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Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn.

Transient receptor potential ankyrin 1 (TRPA1), responding to noxious cold and pungent compounds, is implicated in the mediation of nociception, but little is known about the processing of the TRPA1-mediated nociceptive information within the trigeminal sensory nuclei (TSN) and the spinal dorsal horn (DH). To address this issue, we characterized the TRPA1-positive (+) neurons in the trigeminal ganglion (TG) and investigated the distribution of TRPA1(+) afferent fibers and their synaptic connectivity within the rat TSN and DH by using light and electron microscopic immunohistochemistry. In the

Functional recovery after the repair of transected cervical roots in the chronic stage of injury.

The treatment of root injury is typically performed at the more chronic stages post injury, by which time a substantial number of neurons have died. Therefore, before being applied in the clinical setting, a treatment strategy for these lesions should prove to be as effective in the chronic stages of injury as it is in the acute stage. In this study, we simulated the most severe clinical scenarios to establish an optimal time window for repair at a chronic stage. The sixth to eighth cervical roots on the left side of female SD rats were cut at their junction with the spinal cord. One or three

Peripherally-derived olfactory ensheathing cells do not promote primary afferent regeneration following dorsal root injury.

Olfactory ensheathing cells (OECs) may support axonal regrowth, and thus might be a viable treatment for spinal cord injury (SCI); however, peripherally-derived OECs remain untested in most animal models of SCI. We have transplanted OECs from the lamina propria (LP) of mice expressing green fluorescent protein (GFP) in all cell types into immunosuppressed rats with cervical or lumbar dorsal root injuries. LP-OECs were deposited into either the dorsal root ganglion (DRG), intact or injured dorsal roots, or the dorsal columns via the dorsal root entry zone (DREZ). LP-OECs injected into the DRG o

The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.

Understanding of the sequence and nature of the events that govern neuron-microglia communication is critical for the discovery of new mechanisms and targets for chronic pain treatment. The neuronal chemokine fractalkine (FKN) and its microglial receptor CX3CR1 may mediate such a function in the dorsal horn of the spinal cord after cleavage of the extracellular domain of this transmembrane chemokine by a protease. Here we report that in neuropathic rat dorsal horn, with dorsal root-attached preparations, soluble FKN (sFKN) contents are increased in the superfusates collected after noxious-like

Right ventricular outflow tract transannular patch placement without cardiopulmonary bypass.

In children with pulmonary atresia not amenable to initial complete correction, antegrade pulmonary blood flow can be established with surgical right ventricular outflow tract (RVOT) patch enlargement. An 11-year experience with RVOT transannular patch (TAP) augmentation without the use of cardiopulmonary bypass (off-pump) is reported. From March 1993 to October 2004, off-pump surgical RVOT enlargement with a TAP was attempted in all patients in whom a concurrent procedure that required bypass was not required. The procedure was performed with cardiopulmonary bypass standby. Twenty-two consecu

Imaging and surgical outcomes of spinal tumors in 18 dogs and one cat.

Clinical and magnetic resonance imaging (MRI) findings, histological appearances and surgical outcomes of 18 dogs and one cat with spinal tumors are presented. Medical records of the cases admitted for spinal disorders were reviewed, and cases of spinal tumors that were diagnosed by MRI and confirmed by histological examination were included in this study. T1 weighted, T2 weighted and contrast enhanced T1 weighted images were taken and interpreted to evaluate the spinal tumors. The tumors were diagnosed as: meningioma (n = 6), ependymoma (n = 1), nerve sheath tumor (n = 4), metastatic spinal t

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… Hemilaminectomy with rhizotomy was conducted in all cases with nerve sheath tumor, and they survived for 2 or 3 months, although one case was lost to follow up after 1 month (Case No. 16). Nerve sheath tumor was diagnosed in one dog at L4–L5. …

Progress and research trends in neurogenic bladder after spinal cord injury bibliometric analysis based on web of science database: An observational study.

Neurogenic bladder (NB) is a significant complication that often occurs after spinal cord injury. It results from urinary dysfunction caused by the injury, disrupting the normal neural control of the bladder and urethra. Symptoms of NB can include urinary frequency, urgency, incontinence, and retention, all of which can greatly impact the quality of life of affected individuals. While there are articles and reviews on NB, fewer specifically address NB following spinal cord injury. This study examined 1095 publications from January 1, 2000, to March 27, 2024, in the Web of Science core database

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… Surgical approaches can be broadly categorized into 2 types: those aimed at increasing bladder contractility, such as selective dorsal rhizotomy [ 32 ] and sacral neuromodulation, [ 33 ] and those aimed at reducing bladder sphincter tone. … Selective dorsal rhizotomy for spasticity of genetic etiology. Childs Nerv Syst. 2020;36:1357–65. [33] Mass-Lindenbaum M, Calderón-Pollak D, Goldman HB, Pizarro-Berdichevsky J. Sacral neuromodulation – when and for who. Int Braz J Urol. 2021;47:647–56. …

Postoperative epidural analgesia versus systemic analgesia for thoraco-lumbar spine surgery in children.

BACKGROUND: Spine surgery may be associated with severe acute postoperative pain. Compared with systemic analgesia alone, epidural analgesia … liosis (nine trials), anterior correction for idiopathic scoliosis (one trial), or selective dorsal rhizotomy in children with cerebral palsy (one trial). The mean numbers of vertebrae operated on were between nine and 14.5 and the mean numbers of spinal levels were between three and four and a half. The length of surgery varied between three and six and a …

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

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… concept 68 denervation/or exp neurotomy/or exp nerve block/or exp catheter ablation/or radiofrequency ablation/or radiofrequency catheter ablation/or radiofrequency therapy/or pulsed radiofrequency treatment/or interventional radiology/or nonsurgical invasive therapy/or exp radiosurgery/or neurolysis/or rhizotomy … / (233779) 69 (Adhesiolysis or denervation* or epiduroscopy or neurotomy or neurolysis or rhizotomy or epidurolysis or neuroplasty or lysis or thermocoag* or electrocoag*).ti,ab. (116588) 70 ((nerve or radiofrequency or radio‐frequency or RF) adj3 (ablation or ablative)).mp. (65801) 71 ((lateral or …

Продуктирует ли анальгезия в тригеминальной невралгии? Обновленный системный обзор и метаанализ.

Предыстория/цели: Тригеминальная нейронгия (ТН) представляет собой излучающееся состояние, которое в основном регулируется в рамках первичной медико-санитарной помощи, где карбамазепин остается единственной рекомендуемой терапией первой линии. Предварительные метаанализы сообщают о сокращении боли в конце лечения с помощью иглоукалывания, но не приводят к стратифицированным результатам в силу риска предвзятости, проверяют качество отчетности о результатах боли или изучают вопрос о том, сохраняются ли последствия анальгезии после периода лечения. В рамках этого обновленного систематического обз

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… When medical management fails, the established alternatives are surgical or radiosurgical, including microvascular decompression, percutaneous rhizotomy, and stereotactic radiosurgery [ 12 ]. …

The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).

BACKGROUND & IMPORTANCE: This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare "iatrogenic chronic meningitis" causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward. METHODS: The prospective PRISMA protocol is pu

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… 37.7 | 771 | 1029 | 14 | 63 | 1940 | 2019 | 36-CR | 36-CS | 5-OS Outcomes And Complications Total | 146 | 2229 | 941 | 39.2 | 1042 | 1325 | 35 | 111 | 1930 | 2019 | 81-CR | 57-CS | 7-OS | 1-CCS Treatment | Bladder Stimulation [ 822 ] | 1 | 1 | 0 | 50.0 | 1 | 1 | 0 | 1 | 2008 | 2008 | 1-CR Cordotomy/Rhizotomy … syringomyelia | 77 | 1679 | 258 (25.1) | 1029 (61.3) | 77.7 LM fibrosis | 11 | 206 | 0 | 136 (66.0) | 10.3 Progression | 3 | 6 | 0 | 6 (100) | 0.5 Treatment | TOTAL | 88 | 2278 | 230 (15.6) | 1472(64.6) | 100 Surgical lysis of adhesions from LM fibrosis | 40 | 1089 | 134 (14.5) | 925 (84.9) | 62.8 Cordotomy/Rhizotomy …

Radiosurgery to the Medial Thalamus for Chronic Pain: A Single Group Experience and Review of Literature.

Introduction Chronic pain presents a significant challenge in achieving effective treatment and can greatly reduce patients' quality of life. Many individuals can undergo multiple therapies with limited success. Stereotactic medial thalamotomy is a treatment option for certain types of chronic pain when other measures have failed. This study aims to assess the efficacy and safety of radiosurgical medial thalamotomy based on nearly a decade of experience in managing chronic intractable pain of both malignant and non-malignant origins. Methods This retrospective study included 56 patients who un

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… These conditions can limit the feasibility of traditional approaches such as microsurgical decompression, radiosurgery, or percutaneous rhizotomy [ 9 ]. When the trigeminal nerve is not a viable target, SRS to the thalamus may offer an alternative treatment for these challenging cases. …

Quality of Life in Palliative Care: A Systematic Meta-Review of Reviews and Meta-Analyses.

BackgroundThe area of palliative care is a setting in which the evaluation of the quality of life (QoL) is fundamental. However, the topic has been covered from many different points of view, and there is a lack of comprehensive synthesis of the evidence drawn from the available literature.ObjectiveWe carried out a meta-review of all available systematic reviews and meta-analyses that have dedicated part or most of the investigation to the assessment of QoL in palliative care to provide the most updated and comprehensive depiction of all available information about measurement and intervention

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… Protocols Focused on the Oncological Treatment of the Patient - Radiofrequency ablation (RFA/Rhizotomy), - Delayed chemotherapy, - Surgery combined with chemo and radiotherapy. Special Treatment Protocols - Parenteral nutrition, - Paracentesis. … For example, Rosian et al . reported in their study a noticeable improvement in bone pain in patients with metastatic cancer undergoing rhizotomy. An improvement in general QoL was reported by Burlacu et al . [ 44 ] in dying patients experiencing some sort of religious beliefs. …

Антиконвульсантная терапия в тригеминальной невралгии: системный обзор класса.

Фон/цели Trigemenal Neuralgia (TN) — хроническое нервное заболевание, характеризующееся внезапной, сильной болью в лице. Антиконвульсанты являются краеугольным камнем фармакологического управления, однако сравнительных данных, основанных на фармакологическом классе, по-прежнему недостаточно. Этот систематический обзор был направлен на оценку эффективности и безопасности антиконвульсантов в TN, стратифицированных их механизмом действий. 2020 Руководящие принципы. Исследования с использованием фармакологического подхода, включая пациентов с ТН, опубликованные на английском языке с тех пор 2000,

Глубокая стимуляция мозга в гипоталамической области: систематический обзор.

КОЛИЧЕСТВО: Глубокая стимуляция мозга (БРС) успешно используется для лечения циклопатии, включая движение, беспокойство и поведенческие расстройства. Гипоталамус является важнейшим интеграционным центром для многих периферийных и центральных путей, связанных с сердечно - сосудистыми, метаболическими и поведенческими функциями, и представляет собой потенциальную цель нейромодуляции в лечебных условиях. Проведение систематического обзора, изучение гипоталамических целей в ДБС, их признаков и основных клинических результатов.МЕТОДЫ: База данных PubMed, Scopus и Web of Science была подвергнута обы

Targeting dorsal root ganglia for chemotherapy-induced peripheral neuropathy: from bench to bedside.

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating condition affecting an increasing number of cancer survivors worldwide. However, insights into its pathophysiology and availability of effective therapies remain lacking. Dorsal root ganglia (DRG) have been studied as a key component of chemotherapeutic drug toxicity and a potential therapeutic target for CIPN treatment. This comprehensive review aims to synthesize, summarize, and correlate the results of both preclinical and clinical studies relevant to the pathophysiology and management of CIPN in relation to the DRG. Design

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… Alternative modalities, such as rhizotomy and radiofrequency ablation of the DRG, are also being trialed in similar populations, including patients with cancer pain. 170 Given the mechanistic evidence supporting DRG-targeted therapies in the treatment of peripheral neuropathy, such interventions should …

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… Additionally, one patient was submitted to T3-S1 posterior fixation for progressive scoliosis treatment and another patient underwent T12-L1 laminotomy for selective dorsal rhizotomy. The Charcot level was respectively at L5-S1 and L1-L2 in these patients. …