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Skin-Directed Therapies in Mycosis Fungoides: An Update.

Mycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (CTCL), characterized by monoclonal proliferation of malignant T cells primarily involving the skin. The management of MF, especially in the early stages, involves skin-directed therapies (SDTs) to achieve disease control, alleviate symptoms, and enhance the quality of life (QoL). This review provides an updated overview of SDTs in MF treatment, including topical agents such as corticosteroids, retinoids, mechlorethamine, carmustine, imiquimod, as well as photodynamic therapy (PDT); phototherapy modalities including

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… Clobetasol propionate 0.05% and other high-potency corticosteroids are particularly effective, with the ointment formulation demonstrating superior efficacy compared to the cream form, although patient compliance should be a vital factor in therapy selection [ 14 ]. … One patient underwent 6 weeks of treatment with topical clobetasol propionate, which failed to provide improvement. He was then switched to 5% imiquimod, and after 4–5 months of therapy, the patient achieved CR. …

Two Cases of Hidradenitis Suppurativa Treated with Adalimumab at the Department of Dermatology and Venereology, Clinical Hospital Mostar.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body and presentin … cal severity of HS (10). The treatment of HS includes topical clindamycin, triamcinolone acetonide, clobetasol, topical resorcinol, oral antibiotics, hormonal therapy, oral retinoids, and biologic therapies (11). Biologic therapies are increasingly used in patients who fail to sufficiently respond to antibiotic and hormonal treatments. Adalimumab, infliximab …

Ixazomib Improves Bone Remodeling and Counteracts sonic Hedgehog signaling Inhibition Mediated by Myeloma Cells.

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of plasma cells (PC) in the bone marrow (BM), leading to bone loss and BM failure. Osteolytic bone disease is a common manifestation observed in MM patients and represents the most severe cause of morbidity, leading to progressive skeletal damage and disabilities. Pathogenetic mechanisms of MM bone disease are closely linked to PCs and osteoclast (OCs) hyperactivity, coupled with defective osteoblasts (OBs) function that is unable to counteract bone resorption. The aim of the present study was to investigate t

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… Clobetasol Modulates Adult Neural Stem Cell Growth via Canonical Hedgehog Pathway Activation Int. J. Mol. Sci. 2019 20 1991 10.3390/ijms20081991 31018557 PMC6514872 33. Raje N. Roodman G.D. Advances in the biology and treatment of bone disease in multiple myeloma Clin. …

Вторичные аутоиммунные дерматологические расстройства, вызываемые агентами по биологическому иммунотерапии с множественным склерозом: систематический обзор сообщений о случаях.

ONTEXT: Множественный склероз (MS) является разрушительным аутоиммунным нейродегенеративным заболеванием, в связи с которым лекарственные средства для лечения заболеваний (DMD) ассоциируются с вторичными аутоиммунными дерматологическими расстройствами. ЦЕЛИ: Данный систематический обзор докладов по конкретным делам направлен на изучение документально подтвержденных сообщений о случаях применения биологических препаратов при борьбе с нападениями с применением НР и распространением заболеваний, которые коррелируют с такими дерматологическими осложнениями. ИСТОЧНИКИ: Был проведен систематический

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… areata | MS since 4 years ago /fingolimod | 9 months after the 2nd cycle | Interlesional steroids | Improved but new plaques occured again/NM | A 28 year-old woman | 2017/Spain | Aggressive RRMS Dikeoulia et al., 2021 ( 19 ) | Alopecia areata | MS since 2006 | 18 months after 2nd infusion | Topical clobetasole …

Dermatologic Emergencies

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… Topical or intralesional corticosteroids (clobetasol 0.05 % ointment applied twice a day or intralesional triamcinolone acetonide, respectively) have been successfully used in case reports and retrospective studies. …

Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.

Pharmaceutical companies keep producing novel drugs and drug treatments for improving the life of every sick individual, most often following a pattern; a specific drug for a specific condition. Evidence suggests that different medications can have a positive effect on different pathological conditions. The full potential of existing therapies can be revealed through drug repurposing-also referred to as drug repositioning, reprofiling, or re-tasking-which involves identifying new therapeutic uses for approved or investigational drugs beyond their original indications. One significant target in

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… Multiple Myeloma [ 111 ] | Approved Rare and orphan | Alefacept | Chronic plaque psoriasis [ 112 ] | Memory T cell-mediated autoimmune diseases, organ transplantation and type I diabetes (T1D) [ 113 ] | Investigational | Baclofen | Muscle relaxant [ 114 ] | Alcohol use disorder [ 115 ] | Approved | Clobetasol …

CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment.

Mesenchymal stromal cells (MSCs) within the protective microenvironment of multiple myeloma (MM) promote tumor growth, confer chemoresistance and support metabolic needs of plasma cells (PCs) even transferring mitochondria. In this scenario, heterocellular communication and dysregulation of critical signaling axes are among the major contributors to progression and treatment failure. Here, we report that myeloma MSCs have decreased reliance on mitochondrial metabolism as compared to healthy MSCs and increased tendency to deliver mitochondria to MM cells, suggesting that this intercellular exch

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… Clobetasol modulates adult neural stem cell growth via canonical hedgehog pathway activation. Int J Mol Sci. 2019;20:1991. 25. …

Терапевтический потенциал моделей Purmorphamine через болезни.

Purmorphamine (PUR) — тройная субституция пурина, которая выборочно активирует сгущенный рецептор, тем самым инициируя Sonic Hedgehog (Shhh) сигнализирующий путь, имеющий решающее значение для эмбриональной модели, нейронной спецификации и регенерации тканей в различных системах различных органов. Регулирование сигнала " Шш " причастно к дегенеративным заболеваниям, однако терапевтические меры, направленные на этот путь, по-прежнему ограничены. PUR демонстрирует широкую терапевтическую эффективность различных моделей предклинических заболеваний путем активации как транскрипции с помо

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… Spitale , et al., “ Clobetasol Modulates Adult Neural Stem Cell Growth via Canonical Hedgehog Pathway Activation ,” International Journal of Molecular Sciences 20 , no. 8 ( 2019 ): 1991 . 31018557 10.3390/ijms20081991 PMC6514872 17 J. K. Chen , J. Taipale , K. E. Young , T. Maiti , and P. A. …

Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment.

Pyoderma gangrenosum (PG) is a rare inflammatory skin disease belonging to the group of neutrophilic dermatoses. The pathogenesis of PG involves a predisposing genetic background that facilitates a dysregulated innate and adaptive immune response, with an imbalance between pro-inflammatory and anti-inflammatory mediators, leading to neutrophil-driven inflammatory damage. Several immunosuppressants and immunomodulatory drugs are currently available for the treatment of PG, in combination with topical therapies, wound management and pain control strategies. Systemic corticosteroids and cyclospor

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… The most widely used is clobetasol propionate; in a prospective cohort study of 66 patients under treatment with clobetasol propionate 0.05% cream monotherapy, 43.8% of these patients healed by 6 months. …

Dermatological manifestations of hematologic neoplasms. Part II: nonspecific skin lesions/paraneoplastic diseases.

Cutaneous manifestations occur in the course of hematologic malignancies and precede, accompany or occur late in relation to the diagnosis. They result from paraneoplastic phenomena, tumor infiltrations, immunosuppression resulting from the hematologic disease itself or its treatment. The dermatologist must be aware of these conditions that may be helpful both in the diagnosis of the underlying disease and in reducing patient morbidity. This review (part II) addresses the paraneoplastic dermatological changes associated with systemic hematologic malignancies.

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… The care of the borders of lesions is important, where zinc oxide or petrolatum may be used. 23 Adequate analgesia is also crucial. 18 In mild cases, topical treatment with a high-potency corticosteroid such as clobetasol, a calcineurin inhibitor, or an intralesional corticosteroid may be used. 24 For …

Abstracts From JADPRO Live at APSHO 2015.

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… Grade 2 maculopapular rash following dose 1 was managed by holding the patient’s second dose, referral to dermatology for biopsy, and treatment with clobetasol 0.05% topical cream. …

Algae-Derived Bioactive Compounds as Platforms for Translational Biotechnology and Health Applications.

Marine macroalgae, microalgae, and associated microorganisms are increasingly recognised as valuable sources of bioactive compounds with applications across biotechnology and health. The environmental and ecological conditions they inhabit shape their metabolite diversity, leading to the production of high-value compounds such as sulphated polysaccharides, lipids, pigments, phenolics, and peptides. These compounds exhibit conserved biological activities that underpin potent antioxidant, anti-inflammatory, cytotoxic, and pro-regenerative effects with strong potential for translation. Although e

Стратегии защиты от нейропии в множестве склерозов: обновление статуса и формирующиеся парадигмы.

ВВЕДЕНИЕ: MS представляет собой континуум заболеваний, в котором с момента начала и с течением времени происходит злокачественное воспаление и нейродегенерация. Недавний прогресс в недостатке патобиологии MS создает новые перспективы для новых терапевтических стратегий нейрозащиты. ОБЛАСТЬ ПРИМЕНЕНИЯ: Авторы кратко рассматривают механизмы, лежащие в основе воспаления и нейродегенерации в MS, и обсуждают нынешние и формирующиеся стратегии поощрения нейрозащиты в MS. Данные были получены в значительной степени на основе обширного обзора опубликованной литературы, имеющейся на PubMed (до 5 марта

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… Clobetasol and miconazole have an effect on glucocorticoid receptor signaling and mitogen-activated protein kinase (MAPK), respectively, and promote remyelination in vivo through these actions [ 223 ]. Myelin itself inhibits OPC differentiation [ 224 ]. …

Pemphigus vulgaris.

Pemphigus vulgaris is a chronic autoimmune bullous dermatosis that results from the production of autoantibodies against desmogleins 1 and 3. It is the most frequent and most severe form of pemphigus, occurring universally, usually between 40 and 60 years of age. It usually begins with blisters and erosions on the oral mucosa, followed by lesions on other mucous membranes and flaccid blisters on the skin, which can be disseminated. There is a clinical variant, pemphigus vegetans, which is characterized by the presence of vegetating lesions in the large folds of the skin. Clinical suspicion can

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… More potent gel corticosteroids (clobetasol dipropionate) may be used in the oral mucosa. …

Dermatologic conditions in women receiving systemic cancer therapy.

As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman's self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt canc

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… For higher-grade presentations, topical corticosteroids (e.g., clobetasol ointment) for the hands and feet may be helpful and can be applied under occlusion of cotton gloves to enhance the therapeutic effect. … Tazarotene 0.1% cream, fluorouracil 5% cream, and clobetasol propionate 0.05% ointment may also be used for higher-grade rashes on hyperkeratotic and erythematous areas ( McLellan and Kerr, 2011 ). Application under occlusion of cotton gloves/socks may help. …

Targeting Reactive Oxygen Species Capacity of Tumor Cells with Repurposed Drug as an Anticancer Therapy.

Accumulating evidence shows that elevated levels of reactive oxygen species (ROS) are associated with cancer initiation, growth, and response to therapies. As concentrations increase, ROS influence cancer development in a paradoxical way, either triggering tumorigenesis and supporting the proliferation of cancer cells at moderate levels of ROS or causing cancer cell death at high levels of ROS. Thus, ROS can be considered an attractive target for therapy of cancer and two apparently contradictory but virtually complementary therapeutic strategies for the regulation of ROS to treat cancer. Desp

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… A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer Oncogene 2017 36 37 5285 5295 10.1038/onc.2017.153 2-s2.0-85031682434 28504720 159 Zhou Y. Zhou Y. Yang M. …

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions.

Macrophages and their monocyte precursors mediate innate immune responses and can promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there are few markers that allow for robust dissection of macrophage phenotype. We recently identified CD38 as a marker of inflammatory macrophages in murine in vitro and in vivo models. However, it is unknown whether CD38 plays a similar marker and/or functional role in human macrophages and inflammatory diseases. Here, we establish that CD38 transcript and protein are robustly induced in human macrophages exposed to LPS (±IFN-γ)

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… Group | Healthy | SLE I | SLE A N | 9 | 11 | 10 Average age (years ± SD) a | 39.9 ± 14.1 | 41.5 ± 16.8 | 32.5 ± 7.3 SLE Disease Activity Index (avg ± SD) | N/A | 0.4 ± 0.8 | 9.6 ± 5.7 Gender (F/M) | 6/3 | 9/2 | 10/0 Race (C/A/U) | 5/3/1 | 5/4/2 | 6/3/1 Therapies | | | Azathioprine | 0 | 2 | 4 Clobetasol …

Curcumin and Its Derivatives as Anticancer Agents in Head and Neck Cancer: Molecular Mechanisms and Preclinical Evidence

Head and neck cancer (HNC), particularly oral squamous cell carcinoma (OSCC), remains a major clinical challenge due to its aggressive behavior, high recurrence rates, and frequent resistance to conventional therapies. Natural compounds, especially curcumin and its derivatives, have gained increasing attention as potential anticancer agents due to their ability to target multiple molecular pathways involved in tumor progression. This review critically evaluates the current preclinical and translational evidence supporting curcumin and its derivatives as monotherapeutic agents in HNC, with part

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… In addition, the corticosteroid clobetasol showed superior clinical efficacy compared to curcumin [ 250 ]. …

Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses.

The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-equipped for future pandemics. While unprecedented strides have been made developing vaccines and treatments for COVID-19, there remains a need for highly effective and widely available regimens for ambulatory use for novel coronaviruses and other viral pathogens. We posit that a priority is to develop pan-family drug cocktails to enhance potency, limit toxicity, and avoid drug resistance. We urge cocktail development for all viruses with pandemic potential both in the short term (<1 to 2 years) and longer term wi

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… Sixty-two pairs include RDV ( 101 ), with the partner drug being arbidol, BAY-2402234, brequinar, budesonide, camostat, cepharanthine, cilostazol, clobetasol, clofazimine, cobicistat, conivaptan, dabrafenib, diltiazem, drosiprenone, emetine, ezetimibe, interferon alpha, imino sugars, IQ-1S, ivermectin …

Inflammatory Manifestations, Therapeutic Interventions, and Cancer Risk in Psoriasis: Current Epidemiological and Mechanistic Evidence.

Psoriasis is a chronic, autoimmune skin disease driven by persistent inflammation and immune dysfunction that severely impairs quality of life and is associated with serious comorbidities, including psoriatic arthritis, cardiovascular diseases (CVDs), and depression. Emerging epidemiological evidence suggests an association between psoriasis and an increased risk of certain malignancies, such as breast cancer (BC) and non-Hodgkin's lymphoma (NHL), although the strength and consistency of these associations vary across study designs, and the underlying thrombo-inflammatory mechanisms remain inc

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… Therapeutic Class | Representative Agents | Primary Molecular Target | Main Adverse Effects | Reported Malignancy Risk | Clinical Interpretation Topical Corticosteroids | Clobetasol, Betamethasone | Suppress inflammation gene transcription | Skin atrophy, telangiectasia | No convincing long-term evidence …