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Safety and tolerability of loteprednol etabonate 0.5% and tobramycin 0.3% ophthalmic suspension in pediatric subjects.

BACKGROUND: Loteprednol etabonate 0.5% and tobramycin 0.3% ophthalmic suspension (LE/T) is indicated for steroid-responsive inflammatory ocu … AEs were reported for three LE/T-treated subjects in the first study (conjunctivitis [two events], meibomian gland dysfunction, and corneal staining), and one ocular AE was reported for an LE/T-treated subject in the second study (eye pain). A total of 13 non-ocular AEs were reported for eight LE/T-treated subjects in the two trials. The most prevalent non-ocular AEs were p …

Conjunctivitis in Adults with Atopic Dermatitis Treated with Dupilumab: An Observational Study of Clinical Characteristics, Symptomatology, and Treatment.

INTRODUCTION: Conjunctivitis is more prevalent in patients with atopic dermatitis (AD) than the general population, and is the most common a … ular eczematous rash (65% vs. 18%) and/or lichenification (47% vs. 27%), posterior blepharitis with meibomian gland dysfunction (83% vs. 55%), bulbar hyperemia (89% vs. 46%) and conjunctival papillary pattern (69% vs. 27%); 24% of patients in group 1 and none in group 2 had corneal neovascularization, mostly in a single peripheral quadrant. There was no evidence of tear volu …

The Predictive and Explanatory Power of the Contrast Theory of Myopia.

IMPORTANCE: Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye disease (DED). Medical and surgical management for DED is limited; therefore, new treatment options are sought. OBJECTIVE: To evaluate the efficacy and safety of SHR8058 (perfluorohexyloctane) eye drops in Chinese patients with DED associated with MGD through 57 days. DESIGN, SETTING, AND PARTICIPANTS: This was a randomized, multicenter, double-masked, saline-controlled, phase 3 clinical trial conducted from February 4, 2021, to September 7, 2022. Patients were recruited from the departments of ophthalmol…

[Ocular signs and comorbidities in monoclonal gammopathy: Analysis of 84 eyes of 42 subjects].

UNLABELLED: Összefoglaló. Célkitűzés: A monoklonális gammopathia szemészeti jeleinek és szövődményeinek vizsgálata. Betegek és módszerek: Ké … 3 patients (5.95%). In gammopathy subjects, there was dry eye disease (66.67%), cataract (55.95%), Meibomian gland dysfunction (20.24%), posterior cortical cataract (19.05%), corneal scars and degenerations (17.86%), chronic blepharitis (14.29%), absence of ocular complaint (11.90%), macular or retinal drusen (9.52%), corneal immunoglobulin deposition (5.95%), epiretinal me …

Ocular Signs and Ocular Comorbidities in Monoclonal Gammopathy: Analysis of 80 Subjects.

PURPOSE: To examine the ocular signs of monoclonal gammopathy and to evaluate ocular comorbidities in subjects with monoclonal gammopathy. Patients and Methods. We analyzed patients from two large referral hematology centers in Budapest, diagnosed and/or treated with monoclonal gammopathy between 1997 and 2020. As a control group, randomly selected individuals of the same age group, without hematological disease, have been included. There were 160 eyes of 80 patients (38.75% males; age 67.61 ± 10.48 (range: 38-85) years) with monoclonal gammopathy and 86 eyes of 43 control subjects (32.56% mal

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… The prevalence of Meibomian gland dysfunction was described to be 36% in subjects with 50–59 years of age [ 35 ]. Interestingly, Meibomian gland dysfunction was rather uncommon with 11.63% in our control and with 18.75% in our gammopathy groups, without statistically significant difference. … Prevalence of meibomian gland dysfunction in staffs and faculty members of a Chinese university. International Journal of Ophthalmology. 2020;13(10):1667–1670. doi: 10.18240/ijo.2020.10.23. 36. Liisborg C., Nielsen M. K., Hasselbalch H. C., Sørensen T. L. …

Ophthalmic Manifestations in Patients with Blood Malignancies.

Ocular complications can occur in up to 90% of patients with blood malignancies. Such complications range from direct infiltration to local hemostatic imbalance and treatment-related toxicity. This narrative review is based on a systematic computerized search of the literature conducted until January 2024 and examines the common ocular complications associated with blood cancers. Ocular complications from primary disease include mass effects from ocular adnexal lymphomas and intraocular lymphomas, with B-cell lymphomas accounting for 95% of primary ocular presentations. Secondary disease invol

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… Meibomian gland dysfunction (MGD) is observed in 47.8% of oGVHD, indicating that affected patients may present both evaporative and aqueous-deficient forms of dry eye [ 76 ]. … Foamy secretion from meibomian gland dysfunction. ( B ) Ankyloblepharon, ( C ). Symblepharon. ( D ) Corneal punctate epithelial defects were highlighted using fluorescein staining with cobalt blue and yellow filters. …

Biomarkers of ocular allergy and dry eye disease.

The most common disorders of the ocular surface are dry eye disease (DED) and ocular allergy (OA). These conditions are frequently coexistin … roteins Calcium activated signaling proteins, Th1 = T helper 1 cell, Th17 = T helper 17 cell, MGD = Meibomian gland dysfunction, TFOS = Tear film and ocular surface society, SS-KCS = Keratoconjunctivitis Sicca, MMP-9 = Matrix metalloproteinase 9, MMP-1 = Matrix metalloproteinase 1, ZAG = Zinc alpha glycoprotein, CBA = Cytometric bead array, MALDI TOF-MS = matrix assisted las …

Oral antibiotics for chronic blepharitis.

BACKGROUND: Posterior blepharitis is common and causes ocular surface and lid damage as well as discomfort. It affects 37% to 47% of all oph … h placebo in adult participants with chronic blepharitis (including staphylococcal, seborrhoeic, or Meibomian Gland Dysfunction (MGD)). DATA COLLECTION AND ANALYSIS: We used standard Cochrane methodology and graded the certainty of the body of evidence for six outcomes using the GRADE classification. MAIN RESULTS: We included two studies with 220 participants (numbers of e …

Ocular Surface Side Effects of Novel Anticancer Drugs.

Surgery, anticancer drugs (chemotherapy, hormonal medicines, and targeted treatments), and/or radiation are common treatment strategies for neoplastic diseases. Anticancer drugs eliminate malignant cells through the inhibition of specific pathways that contribute to the formation and development of cancer. Given the ability of such pharmacological medications to combat cancerous cells, their role in the management of neoplastic diseases has become essential. However, these drugs may also lead to undesirable systemic and ocular adverse effects due to cyto/neuro-toxicity and inflammatory reactio

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… Lastly, ocular adnexal side effects, such as blepharitis and meibomian gland dysfunction, can be easily managed with topical therapy, including ocular lubricants, eyelid scrubs, and warm compresses, reserving systemic antibiotics only for severe cases. … gland dysfunction, blepharitis, and corneal alterations; and hormonal dysregulation, principally determining DED. …

Frequency of Topical Immunomodulatory and Immunosuppressive Therapies for Ocular Chronic Graft-versus-Host Disease.

Introduction: The purpose of the study was to evaluate the frequency of topical immunomodulatory and immunosuppressive therapies in patients with ocular chronic graft-versus-host disease (cGVHD) in consideration of inflammatory activity and systemic immunosuppressive therapies in a tertiary care university hospital setting. Methods: We included 95 adult patients (48 male, 47 female) with ocular chronic graft-versus-host disease (cGVHD) after alloHSCT (median age 49.5 years). Clinical ophthalmological findings and the grade of ocular cGVHD according to the NIH eye score and the German-Austrian-

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… Involvement of the lids (e.g., blepharitis, meibomian gland dysfunction, and erythema) c. Involvement of the conjunctiva (e.g., cicatricial conjunctivitis) d. Involvement of the cornea (e.g., keratitis and epithelial defects) e. … Revisiting the vicious circle of dry eye disease: A focus on the pathophysiology of meibomian gland dysfunction. Br. J. Ophthalmol. 2016;100:300–306. doi: 10.1136/bjophthalmol-2015-307415. 17. …

Tea tree oil for Demodex blepharitis.

BACKGROUND: Demodex blepharitis is a chronic condition commonly associated with recalcitrant dry eye symptoms though many people with Demode … ical dandruff or the proportion of participants experiencing conjunctival injection or experiencing meibomian gland dysfunction. Three RCTs provided information on adverse events. One reported no adverse events. The other two described a total of six participants randomized to treatment with tea tree oil who experienced ocular irritation or discomfort that resolved with re-e …

Interventions for chronic blepharitis.

BACKGROUND: Blepharitis, an inflammatory condition associated with itchiness, redness, flaking, and crusting of the eyelids, is a common eye … f the eye (e.g. staphylococcal and seborrheic blepharitis), and posterior, or back of the eye (e.g. meibomian gland dysfunction (MGD)). This review focuses on chronic blepharitis and stratifies anterior and posterior blepharitis. OBJECTIVES: To examine the effectiveness of interventions in the treatment of chronic blepharitis. SEARCH METHODS: We searched CENTRAL (which con …

Development and validation of a diagnostic model for the identification of chronic ocular graft-versus-host disease (oGVHD).

PURPOSE: To verify the International Chronic Ocular Graft-Versus-Host Disease (ICCGVHD) Group diagnostic criteria and establish an easy-to-use and reliable diagnosis model for quick identification of chronic oGVHD. METHODS: This study included 180 patients (355 eyes) who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) and visited the Peking University Third Hospital Cornea and Ocular Surface Disease Specialist Clinic from July 2020 to February 2021. The proportion of chronic oGVHD was 76.06% (279/355). RESULTS: Five complaints, including eye dryness, photophobia, for

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… Discussion OGVHD has at least three important biological processes: lacrimal gland dysfunction, meibomian gland dysfunction, and corneal and conjunctival inflammatory infiltration ( 19 , 20 , 21 ). The pathogenesis of oGVHD can currently be summarized as a three-phase model. …

Drug-Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper.

Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life-threatening complications. Drug-induced ocular adverse reactions are generally classified into two primary categories: toxic reactions and/or allergic hypersensitivity reactions, which can be IgE or non-IgE-mediated. Systemic antibiotics, antivirals, and anticonvulsants can trigger adverse reactions that may involve the OS. Drugs like antihistamines, beta-blockers, antipsychotics, antide

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… gland dysfunction: Drugs like isotretinoin can affect the meibomian glands, causing thickened or absent meibum secretion, leading to gland blockage, inflammation and worsening of evaporative dry eye 3. … Warm compresses, lid hygiene, and oral omega‐3 fatty acids may be effective in meibomian gland dysfunction (MGD). If isotretinoin is the cause of MGD, dose adjustment or drug discontinuation is necessary. …

Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation.

PurposeTo investigate the profile of cytokines in tear fluid of patients after allogeneic stem cell transplantation (allo-SCT) and determine their relation to the presence and manifestations of ocular graft-versus-host disease (GvHD).MethodsIn this cross sectional study tear fluid was collected in 34 consecutive adult patients that previously underwent allo-SCT (16 with ocular GvHD and 18 without) and 16 age- and gender-matched healthy controls using the Schirmer test under local anesthesia. Tear fluid was analyzed by multiplex immunoassay for the presence of interleukin (IL)-2, IL-4, IL-6, IL

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… Ocular GvHD predominantly affects the anterior ocular segment and manifestations include conjunctival or corneal epithelial changes, Meibomian gland dysfunction and dry eye disease (DED) manifesting as keratoconjunctivitis sicca (KCS) [ 1 , 2 ]. … According to NIH consensus criteria [ 3 ], blepharitis, Meibomian gland dysfunction, and chemosis were not taken into account for the diagnosis of ocular GvHD. …

Pharmacological Strategies for Mitigating Cytarabine-Induced Multi-Organ Toxicity: A Scoping Review on Mechanisms, Efficacy and Clinical Implications.

BACKGROUND: Cytarabine (Ara-C) remains the cornerstone of remission-induction and consolidation chemotherapy for acute myeloid leukemia (AML) and related hematological malignancies. Despite more than six decades of clinical use, its multi-organ toxicity continues to be managed almost exclusively through dose attenuation and supportive care, with no approved upstream pharmacological prevention strategy available. OBJECTIVES: This scoping review aimed to systematically map the breadth and nature of pharmacological agents tested in vivo for their capacity to mitigate cytarabine-induced multi-org

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… . × 7 d | C57BL/6J mice, M, 6–8 wk | Ocular: meibomian gland dysfunction, lacrimal hyposecretion | Rosiglitazone 10 mg/kg/day p.o. × 7 d (PPARγ agonist) | Normalized corneal fluorescein score, tear volume, MG acinar area; restored PPARγ/AWAT2/SOAT1/ELOVL4 and Nrf2/HO-1/SOD1 antioxidant signaling. … Cytarabine Chemotherapy Induces Meibomian Gland Dysfunction. Ocul. Surf. 2024;34:444–458. doi: 10.1016/j.jtos.2024.10.002. 13. Namoju R., Chilaka N.K. Alpha-Lipoic Acid Ameliorates Cytarabine-Induced Developmental Anomalies in Rat Fetus. Hum. Exp. …

Management and outcomes of proteasome inhibitor associated chalazia and blepharitis: a case series.

BACKGROUND: The purpose of this case series was to further characterize proteasome inhibitor associated chalazia and blepharitis, to investigate outcomes of different management strategies, and to propose a treatment algorithm for eyelid complications in this patient population. METHODS: This retrospective case series included sixteen patients found to have chalazia and/or blepharitis while receiving proteasome inhibitors for plasma cell disorders at Mount Sinai Hospital in New York, NY from January 2010 through January 2017. Main outcomes were complete resolution of eyelid complications and

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… Previous reports have linked bortezomib with development of severe bilateral blepharitis, a chronic inflammatory eyelid process, and formation of chalazia, lipogranulomatous lesions that develop secondary to Meibomian gland dysfunction [ 1 – 5 , 10 ]. …

Visual and ocular surface benefits of mini-scleral contact lenses in patients with chronic ocular graft-versus-host disease (GvHD).

Graft-versus-Host disease is a major complication of allogeneic stem cell transplantation. The eyes are a frequently affected organ with a severe dry eye disease being the hallmark manifestation. This retrospective study evaluates the effect of mini-scleral contact lenses on visual acuity, eye-related quality of life and the ocular surface. 62 eyes of 31 patients were included and visual acuity, ocular surface disease index (OSDI) questionnaire results and Oxford grades before and after mini-scleral lens fitting were compared. Median Snellen fraction with mini-scleral lenses was 20/25 (1st 20/

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… Meibomian gland dysfunction) that all contribute to potentially vision threatening ocular surface disease 2 . In principle, mini-scleral or scleral contact lenses may be incorporated in the therapy of severe dry eye disease due to chronic ocular GvHD at any point. …

From Sjögren syndrome to Sjögren disease: rethinking classification and diagnostic complexity.

Sjögren syndrome (SS), traditionally regarded as a sicca-predominant condition, is now recognized as a systemic autoimmune disease characterized by type I interferon activation, B-cell hyperactivity, and periepithelial lymphocytic infiltration. This conceptual shift has prompted changes in terminology, with "SS" increasingly replaced by "Sjögren disease (SjD)" and "secondary SS" by "associated SjD," reflecting the concept of polyautoimmunity and ensuring equal clinical standing. In this review, we trace the historical evolution of SS classification criteria and examine their limitations in rea

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… The most common subtype of dry eye is the evaporative type, primarily associated with Meibomian gland dysfunction [ 23 ]. According to the Dry Eye Clinical Survey-Korea study, the prevalence of evaporative versus aqueous-deficient dry eye is 60% and 40%, respectively [ 30 ]. …

Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient.

A 58-year-old man presented with recurrence of chronic myeloid leukemia (CML) after complete molecular remission in the setting of non-compliance with imatinib. He was restarted on imatinib and was also noted to have IgG kappa monoclonal gammopathy of undetermined significance (MGUS). The patient re-achieved molecular remission after resumption of imatinib, but his MGUS progressed to smoldering myeloma and he was eventually diagnosed with multiple myeloma (MM) and initiated on treatment for MM with thalidomide, bortezomib and dexamethasone. He has responded well to treatment of the myeloma and

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… He was seen by ophthalmology and diagnosed to have meibomian gland dysfunction. Due to the rash and ocular symptoms, there were delays in his myeloma treatment but these were not dose-limiting toxicities. …