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Improved outcome of zygomycosis in patients with hematological diseases?

Zygomycosis is an opportunistic fungal infection that is increasingly reported in hematological patients. We describe 2 cases of successfully treated rhino-cerebral zygomycosis and give an overview of 120 patients from the literature with underlying hematological or oncological disorders. These data document the improved survival in sinus (15/17 patients surviving) and cutaneous (6/9 patients surviving) disease. Hematological patients with pulmonary (9/30 patients surviving) or disseminated (4/38 patients surviving) zygomycosis still have a poor prognosis. The clinical course of sinus-orbital

Study of Profile of Mucormycosis During the Second Wave of COVID-19 in a Tertiary Care Hospital.

Introduction and aim Mucormycosis is a lethal opportunistic infection caused by filamentous fungi of the family Mucoraceae (black fungus). There has been a sudden increase in the incidence of these cases during the second wave of the COVID-19 pandemic due to the immunocompromised state caused by the disease and its treatment. Early diagnosis and appropriate medical management are essential to reduce disease morbidity and mortality. Through this study, we aim to study the clinical features, risk factors, laboratory investigations, and radiological findings of patients with mucormycosis as well …

Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhu GM-CSF) as Adjuvant Therapy for Invasive Fungal Diseases.

BackgroundSargramostim (yeast-derived, glycosylated recombinant human granulocyte-macrophage colony-stimulating factor [rhu GM-CSF]) augment … e). Treatment is ongoing in the remaining 3 patients. Among 50 published cases (15 Candida spp., 13 Mucorales, 11 Aspergillus spp., 11 other organisms), 20 (40%) had baseline neutropenia and 36 (72%) were refractory to standard therapy before rhu GM-CSF administration. Consistent with responses in the newly reported patients, the overall response rate i …

Seasonal clustering of sinopulmonary mucormycosis in patients with hematologic malignancies at a large comprehensive cancer center.

BackgroundInvasive Mucorales infections (IMI) lead to significant morbidity and mortality in immunocompromised hosts. The role of season and climatic conditions in case clustering of IMI remain poorly understood.MethodsFollowing detection of a cluster of sinopulmonary IMIs in patients with hematologic malignancies, we reviewed center-based medical records of all patients with IMIs and other invasive fungal infections (IFIs) between January of 2012 and August of 2015 to assess for case clustering in relation to seasonality.ResultsA cluster of 7 patients were identified with sinopulmonary IMIs (…

Fungal, Viral, and Other Oddball Infections and the Immunosuppressed Patient

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… Subtypes Mucormycosis can be caused by hundreds of species but the pertinent species affecting critically ill patients include Rhizopus, Mucor, and Rhizomucor . … Moreover, histopathology can be useful in identifying certain species, e.g., periodic acid-Schiff stains for Mucor , and Grocott-methenamine-silver for yeastlike fungus . …

Molecular diagnostics in cancer patients with suspected respiratory mold infections.

Invasive fungal infections (IFIs), including aspergillosis and mucormycosis, are serious complications in cancer patients. Reliable detection of etiologic agents is challenging but important for optimal patient management. In a prospective multicenter study, we compared fungal detection by culture, specific and unspecific qPCRs, and fluorescence in situ hybridization (FISH) targeting Aspergillus and Mucorales in bronchoalveolar lavage fluid (BALF) and serum of adult cancer patients with suspected fungal pneumonia. In subgroups of patients, fungal DNA was amplified from serum. We evaluated 210 …

Management of Invasive Fungal Infections in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: The Turin Experience.

BACKGROUND: Allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are exposed to an increased risk of invasive fungal infecti … t 30, 180, and 365 days, respectively. Molds were the predominant agents (n = 50 Aspergillus; n = 1 Mucor), followed by invasive candidemia (n = 5 non-albicans Candida; n = 1 Candida albicans; n = 1 Trichosporon). Lung was the most frequent site involved in patients with mold infections (47/51, 92.2%). Median time from HSCT to IFI was 98.44 days (0-365 …

Epidemiological profile and clinical outcomes of patients with mucormycosis: the multicenter retromucor study from Türkiye (2004-2024).

PURPOSE: Mucormycosis is a rapidly progressive angioinvasive fungal infection with limited large-scale outcome data. We aimed to describe the epidemiology, clinical spectrum, treatment strategies, and predictors of outcomes in adult patients with proven mucormycosis in Türkiye. METHODS: We conducted a nationwide, retrospective study of 280 adults diagnosed with proven mucormycosis between 2004 and 2024 across 27 tertiary centers. Case definitions were applied according to the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortiu…

Clinical Outcomes of Oral Suspension versus Delayed-Release Tablet Formulations of Posaconazole for Prophylaxis of Invasive Fungal Infections.

Posaconazole is used for prophylaxis for invasive fungal infections (IFIs) among patients with hematologic malignancies. We compared the incidence of breakthrough IFIs and early discontinuation between patients receiving delayed-release tablet and oral suspension formulations of posaconazole. This was a retrospective cohort study of patients receiving posaconazole between 1 January 2010 and 30 June 2016. We defined probable or proven breakthrough IFIs using the European Organization for Research and Treatment of Cancer (EORTC) criteria. Overall, 547 patients received 860 courses of posaconazol

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… MICs of 0.5 μg/ml ( Candida tropicalis ) and 1 μg/ml ( Candida glabrata ) were observed for the two tested yeast isolates, and MICs of 1 μg/ml ( Mucor spp.) and >16 μg/ml ( Fusarium proliferatum ) were observed for the two tested molds. … Lung | Positive galactomannan only | 25 | 1.80 5 | Yes | M | AML | No | Tablet | Proven | | Lung | Positive cryptococcal antigen only | 13 | NC 6 | No | M | GVHD | Allogeneic (2004) | Suspension | Proven | | Blood | Candida glabrata | 12 | 1.07 7 | No | M | AML | No | Tablet | Proven | | Sinuses | Mucor …

Микробиота грибкового кишечника в педиатрии с множественным склерозом.

По имеющимся данным, кишечный микробиом может играть определенную роль в множестве склероза (MS). Однако в большинстве исследований основное внимание уделяется кишечным бактериальным сообществам; ни одно из них не изучало грибковую микробиоту (mycobiota) у лиц с педиатрическим множественным склерозом (POMS). Мы изучили кишечник микобиота у людей с ПОМС и без нее посредством перекрестного обследования кишечника микобиота из 46 Образцы стульев участниковthree группы: 18 ПОМЫ, 13 приобретенные монофазные демиелинизирующие синдромы [моноАДС], и 15 Не связанные с этим меры контроля). Использование

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… Another six genera were shared among all three groups: Aspergillus , Candida , Cladosporium , Mucor , Penicillium , and an unidentified genus. The Candida genus was generally the second-highest in terms of relative abundance (38.0% for POMS, 9.3% monoADS, and 43.1% for unaffected control). … The genera Aspergillus , Candida , Cladosporium , Mucor , Penicillium , Saccharomyces , and unclassified Eurotiales were found in all three groups. Within the top 10 genera, Agaricus was found to be uniquely abundant in POMS participants, Phoma in monoADS, and Exophiala in unaffected controls. …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… Mucor spp. Rhodoturula spp. | Humidifier ran continuously without cleaning and with water added periodically 2.1. … The inhalation of Mucor stolonifera spores induces paprika slicer’s lung in workers handling moldy paprika pods during paprika slicing [ 83 ]. The above-described cases report occupational lung diseases due to exposure in workplaces. …

Mucormycosis during Imatinib treatment: case report.

UnlabelledPhiladelphia chromosome positive acute lymphoblastic leukemia is classified as a very high-risk group and it requires an intensive chemotherapy regimen associated with tyrosine-kinase inhibitors and allogeneic hematopoietic stem cell transplant from related or unrelated HLA matched donor. Most times, intensive chemotherapy regimens are associated with prolonged and profound pancytopenia when the risk of invasive fungal infection increases. After Candida and Aspergillus species, Mucormycosis is the third frequent fungal infection in hematology patients and it is associated with a redu…

Проблемы с диагностикой и оказанием неотложной медицинской помощи в случае быстро прогрессирующего заболевания лёгких, вторичного и многократного заболевания миеломой.

Одновременное представление множественной миеломы (ММ) и межститиальной болезни легких (МЛ) остается исключительно редким, при этом ограниченная литература описывает оптимальные стратегии управления для этой двойной патологии. Мы сообщаем о сложном случае 62-year-old Мужчина с недавно поставленным диагнозом MM с цитогенетикой промежуточного риска (del13q, набирающий 1q), который одновременно представил быстро прогрессирующий ILD, демонстрирующий обычную интерститальную пневмонию (МСАГВ). Пациентка 6-month Клинический курс был отмечен участием многих организаций, периодическими инфекциями, тром

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… alternata-specific IgG (99 mgA/L; normal <30.0 mgA/L), along with raised Aspergillus fumigatus -specific IgG (35.50 mgA/L; normal <27.0 mgA/L) and pigeon serum protein, feather, and droppings-specific IgG (39.10 mgA/L; normal <30.0 mgA/L), while IgG levels to Cladosporium herbarum , Penicillium chrysogenum , and Mucor …

Unexpected and Deadly: Three Cases of Bone Marrow Necrosis.

Bone marrow necrosis (BMN) is a rare pathological diagnosis, with an incidence of 0.3% to 2%. It is most often associated with hematological malignancies and less commonly due to solid tumors, infections, medications, sickle cell disease, chemotherapy, radiotherapy, or idiopathic causes. We reviewed bone marrow biopsies performed in our institution from 2009 to 2019 and found three cases of BMN. Two cases were secondary to neoplastic causes, while the third one was possibly from alcohol abuse.

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… Nonmalignant causes include infections (i.e., Q fever, mycobacterium, human immunodeficiency virus, parvovirus, mucor), drugs (i.e., sulfasalazine, granulocyte-colony-stimulating factors, fludarabine, interferon-alpha, all-trans retinoic acid), sickle cell disease, hyperparathyroidism, anorexia nervosa …

10th Trends in Medical Mycology Held on 8 to 11 October 2021, Aberdeen, Scotland, Organized by the European Confederation of Medical Mycology (ECMM).

Plenary Sessions: [...].

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… The most common presenting species belong to genera Rhizopus, Lichtheimia, Apophysomyces, Saksenaea and Mucor . …

Metagenomics next-generation sequencing for diagnosis of invasive fungal diseases in patients with hematological diseases.

ObjectivesTo investigate the clinical characteristics and risk factors of invasive fungal disease (IFD) in patients with hematological disor … gy (46.88%, n = 15), followed by Aspergillus (18.75%, n = 6), Penumocystis (12.5%, n = 4), and Rhizomucor (12.5%, n = 4), with other fungal species accounting for the remaining cases (9.37%, n = 3). Multivariate logistic regression analysis revealed six independent risk factors associated with IFD in patients with hematological disorders: cluster of dif …

Novel diagnostic approaches and therapeutic management of mucormycosis: insights from a retrospective monocentric cohort study.

BACKGROUND: Mucormycosis is a rare, opportunistic fungal infection with high mortality rates, predominantly affecting immunocompromised patients. Its management is challenging due to diagnostic complexity and limited therapeutic options. METHODS: This retrospective cohort study analyzed 21 cases of mucormycosis diagnosed at the University Hospital of Liège between July 2018 and August 2023. Clinical, microbiological, and radiological data were evaluated to identify risk factors, treatment modalities, and outcomes. RESULTS: Hematological malignancies (82%) and immunosuppressive therapy (53%) …

Pulmonary and Hepatic Complications of Hematopoietic Cell Transplantation

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… Fungi are historically classified as either yeasts ( Candida , Trichosporon , Cryptococcus ) or molds, with molds subdivided by septate hyphae ( Aspergillus , Scedosporium , Fusarium , Histoplasma , Penicillium ) or aseptate hyphae ( Mucor , Rhizopus ). … Voriconazole provides effective therapy for a wide range of pathogenic fungi, excluding Mucor species. Both posaconazole and lipid formulations of amphotericin B provide coverage for Mucor , in addition to coverage for Aspergillus and Candida species. …

Acute Respiratory Failure After Hematopoietic Stem Cell Transplantation

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… Other fungal species such as Zygomycetes (Mucor, Rhizopus), Fusarium, and Scedosporium require surgical resection of localized lesions. The diagnosis and treatment of Pneumocystis jiroveci pneumonia is identical to nontransplant patients. …

Impact of Hyperglycemia and Diabetes Mellitus on Breakthrough Mucormycosis Outcomes in Patients with Hematologic Malignancies-Complex and Intriguing Associations.

Mucormycosis (MCR) is frequently associated with diabetic ketoacidosis and hyperglycemia, as well as hematologic malignancies (HMs) and hematopoietic stem cell transplantation (HSCT). However, little is known about the effect of hyperglycemia on MCR outcomes in patients with HMs. We therefore conducted a retrospective cohort study of adult patients hospitalized with MCR and HM or HSCT (n = 103) at MD Anderson Cancer Center from April 2000 through to April 2020. Twenty-three patients (22%) had documented episodes of severe hyperglycemia. Sixty patients had >5 serum glucose measurements within 2…