Результаты поиска

Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip.

Fine-needle aspiration biopsy of the abdominal fat pad is considered to be a minimally invasive procedure for diagnosing systemic amyloidosis. However, this procedure is sometimes difficult and can be dangerous for elderly patients whose abdominal fat layer is thin because of malnutrition. In such cases, alternative diagnostic methods are required. We report three elderly patients with heart failure complicated by malnutrition. In all cases, electrocardiogram showed low voltage in the limb leads and a pseudoinfarct pattern in the chest leads, and echocardiography showed left ventricular wall t

Совпадение в полном тексте источника
… Green birefringence of the amyloid deposits can be seen under polarized light but cannot be detected in bone marrow tissue ( B ). … ; G ) and green birefringence of the patch can be seen under polarized light ( H ). …

Sclerotic prostate cancer bone metastasis: woven bone lesions with a twist.

Bone metastases are the most severe and prevalent consequences of prostate cancer (PC), affecting more than 80% of patients with advanced PC. PCBMs generate pain, pathological fractures, and paralysis. As modern therapies increase survival, more patients are suffering from these catastrophic consequences. Radiographically, PCBMs are predominantly osteosclerotic, but the mechanisms of abnormal bone formation and how this pathological increase in bone density is related to fractures are unclear. In this study, we conducted a comprehensive analysis on a cohort of 76 cadaveric PCBM specimens and 1

Совпадение в полном тексте источника
… (E) Polarized light imaging of F, birefringence corresponds to trabeculae (bone), while osteosclerotic shows absence of birefringence. (F) Double stain Sirius red, anti-collagen III of osteoblastic with residual trabeculae PCBM. … While Sirius red staining shows absence of birefringence in these collagen III-rich areas, strong birefringence was observed in collagen III-negative trabeculae ( Figure 6E ). …

NTP Toxicology and Carcinogenesis Studies of Ethylene Glycol (CAS No. 107-21-1) in B6C3F1 Mice (Feed Studies).

Ethylene glycol is a major constituent of motor vehicle antifreeze-coolant fluids and is also found in other commercial products including hydraulic brake fluids, adhesives, printer's inks, and wood stains. It is used in the manufacture of polyester films and fibers, polyethylene terephthalate (PET) solid state resins, plasticizers, elastomers, cellophane, and other products. Previous 13-week and 2-year studies of ethylene glycol in F344 rats were considered adequate to evaluate the toxicology and carcinogenicity of ethylene glycol in this species and strain; therefore, the present studies wer

Dermatological Manifestations of Amyloid Light-Chain (AL) Amyloidosis: A Case Report Highlighting Early Diagnosis and Treatment.

This case report describes a 52-year-old man who presented with gradually progressive dark cutaneous discoloration over the upper trunk and periorbital region, accompanied by painless enlargement of the tongue, which initially interfered with speech and eating. Over the subsequent months, he experienced marked unintentional weight loss, persistent fatigue, and symptoms consistent with autonomic involvement, including postural dizziness and altered bowel habits. Clinical examination revealed waxy skin changes and macroglossia. Laboratory evaluation demonstrated a monoclonal light-chain abnormal

Совпадение в полном тексте источника
… | Should be negative | Congo red staining under polarized light | Birefringence Evaluation | Apple-green birefringence observed | Should be absent | Polarized light microscopy Figure 3 CT scan of the patient showing hepatosplenomegaly (as indicated by the arrows) Axial contrast-enhanced CT scan of … Histopathologically, these lesions exhibit characteristic amyloid deposits in the dermis, which stain positively with Congo red, producing apple-green birefringence under polarized light [ 5 , 8 ]. …

Myocardial amyloidosis following multiple myeloma in a 38-year-old female patient: A case report.

Multiple myeloma (MM) is an immunoglobulin-producing tumor of plasma cells, which occurs commonly in the elderly. The incidence of myocardial amyloidosis with MM is extremely low and early clinical manifestations are nonspecific. The diversity of clinical manifestations and first episode symptoms often cause misdiagnosis in young patients with myocardial amyloidosis following MM. In this study, we analyzed the clinical data of a young woman with MM and impaired cardiac function combined with echocardiography, electrocardiography (ECG), laboratory data, cell Congo Red staining, and other manife

Совпадение в полном тексте источника
… The Congo Red staining showed a yellow birefringence with apple-green birefringence under polarized light. This phenomenon is related to microscopy optics. … Origins of a pervasive, erroneous idea: the “green birefringence” of Congo Red-stained amyloid. Int J Exp Pathol. 2019;100(4):208–21. 10.1111/iep.12330. Howie AJ. Origins of a pervasive, erroneous idea: the “green birefringence” of Congo Red-stained amyloid. …

Amyloidosis in the Context of Renal Cell Carcinoma: A Case Report and Literature Review.

This case study details an 86-year-old male with a history of hypertension, dyslipidemia, and bilateral blindness, who presented with recurrent vomiting and a progressive proteinuric acute kidney injury. Initial evaluations revealed nephrotic syndrome and acute kidney injury, alongside imaging findings consistent with a renal mass, later confirmed as grade 3 clear renal cell carcinoma (RCC) upon biopsy. Concurrently, systemic amyloid A (AA) amyloidosis was diagnosed based on the result of the kidney biopsy. Despite multidisciplinary management, the patient's renal function progressively deteri

Совпадение в полном тексте источника
… Renal amyloidosis is diagnosed histologically by the presence of eosinophilic amorphous deposits that stain positively with Congo red and demonstrate the characteristic apple-green birefringence under polarized light [ 8 ]. … These deposits demonstrated the characteristic salmon-pink appearance on light microscopy and apple-green birefringence under polarized light (Figures 3A - 3D ). …

Oral manifestations of systemic amyloidosis, an aid to diagnosis of multiple myeloma - report of two cases.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… This was confirmed with congo red stain and typical apple-green birefringence under polarized light. General medical evaluation of the patient revealed renal dysfunction, anemia, hypercalcemia, and hyperphosphatemia. … (C) Green birefringence under polarized light. Figure 3 Both patients gave consent for their inclusion in a research study. …

Localized Breast Amyloidosis Associated with Sjörgren Syndrome.

Sjörgren syndrome is a systemic autoimmune disease that is rarely associated with amyloid deposits, and in most reported cases, these deposits are localized to a single organ. Amyloidosis of the breast is a rare and unexpected finding, and only 5 case series with 63 patients have been published in the past 40 years. To date, only 6 cases have been reported in which Sjörgren syndrome is associated with amyloid deposits in the breast. A 61-year-old female diagnosed with Sjörgren syndrome underwent a breast needle core biopsy for calcifications. Microscopic examination revealed amyloid deposits i

Совпадение в полном тексте источника
… Congophilic deposits demonstrated apple green birefringence under polarized light, while areas of collagenous stroma had gray-white birefringence (Figures 1(d) and 1(f) ). No epithelial atypia, neoplasm, or hematolymphoid lesion was present. … (d) Corresponding image under polarized light shows apple green birefringence of periductular (arrows) and perivenular (arrowheads) amyloid deposits as well as gray-white birefringence of interstitial collagen (Congo red, 200x). …

Ларингейл амилоидоз: один центр four- Серия пациентов, освещающих диагностические проблемы и клиническую неоднородность.

Ларингейл амилоидоз является редким заболеванием, которое может имитировать доброкачественные, злокачественные или функциональные расстройства гортани. Мы представляем единый центр four- Серия пациентов, демонстрирующих клиническую неоднородность при анатомическом распределении, амилоидном печатании, системном взаимодействии и управлении. Все four Эти случаи были подтверждены гистологически. Two Пациенты, по результатам специализированной оценки, имели локальный ларингеальный амилоидоз, one У пациента было ларинготражающее амилоидное осаждение в контексте известной множественной миэломы, и one

Совпадение в полном тексте источника
… Diagnosis is established histologically, typically with Congo red staining and polarized light birefringence. The value of this case series lies in comparing four patients with laryngeal amyloidosis who differed in anatomical site, amyloid typing, systemic association and management. … Biopsies from the right ventricle, left ventricle and anterior commissure showed dense eosinophilic amorphous deposits, strongly Congo red-positive with apple-green birefringence, confirming laryngeal amyloidosis. Amyloid typing was not performed. …

Amyloidosis: A story of how inframammary erosions eclipsed inconspicuous periorbital ecchymoses.

Systemic amyloidosis is a rare disease that can be rapidly progressive due to widespread organ involvement. There are well-described renal, cardiac, pulmonary, neurological, and dermatologic findings. Here, we outline one patient's experience with the condition from presentation to making the diagnosis. She presented with pathognomonic dermatologic findings including pinch purpura and ecchymoses found in the skin folds.

Совпадение в полном тексте источника
… The diagnosis of amyloidosis was confirmed by apple-green birefringence on polarization and positive staining for Congo red ( Fig. 5 , Fig. 6 ). Fig. 3 Hematoxylin and eosin slide from a punch biopsy showing amorphous, eosinophilic material in the dermis. … Staining with Congo red will be positive in 85% of patients and apple-green birefringence will be exhibited when exposed to polarized light ( Falk et al., 1997 , Merlini and Bellotti, 2003 ). If the biopsy is positive, then the type of amyloidosis should be determined. …

Реналь-лимитированный амилоидный лайт-чаин (Ламбда) Амилоидоз, представленный как Моноклональная Гаммопатия Ренального Значения: доклад по делу.

Моноклональная гаммопатия почечной значимости (MGRS) охватывает почечные заболевания, вызываемые нефротоксичными моноклональными иммуноглобулинами, производимыми небольшими клонами B-клеток или плазменными клонами, которые не отвечают критериям явной гематологической злокачественности. Ренал амилоидный светоцепный (AL) амилоидоз — признанное повреждение в диапазоне MGRS. Мы сообщаем о случае 66-year-old Женщина с нефротическим синдромом и почечной дисфункцией, связанными с моноклональными лямбдами. Биопсия реала подтвердила амилоидоз AL (ламбда), в то время как анализ костного мозга и системна

Совпадение в полном тексте источника
… Figure 2 Apple-green birefringence under polarized light confirming amyloid (×200). Renal amyloidosis was diagnosed following extensive clinical, laboratory, and histopathological evaluation. … Congo red positivity with apple-green birefringence and light-chain restriction on immunofluorescence establishes the diagnosis and prevents delay. …

Breast calcifications on mammography from systemic amyloidosis: A case report.

Calcifications on mammography from systemic disease at times meet diagnostic criteria for histologic sampling to exclude malignancy. We present a case of bilateral groups of new calcifications on mammography that yielded amyloidosis on core biopsy. Awareness of our patient's known diagnosis of systemic light chain amyloidosis (AL) prompted use of Congo red staining to confirm the histologic diagnosis. Knowledge of systemic diseases with possible manifestations on mammography can facilitate cogent and clinically relevant radiology-pathology correlation.

Совпадение в полном тексте источника
… Congo red stain showing orange-red staining of perivascular amyloid deposits (B), with anomalous birefringence (green, yellow, red) in polarized light (C). … Amyloid has an affinity for the Congo red stain where it is usually described as showing characteristic “apple-green” birefringence in polarized light [4] . …

A 65-Year-Old Woman with an Enlarged Tongue Due to Amyloidosis.

BACKGROUND Amyloidosis is a clinical condition characterized by the extracellular deposition of insoluble, abnormal amyloid fibrils in various body tissues. It is generally categorized into 2 forms - localized and systemic - with a wide range of signs and symptoms. This case report discusses the localized amyloidosis involvement of the oral cavity and its treatment. CASE REPORT A 65-year-old woman presented to the oral medicine clinic reporting painless tongue enlargement, which has been slowly progressing over several years, leading to difficulty in tongue movement, eating, and swallowing. Ex

Совпадение в полном тексте источника
… Congo red staining of the specimen showed vascular connective tissue with orange-red deposits in the lamina propria under normal light and areas of apple-green birefringence of the amyloid deposits under polarized light, which is diagnostic for amyloidosis. Figure 1. … Histopathological examination of biopsied tissues is usually diagnostic when examined with Congo red stain under polarizing light demonstrating the fibril deposits as apple-green birefringence [ 13 ]. …

A Case of AL Amyloidosis With Hepatomegaly as the Main Clinical Manifestation.

Light chain (AL) amyloidosis presenting predominantly with hepatomegaly is a rare and frequently misdiagnosed condition. While clinical features are non-specific, elevated ALP/GGT should raise suspicion. A liver biopsy remains the gold standard for diagnosis. Although there is no disease-specific therapy for hepatic amyloidosis, timely chemotherapy initiation-particularly monoclonal antibody-based regimens-can significantly improve prognosis and lead to symptom resolution.

Совпадение в полном тексте источника
… (D) Polarized light examination of a Congo red–stained section reveals classic apple‐green birefringence. FIGURE 2 (A) Serum immunofixation electrophoresis demonstrates monoclonal IgG and kappa light chain. … The pathological diagnosis is based on the β‐sheet structure of amyloid fibrils, which shows apple‐green birefringence under polarized light after Congo red staining [ 16 ]. …

Primary Amyloidosis Unmasked by Gastric Biopsy: A Case Report.

Amyloidosis is a broad category of diseases characterized by the extracellular accumulation of misfolded fibrillar proteins, which disrupt organ architecture and causes cellular toxicity. This ultimately results in vascular compromise and progressive organ dysfunction. Despite advances in serum free light chain assays and imaging modalities, diagnostic delays persist due to the underestimation of early signs and the need for multidisciplinary correlation. Our case report highlights a unique case of a patient with systemic AL amyloidosis involving the gastrointestinal (GI) system, who initially

Совпадение в полном тексте источника
… Pathology revealed mild chronic active gastritis with extensive deposition of amorphous material displaying apple-green birefringence with Congo red staining, consistent with amyloid. Table 1. Initial Laboratory Results for Diarrhea and Weight Loss Investigation. … Patient’s tests | Patient’s results Calcium | 8.7 mg/dL Urine analysis | No proteinuria EGD | Marked gastric nodularity + friable mucosa at the gastric fundus Pathology | Amorphous material with apple-green birefringence with Congo Red staining Urine and serum protein electrophoresis | Elevated β-1 globulin …

Extraluminal amyloidoma of the pelvic cavity causing large bowel obstruction.

AMYLOIDOSIS IS A GROUP OF DIVERSE DISORDERS THAT FALL INTO SEVERAL MAJOR CATEGORIES: primary, secondary, dialysis-associated, and hereditary forms. Clinically, amyloidosis may be categorized as localized or systemic. The gastrointestinal tract is among the most common places for deposition of amyloid, but large, localized amyloid deposits are an uncommon occurrence and rarely cause extraluminal bowel compression resulting in obstruction as was seen in the case presented in this clinical scenario.

Совпадение в полном тексте источника
… These deposits appear pink under bright-field microscopy and have apple-green birefringence under polarized light. These two characteristics in combination are considered diagnostic of amyloid. Clinically, amyloidosis may be categorized as localized or systemic [ 1 ]. … Staining with Congo Red and observation of apple-green birefringence under polarized light is essential to detect amyloid deposits [ 1 ]. Management of this patient's disease was complicated due to extensive spread throughout the peritoneal cavity and its proximity to vital structures. …

The Story of Localized Amyloidosis: Something Old and Something New - A Case Series.

Localized amyloidosis is a rare benign disease characterized by extracellular deposition of misfolded proteins in a specific organ without systemic involvement, which might lead to organ dysfunction. Patients with localized amyloidosis do not develop systemic diseases such as cardiac, renal, hepatic, or nerve involvement. Typically, the localized disease is managed by surgical resection, while the systemic disease is treated with a combination chemotherapy and immunotherapy. However, some patients can have challenging clinical presentations, delaying diagnosis and organ dysfunction, and they m

Совпадение в полном тексте источника
… A biopsy remains the gold standard for diagnosis, with characteristic findings of Congo red-positive amyloid deposits that exhibit apple-green birefringence under polarized light. 3 Figure 1. Pathobiology of amyloidosis. … Congo-red staining of the deposits was congophilic with weak apple-green birefringence, and immunostains revealed a kappa predominant plasma-cell infiltrate, supporting light-chain-related amyloid deposition. …

Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review.

Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a d

Совпадение в полном тексте источника
… Amyloidogenic proteins produce a characteristic apple-green birefringence after Congo red staining [ 5 ]. … “Green (or apple-green) birefringence” of Congo red-stained amyloid. Amyloid. 2015;22:205–206. doi: 10.3109/13506129.2015.1054026. 6. Gras S.L., Waddington L.J., Goldie K.N. Transmission Electron Microscopy of Amyloid Fibrils. Program. …

Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure.

Although hepatic involvement in light chain-associated amyloidosis is common, clinical manifestations of hepatic amyloidosis are rare. In most cases, hepatomegaly serves as a clue to diagnosis. We report a unique case of a 48-year-old man from China with jaundice and noncirrhotic portal hypertension, with rapidly progressive liver failure, in the absence of hepatomegaly, secondary to systemic light chain-associated amyloidosis associated with multiple myeloma.

Совпадение в полном тексте источника
… Congo red stain confirmed the presence of perisinusoidal and perivascular amyloid deposition with characteristic apple-green birefringence under the polarizer (Figure 3 ). … Liver biopsy showing (A) the sinusoidal and perivascular space (Congo red stain, 100×) and (B) apple-green birefringence (Congo red stain, 200×). Figure 4. Upper endoscopy shows 3–4 mm yellow ulcerations within the mid-esophagus. Figure 5. …

The long road to recognition: a historical review of amyloidosis from early pathology to disease-modifying therapy.

Within the last several decades, great strides are being made in both the diagnosis and treatment of cardiac amyloidosis, yet the condition itself has been a severely under-recognized cause of heart failure for centuries. For much of medical history, the accumulation of these insoluble fibril deposits was an enigmatic finding, observed primarily post-mortem in patients suffering from chronic inflammatory conditions. This review traces the fascinating evolution of amyloidosis: from its origins as a botanical term mistakenly applied to human pathology, through the serendipitous discoveries of hi

Совпадение в полном тексте источника
… This is due to birefringence exhibited by the dye molecules. … What began as vague descriptions of “sago” and “lardaceous” organs in the 17th and 18th centuries eventually yielded to the histological precision of Congo red birefringence. …