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Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling.

Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic prevalence between 1:400 and 1:1,000 individuals, is the third most common cause of end stage kidney disease after diabetes mellitus and hypertension. Over the last 3 decades there has been great progress in understanding its pathogenesis. This allows the stratification of therapeutic targets into four levels, gene mutation and polycystin disruption, proximal mechanisms directly caused by disruption of polycystin function, downstream regulatory and signaling pathways, and non-specific pathophysiologic processes sha

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… The proton pump inhibitor Lansoprazole has also been recently proposed to reduce kidney cysts in vitro (MDCK cells) and in vivo (PCK rat) via activation of the liver X receptor and subsequent down-regulation of CFTR ( Nantavishit et al., 2018 ). …

A novel approach to enhance glioblastoma multiforme treatment efficacy: non-coding RNA targeted therapy and adjuvant approaches.

BackgroundGlioblastoma multiforme (GBM) is a lethal brain tumor. With the current gold standard chemotherapy treatment, temozolomide (TMZ), many patients do not survive beyond one year. While the urgency of researching novel treatments is understandable, the prohibitively high costs and the prolonged duration of research and clinical trials significantly delay the availability of medical advancements to the general public. This highlights the urgent need for adjuvant therapies to enhance treatment effectiveness.Main bodyRecent research has suggested the potential of repurposing FDA-approved dr

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… regulates cell signaling pathway Metformin | Hypoglycemic | Cardiovascular protection, tumor suppression, anti-aging | Regulate cell metabolism and induce cell apoptosis Thalidomide | Antiemetic for pregnant women (banned) | Multiple myeloma, leprosy erythema nodosum | Promotes TNF-α mRNA degradation Lansoprazole …

Drug Repurposing at the Interface of Melanoma Immunotherapy and Autoimmune Disease.

Cancer cells have a remarkable ability to evade recognition and destruction by the immune system. At the same time, cancer has been associated with chronic inflammation, while certain autoimmune diseases predispose to the development of neoplasia. Although cancer immunotherapy has revolutionized antitumor treatment, immune-related toxicities and adverse events detract from the clinical utility of even the most advanced drugs, especially in patients with both, metastatic cancer and pre-existing autoimmune diseases. Here, the combination of multi-omics, data-driven computational approaches with

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… The mixture of aspirin with vitamin D, cyclophosphamide, and lansoprazole forms an immunomodulatory cocktail that can be combined with pembrolizumab and radiotherapy ([ 110 ], NCT03192059 ). …

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2018

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Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives.

Cancer persists as a significant global health challenge, claiming millions of lives annually despite remarkable strides in therapeutic innovation. Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. In this context, the repurposing of antibiotics as anti-cancer agents has emerged as an attractive prospect for investigation. Diverse classes of antibiotics have exhibited promising anti-cancer properties in both in vitro and in vivo studies. These mechanisms include the induction of apoptosis and cell cycle arrest, generation o

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… Macrolide Antibiotics Enhance the Antitumor Effect of Lansoprazole Resulting in Lysosomal Membrane Permeabilization-Associated Cell Death. Int. J. Oncol. 2020;57:1280–1292. doi: 10.3892/ijo.2020.5138. 65. Sehgal S.N. Sirolimus: Its Discovery, Biological Properties, and Mechanism of Action. …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.

The tumor microenvironment (TME) is an ensemble of non-tumor cells comprising fibroblasts, cells of the immune system, and endothelial cells, besides various soluble secretory factors from all cellular components (including tumor cells). The TME forms a pro-tumorigenic cocoon around the tumor cells where reprogramming of the metabolism occurs in tumor and non-tumor cells that underlies the nature of interactions as well as competitions ensuring steady supply of nutrients and anapleoretic molecules for the tumor cells that fuels its growth even under hypoxic conditions. This metabolic reprogram

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… Therapeutic effects of several other proton pump inhibitors such as omeprazole, esomeprazole, rabeprazole, pantoprazole, and lansoprazole (Table 1 ) have been investigated suggesting the potential of these inhibitors in cancer therapy ( 329 ). …

Selected abstracts from the XXXVIII National Congress of the Italian Society of Hypertension (SIIA)

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Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer.

Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic

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… | NCT04287660 | First Affiliated Hospital of Soochow Uni Omeprazole, Amoxicillin, | Gastric MALT Lymphoma | NA/C | NCT00327132 | National Health Research Institutes, Taiwan Amoxicillin, Metronidazole | B-cell Lymphoma | 2/R | NCT02388581 | National Health Research Institutes, Taiwan Ciprofloxacin, lansoprazole …

2020 ACVIM Forum On Demand Research Abstract Program.

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Неделя ГЭЭ 2018 Презентации на плакате

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Семья гистона деацетилазы в здравии и болезни.

Классические деацетилазы, включая классы I, II и IV, в зависимости от цинка, повсеместно присутствуют у млекопитающих и играют жизненно важную роль в многочисленных биологических процессах. На сегодняшний день eleven Были выявлены члены < < хисттон деацетилаза > > , а именно < < хиттон деацетилаза > > . 1 через гистонную деацетилазу 11. Растущий объем данных подчеркивает важнейшую роль этих гистоновых деацетилазов как в физиологических, так и патологических условиях. В частности, эти гистонные деацетилазы участвуют в различных клеточных процессах, включая воспаление, ме

Неделя ГЭЭ 2017 Презентации на плакате

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Disorders of the Gastrointestinal System

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UEG Week 2015 Poster Presentations

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… Influence of Helicobacter pylori eradication therapy on 13Caminopyrine breath test: comparison among omeoprazole-, lansoprazole-, or pantoprazole-containing regimens. Am J Gastroenterol 10.1111/j.1572-0241.2000.03184.x 11051345 2 McColl KEL, Kennerley P. …

Transforming cancer immunotherapy: integration of distinct immune-based approaches as redefined dual immunotherapy with potential third-sensitizer.

This review introduces a paradigm-shifting concept of Dual Distinct Immunotherapy (DDI), which strategically integrates two distinct immunotherapeutic modalities to overcome the limitations of current monotherapies and dual immune checkpoint inhibitor (ICI) combinations. The concept of DDI extends beyond traditional ICI combinations to encompass various innovative pairings: ICIs with oncolytic viruses (OVs), adoptive cell therapies (CAR-T/TIL), cancer vaccines, or cytokine therapies. These combinations demonstrate unique synergistic mechanisms and enhanced therapeutic potential through multi-f

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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UEG Week 2017 Oral Presentations

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The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Session (P001-P706).

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Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

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