Результаты поиска

Age-Related Pathology in Corticobasal Degeneration.

Elderly human brains are vulnerable to multiple proteinopathies, although each protein has a different transmission pathway. Tau-immunoreactive astrocytes are well-known in elderly brains. In contrast, astrocytic plaques, a hallmark in corticobasal degeneration (CBD), rarely occur in aging and neurodegenerative disease other than CBD. To elucidate the clinicopathological correlation of aging-related pathology in CBD, we examined 21 pathologically proven CBD cases in our institute (12 males and 9 females, with a mean age of death 70.6 years). All CBD cases showed grains and neurofibrillary tang…

Liver fibrosis analysis using digital pathology.

Digital pathology has enabled the noninvasive quantification of pathological parameters. In addition, the combination of digital pathology and artificial intelligence has enabled the analysis of a vast amount of information, leading to the sharing of much information and the elimination of knowledge gaps. Fibrosis, which reflects chronic inflammation, is the most important pathological parameter in chronic liver diseases, such as viral hepatitis and metabolic dysfunction-associated steatotic liver disease. It has been reported that the quantitative evaluation of various fibrotic parameters by …

Nucleotide metabolism, leukodystrophies, and CNS pathology.

The balance between a protective and a destructive immune response can be precarious, as exemplified by inborn errors in nucleotide metaboli … understanding about AGS, there are still many gaps in our understanding of the cell-type drivers of pathology and characterization of modifying variables that influence clinical outcomes and achievement of timely diagnosis.

RISK FACTORS ASSOCIATED WITH CANCER PATHOLOGY.

OBJECTIVE: The aim of the study is comparative assessment of the main risks of the global burden of cancer in the total burden of death. PATIENTS AND METHODS: Materials and methods: A comparative assessment of the main risks of the global burden of cancer within the overall burden of deaths was carried out based on the data of the Global Burden of Disease Study (GBD), data from the Center for Medical Statistics of the Ministry of Health of Ukraine, the National Cancer Registry of Ukraine. The methods of comparative analysis, systematic approach and system analysis, bibliosemantic and medical-

The Optic Nerve: Anatomy and Pathology.

The optic nerve is the second cranial nerve but is not a true cranial nerve. Instead, it's an extension of the brain parenchyma. The optic nerve transmits electrical impulses from the retina to the brain, which will be processed in visual information. Often, the clinical definition of a lesion in the optic nerves is not clear, and magnetic resonance imaging (MRI) plays a crucial role. In addition, the optic nerves can be affected by several diseases, such as congenital malformations, inflammatory, vascular, and neoplastic diseases. This article aims to review the optic nerve anatomy, discuss t

Budd-Chiari-like pathology in dolphins.

Nearly two decades ago, pathologic examination results suggested that acoustic factors, such as mid-frequency active naval military sonar (MFAS) could be the cause of acute decompression-like sickness in stranded beaked whales. Acute systemic gas embolism in these whales was reported together with enigmatic cystic liver lesions (CLL), characterized by intrahepatic encapsulated gas-filled cysts, tentatively interpreted as "gas-bubble" lesions in various other cetacean species. Here we provide a pathologic reinterpretation of CLL in odontocetes. Among 1,200 cetaceans necropsied, CLL were only ob

The Facial Nerve: Anatomy and Pathology.

The facial nerve is the seventh cranial nerve and consists of motor, parasympathetic and sensory branches, which arise from the brainstem through 3 different nuclei (1). After leaving the brainstem, the facial nerve divides into 5 intracranial segments (cisternal, canalicular, labyrinthine, tympanic, and mastoid) and continues as the intraparotid extracranial segment (2). A wide variety of pathologies, including congenital abnormalities, traumatic disorders, infectious and inflammatory disease, and neoplastic conditions, can affect the facial nerve along its pathway and lead to ​​weakness or p

34th Европейский конгресс патологии - резюме.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Funding: Ontario Molecular Pathology Research Network CPTRG Pathology Image Analysis Fund OFP-01-015 MMR-deficient crypts detection by immunohistochemistry in normal colonic mucosa of patients with MMR deficient (dMMR)/MicroSatellite Instable (MSI) colorectal cancer: a helpful tool for the diagnosis … Funding: Deutsche Forschungsgemeinschaft, project number ES 285/8-1 OFP-04 | Joint Oral Free Paper Session Soft Tissue and Bone Pathology / Infectious Diseases Pathology OFP-04-001 Whole-exome sequencing of chordoma with special emphasis on chromatin regulatory genes and recurrences S.R. …

[Development and task of gynecologic pathology].

Gynecological pathology, formed in the late 19th century, has greatly prompted the development of gynecology with its continuous exploration since the early time. In the progress of over 130 years, gynecological pathology has formed a completed set of scientific system by absorbing the contemporary advanced technologies and cooperating with gynecologists. In China, the late-started gynecological pathology has been faced with the dilemma of imbalanced regional development and endowed with the dual tasks of dissemination and self-improvement. In future, gynecological pathology in China needs to …

The Oculomotor Nerve: Anatomy and Pathology.

The oculomotor nerve is the third cranial nerve, exiting the brainstem in the medial border of the cerebral peduncle, from where it crosses straight to the superior orbital fissure. It is a purely motor nerve responsible for the innervation of all the extraocular muscles, except the superior oblique and lateral rectus muscles. It also has parasympathetic pre-ganglionic fibers, responsible for the innervation of sphincter pupillae and ciliary muscles. Magnetic resonance imaging (MRI) is the best imaging exam to evaluate patients with clinical signs of third cranial nerve palsy. The oculomotor n

Management of proximal biceps tendon pathology.

The long head of the biceps tendon is widely recognized as an important pain generator, especially in anterior shoulder pain and dysfunction with athletes and working individuals. The purpose of this review is to provide a current understanding of the long head of the biceps tendon anatomy and its surrounding structures, function, and relevant clinical information such as evaluation, treatment options, and complications in hopes of helping orthopaedic surgeons counsel their patients. An understanding of the long head of the biceps tendon anatomy and its surrounding structures is helpful to det

Meniscus Tear: Pathology, Incidence, and Management.

Meniscus tears are a common orthopedic pathology and planning a single, effective treatment is challenging. The diagnosis of meniscal tears requires detailed history-taking, physical examinations, special diagnostic tests, and most likely magnetic resonance imaging (MRI) to confirm the lesion. A good understanding of the meniscal structure including vascularity, zones, function, and affected movements with associated symptoms plays a crucial role in establishing an optimal management plan. A careful assessment of the patient's characteristics, comorbidities, post-repair rehabilitation, and pat…

Surgical Pathology Diagnostic Pitfalls of Hepatoblastoma.

Hepatoblastoma (HB) is the most common malignancy within the rare cohort of pediatric primary liver tumors. It may arise sporadically or in … pearance and alpha feto-protein (AFP) serology, forming a diagnostic consensus within the pediatric pathology community and choosing a shrewd immunohistochemical panel. This review discusses the sequence of events leading up to histologic assessment, and the nuances of microscopic evaluation. Along the way, pitfalls are highlighted, providing a tool for the …

The Abducens Nerve: Anatomy and Pathology.

The abducens, or the sixth cranial nerve, is purely motor and runs a long course from the brainstem to the lateral rectus. Travels with the inferior petrosal sinus through the Dorello's canal before entering the cavernous sinus. Based on the location of an abnormality, other neurologic structures may be involved with the disturbs related to this nerve. This article aims to review the abducens nerve anatomy and demonstrates the imaging aspect of the diseases that most commonly affect it.

The Olfactory Nerve: Anatomy and Pathology.

The human sense of smell is the unique sense through which the olfactory system can identify aromatic molecules within the air and provide a taste sensation. Still, also it plays an essential role in several other functions, warning about environmental safety and even impacts our emotional lives. Recently, olfactory impairment has become an issue of interest due to the COVID-19 pandemic. The dysfunction may vary from only reduced smell detection (hyposmia) to complete loss of it (anosmia) but also includes changes in the normal perception of odors (parosmia). Computed tomography and magnetic i

Connecting TDP-43 Pathology with Neuropathy.

Transactive response DNA-binding protein 43 kDa (TDP-43), a multifunctional nucleic acid-binding protein, is a primary component of insoluble aggregates associated with several devastating nervous system disorders; mutations in TARDBP, its encoding gene, are a cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we review established and emerging roles of TDP-43 and consider how its dysfunction impinges on RNA homeostasis in the nervous system, thereby contributing to neural degeneration. Notably, improper splicing of the axonal growth-associated facto

33rd Европейский конгресс патологии - резюме.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Oral Free Paper Sessions OFP-01 | Autopsy Pathology OFP-01-001 Myocardial pathology in pregnancy - an autopsy study P. Zare* , P. Vaideeswar *Seth G.S. Medical College and K.E.M. … of Breast Pathology databases, and responses collected anonymously. …

Congenital amusia-pathology of musical disorder.

Amusia also known as tone deafness affects roughly 1.5% population. Congenital amusia appears from birth and lasts over life span. Usually, it is not associated with other diseases. Its link to hearing impairment has been definitively excluded. Neurobiological studies point to asymmetrical processing of musical signals in auditory cortex of left and right brain hemispheres. The finding was supported by discovering microlesions in the right-side gray matter. Because of its connection with asymmetry, amusia has been classified to disconnection syndromes. Alternatively to the neurobiological expl