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Lichenoid mucocutaneous reactions associated with sintilimab therapy in a non-small cell lung adenocarcinoma patient: case report and review.

The immune checkpoint inhibitor (ICI), anti-programmed cell death receptor-1 (PD-1) antibody, has gained widespread approval for treating various malignancies. Among the immune-related adverse reactions (irAEs) during ICI treatment, the lichenoid reaction is noteworthy. Sintilimab, a new PD-1 inhibitor, has secured approval in China for treating refractory non-Hodgkin's lymphoma, and phase I/II clinical trials for other solid tumors are ongoing both domestically and abroad. This paper presents a case of a mucocutaneous lichenoid reaction associated with sintilimab therapy, its diagnosis, and m

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… . | F/NA | RCC | 2 | Reticular lesions | Papular (palms、soles) | Lichenoid mucositis | NR | Clobetasol, PUVA | Complete Resolution | Y Shi et al. | F/NA | Lung Cancer | 14 | Erosive lesions | None | Lichenoid mucositis | NR | Clobetasol, Valacyclovir | Complete Resolution | Y Sibaud et al. | M/NA | Metastatic … melanoma | 1 | Erosive lesions | Erosive genital lichen planus | Lichenoid mucositis | NR | Clobetasol | Complete Resolution | N Sibaud et al. | M/53 | Multiple myeloma | 2 | Reticular lesions | Cutaneous lichenoid eruption, with genital involvement | NR | NR | Topical dexamethasone | Complete Resolution …

Concomitant bullous pemphigoid and dermatitis herpetiformis.

Dermatitis herpetiformis and bullous pemphigoid are bullous autoimmune diseases of the skin microscopically characterized by subepidermal blisters. We present a 77-year-old patient with an 18-month history of disseminated pruritic papular lesions. Direct immunofluorescence microscopy revealed linear deposition of IgG at the basement membrane zone as well as granular deposits of IgA in the papillary dermis. Circulating IgG antibodies against BP180, BP230 and gliadin as well as IgA reactivity against endomysium, tissue transglutaminase, and gliadin were detected compatible with both bullous pemp

[Bullous pemphigoid: diagnostics and new therapeutic strategies].

Bullous pemphigoid, the most frequent bullous autoimmune dermatosis of the adult, typically presents as disseminated tense blisters on normal or erythematous skin. The diagnosis can be confirmed by direct and indirect immunofluorescence, the detection of circulating autoantibodies against the basement membrane proteins collagen XVII/BP180 and BP230, and histopathology. Autoantibody reactivity against collagen XVII can be measured by ELISA and correlates with disease activity. The ELISA therefore provides a useful tool for monitoring disease activity. Treatment of bullous pemphigoid usually con

Dose Optimization of Targeted Therapies for Oncologic Indications.

Therapeutic advances in oncology in the 21st century have contributed to significant declines in cancer mortality. Notably, targeted therapies comprised the largest proportion of oncology drugs approved by the United States (US) Food and Drug Administration (FDA) over the past 25 years and have become the standard of care for the treatment of many cancers. However, despite the metamorphosis of the therapeutic landscape, some aspects of cancer drug development have remained essentially unchanged. In particular, the dose-finding methodology originally developed for cytotoxic chemotherapy drugs c

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… In the reDOS trial ( NCT02368886 ), 123 patients were randomized to one of four regorafenib treatment groups: standard dosing plus preventive clobetasol cream (for PPES), dose escalation plus preventive clobetasol cream, standard dosing plus reactive preventive clobetasol cream, and dose escalation plus … reactive preventive clobetasol cream [ 28 ] ( Figure 2 ). …

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice.

In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain associated with mIAS, this review also specifically highlights new research focusing on the study of the molecular basis of pain. The incidence of mIAS varies widely (2-78%

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… This outcome is consistent with the report that topical clobetasol treatment reduced aphthous ulceration in renal transplant patients receiving sirolimus 50 . … Langone . 2007 Clobetasol ameliorates aphthous ulceration in renal transplant patients on sirolimus . Am. J. Transplant. 7 : 714 – 717 . 17250555 10.1111/j.1600-6143.2006.01678.x 51 Raymond , E. , J. Alexandre , S. Faivre , K. Vera , E. Materman , J. …

Interventions for nail psoriasis.

BACKGROUND: Psoriasis is a common skin disease that can also involve the nails. All parts of the nail and surrounding structures can become … lcipotriol 50 ug/g, calcipotriol 0.005%) better than their respective comparators: Belanyx® lotion, clobetasol propionate, betamethasone dipropionate with salicylic acid, or betamethasone dipropionate.Of our secondary outcomes, not all included studies reported adverse events; those that did only reported mild adverse effects, and there were more in studies …

Efficacy and safety of dupilumab in a patient with metastatic clear cell renal cell carcinoma.

This case report evaluated the efficacy and safety of dupilumab, a monoclonal antibody targeting interleukin-4 and interleukin-13, in a patient with atopic dermatitis (AD) and a history of metastatic renal cancer. Over 20 months of follow-up, the patient experienced significant improvement in AD symptoms without any recurrence of cancer. In addition to not stimulating carcinogenesis, dupilumab might synergistically inhibit tumor-induced immunosuppression, thereby potentially preventing tumor progression. This case suggests that dupilumab could be a viable treatment option for patients with AD

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… Adverse effect Fowler et al. 2019 22 Asthma intermittent Melanoma (ganglion sentinel +) After the diagnosis of cancer Mometasone topic EASI 62NRS 10/10 EASI 1.8NRS 3/10 No recurrence 18 months – (no report) Fowler et al. 2019 43 HIV+ on antiretroviral therapy Squamous cancer of the anus (IIIb) After Clobetasol … | 22 | Asthma intermittent | Melanoma (ganglion sentinel +) | After the diagnosis of cancer | Mometasone topic | EASI 62NRS 10/10 | EASI 1.8NRS 3/10 | No recurrence | 18 months | – (no report) Fowler et al. | 2019 | 43 | HIV+ on antiretroviral therapy | Squamous cancer of the anus (IIIb) | After | Clobetasol …

Lipid metabolism analysis for peripheral blood in patients with alcohol-induced and steroid-induced osteonecrosis of the femoral head.

OBJECTIVES: Osteonecrosis of the femoral head (ONFH), also known as vascular necrosis of the femoral head, is combined with lipid metabolism … D-myo-Inositol 1,2-cyclic phosphate, L-pyroglutamic acid, DL-carnitine, 8-amino-7-oxononanoic acid, Clobetasol, and presqualene diphosphate. In the AONFH group, there were 9 differential lipid metabolites related to the disease stages, including LPG 18:1, serotonin, PC (22:4e/23:0), PC (19:2/18:5), hypoxanthin, PE (18:1/20:3), LPE 18:1, 1-stearoyl-2-arachido …

Oral Graft-Versus-Host Disease: A Pictorial Review and a Guide for Dental Practitioners.

IntroductionGraft-versus-host disease (GVHD) is a complication of haematopoietic stem cell transplantation (HSCT). GVHD may also develop following solid transplants or blood transfusions if white blood cells are transferred. GVHD affects multiple organs, including the oral tissues.ObjectiveThis pictorial review provides a background of GVHD to dental practitioners, describes the most common oral manifestations of GVHD and highlights the main treatment modifications needed to deliver dental care to patients with GVHD.MethodsA narrative review enhanced with clinical photographs.ResultsAcute GVHD

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… Other topical steroids suggested in the literature as expert opinions include triamcinolone, fluocinonide, clobetasol, betamethasone and prednisolone. 35 , 36 , 37 , 38 , 39 , 40 The selection of a particular topical steroid is based on the size of the area involved, the severity of the lesions, the … Solutions | Steroids | Dexamethasone | 0.1 mg/mL (0.01%) | 10 mL, 3–6 times daily | Yes | | Dexamethasone | 0.4 mg/mL (0.04%) † | 10 mL, 3–6 times daily | No | | Prednisolone | 3 mg/mL (0.3%) | 5 mL, 3–6 times daily | Yes | | Budesonide | 0.3 mg/mL (0.03%) | 10 mL, 2–4 times daily | No | | Clobetasol …

Ruxolitinib Cream Has Dual Efficacy on Pruritus and Inflammation in Experimental Dermatitis.

The goal of this study was to elucidate the anti-pruritic and anti-inflammatory efficacy of ruxolitinib cream in experimentally-induced dermatitis. Atopic dermatitis (AD), the most common chronic relapsing inflammatory skin disease, significantly impairs patients' quality of life, with pruritus being a common complaint. The sensation of itch results from the interplay between epidermal barrier dysfunction, upregulated immune signaling and the activation of the central nervous system. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a central role in

Гипоксичная нейроинфламмация в патогенезе множественного склероза.

Множественный склероз (MS) — аутоиммунная болезнь, которая повреждает миелиновую оболочку вокруг аксонов центральной нервной системы, что приводит к неврологической дисфункции. Хотя первоначальное повреждение вызвано воспалением, гипоксия была зарегистрирована в нескольких районах мозга пациентов MS, однако значение этого для прогнозирования и лечения остается неясным. Нейроинфламмация может вызывать гипоксию, а гипоксия может вызывать и усугублять нейроинфламму, образуя порочный круг. Повреждения MS часто сопровождаются обезвоживанием, которое может восстановить неврологическую функцию. Однак

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… Clobetasol and Miconazole Najm et al. [ 107 ] demonstrated that the treatment with Clobetasol and Miconazole enhanced remyelination and promoted oligodendrocyte differentiation. Guanabenz Guanabenz is an α2 adrenergic receptor agonist. …

The Pathophysiology and Treatment of Pyoderma Gangrenosum-Current Options and New Perspectives.

Pyoderma gangrenosum (PG) is an uncommon inflammatory dermatological disorder characterized by painful ulcers that quickly spread peripherally. The pathophysiology of PG is not fully understood; however, it is most commonly considered a disease in the spectrum of neutrophilic dermatoses. The treatment of PG remains challenging due to the lack of generally accepted therapeutic guidelines. Existing therapeutic methods focus on limiting inflammation through the use of immunosuppressive and immunomodulatory therapies. Recently, several reports have indicated the successful use of biologic drugs an

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… The study involved 66 PG patients, with 49 treated with clobetasol propionate 0.05%, 10 with tacrolimus 0.03% or 0.1%, and 8 using other topical preparations. In the clobetasol group, twenty patients (43%) benefited from the treatment. … In total, 13 patients received topical clobetasol 0.05%, and 11 received topical tacrolimus 0.3%. Topical tacrolimus showed significantly better effectiveness in managing peristomal PG than corticosteroids. …

Cabozantinib Cutaneous Toxicity-Comprehensive Review.

BackgroundIn the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar-plantar erythrodysesthesia, stomatitis, hair alterations,

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… hyperkeratotic and callused areas Use a solution of recombinant human basic endothelial or fibroblast growth factor or vitamin B on skin areas showing minor wear Use magnesium sulphate cooling baths for hands and feet to reduce pain and soften calluses Use topical treatments such as bethametosone, clobetasol … Grade 2 | The prior treatment should be maintained along with the following: Apply clobetasol 0.05% ointment to affected erythematous areas twice daily. Use topical analgesics like 2% lidocaine and systemic pain relievers (e.g., nonsteroidal anti-inflammatory drugs, codeine, pregabalin). …

Успешное лечение трифаротена типичной болезни Кирла с обзором тематической терапии.

Болезнь Кирла - это редкое кожное расстройство, связанное с диагностикой трансэпидермального кератина, обычно связанного с системными заболеваниями. Мы сообщаем об уникальном случае, когда здоровый 26-летний человек сопротивляется стандартной терапии. В течение восьми недель была достигнута ремиссия с ежедневным тематическим трифаротеном 0,005%. Это первый, о котором сообщалось, случай КД, успешно обработанный трифаротином, избирательным RAR-__ retinoid, ориентированным на дифференциацию кератиноцитов и воспаление. Его эффективность и безопасность дают возможность пациентам, не пригодным для с

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… occlusion Improvement Kumar H. et al. (2010) [ 12 ] 52‐year‐old man Extensor surfaces of the legs and both arms Hyperkeratotic papules N/A Transepithelial elimination of subepithelial material with epidermal invagination, Van Gieson staining—negative Type 2 diabetes, chronic kidney disease, dialysis Clobetasol …

Ulcerating necrobiotic xanthogranuloma: A clinical sign to reconsider progression from MGUS to multiple myeloma.

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… He was started on topical clobetasol ointment and intravenous immunoglobulin (IVIg) every 4 weeks. Based on multidisciplinary discussions with his oncologist, his large granular lymphocytic (LGL) was also treated with cyclophosphamide in the event it could be contributing. …

Interventions for vitiligo.

BACKGROUND: Vitiligo is a chronic skin disorder characterised by patchy loss of skin colour. Some people experience itching before the appea … e studies ginkgo biloba was better than placebo (RR 4.40, 95% CI 1.08 to 17.95, one study, N = 47); clobetasol propionate was better than PUVAsol (PUVA with sunlight) (RR 4.70, 95% CI 1.14 to 19.39, one study, N = 45); split skin grafts with PUVAsol was better than minipunch grafts with PUVAsol (RR 1.89, 95% CI 1.25 to 2.85, one study, N = 64).We performed o …

Case Report: Erythema gyratum repens associated with adenomyosis and endometriosis: an immunological twist?

A 37-year-old non-Caucasian woman presented with a 2-year history of pruritic, concentric erythematous plaques refractory to multiple topical and systemic therapies. The clinical findings were highly suggestive of erythema gyratum repens (EGR), a rare figurate dermatosis classically associated with paraneoplastic syndromes. Routine laboratory investigations and an autoantibody panel were unremarkable, except for a significantly elevated CA-125 level. A targeted gynecological assessment, prompted by a chronic history of pelvic pain and menorrhagia, identified severe adenomyosis with concomitant

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… Prior empiric treatments included topical clobetasol propionate 0.05% ointment twice daily for 6 weeks, oral prednisone (0.5 mg/kg/day) for 2 weeks, topical ketoconazole 2% cream for 4 weeks, and oral fluconazole 150 mg weekly for 4 weeks, all without clinical improvement. …

Glucocorticoids-based prodrug design: Current strategies and research progress.

Attributing to their broad pharmacological effects encompassing anti-inflammation, antitoxin, and immunosuppression, glucocorticoids (GCs) are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus, nephritis, arthritis, ulcerative colitis, asthma, keratitis, macular edema, and leukemia. However, long-term use often causes undesirable side effects, including metabolic disorders-induced Cushing's syndrome (buffalo back, full moon face, hyperglycemia, etc.), osteoporosis, aggravated infection, psychosis, glaucoma, and cataract. These notorious side e

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… acetonide | Nasal | 0.055 mg/spray | NASACORT ALLERGY 24 HOUR Flunisolide | Nasal | 0.025 mg/spray | FLUNISOLIDE Mometasone furoate | Nasal | 0.025 mg/spray | RYALTRIS Paste | Triamcinolone acetonide | Dental | 0.1% | TRIAMCINOLONE ACETONIDE Foam | Halobetasol propionate | Topical | 0.05% | LEXETTE Clobetasol … propionate | Topical | 0.05% | CLOBETASOL PROPIONATE Shampoo | Clobetasol propionate | Topical | 0.05% | CLOBEX Fluocinolone acetonide | Topical | 0.01% | CAPEX Implant | Fluocinolone acetonide | Intravitreal | 0.18 mg | YUTIQ Dex | Intravitreal | 0.7 mg | QZURDEX Therefore, novel drug delivery systems …

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series.

Palmitoylethanolamide (PEA), an endogenous fatty acid amide, has been demonstrated to bind to a receptor in the cell nucleus - the peroxisome proliferator-activated receptor - and performs a great variety of biological functions related to chronic and neuropathic pain and inflammation, as has been demonstrated in clinical trials. These include peripheral neuropathies such as diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, sciatic pain, osteoarthritis, low-back pain, failed back surgery syndrome, dental pains, neuropathic pain in stroke and multiple scle

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… Her gynecologist prescribed a very strong local corticosteroid, clobetasol, after which the pain worsened to 9–10 on the NRS. The patient became desperate and asked for advice in our clinic. She was unable to ride her bicycle and her quality of life was severely compromised. …

Cutaneous Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Center Retrospective Cohort Study of Clinical Spectrum and Treatment Patterns.

Cutaneous graft-versus-host disease (GVHD) is a common complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT). Despite established guidelines, discrepancies persist between clinical trial evidence and real-world practice, particularly for newer agents such as ruxolitinib. To characterize the phenotypic spectrum of cutaneous GVHD, evaluate real-world treatment strategies-with a specific focus on systemic and topical ruxolitinib-and assess adherence to national and international guidelines, we conducted a retrospective observational study of patients undergoing allo-HSCT

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… Betamethasone was employed in roughly 50% of the patients with aGVHD, followed by mometasone, beclomethasone, deoxymethasone, and clobetasol, each of which were employed in 13% of patients. …