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Albumin-Based Drug Delivery for Glioblastoma Treatment: Mechanistic Rationale, Preclinical Evidence, and Clinical Translation.

Glioblastoma remains the most aggressive primary brain malignancy, with poor survival despite maximal safe resection, radiotherapy, and temo … BBB/BTB-opening technologies. Early clinical studies combining low-intensity pulsed ultrasound with microbubbles and albumin-bound paclitaxel provide human proof of concept for regional pharmacokinetic enhancement in recurrent glioblastoma, although survival benefit remains unproven. The available evidence supports albumin-based delivery as a rational formulat …

Janus porphyrin-stabilized phase-transition theranostics for multimodal imaging-guided synergistic cancer therapy.

Acoustic and optical droplet vaporization (ADV/ODV) enables localized energy conversion through nanoscale phase transitions, offering a mech … ultimodal theranostics. TFNP responds to optical or acoustic excitation by converting droplets into microbubbles, amplifying fluorescence, photoacoustic, and ultrasound signals, while simultaneously activating photodynamic and sonodynamic therapy. Structure-property optimization identified TP2 as an effective interfacial energy mediator, fluorophore, sonosensi …

CXCR4-Targeted Nanotherapeutics: A Promising Approach for Liver Fibrosis and Hepatocellular Carcinoma Management.

CXCR4 plays a pivotal role in liver fibrosis (LF) by mediating the activation of hepatic stellate cells (HSCs), which contribute to extracel … w also highlights various CXCR4-targeted nano therapeutic strategies, such as liposomes, lipid NPs, microbubbles, polymeric NPs incorporating siRNA, miRNA, small molecules, peptides etc for the management of LF and HCC. Additionally, the review addresses the clinical progress of monoclonal antibodies, small molecules, and peptides targeting CXCR4 in both precl …

Advancements in Noncontrast Ultrasound Imaging for Low-Velocity Flow: A Technical Review and Clinical Applications in Vascular Medicine.

Visualizing the arterial tree using ultrasound, from the aorta to the small vessels, has significantly improved over time due to advances in ultrasound imaging technology. Initially limited to exploring the major vessels, ultrasound analysis has made considerable progress with enhanced image quality. While injecting microbubbles as a contrast agent partially addresses this limitation, its use is constrained by the need for intravenous injection, making the examination more complex and time-consuming. To address these drawbacks, new commercial modes have emerged, distinct from conventional colo…

Advances and innovations in ultrasound-based tumor management: current applications and emerging directions.

As a crucial medical imaging modality, ultrasonography has emerged as a pivotal tool for tumor diagnosis and treatment owing to its non-invasive nature, real-time imaging capability, and superior resolution. Recent technological advancements have demonstrated unique advantages in early tumor screening, staging, and localization. Contrast-enhanced ultrasound (CEUS), utilizing microbubbles (MBs) and nanobubbles (NBs) to target vascular biomarkers, significantly enhances tumor visualization and demonstrates high sensitivity in molecular imaging. Multimodal ultrasound (MU), incorporating technique…

Ultrasonographic features of gastrointestinal ulcerations in cats.

BACKGROUND: Gastrointestinal ulceration in cats can be life threatening due to the risk of perforation and septic peritonitis. However, the … were included. On ultrasound examination, all cases showed a mucosal defect filled with hyperechoic microbubbles located in the stomach (29.2%), pylorus (16.7%), duodenum (29.2%), jejunum (20.8%) or ileocecocolic junction (4.2%). Single lesions were present in 75% of cases. Perforations occurred in 16.7% of cases. Wall thickening was detected in 62.5% of the c …

Ultrasound Visualization of Spatiotemporal Autophagy-Regulated Nanodroplets for Amplifying ICB in Melanoma via Remodeling Tumor Inflammatory Microenvironment.

Immune checkpoint blockade (ICB) therapy, represented by anti-PD-1/PD-L1 antibodies, is confronted with difficulties of unsatisfied response … oplets effectively accumulate into the tumor site. Upon LIFU activation, SP@Lip-PEG transforms into microbubbles through acoustic droplet vaporization (ADV) effects, enabling the controlled release of SAR405 under ultrasound imaging guidance. The released SAR405 significantly triggered the upregulation of proinflammatory factors CCL5 and CXCL10 through autopha …

Development of a Polymersome-Based Nanomedicine for Chemotherapeutic and Sonodynamic Combination Therapy.

In anticancer therapy, combination therapy has been suggested as an alternative to the insufficient therapeutic efficacy of single therapy. … s is desirable for sufficient drug efficacy for combination therapy. However, nanocarriers, such as microbubbles, and albumin nanoparticles, are unstable in the body and show low drug-loading efficiency. Here, we propose polylactide (PLA)-poly (ethylene glycol) (PEG) polymersomes (PLs) with a high drug loading rate of doxorubicin (DOX) and verteporfin (VP) for …

Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound.

In brain-targeted delivery, the transport of drugs or genes across the blood-brain barrier (BBB) is a major obstacle. Recent reports found that focused ultrasound (FUS) with microbubbles enables transient BBB opening and improvement of drug or gene delivery. We previously developed nano-sized bubbles (NBs), which were prepared based on polyethylene glycol (PEG)-modified liposomes containing echo-contrast gas, and showed that our NBs with FUS could also induce BBB opening. The aim of this study was to enhance the efficiency of delivery of pDNA into neuronal cells following transportation across…

An in vitro model of temporal enhancement of epithelium barrier permeability by low-energy shock waves without contrast agents.

One of the commonly used techniques for drug delivery is to temporarily increase the permeability of tissue barriers. Acoustic energies such as ultrasound and shock waves are known to modulate tissue permeability. Recently, it was found that shock waves modulate the blood-brain barrier in the rat brain without injection of contrast agents such as microbubbles. This finding implies that modulation of other tissue barriers by shock wave exposure without contrast agents may be possible. To examine whether the modulation is also possible with other tissue barriers, we here investigated whether sho…

Hepatopulmonary Syndrome in a Thirteen Year Old Boy: A Case Report.

Hepatopulmonary syndrome (HPS) is a late complication associated with liver cirrhosis. Recent studies have suggested that it can also occur … cardiography has emerged to be a very sensitive test for its diagnosis. The timing of appearance of microbubbles help to differentiate between intracardiac and intrapulmonary shunting, with the latter being the hallmark of HPS. The only curative treatment available is liver transplantation. Here we present a case of a 13-year-old patient who presented in Nisht …

Suspected fatal venous air embolism during anaesthesia in a Pomeranian dog with pulmonary calcification.

CASE HISTORY: Death occurred in a 1.25 kg, 9-month-old female Pomeranian dog undergoing anaesthesia for surgical repair of partially healed … and the lungs appeared diffusely mineralised. The origin of the air was probably small bubbles and microbubbles that may have been present in the extension set and 20 ml syringe used for the administration of fentanyl and I/V fluids to the dog. DIAGNOSIS: Renal dysplasia and diffuse pulmonary calcification, with VAE as the probable cause of death. CLINICAL …

Tumor vascularity of breast lesions: potentials and limits of contrast-enhanced Doppler sonography.

OBJECTIVE: We investigated improving the evaluation of benignity in breast lesions using Doppler sonography with galactose palmitic acid-coated microbubbles. SUBJECTS AND METHODS: In 77 patients with 84 breast tumors scheduled for surgical tumor removal, color-coded duplex sonography was performed before and after administration of Levovist. Of the 77 patients, 25 with 28 lesions had been treated for prior breast carcinoma. The parameters investigated were the following: degree of enhancement, number of tumor vessels, time to maximum enhancement, and the pattern of vascular morphology and cou…

Power doppler harmonic imaging: a feasibility study of a new technique for the assessment of myocardial perfusion.

BACKGROUND: The aim of the study was to assess the feasibility of a new technique, power Doppler harmonic imaging (PDHI), for assessing myocardial perfusion through a venous injection of microbubbles, with the use of a new ultrasound contrast agent. METHODS AND RESULTS: Fifteen patients with known coronary artery disease and a resting perfusion abnormality on Tc-99m sestamibi single-photon emission computed tomography (SPECT) underwent PDHI at rest during intravenous injections of 2 to 3 mL of Sonovue (Bracco SpA, Milan, Italy), a new second-generation ultrasound contrast agent. Myocardial pe…

Contrast-enhanced sonography of vesicoureterorenal reflux in children: preliminary results.

OBJECTIVE: The aim of our study was to evaluate contrast-enhanced sonography as an alternative to radiographic voiding cystourethrography in … as repeated. Documentation was done using S-VHS video and a laser camera. Reflux was diagnosed when microbubbles were observed in the ureter or in the renal pelvis. In addition, conventional voiding cystourethrography was performed. Patients without micturition during either sonography or radiographic examination were excluded (eight ureterorenal units). RESU …

Ultrasound-controlled therapeutics for bladder cancer: Mechanisms, recent advances, and future perspectives.

Bladder cancer remains a significant clinical challenge, characterised by a high recurrence rate and substantial healthcare costs. Although … ntensity focused ultrasound (HIFU) ablation. It describes how ultrasound, often in combination with microbubbles or nanobubbles, enhances the delivery of chemotherapeutic drugs and therapeutic genes through cavitation-induced permeabilisation of biological barriers. It then examines the mechanisms underlying SDT-induced reactive oxygen species generation and i …

Доставка гена для церебральных нейродегенеративных расстройств: текущие достижения и ограничения.

Доставка гена для нейродегенеративных заболеваний мозга сталкивается с огромными структурными и практическими проблемами. Кровеносные мозги, кровообращения и аракноидные барьеры жестко регулируют молекулярный трафик, ограничивают диффузию параклетки и активно очищают ксенобиотики, ограничивая проникновение в мозг и удержание крупных молекул и нуклеиновых кислотных препаратов. Дополнительные барьеры включают разнородную и диффузную патологию, необходимость точного анатомического целеопределения, ограничение токсических свойств векторами, ранее существовавший и вызванный терапией иммунитет к вир

Совпадение в аннотации оригинала
Gene delivery for neurodegenerative cerebral disorders faces formidable structural and practical challenges. The blood-brain, blood-cerebros … eceptor- and transporter-mediated transcytosis, nanoparticle platforms, and focused ultrasound with microbubbles, have demonstrated compelling yet preclinical proof of concept. Future progress will likely depend on convergent advances in machine-learning-guided capsid, more controllable blood-brain barrier modulation, rational route selection tailored to disea …

The Thermal Ablation with MRgFUS: From Physics to Oncological Applications.

The growing interest in minimal and non-invasive therapies, especially in the field of cancer treatment, highlights a significant shift towa … . In neuro-oncology, MRgFUS utilizes low-intensity focused ultrasound (LIFU) along with intravenous microbubbles to open the blood-brain barrier (BBB) and enhance the intra-tumoral delivery of chemotherapy drugs.

Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas.

Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed ultrasound (LIPU) and intravenously administered microbubbles (MB) to open the blood-brain barrier and increase the concentration of liposomal doxorubicin and PD-1 blocking antibodies (aPD-1). We report results on a cohort of 4 GBM patients and preclinical models treated with this approach. LIPU/MB increases the concentration of doxorubicin by 2-fold and 3.9-fold in the human and murine brains two days after soni…

Contrast-enhanced intraoperative ultrasound improved hepatic recurrence-free survival in initially unresectable colorectal cancer liver metastases.

BACKGROUND: We aimed to evaluate the role of Contrast-enhanced intraoperative ultrasound (CE-IOUS) with perfluorobutane microbubbles (Sonazoid) in improving the prognosis of patients with unresectable colorectal cancer liver metastases (CRLM). METHODS: A total of 130 Patients with unresectable CRLM who underwent curative hepatic resection at our institute were retrospectively analyzed. Of these 130 enrolled patients, 67 underwent intraoperative ultrasound alone (IOUS group); 63 underwent additional CE-IOUS and IOUS (CE-IOUS group). Normalized inverse probability treatment weighting (IPTW) was…