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The use of interventional procedures for cancer pain. A brief review.

ContextPain is a common experience in people living with cancer. Concerns around opioid prescribing have seen a move toward a multi-modality management approach, which includes interventional pain procedures.PurposeIn this paper we discuss the interventional pain procedures used to treat cancer pain at two major tertiary centers in Australia.Methods and resultsThis expert review provides practical insights on cancer pain management from healthcare providers in different specialties. These insights can be used to guide the management of a wide range of cancer pain types.ConclusionsFurthermore,

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… Glare PA, Davies PS, Finlay E, Gulati A, Lemanne D, Moryl N, et al. Pain in cancer survivors. J Clin Oncol. 2014;32(16):1739. doi: 10.1200/JCO.2013.52.4629. 4. Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, et al. … Glare P, Aubrey K, Gulati A, Lee YC, Moryl N, Overton S. Pharmacologic management of persistent pain in cancer survivors. Drugs. 2022;82(3):275–291. doi: 10.1007/s40265-022-01675-6. 47. Gallaway MS, Townsend JS, Shelby D, Puckett MC. Pain among cancer survivors. …

Conjunctival HLA-DR and CD8 expression detected by impression cytology in ocular graft versus host disease.

PurposeTo assess the expression of human leucocyte antigen (HLA)-DR in epithelial cells and cluster of differentiation (CD8)-positive lymphocytes as possible markers of chronic ocular graft versus host disease (cGvHD) after hematological stem cell transplantation (HSCT).MethodsTwenty-seven consecutive patients with dry-eye symptoms following HSCT (24 [89%] with peripheral blood stem cell transplantation and 3 [11%] with bone marrow transplants; 17 [63%] familiar allogenic grafts) and 19 age-matched controls were included. Conjunctival impression cytology specimens were stained for HLA-DR, cyto

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… Depending on the severity of ocular involvement, patients complain about foreign-body sensation, reduced vision (due to corneal epithelial microdefects), and severe blepharospasm induced by extensive glare and light sensitivity [ 3 ]. … Frequent and forced blinking was evident only in the patient group, accompanied by high sensitivity to light and glare. Patients also had significantly reduced Schirmer test results ( Table 2 ). Table 3 provides a further comparison of clinical data between patients with and without ocular cGvHD. …

Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study.

BACKGROUND: Pain is a common symptom in patients with multiple myeloma (MM). Many patients are dependent on analgesics and in particular opioids, but there is limited information on the impact of these drugs and their side effects on health-related quality of life (HRQoL). METHOD: In a cross-sectional study, semi-structured interviews were performed in 21 patients attending the hospital with symptomatic MM on pain medications. HRQoL was measured using items 29 and 30 of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30. RESULTS: Patients were able to recall a med

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… Subjects studied by Glare et al. (2006) were in a palliative care programme, had predominantly solid tumours and the majority (74 %) were of poor performance status (Eastern Cooperative Oncology Group [ECOG] 3-4) [ 16 ]. … Glare P, Walsh D, Sheehan D. The adverse effects of morphine: a prospective survey of common symptoms during repeated dosing for chronic cancer pain. Am J Hosp Palliat Care. 2006;23:229–235. doi: 10.1177/1049909106289068. 17. Gulbrandsen N, Wisloff F, Brinch L, et al. …

Identification of high-impact chronic pain among cancer survivors: a cross-sectional study using the Graded Chronic Pain Scale framework

PURPOSE: Chronic cancer-related pain is a prevalent and often under-recognized issue among individuals living with or after cancer. Clinically useful tools are needed to classify pain severity and impact and to identify those requiring targeted support. This study applied the Graded Chronic Pain Scale-Revised (GCPS-R) in a cohort of cancer survivors and examined differences in pain characteristics and psychosocial factors across GCPS-R subgroups. Secondly, the study compared pain characteristics in cancer survivors with high-impact chronic pain (HICP) to an age- and sex-matched sample of patie

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… Glare et al. reported moderate levels of pain intensity and interference, psychological distress, and pain catastrophizing among cancer survivors referred to a multidisciplinary pain clinic [ 29 ]. … Glare PA, Costa DJ, Nicholas MK (2022) Psychosocial characteristics of chronic pain in cancer survivors referred to an Australian multidisciplinary pain clinic. Psychooncology 31(11):1895–1903 30. …

Delivering bad news in clinical hematology: a personal perspective.

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… N., Walder S., Carrick S., Currow D., Ghersi D., Glare P., Hagerty R., Olver I. N., Tattersall M. H. 2008Psychooncology. 17(7):641–59. doi: 10.1002/pon.1288. Breaking bad news: a guide for effective and empathetic communication. Rosenzweig M. …

Изолированное явление Утхоффа как первое проявление множественного склероза: отчет о деле.

Эпидемия Утоффа (UP) является временным ухудшением неврологических симптомов в связи с повышением температуры тела, которое обычно наблюдается в демиелионирующих заболеваниях, особенно в случае множественного склероза (MS). ПРЕДСТАВЛЕНИЕ КИСЛОТА: 37-летняя женщина, имеющая четырехлетнюю историю нарушения зрения в течение переходного периода, особенно во время танцев. Визуальный потенциал (ВВП) выявил продолжительную латентность P100 и уменьшенную амплитуду правого глаза. Томография оптической непротиворечивости (OCT) подтвердила утончение ячеек и внутреннего плексикулярного слоя (GCIPL) и пери

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… The symptoms included blurred vision across the entire field of vision, reduced contrast perception and increased glare. She had a high-demanding full-time employment but did not describe any association of visual disturbances with work-related stressors. …

Integrative Medicine for Cancer-Related Pain: A Narrative Review.

Cancer-related pain (C-RP) is a prevalent and debilitating concern among patients with cancer, with conventional treatments limited in their ability to provide adequate relief, and by the adverse effects associated with their use. Complementary and integrative medicine (CIM) modalities have been shown to be potentially effective and safe for the treatment of pain and related symptoms, when used in conjunction with conventional medications and under medical supervision. An increasing number of oncology centers provide CIM within their conventional supportive and palliative care service, in an "

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… Paice J.A., Portenoy R., Lacchetti C., Campbell T., Cheville A., Citron M., Constine L.S., Cooper A., Glare P., Keefe F., et al. Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline. J. Clin. … Glare P.A., Davies P.S., Finlay E., Gulati A., Lemanne D., Moryl N., Oeffinger K.C., Paice J.A., Stubblefield M.D., Syrjala K.L. Pain in cancer survivors. J. Clin. Oncol. 2014;32:1739–1747. doi: 10.1200/JCO.2013.52.4629. 7. Deandrea S., Montanari M., Moja L., Apolone G. …

Crystalline deposits in the cornea and various areas of the kidney as symptoms of an underlying monoclonal gammopathy: a case report.

BACKGROUND: Plasma cell dyscrasias (PCD) are characterized by an abnormal production of intact monoclonal immunoglobulins or parts such as heavy or light chains. In most cases, the monoclonal protein (also termed paraprotein) is produced by a clonal plasma cell population. The production of monoclonal proteins can result in deposits of various types and localization depending on the type, amount, and electrochemical properties of the paraprotein. One histopathologic presentation, albeit rare, are crystalline deposits. They can form in various organs and hence cause a wide spectrum of symptoms.

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… Patients usually present with a decrease in visual acuity, glare, blurring, and optical aberrations [ 18 ]. …

Complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors: WFNS spine committee recommendations.

ObjectiveThis review aims to formulate the most current, evidence-based recommendations regarding complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors.MethodsA systematic literature search in PubMed and MEDLINE, and was performed from 2013 to 2023 using the search terms "complications" + "spine metastases", "spine metastases" + + "rehabilitation", "spine metastases" + "pain therapy" + "palliative care". Screening criteria resulted in 35, 15 and 56 studies respectively that were analyzed. Using the Delphi method and two rounds of vot

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… Maltoni M Caraceni A Brunelli C Broeckaert B Christakis N Eychmueller S Glare P Nabal M Viganò A Larkin P Prognostic factors in advanced cancer patients: evidence-based clinical recommendations–a study by the Steering Committee of the European Association for Palliative Care J Clin Oncol 2005 23 25 6240 … 6248 10.1200/JCO.2005.06.866 16135490 Maltoni M, Caraceni A, Brunelli C, Broeckaert B, Christakis N, Eychmueller S, Glare P, Nabal M, Viganò A, Larkin P et al (2005) Prognostic factors in advanced cancer patients: evidence-based clinical recommendations–a study by the Steering Committee of the European …

Estimating survival in patients with operable skeletal metastases: an application of a bayesian belief network.

BackgroundAccurate estimations of life expectancy are important in the management of patients with metastatic cancer affecting the extremities, and help set patient, family, and physician expectations. Clinically, the decision whether to operate on patients with skeletal metastases, as well as the choice of surgical procedure, are predicated on an individual patient's estimated survival. Currently, there are no reliable methods for estimating survival in this patient population. Bayesian classification, which includes bayesian belief network (BBN) modeling, is a statistical method that explore

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… Glare P, Virik K, Jones M, Hudson M, Eychmuller S, et al. A systematic review of physicians' survival predictions in terminally ill cancer patients. BMJ. 2003;327:195–198. doi: 10.1136/bmj.327.7408.195. 24. Mackillop WJ, Quirt CF. Measuring the accuracy of prognostic judgments in oncology. …

Rechallenge of denosumab in jaw osteonecrosis of patients with unresectable giant cell tumour of bone: a case series analysis and literature review.

OBJECTIVES: Giant cell tumour of bone (GCTB) is a rare tumour, generally managed with surgery. Treatment of the very rare unresectable advanced/metastatic GCTB is challenging and denosumab is the only current available medical option, an anti-RANKL monoclonal antibody inhibiting osteolysis. An uncommon but severe and treatment-limiting adverse event of denosumab is the osteonecrosis of the jaw (ONJ). The clinical management of GCTB patients stopping denosumab for medication-related (MR)-ONJ and the possible reintroduction of denosumab after MR-ONJ resolution is matter of debate. We performed a

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… Lancet Oncol 2013 ; 14 : 901 – 8 . 10.1016/S1470-2045(13)70277-8 23867211 19 Martin-Broto J , Cleeland CS , Glare PA , et al Effects of denosumab on pain and analgesic use in giant cell tumor of bone: interim results from a phase II study . …

Human resources for cancer control in uttar pradesh, India: a case study for low and middle income countries.

For addressing the growing burden of cancer in low and middle income countries, an important first step is to estimate the human resources required for cancer control in a country, province, or city. However, few guidelines are available to decision makers in that regard. Here, we propose a methodology for estimating the human and other resources needed in the state of Uttar Pradesh (UP), India as a case study. Information about the population of UP and its cities was obtained from http://citypopulation.de/. The number of new cancer cases annually for the commonest cancers was estimated from G

Clinical Presentation, Renal Histopathological Findings, and Outcome in Patients with Monoclonal Gammopathy and Kidney Disease.

Monoclonal gammopathies are associated with acute and chronic kidney injury. Nephrotoxicity of the secreted monoclonal (M)-protein is related to its biological properties and blood concentration. Little is known about epidemiology, clinical manifestations, and outcome of monoclonal gammopathies in patients with kidney disease. We retrospectively collected data about demographics, clinical manifestations, and renal histological lesions of all patients (n = 1334) who underwent kidney biopsy between January 2000 and March 2017. Monoclonal gammopathy was detected in 174 (13%) patients with a mean

Pain prevalence and treatment in patients with metastatic bone disease.

The accomplishment of successful pain treatment requires evaluation, characterization and quantification. The present study characterized pain and survival in a cohort of patients with cancer with bone metastasis who were treated with intravenous bisphosphonates. A total of 84 patients self-completed the Brief Pain Inventory (BPI) and 36-Item Short Form Survey (SF-36), between November 2010 and March 2011 with a 5-year survival follow-up as a surrogate marker of cancer burden. The median age was 62 years old (34-85), 64% of patients were female and 58% of these females had breast cancer. In th

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… Innos K Katalinic A Langseth H Survival of women with cancers of breast and genital organs in Europe 1999–2007: Results of the EUROCARE-5 study Eur J Cancer 51 2191 2205 2015 10.1016/j.ejca.2015.07.022 26421822 61 Paice JA Portenoy R Lacchetti C Campbell T Cheville A Citron M Constine LS Cooper A Glare …

Large variation in radiation therapy fractionation for multiple myeloma in Australia.

AIM: To evaluate the patterns of use of different radiation therapy (RT) fractionation for multiple myeloma (MM) bone disease. METHODS: This is a population-based cohort of patients with MM who had RT between 2012 and 2017 as captured in the statewide Victorian Radiotherapy Minimum Data Set in Australia. Data linkage was performed to identify subsets of RT delivered within 3 months of death. RT fractionation was classified into four groups: single-fraction (SFRT), 2-5, 6-10, and > 10 fractions. Changes in RT fractionation use over time were evaluated with the Cochran-Armitage test for trend.

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… Glare P, Virik K, Jones M, et al. A systematic review of physicians' survival predictions in terminally ill cancer patients. BMJ. 2003;327(7408):195‐198. 19. Fogarty T, Tacey M, McCorkell G, et al. …

Beyond CAR T-Cell Therapy: Continued Monitoring and Management of Complications.

Chimeric antigen receptor (CAR) T-cell therapy has recently emerged as a groundbreaking treatment for CD19-expressing hematologic malignancies and received rapid approval by the U.S. Food & Drug Administration. Tisagenlecleucel and axicabtagene ciloleucel are now widely available at CAR T-cell therapy centers around the United States. Many patients have achieved complete response or remission despite failing multiple previous lines of therapy, but some patients endure the severe risks of cytokine release syndrome, neurotoxicity, and other immunologic effects. As more patients receive this ther

Why pharmacogenomic biomarkers for chemotherapy-induced peripheral neuropathy fail: a systematic review of genetic associations, replication, and clinical translation.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting toxicity of cancer treatment, yet reliable biomarkers to predict individual susceptibility remain lacking. Germline genetic variation has been widely investigated as a potential contributor to CIPN risk; however, the consistency and clinical utility of these associations remain unclear. We performed a systematic review of genetic association studies evaluating CIPN across neurotoxic chemotherapies. PubMed, Embase, Web of Science, and the Cochrane Library were searched (April 2025) for human studies assessing germline

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… As a result of recent advances in the early detection of cancer as well as improved survival outcomes ( Zajączkowska et al., 2019 ), the long-term adverse effects of cancer treatment have become increasingly important factors related to an individual’s quality of life ( Glare et al., 2014 ). … Pharmacol. 68 (6), 1633–1638. 10.1007/s00280-011-1745-2 Glare P. A., Davies P. S., Finlay E., Gulati A., Lemanne D., Moryl N., et al. (2014). Pain in cancer survivor. J. Clinical Oncology 32 (16), 1739–1747. 10.1200/JCO.2013.52.4629 Goodenough C. G., Diouf B., Yang W., Sapkota Y., Finch E. …

Incurable but treatable: Understanding, uncertainty and impact in chronic blood cancers-A qualitative study from the UK's Haematological Malignancy Research Network.

OBJECTIVE: Most blood cancers are incurable and typically follow unpredictable remitting-relapsing pathways associated with varying need for treatment, which may be distressing for patients. Our objective was to conduct a qualitative study to explore understanding among patients with such malignancies, including the explanations given by HCPs and the impact of uncertain trajectories, to generate evidence that could guide improvements in clinical practice. METHODS: The study is set within a population-based patient cohort (the Haematological Malignancy Research Network), in which care is deliv

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… Glare P, Virik K, Jones M, Hudson M, Eychmuller S, Simes J, et al. A systematic review of physicians’ survival predictions in terminally ill cancer patients. BMJ. 2003. Jul 24;327(7408):195. doi: 10.1136/bmj.327.7408.195 39. Amano K, Maeda I, Shimoyama S, Shinjo T, Shirayama H, Yamada T, et al. …

Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer.

Predicting survival accurately in patients with advanced cancer is important in guiding interventions and planning future care. Objective tools are therefore needed. Blood biomarkers are appealing due to their rapid measurement and objective nature. Thrombosis is a common complication in cancer. Recent data indicate that tumor-induced neutrophil extracellular traps (NETs) are pro-thrombotic. We therefore performed a comprehensive investigation of circulating markers of neutrophil activation, NET formation, coagulation and fibrinolysis in 106 patients with terminal cancer. We found that neutrop

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… Glare P. A systematic review of physicians' survival predictions in terminally ill cancer patients. BMJ. 2003;327:195–190. doi: 10.1136/bmj.327.7408.195. 4. Maltoni M, et al. Successful validation of the palliative prognostic score in terminally ill cancer patients. J. …

Spinal metastasis: narrative reviews of the current evidence and treatment modalities.

The treatment for spinal metastasis has evolved significantly during the past decade. An advancement in systemic therapy has led to a prolonged overall survival in cancer patients, thus increasing the incidence of spinal metastasis. In addition, with the improved treatment armamentarium, the prediction of patient survival using traditional prognostic models may have limitations and these require the incorporation of some novel parameters to improve their prognostic accuracy. The development of minimally-invasive spinal procedures and minimal access surgical techniques have facilitated a quicke

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… Glare P, Virik K, Jones M, et al. A systematic review of physicians' survival predictions in terminally ill cancer patients. BMJ 2003; 327: 195–198. 53. Tokuhashi Y, Matsuzaki H, Oda H, et al. A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. …