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Occurrence of oligoclonal gammaglobulin in the CSF of children with prolonged and chronic CNS-infections.

CSF-proteins of 1770 children and adolescents with different neurological diseases and of 75 controls were examined by zone electrophoresis … en oligoclonal IgG fractions were detected in each of 16 children with SSPE. All 6 adolescents with multiple sclerosis had 2--5 oligoclonal IgG fractions. One to five oligoclonal gamma-bands occurred transiently in the CSF of 4 children with prolonged meningoencephalitis caused by different viruses, in 3 children with a prolonged non-bacterial meningitis of probable …

Воздействие перорального иммунитета на нейроинфламму и нейродегенеративные заболевания.

Все чаще признается, что здоровье полости рта является важным фактором регулирования системной иммунной реакции и неврологического здоровья. Разрушение иммунного гомеостазиса в оральных тканях, особенно в таких хронических заболеваниях, как периодонтит, связано с развитием и развитием таких нейродегенеративных заболеваний, как болезнь Альцгеймера (AD), болезнь Паркинсона (PD) и множественный склероз (MS). В этой главе рассматривается вопрос о том, каким образом хроническое воспалительное состояние пероральной полости, оральный дисбиоз и наличие конкретных периодонтропотогенов способствуют сист

Совпадение в аннотации оригинала
Oral health is increasingly recognized as an important factor in the regulation of systemic immune responses and neurological health. Disrup … sion of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). This chapter explores how chronic inflammatory conditions in the oral cavity, oral dysbiosis, and the presence of specific periodontopathogens contribute to systemic immune activation, microglial priming, and blood-brain barrier dysfunction. T …

Transcranial magnetic stimulation outcomes as biomarkers of multiple sclerosis disease progression: A structured literature review.

Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS) disease and a leading cause of disability in young adults. Chronic disability progression is an unmet challenge for persons with MS and an area of interest for the development of biomarkers. Transcranial magnetic stimulation (TMS) is a putative technique for the development of MS biomarkers. However, TMS outcomes have not been extensively reviewed as biomarkers of disability progression in MS to date. This structured literature review assessed longitudinal and cross-sectional studies of TMS and disability progression in…

Formation and immunomodulatory function of meningeal B cell aggregates in progressive CNS autoimmunity.

Meningeal B lymphocyte aggregates have been described in autopsy material of patients with chronic multiple sclerosis. The presence of meningeal B cell aggregates has been correlated with worse disease. However, the functional role of these meningeal B cell aggregates is not understood. Here, we use a mouse model of multiple sclerosis, the spontaneous opticospinal encephalomyelitis model, which is built on the double transgenic expression of myelin oligodendrocyte glycoprotein-specific T-cell and B-cell receptors, to show that the formation of meningeal B cell aggregates is dependent on the ex…

Temporal Dynamics of Pulmonary Fibrosis and Immune Dysregulation in a Collagen V-Driven Systemic Sclerosis Model.

Systemic sclerosis (SSc) is a complex autoimmune disease characterized by progressive fibrosis and immune dysregulation, with lung involvement being a major cause of morbidity and mortality. Type V collagen (COLV), a cryptic self-antigen, has been implicated in the pathogenesis of fibrosis in both SSc and lung allograft dysfunction. To characterize the early histological, molecular, and immunological events associated with lung remodeling following immunization with COLV in a murine model (IMU-COLV), and to establish a temporal framework for fibrosis progression. Using a time-course design, lu

Wearable-based physiological monitoring and brain magnetic resonance imaging metrics in multiple sclerosis: A feasibility study.

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Physiological monitoring may be useful for monitoring the progression of MS and its underlying neurodegenerative processes OBJECTIVE: This cross-sectional study evaluated the feasibility of assessing associations of physiological parameters measured by a wearable sensor with CNS atrophy and lesion burden in individuals with MS. METHODS: Thirty MS patients (relapsing-remitting [n = 23], secondary progressive [n = 5], primary progressive [n = 2]) were monitored using a wrist-worn sensor (F…

Клеточная терапия в многоразовом склерозе: Клинические достижения, ограничения и перспективы на будущее из клинических исследований - систематический обзор.

Фон: Множественный склероз (MS) — хроническое аутоиммунное демиелинирующее заболевание центральной нервной системы (CNS), характеризующееся воспалением, обезвоживанием и прогрессивным нейродегенерацией. Несмотря на то, что нынешняя медикаментозная терапия (ДМТ) может снизить частоту рецидивов и провокационной активности, они редко останавливают долгосрочное развитие или устраняют неврологические повреждения. В последние годы клеточная терапия стала многообещающим подходом к содействию иммунальному регулированию и нейрогенерации в MS. Методы: Настоящий обзор резюмирует текущие клинические данны

Совпадение в аннотации оригинала
Background: Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS), characterised by inflammation, demyelination, and progressive neurodegeneration. Although current disease-modifying therapies (DMTs) can reduce relapse rates and inflammatory activity, they rarely stop long-term progression or repair neurolo…

Epilepsy progression is associated with cumulative DNA methylation changes in inflammatory genes.

Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is the most common focal epilepsy in adults. It is characterized by alarming rates of pharmacoresistance. Epileptogenesis is associated with the occurrence of epigenetic alterations, and the few epigenetic studies carried out in MTLE-HS have mainly focused on the hippocampus. In this study, we obtained the DNA methylation profiles from both the hippocampus and anterior temporal neocortex of MTLE-HS patients subjected to resective epilepsy surgery and autopsied non-epileptic controls. We assessed the progressive nature of DNA me

Human Dental Pulp Stem Cells Attenuate Neuroinflammation and Neurological Deficit in a Murine Model of Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system mediated by autoimmune demyelination. While treatments targeting the peripheral immune system have been effective in reducing relapse risks for MS patients, the neuroinflammation within the central nervous system, which is believed to contribute to neurodegeneration, has not been successfully addressed. Human Dental Pulp Stem Cells (hDPSCs) have shown potential in entering the CNS and exerting anti-inflammatory effects, making them a promising candidate for treating neurological disorders. In experimental a…

What Roles Does EBV Play in Systemic Lupus Erythematosus? A Synthesis of Its Action Mechanisms.

Systemic lupus erythematosus (SLE) is a heterogeneous chronic autoimmune disease. Exogenous pathogen infections act as key environmental triggers for autoimmune activation and the development of SLE, with Epstein-Barr virus (EBV) being a particularly prominent one. EBV, a gamma herpesvirus, has been associated with the development of various autoimmune diseases, including SLE, rheumatoid arthritis, Sjögren's syndrome, and multiple sclerosis. Current studies provide sufficient evidence supporting an association between EBV and SLE; however, the specific underlying mechanisms remain unclear. In …

Улучшение положения и проблемы в области оказания многочисленных услуг по склерозу в Уругвае: всеобъемлющий обзор.

Множественный склероз (MS) является хроническим неврологическим расстройством, которое может привести к значительной инвалидности при отсутствии лечения. За последние годы Уругвай добился заметного прогресса в области ухода за больными, включая улучшение эпидемиологического понимания, повышение доступности высокоэффективных методов лечения заболеваний и создание специализированных рабочих групп, занимающихся вопросами совершенствования методов лечения пациентов. Несмотря на эти успехи, проблемы сохраняются. Доступ к методам диагностики, многодисциплинарному уходу и реабилитационным услугам по-

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic neurological disorder that can lead to significant disability if untreated. Over the past years, Uruguay has made notable progress in MS care, including improved epidemiological understanding, better accessibility to high-efficacy disease-modifying therapies, and the formation of specialized workgroups dedicated to enhanc…

Множественный склероз и инфекция: история, ЭБВ и поиск механизма.

В качестве причины множественного склероза (МС) уже давно гипотезуется резкий инфекция, и недавние данные о вирусе Эпштейн-Барр (ЭБВ) как источнике НР являются ясными и убедительными. Эта ясность контрастирует с еще неопределенными вирусными механизмами и их отношением к нейроинфламму MS и обезвоживанию. До тех пор пока это неравенство будет сохраняться, оно будет стимулировать вирусологов, молекулярных биологов, иммунологов и клинических работников, чтобы выяснить, как EBV воздействует на MS и, возможно, на хроническую активность и прогрессию болезни. Такие усилия должны осуществляться с испо

Совпадение в аннотации оригинала
SUMMARYInfection has long been hypothesized as the cause of multiple sclerosis (MS), and recent evidence for Epstein-Barr virus (EBV) as the trigger of MS is clear and compelling. This clarity contrasts with yet uncertain viral mechanisms and their relation to MS neuroinflammation and demyelination. As long as this disparity persists, it will invigorate viro…

Schistosomiasis protects against multiple sclerosis.

The incidences of schistosomiasis and multiple sclerosis (MS) are mutually exclusive worldwide suggesting that schistosomiasis may offer protection against the induction of the immune-mediated disease, MS. Recent studies using the mouse model of MS, experimental autoimmune encephalomyelitis, support a direct suppression of the onset of MS by chronic Schistosoma mansoni infection. Self-reactive Th1 but not Th2 responses develop in infected mice immunized with myelin oligodendrocyte glycoprotein albeit at reduced levels indicating that the induction of auto-reactive T cells is not abolished nor …

Jacqueline du Pré and her alternative diagnosis.

JacquelineduPré (26 January 1945-19 October 1987) is one of the greatest cellists in the 20th century. Her musical career was terminated at age 28, allegedly due to multiple sclerosis (MS). MS is an immune-mediated demyelinating disease of the central nervous system with axonal involvement, characterized by the dissemination in time and space of the lesions (plaques). Diverse neurological symptoms may occur in MS, and a variety of symptoms relentlessly accumulated in her case after the diagnosis in 1973, which is concordant with primary progressive rather than relapsing-remitting form of MS. N…

Therapeutic Potential of Stem Cells From Human Exfoliated Deciduous Teeth and Their Derivatives in Immune-Mediated Inflammatory Diseases: Mechanisms and Perspectives.

Stem cells from human exfoliated deciduous teeth (SHED) and their derivatives have emerged as promising therapeutic agents for treating immu … and their derivatives in multiple IMIDs, such as systemic lupus erythematosus, Sjögren's syndrome, multiple sclerosis, and rheumatoid arthritis. Critically, the aim of this review is not only to synthesize recent progress in SHED research for IMID treatment but also to highlight the strategic significance of innovative therapies emerging from the intersection of re …

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.

Since the successful conquest of many acute, communicable (infectious) diseases through the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and progressive in nature, and are all accompanied by inflammation. These diseases include neurodegenerative (e.g. Alzheimer's, Parkinson's), vascular (e.g. atherosclerosis, pre-eclampsia, type 2 diabetes) and autoimmune (e.g. rheumatoid arthritis and multiple sclerosis) diseases that may appear to have little in common. In fact they all share significant features, in particular chronic inflammation and its attendant infl…

Immunotherapies for risk reduction in age-associated neurodegenerative diseases: impact of sex and treatment duration.

INTRODUCTION: Neurodegenerative diseases (NDDs) including Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and non-AD dementias share chronic neuroinflammatory mechanisms that contribute to neuronal injury and disease progression. While anti-inflammatory therapies (AITs) are associated with reduced neurodegenerative disease risk, knowledge regarding the impact of biological sex and treatment duration across multiple NDDs remains limited. METHODS: We conducted a retrospective cohort analysis using a large propensity-score-matched…

Anti-inflammatory and immunomodulatory therapies are associated with reduced risk of age-associated neurodegenerative diseases: impact of sex and treatment duration.

INTRODUCTION: Neurodegenerative diseases (NDDs) including Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and non-AD dementias share chronic neuroinflammatory mechanisms that contribute to neuronal injury and disease progression. While anti-inflammatory therapies (AITs) are associated with reduced neurodegenerative disease risk, knowledge regarding the impact of biological sex and treatment duration across multiple NDDs remains limited. METHODS: We conducted a retrospective cohort analysis using a large propensity-score-matched…

Toxoplasma gondii attenuates the ethidium bromide induced demyelination lesions in multiple sclerosis model rats.

Multiple sclerosis (MS) is an autoimmune neurodegenerative disease. Since the modulation of the immune system by parasites has been proven, and there have been reports of a reduction in the clinical symptoms of MS in people with toxoplasmosis, this study aimed to investigate the effect of toxoplasmosis on MS in an animal model. MS model was induced by the ethidium bromide injection in the areas specified in the Rat's brain in the stereotaxic device and Toxoplasma gondii RH strain injection of the rat's peritoneal for creation of toxoplasmosis. The effect of acute and chronic toxoplasmosis on t…

Tau Protein and Its Role in Blood-Brain Barrier Dysfunction.

The blood-brain barrier (BBB) plays a crucial role in maintaining the specialized microenvironment of the central nervous system (CNS). In a … erent diseases, including vascular dementia, stroke, Alzheimer's disease (AD), Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, hypoxia, ischemia, and diabetes mellitus. The BBB damage is also observed in tauopathies that lack amyloid-β overproduction, suggesting a role for tau in BBB damage. Tauopathies represent a heterogeneous group of arou …