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An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections.

Neutrophils are classically defined as terminally differentiated, short-lived cells; however, neutrophils can be long-lived with phenotypic plasticity. During inflammation, a subset of neutrophils transdifferentiate into a population called neutrophil-DC hybrids (PMN-DCs) having properties of both neutrophils and dendritic cells. While these cells ubiquitously appear during inflammation, the role of PMN-DCs in disease remains poorly understood. We observed the differentiation of PMN-DCs in pre-clinical murine models of fungal infection: blastomycosis, aspergillosis and candidiasis. Using repor

Infection related membranoproliferative glomerulonephritis secondary to anaplasmosis: A case report.

BACKGROUND: Anaplasmosis is a tick-borne disease with a range of clinical manifestations, from a flu-like illness with fever and myalgias to a severe systemic disease with multisystem organ failure. Although renal involvement is not a common presentation, there have been few cases reporting acute kidney injury from Anaplasmosis. CASE SUMMARY: We present a 55-year-old female with anaplasmosis who developed acute kidney injury due to membranoproliferative glomerulonephritis (MPGN). The patient originally presented with cough and shortness of breath. She was admitted to the hospital with a diagn

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… Anaplasma phagocytophilum, PCR | Undetected | Undetected Serum Anaplasma phagocytophilum antibody, IgG | < 1:64 titer | 1:512 Ehrlichia chaffeensis, PCR | Negative | Negative Ehrlichia chaffeensis (HME) antibody, IgG | < 1:64 | < 1:64 Bartonella antibody panel, IgG and IgM | Negative | Negative Serum Blastomyces … A repeat workup with urine cultures, blood cultures, human immunodeficiency virus (HIV) testing, viral hepatitis panel, Histoplasma antibodies, Blastomyces antibodies, Bartonella antibodies, and PCR for Epstein–Barr virus (EBV), Cytomegalovirus (CMV), Anaplasma, Methicillin-resistant Staphylococcus aureus …

Global control of dimorphism and virulence in fungi.

Microbial pathogens that normally inhabit our environment can adapt to thrive inside mammalian hosts. There are six dimorphic fungi that cause disease worldwide, which switch from nonpathogenic molds in soil to pathogenic yeast after spores are inhaled and exposed to elevated temperature. Mechanisms that regulate this switch remain obscure. We show that a hybrid histidine kinase senses host signals and triggers the transition from mold to yeast. The kinase also regulates cell-wall integrity, sporulation, and expression of virulence genes in vivo. This global regulator shapes how dimorphic fung

Adverse human health effects associated with molds in the indoor environment.

Molds are common and important allergens. About 5% of individuals are predicted to have some allergic airway symptoms from molds over their … impaired immune systems. The leading pathogenic fungi for persons with nonimpaired immune function, Blastomyces, Coccidioides, Cryptococcus, and Histoplasma, may find their way indoors with outdoor air but normally do not grow or propagate indoors. Due to the ubiquity of fungi in the environment, it is not possible to prevent immunecompromised individuals fro …

Cross-reactivity of a Histoplasma capsulatum antigen enzyme immunoassay in urine specimens from persons with emergomycosis in South Africa.

UNLABELLED: Histoplasma antigen detection in urine is a rapid diagnostic method for disseminated histoplasmosis, although cross-reactivity h … nts with Emergomyces africanus infection and in culture filtrates of E. africanus, T. marneffei and Blastomyces species. A commercial Histoplasma EIA had satisfactory accuracy for diagnosis of culture-confirmed histoplasmosis, but cross-reacted in urine specimens from patients with invasive disease caused by the closely-related pathogen, E. africanus and in c …

Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia.

Fungal infections have skyrocketed in immune-compromised patients lacking CD4+ T cells, underscoring the need for vaccine prevention. An understanding of the elements that promote vaccine immunity in this setting is essential. We previously demonstrated that vaccine-induced IL-17A+ CD8+ T cells (Tc17) are required for resistance against lethal fungal pneumonia in CD4+ T cell-deficient hosts, whereas the individual type I cytokines IFN-γ, TNF-α and GM-CSF, are dispensable. Here, we report that T cell-intrinsic MyD88 signals are crucial for these Tc17 cell responses and vaccine immunity against

Infectious Diseases

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… burgdorferi (Lyme erythema migrans), Treponema pallidum (chancre, secondary syphilis) rickettsial —Rocky Mountain spotted fever, ehrlichiosis, typhus viral exanthem —acute HIV, mononucleosis, rubella, measles, roseola, erythema infectiosum, chickenpox, shingles, coxsackie virus, echovirus fungal — Blastomyces … Endemic fungal infections include Blastomyces dermatitidis (southeastern states, Manitoba, and Ontario), Coccidioides immitis (southwestern states), and Histoplasma capsulatum (Mississippi, Ohio River valleys, and Quebec) HISTORY —pattern and duration of fever, associated symptoms (cough, dyspnea, …

Infectious Diseases

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… burgdorferi (Lyme erythema migrans), Treponema pallidum (chancre, secondary syphilis) rickettsial —Rocky Mountain spotted fever, ehrlichiosis, typhus viral exanthem —acute HIV, mononucleosis, rubella, measles, roseola, erythema infectiosum, chickenpox, shingles, coxsackie virus, echovirus fungal —Blastomyces … Endemic fungal infections include Blastomyces dermatitidis (southeastern states, Manitoba, and Ontario), Coccidioides immitis (southwestern states), and Histoplasma capsulatum (Mississippi, Ohio River valleys, and Quebec) HISTORY —pattern and duration of fever, associated symptoms (cough, dyspnea, chest …

Pneumonia in the Cancer Patient

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… Salmonella species Rhodococcus equi R. bronchialis Listeria monocytogenes Mycobacterium tuberculous Nontuberculous mycobacteria Aspergillus and non- Aspergillus filamentous molds Pneumocystis jiroveci (P. carini) Cryptococcus neoformans Endemic mycoses due to Histoplasma capsulatum, Coccidioides immitis, Blastomyces … Salmonella species Rhodococcus equi R. bronchialis Listeria monocytogenes Mycobacterium tuberculous Nontuberculous mycobacteria | Aspergillus and non- Aspergillus filamentous molds Pneumocystis jiroveci (P. carini) Cryptococcus neoformans Endemic mycoses due to Histoplasma capsulatum, Coccidioides immitis, Blastomyces …

babesiosis при ультранизком паразите, представляющем в качестве вторичного гемофагоцитического лимфохистиоцитоза у пациента на клеточной терапии B.

Бэбэзия микроти, паразит, передающийся клещами иксодов, может вызывать инфекции, начиная от асимптоматических и заканчивая болезненными, угрожающими жизни болезнями. Ocrelizumab, anti-CD20 Б-лимфоциты моноклональные антитела, используемые для лечения множественных склерозов, повышают риск серьезных или повторных инфекций патогенами, передаваемыми тиками. В редких случаях младециоз может вызвать гемофагоцитический лимфохистицитоз (HLH). КАСЕ КРАТКОЕ ИЗЛОЖЕНИЕ: Мы сообщаем о случае, когда педициоз проявляется в субакуте с вторичным HLH. 51-year-old Женщина с клеточной терапией B. Она представила

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… Notable negative infectious workup included Histoplasma and Blastomyces antigen and antibodies, Bartonella IgG/IgM and PCR, Coxiella PCR, Brucella antibodies, EBV DNA PCR, CMV PCR, adenovirus PCR in blood, and beta-D-glucan in blood. Additionally, all blood and urine cultures were without growth. …

Совместное обнаружение вируса кори и сезонного коронавируса у иммунокомпромиссированного пациента с пневмонией.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Рекомендована вакцинация от кори для лиц, получающих трансплантацию стволовых клеток (ГХЦТ) ≥24 месяцев после трансплантации в отсутствие трансплантации и иммунодепрессивной терапии. Управление живыми вакцинами во время иммунодепрессии может привести к иатрогенным повреждениям. РЕЗЮМЕ: Мы описываем 76-year-old пациент со сценой 3 Множественная миэлома, которая прошла аутологический HSCT и получила многотрадиционную терапию, включая химерик антигенный рецептор Т-клеток и недавнюю терапию даратумумаба. Примерно 1 Через месяц после прививки от кори, свинки и краснухи у неё

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… Other BAL studies were negative, including bacterial, fungal, Nocardia , and AFB cultures; Legionella PCR; Coccidioides PCR; Histoplasma / Blastomyces PCR; Aspergillus PCR; Aspergillus galactomannan; and Pneumocystis jirovecii PCR. …

Biological implant-associated granulomatous inflammation resulting in secondary hypercalcemia and azotemia in a dog.

Implant associated granulomatous inflammation causing hypercalcemia can occur following use of commercial xenogeneic pericardial tissue patches in dogs. Removal of the implant can result in resolution of the hypercalcemia, suggesting a causal relationship between the tissue reaction to a xenogeneic implant and development of hypercalcemia.

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… Specific agents reported to induce granulomatous inflammation and hypercalcemia in dogs include Aspergillus , Mycobacteria , Pythium , Leishmaniasis , Blastomyces , and Heterobilharzia (schistosomiasis) 28 , 29 , 30 , 31 , 32 , 33 , 34 While it is possible that one of these agents may have caused the …

Localized fungal osteomyelitis caused by Aspergillus sp. in the ilium and acetabulum of a dog with disseminated aspergillosis: A case report.

BACKGROUND: Osteomyelitis caused by Aspergillus sp. is uncommon in dogs and cats and may occur in cases of disseminated aspergillosis, a rare and poorly described condition in veterinary medicine. CASE DESCRIPTION: Due to the scarcity of reports documenting this disease, particularly with localized involvement of the pelvic bones, the present case report aimed to describe the condition in an 8-year-old mixed-breed dog presenting with severe pain and lameness of the right pelvic limb. Radiographic examination revealed marked periosteal bone proliferation and osteolysis extending from the right

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… The infecting fungal species vary according to geographic distribution ( Thrall, 2010 ; Schulz, 2013 ); however, Coccidioides immitis , Blastomyces dermatitidis , Histoplasma capsulatum , Cryptococcus neoformans , and Aspergillus spp. are the most frequently reported fungi in osteomyelitis cases ( Oxenford …

Mycobiota и Antifungal Antibodies как новые целевые показатели для диагностики и прогнозирования болезней человека.

Человеческое тело колонизируется различными микроорганизмами, при этом наиболее активно изучаются бактерии. Однако грибы, которые в совокупности известны как «микобиота», все чаще признаются в качестве составных компонентов микробиоты, населяющей почти все мукосальные поверхности. Комменсальные грибы оказывают влияние на иммунитет хост-приемника, как и бактерии, и способствуют выполнению других важных функций, включая метаболизм. В этом новом понимании грибы рассматриваются как потенциальные биомаркеры для диагностики и прогнозирования различных заболеваний. В этом обзоре мы изучаем двойную ро

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… These fungi, including genera like Coccidioides spp., Histoplasma spp., Paracoccidioides spp., and Blastomyces spp., possess the unique ability to switch between hyphal and yeast forms, a key factor in their pathogenicity. …

Neurology

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… Other fungal infections, such as Blastomyces dermatitidis , Histoplasma capsulatum , and Cladophialophora spp., are sporadically reported in endemic areas and are typically associated with a grave prognosis. 74 , 127 Borna Disease Borna disease virus (BDV) is the cause of a severe nonsuppurative encephalomyelitis …

10th Trends in Medical Mycology Held on 8 to 11 October 2021, Aberdeen, Scotland, Organized by the European Confederation of Medical Mycology (ECMM).

Plenary Sessions: [...].

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… Blastomycosis Blastomycosis is a fungal infection caused by Blastomyces spp. (e.g., B. dermatitis , B. gilchristii , B. helices , B. parvus , and B. percursus )—a dimorphic pathogen ( Table S2 ). … However, if Blastomyces is in its yeast-like form, the thick wall avoids phagocytosis and killing, and the patient develops a symptomatic infection [ 220 ]. The lungs are the most affected organs. …

Disorders of the Spinal Cord

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… Fungal causes include Cryptococcus neoformans , Blastomyces dermatitidis , Histoplasma capsulatum , and Coccidioides immitis . Pathophysiology FIP causes granulomatous inflammation of the meninges, ependymal cells, and choroid plexus. …

Pneumonia in Transplant Recipients: A Comprehensive Review of Diagnosis and Management.

Transplant recipients have an increased risk of complications, including graft dysfunction and infections, which can be life-threatening if not recognized early. Pneumonia ranks as one of the most frequent complications in both solid organ and hematopoietic stem cell transplants. Clinical symptoms manifest late during infections in immunocompromised patients. An aggressive approach centered on early confirmatory diagnosis and a low threshold for empiric therapy is often the most effective strategy. The isolation of a pathogen in an upper airway sample does not necessarily mean the same organis

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… Geographic exposure can increase susceptibility to endemic fungal infections of Histoplasma (Ohio and Mississippi River valleys), Coccidioides (Southwest US), Paracoccidioides (Central and South America), Cryptococcus , and Blastomyces (Mid West, South-central, and Southeastern United States). …