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[Investigation on natural foci of autumn-winter type tsutsugamushi disease in Shandong province].

OBJECTIVE: In order to provide basic data of tsutsugamushi disease in Shandong province, for the control and prevention of this disease in residents and army-men. METHODS: Aetiological, serological and epidemiological methods were used to investigate the natural foci of autumn-winter type tsutsugamushi disease. RESULTS: The peak of tsutsugamushi disease epidemic in Shandong province was in October with cases in this month accounted for 80% of all in a year, that showed autumn-winter type. The main reservoir hosts were Apodemus agrarius, Rattus norvegicus and Cricetulus triton, accounted for

[The natural foci of the tsutsugamushi disease in the suburbs of Hang Zhou City].

In 1986, investigating tsutsugamushi disease in the suburbs of Hangzhou, We isolated Rickettsia tsutsugamushi from leptotrombidium gaohuense and its reservoir hosts, Rattus confucianus and Rattus fulvescens, which were collected in Yang Shan Wu village, Linan county. It proved there was a natural focus of tsutsugamushi disease in the suburbs of Hang zhou. Which is located at 30 degrees 35'. North latitude, and main forest of the East Tianmu Mountain, covered by wide and needle leaves, with more wide leaves than needle one. The vector is leptotrombidium gaohuense. The host are Rattus confucianu

[The first case of tsutsugamushi disease in Ehime Prefecture].

The first case of tsutsugamushi disease in Ehime Prefecture was experienced in December 1987 with successful isolation of the causative agent. The patient was taken ill twelve days after infection. Immunofluorescent antibody tests using the isolate, Yamazaki strain, and Gilliam, Karp, Kato, Irie and Shimokoshi strains as antigens revealed that the specific antibodies against these antigens appeared and increased in the blood of the patient during the course of the disease. And the antibody titers to the Yamazaki antigen were the highest of these antigens. Agglutinin for Proteus OXK did not app

[A study on immunity in tsutsugamushi disease].

The immune response in human tsutsugamushi disease (scrub typhus) was studied. Anti-rickettsial activity of sera, peripheral mononuclear cells and their culture supernatants from patients on in vitro growth of Rickettsia tsutsugamushi proliferating in normal human peripheral macrophages was examined. The results obtained were as follows. 1) Sera from patients at the early convalescent stage, which exhibited high antibody titers against R. tsutsugamushi, effectively inhibited their growth in macrophages. 2) Sera from patients after a long period from the onset showed low antibody titers and did

Epidemiological and clinical characteristics of scrub typhus in Guizhou Province, China: An outbreak study of scrub typhus.

The reported cases of scrub typhus (ST) have continued to escalate, with outbreaks occurring regionally in China. These pose an increasing p … . Through semi-nested PCR, Sanger sequencing and phylogenetic tree construction, the Karp strain of Orientia tsutsugamushi (O. tsutsugamushi) was confirmed as the pathogen causing ST in Rongjiang County, which shared the same evolutionary branch with O. tsutsugamushi isolated from wild mouse liver or spleen, indicating that the wild mouse plays an importan …

Innovative Distance Learning Tool for Morphological Identification of Chigger Mites (Actinotrichida) as Vectors of Scrub Typhus: A Pilot Study.

Scrub typhus, a disease caused by Orientia tsutsugamushi, affects more than one billion people globally with an average fatality rate of 6%. Humans are accidentally infected through the bite of trombiculid mite larvae (chiggers). Chiggers feed on hosts' extracellular fluid for survival and development. O. tsutsugamushi is maintained throughout the chigger's lifespan and over several generations. Although disease-related knowledge is essential in designing effective control strategies, many personnel in related sectors are unfamiliar with this disease and its vector. To tackle this issue, we de…

Скруб Тифус: растущая угроза.

Scrub tyhus вызывается Orientia tsutsugamushi (бывший Рикитсия) и передается людям артхроподовым вектором семейства Тромбикулида (Leptotrombidium dliense and L. akamushi). Это самая распространенная новая Рикитциальная инфекция в Индии и многих других странах Юго-Восточной Азии. Фактически, скруб тифа географически ограничен Азиатско-Тихоокеанским регионом, миллиард человек подвергается риску, и каждый год сообщается о почти миллионе случаев. Скруб тифа, как представляется, особенно распределен в треугольнике Цутсугамуши, который распределен по очень обширной площади 13 млн. км2, примыкающей к…

Dot-ELISA Rapid Test Using Recombinant 56-kDa Protein Antigens for Serodiagnosis of Scrub Typhus.

We developed a rapid dot-enzyme-linked immunosorbent assay (dot-ELISA) using the combination of recombinant 56-kDa protein antigens that exhibited broad reactivity with serum antibodies against the four most prevalent strains (Karp, Kato, Gilliam, and TA763) of Orientia tsutsugamushi. The assay is rapid (30 minutes), and can be done at room temperature, and results can be read by the naked eye. Only a simple shaker is required to wash the membrane. Sera from 338 patients suspected of being ill with scrub typhus from rural hospitals around Thailand were tested using this dot-ELISA. Seventy-five…

Current situation of scrub typhus in South Korea from 2001-2013.

BACKGROUND: The bacteria Orientia tsutsugamushi is the causative agent of scrub typhus, mite-borne disease, which causes an acute febrile illness in patients. An epidemiologic study was conducted to understand the characteristics of scrub typhus in South Korea. FINDINGS: Reporting of tsutsugamushi disease is mandatory in South Korea since 1994. To investigate the prevalence of tsutsugamushi disease from 2001 to 2013, medical records from the Korea Center for Disease Control and Prevention were reviewed. In total, 70,914 cases were reported during 2001-2013. Of these, 37.16% (26,349) were male…

Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam.

A descriptive study on rickettsiosis was conducted at the largest referral hospital in Hanoi, Vietnam, to identify epidemiological and clinical characteristics of specific rickettsiosis. Between March 2001 and February 2003, we enrolled 579 patients with acute undifferentiated fever (AUF), excluding patients with malaria, dengue fever, and typhoid fever, and serologically tested for Orientia tsutsugamushi and Rickettsia typhi. Of the patients, 237 (40.9%) and 193 (33.3%) had scrub and murine typhus, respectively, and 149 (25.7%) had neither of them (non-scrub and murine typhus [non-ST/MT]). Th…

Rickettsia serosurvey in Kimberley, Western Australia.

To determine if antibodies to rickettsiae (scrub typhus, spotted fever, and typhus group rickettsiae) occur among persons living in the Kimb … of rickettsial microorganisms. The largest group of sera (24; 2.6%) were positive for scrub typhus (Orientia tsutsugamushi). Eleven other sera (1.2%) were positive for scrub typhus and spotted fever group rickettsiae and four (0.4%) were positive for scrub typhus, spotted fever group, and typhus group rickettsiae. In addition 13 sera (1.4%) were positive o …

Сопутствующая селезенка и почечная инфарктация в скруб-тифе: расширение васкулитического спектра.

Скруб тифа — зоонотическая инфекция, вызванная цетуцугамуши, которая характеризуется системным васкулитом и многоорганическим участием. Хотя печеночная, легочная и почечная дисфункция хорошо известны, ишемическая инфарктация твердых органов является явно редкостью. КИСЛОТА: 35-летняя женщина, которая ранее была здоровой, страдала острым фебриальным заболеванием, респираторными симптомами и болью в животе в левом верхнем квадрате. Проверка показала, что брюшная нежность тахипнея, гипоксии и фокуса без сыпания или эшара. Лабораторная оценка показала, что нейтрофильный лейкоцитоз, тромбоцитопенси

Совпадение в аннотации оригинала
BACKGROUND: Scrub typhus is a mite-borne zoonotic infection caused by Orientia tsutsugamushi, characterized by systemic vasculitis and multiorgan involvement. While hepatic, pulmonary, and renal dysfunction are well recognized, ischemic infarction of solid organs is distinctly uncommon. CASE PRESENTATION: A 35-year-old previously healthy woman presented with…

Eschar in scrub typhus: clinical signature, immunopathogenesis, and diagnostic implications.

SUMMARYScrub typhus, caused by Orientia tsutsugamushi, remains a major cause of acute undifferentiated febrile illness with an expanding global footprint. Early diagnosis is frequently delayed because of nonspecific systemic manifestations and geographic heterogeneity. The eschar, traditionally regarded as a characteristic but unreliable clinical sign, is better understood as a dynamic and biologically active lesion rather than a static cutaneous finding. Accumulating clinical, epidemiologic, and pathologic evidence demonstrates that eschar morphology and detectability vary widely with timing,…

Scrub and murine typhus seroprevalence among blood donors in Laos.

BACKGROUND: Scrub typhus and murine typhus, caused by Orientia tsutsugamushi and Rickettsia typhi, respectively, are important causes of febrile illness in Laos. Although several studies have assessed rickettsial infection in selected provinces, the nationwide distribution remains unclear. This study aimed to estimate exposure to scrub typhus group (STG) and typhus group (TG) across twelve provinces of Laos and identify potential hotspots. METHODOLOGY: We screened 1,200 serum samples from blood donors (100 per province) for STG and TG IgG antibodies using enzyme-linked immunosorbent assays (E…

Scrub Typhus Combined With Septic Shock Disseminated Intravascular Coagulation and Significant Hyperfibrinolysis: A Case Report and Review of the Literature.

Introduction: Scrub typhus is an acute infectious disease caused by Orientia tsutsugamushi, whose pathophysiology is characterized by systemic small-vessel vasculitis. Its high misdiagnosis rate stems from its nonspecific clinical features. If not diagnosed and treated in time, patients may rapidly progress to multiorgan dysfunction syndrome (MODS) or even disseminated intravascular coagulation (DIC), posing a severe threat to life. Case Presentation: The patient was a 68-year-old male with "recurrent fever and dry cough for six days." He was admitted to the hospital with a diagnosis of scrub …