopurinol Chemotherapy 2009 55 4 197 199 19439939 10.1159/000218097 122 Severino G Chillotti C de Lisa R del Zompo M Ardau R Adverse reactions during imatinib and lansoprazole …

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… PC-169 Clinical pharmacists impact on validation orders: application to innovative drugs PC-178 Challenge for clinical pharmacist in education of patients with type 2 diabetes PC-183 Evaluation of pharmaceutical care at hospital admission PC-189 Comparison of the administration of esomeprazole and lansoprazole …

Prevalence, Attributes, and Risk Factors of QT-Interval-Prolonging Drugs and Potential Drug-Drug Interactions in Cancer Patients: A Prospective Study in a Tertiary Care Hospital.

Introduction Cancer chemotherapy regimens include multiple classes of adjuvant drugs as supportive therapy. Because of the concurrent intake of other drugs (like antiemetics, antidepressants, analgesics, and antimicrobials), there is a heightened risk for possible QT interval prolongation. There is a dearth of evidence in the literature regarding the usage of QT-prolonging anticancer drugs and associated risk factors that have the propensity to prolong QT interval. The purpose was to explore the extent of the use of QT-interval-prolonging drugs and potential QT-prolonging drug-drug interaction

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… N07XX59) | 6 (0.4) Diuretic (n=7) | Conditional risk of TdP (n=4) | Furosemide (C03CA01) | 3 (0.2) Torsemide (C03CA04) | 1 (0.1) Possible risk of TdP (n=3) | Hydrochlorothiazide (C03AA03) | 3 (0.2) Proton pump inhibitor (n=632) | Conditional risk of TdP (n=632) | Pantoprazole (A02BC02) | 616 (46.2) Lansoprazole …