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Exploring signs of central sensitization in adolescents with hypermobility Spectrum disorder or hypermobile Ehlers-Danlos syndrome.

BACKGROUND: Hypermobility Spectrum Disorder (HSD) and Hypermobile Ehlers-Danlos Syndrome (hEDS) are two overlapping heritable connective tissue disorders characterized by joint hypermobility, chronic pain, impaired body perception, and musculoskeletal symptoms. Central sensitization has been proposed as a plausible explanation for symptoms like widespread pain, fatigue, mood disorders, and sleep disturbances in patients with HSD/hEDS. OBJECTIVE: The aim of this study was to investigate signs of central sensitization, including exercise-induced hypoalgesia (EIH), and fatigue severity in adoles

Changes in Fatigue Are the Same for Trained Men and Women after Resistance Exercise.

PURPOSE: To measure changes in fatigue and knee-extensor torque in the 48 h after trained men and women completed a full-body resistance exercise session. METHODS: Eight trained women (mean ± SD: age, 25.6 ± 5.9 yr; height, 1.68 ± 0.06 m; mass, 71.0 ± 8.6 kg) and eight trained men (age, 25.5 ± 6.2 yr; height, 1.79 ± 0.05 m; mass, 86.4 ± 9.8 kg) performed a full-body resistance exercise session based on real-world athletic practice. Measurements were performed before and after the exercise session, as well as 1, 24, and 48 h after the session. Fatigue and pain were measured with standardized s

Improving wheelchair user sitting posture to alleviate lumbar fatigue: a study utilizing sEMG and pressure sensors.

BACKGROUND: The wheelchair is a widely used rehabilitation device, which is indispensable for people with limited mobility. In the process of using a wheelchair, they often face the situation of sitting for a long time, which is easy to cause fatigue of the waist muscles of the user. Therefore, this paper hopes to provide more scientific guidance and suggestions for the daily use of wheelchairs by studying the relationship between the development of muscle fatigue and sitting posture. METHODS: First, we collected surface Electromyography (sEMG) of human vertical spine muscle and analyzed it i…

Different Properties of the Erector Spinae and Multifidus Muscles on Physical Performance in Patients With Chronic Obstructive Pulmonary Disease.

BACKGROUND: Muscle atrophy in the dorsal muscle group (DMG) is associated with physical activity (PA) in patients with chronic obstructive p … MCSA) on chest computed tomography and PA parameters. In Study 2, as a pilot study, we analyzed the muscle fatigue characteristics of ESM and MM using a trunk holding test and electromyographic (EMG) power spectrum analysis to evaluate the median frequency (MF) slope. We then evaluated the differences in the MF slopes of both muscles in patients with COPD compar …

Пространственно распределенная последовательная стимуляция применяется к парализованным квадрицепсам при циклическом движении FES с помощью двигателя.

Пространственное распределение последовательной стимуляции (SDSS) продемонстрировало более высокую способность к снижению усталости и выходную мощность при осуществлении изометрических или изокинетических сокращений парализованных квадрицепсов по сравнению с эквивалентными функциональными стимуляторами (FES) в одной конфигурации стимулятора электрода (SES). Целью настоящего исследования является систематическая оценка выходной мощности и факторов, снижающих усталость, которые применяются в отношении парализованных квадрицепсов субъектов, осуществляющих циклическое движение FES с помощью двигат

Совпадение в аннотации оригинала
Spatially distributed sequential stimulation (SDSS) demonstrated greater fatigue-reducing ability and power output when performing isometric … W ± 1.4 W), corresponding to an increase of approximately 144%, while inducing a similar amount of muscle fatigue (SDSS: 68.9% ± 8.0% vs. SES: 75.3% ± 13.4%). These findings suggest that SDSS is superior to SES when applied to paralyzed quadriceps muscles of the subjects performing FES cycling using moderate-intensity stimulation. Further research with larger s …

PAIN IN POST-POLIO SYNDROME: A SEPARATE PAIN ENTITY?

BACKGROUND: Most patients with polio recover from the initial infection, but develop muscle weakness, pain and fatigue after 15-40 years, a condition called post-polio syndrome. Although poliovirus has been almost eliminated, 12-20 million people worldwide still have polio sequelae. The pain is described mainly as nociceptive, but some patients experience neuropathic pain. The aim of this study was to further characterize post-polio pain. PATIENTS AND METHODS: A total of 20 patients with post-polio syndrome participated in the study. Physical examination was performed, and questionnaires cont

Effects of vibration therapy on neuromuscular efficiency & features of the EMG signal based on endurance test.

BACKGROUND: Vibration Therapy (VT) stimulate the muscle spindles, which in turn enhances its afferent activities. OBJECTIVE: The present study was designed to investigate the effect of VT at 23 and 35 Hz on muscle performance. The EMG features (six time-domain (TD) and four frequency-domain (FD)) and a new formula for computing neuromuscular performance were used as dependent variables to evaluate the effect of VT. METHOD: The EMG recording was performed at 50% MVC during grip endurance test before and after VT. The EMG features were extracted out of raw EMG signals acquired from four forear

Short- and long-term effects of exercise on neck muscle function in cervical radiculopathy: A randomized clinical trial.

OBJECTIVE: To compare short- and long-term changes in neck muscle endurance, electromyography measures of neck muscle activation and fatigue and ratings of fatigue and pain after neck-specific training or physical activity in people with cervical radiculopathy. DESIGN: Randomized clinical trial. SUBJECTS/PATIENTS: Seventy-five patients with cervical radiculopathy. METHODS: Patients underwent neck-specific training in combination with a cognitive behavioural approach or prescribed physical activity over a period of 14 weeks. Immediately after the intervention and 12 months later, surface ele

Morphological aspects of neuromuscular junctions and gene expression of nicotinic acetylcholine receptors (nAChRs) in skeletal muscle of rats with heart failure.

HF is syndrome initiated by a reduction in cardiac function and it is characterized by the activation of compensatory mechanisms. Muscular fatigue and dyspnoea are the more common symptoms in HF; these may be due in part to specific skeletal muscle myopathy characterized by reduced oxidative capacity, a shift from slow fatigue resistant type I to fast less fatigue resistant type II fibers and downregulation of myogenic regulatory factors (MRFs) gene expression that can regulate gene expression of nicotinic acetylcholine receptors (nAChRs). In chronic heart failure, skeletal muscle phenotypic c

Changes in EMG activity in the upper trapezius muscle due to local vibration exposure.

Exposure to vibration is suggested as a risk factor for developing neck and shoulder disorders in working life. Mechanical vibration applied to a muscle belly or a tendon can elicit a reflex muscle contraction, also called tonic vibration reflex, but the mechanisms behind how vibration could cause musculoskeletal disorders has not yet been described. One suggestion has been that the vibration causes muscular fatigue. This study investigates whether vibration exposure changes the development of muscular fatigue in the trapezius muscle. Thirty-seven volunteers (men and women) performed a sub-max

Effect of a Novel Adaptive Handle Design on the Ergonomic Performance of Periodontal Curettes in Dental Hygienists with and without Musculoskeletal Disorders: A Pilot Clinical Study.

(1) Background: Musculoskeletal disorders (MSDs), discomfort, fatigue, pain, and other acute and chronic work-related injuries are common among dental clinicians. Hand instruments constitute a primary risk factor for these conditions. The overall goal of this study was to compare in dental hygienists with healthy hands, and in those with MSDs, the effect of three different handle designs on instrumentation-related muscle work, comfort, fatigue, and quality of tactile feedback. (2) Methods: Clinicians tested three periodontal curettes: one with a novel adaptive silicone handle, another with a r

Serum insulin-like growth factor-I (IGF-I) does not correlate positively with isometric strength, fatigue, and quality of life in post-polio syndrome.

OBJECTIVES AND BACKGROUND: To determine if serum insulin-like growth factor-I (IGF-I) levels are associated with strength, body mass index (BMI), fatigue, or quality of life in post-poliomyelitis syndrome (PPS). PPS is likely due to a distal disintegration of enlarged post-polio motor units as a result of terminal axonal sprouting. Age-related decline in growth hormone and IGF-I (which support terminal axonal sprouts) is proposed as a contributing factor. METHODS: As part of the North American Post-Poliomyelitis Pyridostigmine Study (NAPPS), baseline data on maximum voluntary isometric contra

Activity-dependent conduction block in multifocal motor neuropathy.

Patients with multifocal motor neuropathy may complain of muscle fatigue, even though the degree of conduction block assessed at rest has improved with treatment. To explore the mechanism involved, we examined changes in muscle force during maximum voluntary contraction (MVC) and monitored conduction block before and after MVC in five patients with multifocal motor neuropathy. The results were compared with those for the contralateral unaffected homonymous muscles. For one patient, who had bilateral involvement, a normal subject of a similar age and stature served as the control. Results of co…

Anticholinesterase-responsive neuromuscular junction transmission defects in post-poliomyelitis fatigue.

Disabling generalized fatigue and muscle fatiguability are common features of post-poliomyelitis syndrome (PPS). In 17 fatigued PPS patients, we measured jitter on stimulation single-fiber electromyography (S-SFEMG) for at least 3.5 min before and after i.v. injection of 10 mg edrophonium. We observed reduction in jitter (defined as a significant difference in jitter means before and after edrophonium, unpaired t-test P < 0.05) in 7 patients, no change in 8, and a significant increase in 2 patients. Blinded to their edrophonium results, the 17 patients were treated with pyridostigmine 180 mg/d

Disrupting the feed-forward cycle of RyR1 Ca2+ leak and oxidative stress mitigates doxorubicin-induced skeletal myopathy.

Doxorubicin (DOX) is a highly effective and widely used chemotherapeutic agent used to treat various types of cancer. Unfortunately, DOX als … apy agent, causes off-target cytotoxicity in healthy cells and often leads to debilitating skeletal muscle fatigue and weakness. In this study, we examined the effects of DOX on excitation-contraction coupling. From single RyR1 channel properties to muscle force production, we identified the underlying mechanisms of muscle dysfunction. We also evaluated novel sm …

The efficacy of a telerehabilitation-based clinical Pilates program on lumbopelvic muscle morphology and strength in female patients with fibromyalgia syndrome: a randomized controlled trial.

INTRODUCTION: The current study aims to assess the effects of a tele-rehabilitation-based clinical Pilates exercise program on morphological structure, endurance, central sensitization, pain, fatigue, anxiety, and depression in Fibromyalgia syndrome (FMS) patients. METHOD: Thirty women with FMS were randomized into two groups: the telerehabilitation group (TG) or the control group (CG). An online clinical Pilates-based exercise program targeting stability and strength that was conducted for 8 weeks with 2 sessions per week was developed for TG. The same exercise programs for the CG were provi

Longitudinal study of changes observed in quality of life, psychological state cognition and pulmonary and functional capacity after COVID-19 infection: A six- to seven-month prospective cohort.

AIMS: To investigate the health-related quality of life (HRQoL), symptoms, psychological and cognitive state and pulmonary and physical func … dicted with 82.4% accuracy (86.7% sensitivity and 83.3% specificity) by the presence at 3 months of muscle fatigue/muscle weakness (OR = 5.7 (1.8-18.1)), PTSD (OR = 6.0 (1.7-20.7)) and impaired HRQoL (OR = 11.7 (3.7-36.8)). CONCLUSION: A high proportion of nonhospitalised patients with COVID-19 experience an impaired HRQoL, cognitive and psychological function …

Overstimulation of the ergoreflex-A possible mechanism to explain symptoms in long COVID.

Long COVID refers to a multitude of symptoms that persist long after SARS-CoV-2 infection. Fatigue and breathlessness are the most common symptoms of long COVID across a range of studies. They are also cardinal symptoms of chronic heart failure (CHF). In this review, we propose that fatigue and breathlessness in patients with long COVID may be explained by skeletal muscle abnormalities, in a manner similar to patients with CHF. The ergoreflex is a cardiorespiratory reflex activated by exercise, which couples ventilation and cardiovascular function to exercise intensity. At least part of the sy

Effects of 8 weeks of masticatory muscles focused endurance exercises on women with oro-facial pain and temporomandibular disorders: A placebo randomised controlled trial.

BACKGROUND: Exercises are used to treat temporomandibular disorders (TMD), but they are often assessed with other therapies. Local endurance exercises may alter the resistance to fatigue and pain. OBJECTIVE: To assess the effects of an 8-week protocol of local endurance exercises of masticatory muscles on muscle excitation, force response, perceived pain and over muscle efficiency. DESIGN: Randomised controlled trial. SETTING: Ambulatory care. SUBJECTS: In a placebo randomised controlled trial, 46 women with TMD and oro-facial pain were randomised into intervention group and placebo group.

Two repetitive bouts of intense eccentric-concentric jaw exercises reduce experimental muscle pain in healthy subjects.

High-intensity eccentric-concentric contractions of the jaw-closing muscles induce muscle soreness, fatigue and functional impairment of the … ercises comprises 6 sets of 5-minute-long bouts of concentric-eccentric contractions. Self-reported muscle fatigue and pain, maximum mouth opening without pain (MMO), pain pressure thresholds (PPTs) of temporalis and masseter muscles and maximum voluntary bite force (MVBF) were recorded before, immediately after, 24 and 48 hours after each bout of exercises. ANO …