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Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation.

BackgroundCytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms.MethodsThis study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed correlations with JAK2 V617F status and clinical-hematological parameters.ResultsThe proinflammatory cytokine levels were increased in myeloproliferative neoplasm patients, and the presence of the JA

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… (B) Radar chart representation of the immune profile of healthy subjects (CTRL) and patients with essential thrombocythemia (ET), primary myelofibrosis (PMF), and polycythemia vera (PV). Radar charts summarize the percentage of high producers of each cytokine/chemokine in the study groups. … (B) Radar chart representation of the immune profile of healthy subjects (CTRL) and patients with essential thrombocythemia (ET), primary myelofibrosis (PMF), and polycythemia vera (PV). Radar charts summarize the percentage of high producers of each cytokine/chemokine in the study groups. …

The Complex Behaviour of High-Frequency Currents in Simple Circuits.

The fact that standing wave phenomena exist along transmission lines and loops conducting high-frequency electrical energy is responsible fo … . Those who have some technical knowledge of such matters will readily recognize an application of "Radar" technique in this.

Сопоставим тесты на стриптиз JCVTM DxSelectTM и IMMUNOWELTM JCV в RRMS для оценки риска PML.

Риск развития прогрессивной многофукальной лейкоэнцефалопатии (ПМЛ), редкой, но потенциально смертельной оппортунистической инфекции центральной нервной системы, вызванной вирусом Дж.К. (JCV), по-прежнему является одной из главных проблем, связанных с наследственной терапией при клиническом лечении пациентов с множественным склерозом (MS). МАТЕРИАЛЫ И МЕТОДЫ: two - анализы на антитела, анализы на степию JCVTM DxSelectTM и анализы на антитела IMMUNOWELLT TM для оценки риска PML у пациентов, у которых диагностирован повторный склероз (RRMS), получивших терапию с модифицирующими заболеваниями (DM

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… The radar chart highlighted the distribution of risk changes, emphasizing the tendency of IMMUNOWELL™ JCV to classify patients into higher risk categories (Fig. 1 ). The heatmap (Fig. 2 ) confirms these results. … Radar chart for the distribution of risk classes (Low, Intermediate, High) for both STRATIFY JCV™ DxSelect™ and IMMUNOWELL™ JCV tests. Blue lines= STRATIFY JCV™ DxSelect™, orange lines= IMMUNOWELL™ JCV. L=Low; I=Intermediate; H=High. …

The effects of radiofrequency exposure on adverse female reproductive outcomes: A systematic review of human observational studies with dose-response meta-analysis.

BACKGROUND: To inform radiofrequency electromagnetic field (RF-EMF) exposure guidelines the World Health Organization (WHO) is bringing toge … outcomes. In occupational settings, each study was of heterogenous whole-body RF-EMF exposure from radar, short or microwave diathermy, surveillance and welding equipment and its effect on female reproductive outcomes. Overall, the body of evidence is very uncertain about the effect of RF-EMF exposure on female reproductive outcomes. Further prospectiv …

Evaluating clinical heterogeneity in relapsing polychondritis through unsupervised cluster analysis.

BACKGROUND: As a rare autoimmune disease, relapsing polychondritis (RP) exhibits individual variations in clinical manifestations, treatment response and prognosis. To date, no biomarkers have been implemented to clinical practice.This study aimed to apply cluster analysis to identify the clinical phenotype, clarify their prognosis predictor, and monitor treatment decisions to improve the outcomes of patients. METHODS: A total of 135 RP patients hospitalized in two centers from January 2005 to December 2024 were involved in the study.The K-means clustering algorithm was used as the core clust

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… (Fig. 1 ) Heat maps of cluster feature variables and radar charts illustrate the distinct performance of each variable across the identified clusters (Figs. 2 and 3 ).Notably, inflammatory indicators such as CRP and CAR, appear to play a more important role in clustering than clinical symptoms. … The radar chart represented the multidimensional distribution characteristics of three Clusters across all included features. …

Minimal Residual Disease-Adapted Therapy in Multiple Myeloma: Current Evidence and Opinions.

Purpose of reviewMultiple myeloma (MM) is a biologically heterogeneous malignancy with relatively uniform treatment paradigms. This review aims to assess the growing role of Minimal Residual Disease (MRD) assessment in facilitating response-adapted therapeutic decision making to individualize therapy in MM.Recent findingsMRD has been repeatedly demonstrated to provide strong prognostic information, superseding traditional IMWG response criteria. The use of MRD to modulate therapy remains controversial. Here, we review the existing landscape of MRD-adapted trial designs in both induction/consol

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… cease maintenance Maintenance Cessation 50 Can maintenance be stopped with sustained MRD-negativity MFC/NGS (10 –5 ) NCT04108624 (MRD2STOP) 1 year of maintenance and MRD- cease maintenance Maintenance Cessation 56 Can maintenance be stopped with sustained MRD-negativity NGS (10 –6 ) ISCRTN4684186 (RADAR … Yong K Risk-adapted therapy directed according to response (RADAR, UK-MRA myeloma XV) - comparing MRD-guided treatment escalation and de-escalation strategies in patients with newly diagnosed myeloma suitable for stem cell transplantation Blood 2022 140 Supplement 1 1844 1846 10.1182/blood-2022-168842 …

Deep Learning-Based 30-Day Mortality Prediction in Critically Ill Bone and Bone Marrow Metastasis Patients: A Multicenter Retrospective Cohort Study.

Bone and bone marrow Metastasis (BBM) are life-threatening complications of advanced malignancies, frequently requiring intensive care and associated with high short-term mortality. However, prognostic tools specifically tailored to critically ill BBM patients are limited. This multicenter cohort study aimed to develop and validate deep learning models for predicting 30-day mortality using ICU data from MIMIC-IV, eICU-CRD, and the First Affiliated Hospital of Xinjiang Medical University. After univariate screening, XGBoost-Boruta and Lasso regression identified 11 key clinical features within

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… Radar plots confirmed balanced classification metrics across these five models, supporting their use in high-risk settings. … Radar plots ranked DLR and Transformer lowest in all classification measures, suggesting limited applicability. 3.4. …

Различные аутоиммунные полигландские фенотипы у пациентов с заболеваниями щитовидной железы.

ЦЕЛЬ: Характеристика и сопоставление аутоиммунной коморбидности и временной динамики у пациентов с щитовидным гепатитом (HT) и болезнью Грейвса (GD) в рамках аутоиммунного полигениального синдрома (APS). Мы провели ретроспективный анализ пациентов с аутоиммунной болезнью щитовидной железы (АИРТ) и по крайней мере one дополнительные аутоиммунные заболевания, отвечающие критериям АПС, которые следуют в третичном справочном центре АПС между 2000 и 2025. Показатели распространенности сопутствующих аутоиммунных заболеваний были сопоставлены между ГТ и ГД. Время для развития последующих аутоиммунных

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… A two-panel radar plot illustrating the distribution of associated AID in patients who have, or will later develop, HT or GD is shown in Fig.  1 . Type 1 diabetes represented the most frequent autoimmune comorbidity in both HT (52%) and GD (34%) patients. … A two-panel radar plot illustrating the distribution of associated AID stratified by the first disease (HT vs. GD) is shown in Fig.  2 . …

Radiomics models to predict bone marrow metastasis of neuroblastoma using CT.

BACKGROUND: Bone marrow is the leading site for metastasis from neuroblastoma and affects the prognosis of patients with neuroblastoma. However, the accurate diagnosis of bone marrow metastasis is limited by the high spatial and temporal heterogeneity of neuroblastoma. Radiomics analysis has been applied in various cancers to build accurate diagnostic models but has not yet been applied to bone marrow metastasis of neuroblastoma. METHODS: We retrospectively collected information from 187 patients pathologically diagnosed with neuroblastoma and divided them into training and validation sets in

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… The radiomics features included in these approaches are shown in Supporting Information S1: Figure S1i–k as radar plots. … The calibration curves and radar plots for the included features are presented in Figure 3c–k . From the above results, we can conclude that the prediction accuracy of most approaches will increase when clinical variables are included. …

Дополнительная ценность МРТ ZTE для оценки диабетического заболевания ног.

:: Анализ дополнительной ценности Zero МРТ " Эхо времени " (ZTE) по сравнению со стандартным протоколом МРТ для обнаружения многочисленных изменений в диабетической ступне. Для сравнения эффективности ZTE с КТ для выявления многочисленных аномалий и оценки воспроизводимости данных между наблюдателями с использованием коэффициента каппы Коэна. 46 (больные)33 мужчины, 13 женщины; средний возраст, 64 годы) с клинически подтвержденным сахарным диабетом и клинически предполагаемыми диабетическими осложнениями ног. Стандартный протокол МРТ, включающий последовательность ZTE, был выполнен в

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… Fig. 6  Radar chart illustrating interobserver agreement (Cohen's Kappa) for Detection of Bone Abnormalities on ZTE Sequences. … Values plotted further from the centre indicate higher agreement, with the outermost edge representing perfect agreement (Kappa = 1.0) Radar chart illustrating interobserver agreement (Cohen's Kappa) for Detection of Bone Abnormalities on ZTE Sequences. …

Comprehensive analysis of pan-cancer reveals potential of ASF1B as a prognostic and immunological biomarker.

BackgroundAnti-silencing function 1 (ASF1) is a conserved histone H3-H4 chaperone protein. ASF1B, a paralog of ASF1, acts by promoting cell proliferation and influencing cell cycle progression. Although there is some evidence demonstrating that ASF1B plays a key role in the development, progression, and prognosis of certain cancers, there are no pan-cancer analyses of ASF1B.MethodsWe used a range of bioinformatics approaches to investigate the predictive role of ASF1B, including its correlation with prognosis, tumor mutational burden (TMB), microsatellite instability (MSI), tumor microenvironm

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… The two metrics were visualized using radar plots, which were generating using the R package “fmsb.” … (A) Radar plot showing the correlation between ASF1B expression and TMB across all cancer types. Red lines represent correlation coefficients, and blue values represent ranges. (B) Radar plot showing the correlation between ASF1B expression and MSI across all cancer types. …

Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers.

Cancer is a life-altering event causing considerable psychological distress. However, information on the total burden of psychiatric disorders across all common adult cancers and therapy exposures has remained scarce. Here, we estimated the risk of self-harm after incident psychiatric disorder diagnosis in patients with cancer and the risk of unnatural deaths after self-harm in 459,542 individuals. Depression was the most common psychiatric disorder in patients with cancer. Patients who received chemotherapy, radiotherapy and surgery had the highest cumulative burden of psychiatric disorders.

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… Radar plots depict the difference in YLL between matched cases and controls. Excess YLL was estimated based on the age of onset of a psychiatric disorder. All data and 95% CIs are provided in Supplementary Table S7. … Radar plots depict the difference in YLL between matched cases and controls. Excess YLL was estimated based on the age of onset of a psychiatric disorder. All data and 95% CIs are provided in Supplementary Table S7. …

Interpretable machine learning model to predict 90-day radiographically confirmed pneumonia after chemotherapy initiation in non-Hodgkin lymphoma: development and internal validation of a single-center cohort.

BackgroundRadiographically confirmed pneumonia within 90 days of chemotherapy initiation is a frequent and clinically important complication in patients with non-Hodgkin lymphoma, yet interpretable tools for early individualized risk estimation are limited.ObjectiveTo develop and internally validate an interpretable machine-learning model that predicts the 90-day risk of radiographically confirmed pneumonia after chemotherapy initiation in non-Hodgkin lymphoma.MethodsWe retrospectively analyzed 205 chemotherapy-treated NHL patients. A two-step feature selection (LASSO followed by random-forest

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… Panels C and D provide radar charts summarizing performance metrics like AUC, F1, and specificity. Panels E and F display calibration plots with Brier scores. Panels G and H present decision curve analyses. … As illustrated in the radar plots ( Figures 3C – D ), GBM outperformed the other algorithms in terms of overall discrimination (AUC) and achieved balanced sensitivity and predictive values. …

Стратегия Монте-Карло по планированию последующей медицинской деятельности: пример множественных данных о миеломе.

Ключевое значение для индивидуального лечения раковых заболеваний имеет разработка стратегий последующей деятельности в интересах конкретных пациентов. Весьма полезными были бы инструменты оказания помощи врачам в принятии решений о лечении и планировании последующих мероприятий на основе предпочтений пациентов и медицинских данных. Эти инструменты должны включать реалистичные модели развития заболеваний в рамках лечения, многоцелевую оптимизацию стратегий лечения и эффективные алгоритмы для индивидуализации последующих мер с учетом истории пациента. Мы предлагаем модель эволюции рака с исполь

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… The results are summarized in the Radar plot of Fig 4 , and additional visual information on average trajectory cost is given in the barplots. … In the Radar plot representation, a perfect strategy should delimitate the inner circle. 10.1371/journal.pone.0315661.g004 Fig 4 a) Radar plot comparing performances of 4 solution strategies on death rate, progression-free survival (PFS), time spent under treatment, average number of visits per patient …

Multi-omics Analysis Reveals the Correlation of Gut Microbiota and Metabolites With Thalidomide Treatment for Chemotherapy-Induced Nausea and Vomiting in Small Cell Lung Cancer.

Small cell lung cancer (SCLC) is a highly aggressive malignancy, and chemotherapy frequently causes nausea and vomiting, which can impair treatment tolerance. Because thalidomide (THD) has shown potential clinical benefit in alleviating nausea and anorexia, we investigated whether its effects might be associated with changes in gut microbial composition and metabolite profiles. Fecal samples were collected from patients with SCLC and categorized into THD-treated and control groups. Metagenomic sequencing and nontargeted metabolomic profiling were performed to characterize microbial composition

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… (C‐D) Volcano plots and radar plots illustrate the enrichment of differential metabolites. (E‐H) ROC curves and related box plots illustrating the diagnostic performance and group‐wise abundance of selected metabolites. (I) Enrichment analysis of metabolic pathways annotated by KEGG database. … THD Causes Noticeable Changes in Fecal Metabolite Levels To identify group‐specific metabolic alterations, volcano plots and radar charts were generated, and significantly upregulated or downregulated metabolites were identified. …

Подтверждение того, что качество жизни, связанное со здоровьем, ухудшается для мониторинга долгосрочного прогресса в борьбе с заболеваниями, связанными с MS: продольный анализ из швейцарского регистра множественного склероза.

Мониторинг развития склероза (MS) традиционно опирается на клинические меры, которые могут игнорировать симптомы, влияющие на качество жизни. Включение результатов, сообщаемых пациентами, могло бы улучшить понимание ухудшения состояния заболеваний. ЦЕЛЬ: Оценить алгоритм на основе EQ-5D для обнаружения ухудшения болезни и сравнить его с ухудшением EDS. Мы проанализировали продольные данные EQ-5D и EDS из швейцарского регистра MS. Ухудшение состояния системы EQ-5D было определено как устойчивое сокращение по сравнению с двумя оценками; ухудшение состояния системы EDS осуществлялось в соответств

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… Descriptive analyses were stratified by confirmed worsening status, with the results visualized in radar plots. Furthermore, we used confounder‐adjusted multivariable logistic regression to investigate associations between individual symptoms and worsening status, separately for EQ‐5D and EDSS. … Radar plots of burden of specific MS symptoms. …

Последние достижения и проблемы в области лечения рака с уделением особого внимания множественной миеломе, лимфоме и раку легких: основные выводы Встречи на высшем уровне в Онко 2024-The Глава АПАК.

Встреча на высшем уровне в Онко 2024:: Глава АПАК была проведена 2 дней, между 16th и 17th Февраль 2024В Южной Корее. Цель этого мероприятия состояла в том, чтобы предоставить специалистам в области здравоохранения самую последнюю информацию по различным онкологическим дисциплинам и обменяться передовым опытом и стратегиями для обеспечения оптимального ухода за пациентами. Цель Встречи на высшем уровне заключалась в развитии международного и местного сотрудничества в целях решения проблем, понимания будущего онкологии и изучения возможностей для улучшения ухода за больными раком, особенно в Аз

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… Completed (STAMINA, EMORY 1000, PERSEUS, FORTE, and EMNO2 trials) and ongoing (FITness and RADAR trials) clinical trials can support and guide stratification and tailoring decisions [ 11 - 14 ]. … Risk and response adapted therapy following autologous stem cell transplant in patients with newly diagnosed multiple myeloma (radar (uk-mra myeloma xv trial): Study protocol for a phase ii/iii randomised controlled trial. BMJ Open. 2022;12(11):e063037 . doi: 10.1136/bmjopen-2022-063037. 15. …

За пределами здоровых границ: контрольные интервалы для населения и индивидуального медицинского анализа речи.

Интервалы справочной информации (РИ) являются хорошо зарекомендовавшим себя клиническим инструментом для определения здоровых границ лабораторных измерений. В последнее время они применяются к акустическим особенностям, извлекаемым из речи, в целях обеспечения транспарентности и агностической оценки симптомов. Мы оцениваем потенциал и ограничения RI в трех наборах данных: чистые, лабораторные записи людей с множественным склерозом (PwMS) и два шумных набора данных, ориентированных на респираторные симптомы и стресс, связанный с работой, которые собираются в условиях повседневной жизни. Что кас

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… Figure 2 Radar plot profiles of one control (left) and one symptomatic (right) speaker from the male people with multiple sclerosis (pwMS) read speech partition of the COMMITMENT dataset. Speakers were selected as those closest to the median deviation score within their respective group. … Two radar charts comparing 28 speech features for a male control speaker and a symptomatic speaker during a reading task, with the control in blue and symptomatic in orange. …

Редкий случай конъюнктурного уринотракса и миэломатного плеурального эфлюмилия.

ВВЕДЕНИЕ: миэломатное плевральное эфилирование (МПЭ) представляет собой редкое осложнение множественной миеломы, происходящее в < 1% - случаи, связанные с плохим прогнозом. Еще одной редкой причиной плевральной эфлуции является утечка мочи в плевральную полость, как правило, из-за обструктивной урпатии или травмы. Несмотря на то, что оба условия в индивидуальном порядке являются редкими, об их параллельных случаях ранее не сообщалось. ПРЕДОСТАВЛЕНИЕ СЛУЧАИ: 81-year-old У человека с рецидивированной множественной миеломой были диспнея, гематурия и острая почечная недостаточность. Воображение вы

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… This needs a higher radar of suspicion for further differentials. Although elevated pleural fluid creatinine is a hallmark of urinothorax, renal impairment secondary to MM can complicate its interpretation. …

Epidemiological profile and clinical outcomes of patients with mucormycosis: the multicenter retromucor study from Türkiye (2004-2024).

PURPOSE: Mucormycosis is a rapidly progressive angioinvasive fungal infection with limited large-scale outcome data. We aimed to describe the epidemiology, clinical spectrum, treatment strategies, and predictors of outcomes in adult patients with proven mucormycosis in Türkiye. METHODS: We conducted a nationwide, retrospective study of 280 adults diagnosed with proven mucormycosis between 2004 and 2024 across 27 tertiary centers. Case definitions were applied according to the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortiu

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… This radar plot depicts the distribution of presenting symptoms at diagnosis, stratified by clinical outcomes at 90 and 365 days in patients with mucormycosis. Values represent the proportion of patients within each outcome group exhibiting the respective symptom at presentation. … This radar plot depicts the distribution of physical examination findings at diagnosis, stratified by clinical outcomes at 90 and 365 days in patients with mucormycosis. Values represent the proportion of patients within each outcome group exhibiting the respective finding at presentation. …