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Количественность подмножеств лимфоцитов помогает отличать геморрагическую лихорадку денге от классической лихорадки денге во время острой стадии фебрилляции.

В вирусной инфекции денге наблюдается активация подмножеств иммунорегулирования Т лимфоцитов, что более заметно в геморрагической лихорадке денге, чем в классической лихорадке денге (ДФ). Однако пока еще нет четко определенных маркеров для определения того, у каких пациентов с вирусной инфекцией денге возникнут серьезные осложнения во время острого фебрилального этапа заболевания. Было проведено исследование для сопоставления клеточного иммунного статуса в ДГФ, ДФ и вирусных инфекциях, не связанных с бенге, с целью определения значения этих параметров при проведении различия между ДГФ и класси

Совпадение в аннотации оригинала
Activation of immunoregulatory T lymphocyte subsets has been observed in dengue viral infection, being more evident in dengue hemorrhagic fever (DHF) than in classical dengue fever (DF). There are, however, as yet no well-defined host markers to determine which patients with dengue viral infection will develop severe complications during the acute febrile st…

Psychiatric manifestations in dengue: A case series and review.

Dengue virus fever is a mosquito-borne disease resulting in a serious flu-like sickness with high temperature, intense joint and muscle ache, reduced blood platelets, skin rashes, and a tendency to bleed. Neurological complications following dengue infection are common. Although psychiatric sequelae have been rarely recognised, a few cases have been documented in the last 5-7 years. In this set of instances, we describe four individuals, who experienced acute psychiatric symptoms during or the right after a dengue infection and had no history of mental disease in the past or their family.

Arrhythmias in Dengue: A Systematic Review and Meta-Analysis.

BACKGROUND: Cardiac involvement in dengue has been increasingly recognized, yet the true burden and spectrum of arrhythmias remain uncertain due to heterogeneous and fragmented evidence. We conducted a systematic review and meta-analysis to estimate the proportion of cardiac arrhythmias in patients with dengue and to describe the distribution of major arrhythmia subtypes. METHODS: We searched PubMed/MEDLINE, EMBASE, LILACS, Global Index Medicus, and Google Scholar from inception to November 2025 without language restrictions. Observational studies reporting the number of dengue patients evalu…

Supraventricular Tachycardia as an Uncommon Presentation of Dengue Myocarditis.

BACKGROUND: Dengue myocarditis has been increasingly reported, but supraventricular tachycardia (SVT) is a rare manifestation. CASE SUMMARY: A 49-year-old woman presented to the emergency department with sudden-onset palpitations and lightheadedness. She was tachycardic but otherwise hemodynamically stable. An electrocardiogram demonstrated paroxysmal SVT. Laboratory tests demonstrated thrombocytopenia. Echocardiography showed preserved left ventricular systolic function (60%), with normal left ventricular chamber volumes. Cardiac biomarkers were negative. Given positive dengue NS1 antigen te…

Mosquito and global dengue cases in a warming world.

Dengue presents a significant global health challenge, affecting 50-100 symptomatic infections every year and placing immense strain on healthcare systems in tropical and subtropical regions. However, future projections of dengue infections in a warming world remain unclear. We used the support vector machine (SVM) and artificial neural network (ANN) models with Aedes mosquitoes and dengue records from 1960 to 2019 to comprehensively assess the effects of climate change and socioeconomic conditions on the distribution of mosquitoes and the global dengue incidence rate. The SVM and ANN models w…

Recurrent apnoea: a neurological manifestation of congenital dengue.

Congenital dengue is seen in endemic areas during monsoon seasons. The clinical manifestations can vary from an asymptomatic newborn to mild symptoms like fever and rash to severe manifestations like shock and bleeding. The neurological manifestations of congenital dengue are uncommon compared with older children. The described symptoms/complications in the literature include congenital birth defects such as microcephaly, encephalitis and intraventricular haemorrhage. Apnoea as a manifestation of dengue has not yet been described in the literature. Here, we discuss a newborn baby with congenit…

Critical analysis of advanced nanosensors for dengue detection.

Dengue, a major global health risk, is a virus spread by Aedes aegypti and Aedes albopictus mosquitoes. It is most common in subtropical and tropical areas. For efficient epidemic management and control, dengue virus (DENV) identification must be performed accurately and in a timely manner. Traditional diagnostic techniques, such as molecular detection, antigen detection, and serological testing, have several drawbacks, including being expensive and time-consuming, having high turnaround times, having low sensitivity, and showing delayed results. With the advent of nanotechnology, these issues…

Dengue Outbreaks and Antibody Seroprevalence in Buenos Aires.

Buenos Aires, Argentina, a city with 3.1 million inhabitants, had a minimal prevalence of dengue until 2022, with nearly 25,000 cumulative reported cases. However, consecutive outbreaks in 2023 and 2024 significantly altered the epidemiological landscape, raising concerns about increasing viral circulation and a potential shift from a low-incidence, seasonal pattern toward more sustained transmission in this major urban setting. To assess the aftermath of the largest recorded dengue epidemic in Buenos Aires, we conducted a probabilistic, stratified, multistage serosurvey during the inter-epide…

Role of anakinra in the management of children with severe dengue.

OBJECTIVE: Severe dengue in children may present with a hyperinflammatory phenotype resembling cytokine storm or secondary haemophagocytic lymphohistiocytosis, characterised by refractory shock, hepatic dysfunction and multiorgan failure. We evaluated the use of interleukin 1 receptor antagonist therapy (anakinra) in children with severe dengue. DESIGN: We conducted a retrospective study of children admitted to a tertiary paediatric intensive care unit in India between May 2021 and December 2023 with confirmed severe dengue who received anakinra. Cytokine storm was suspected based on clinical…

TAK-003: development of a tetravalent dengue vaccine.

INTRODUCTION: Dengue incidence has increased over the past few decades. One tetravalent dengue vaccine based on a yellow fever backbone has been approved, but due to increased risk of severe disease in dengue-naïve recipients, its use is limited to individuals with prior dengue exposure. AREAS COVERED: We summarize the clinical development of TAK-003, a tetravalent dengue vaccine based on a live-attenuated DENV-2 backbone. We discuss vaccine development and preclinical and clinical work leading to a commercially available formulation. TAK-003 is approved in several countries and the WHO-SAGE …

Dengue pancreatitis with ketoacidosis-a rare manifestation in Endemicity.

Dengue may begin as a straightforward fever episode with or without rash also it may affect some organs and cause serious symptoms. Although it is uncommon, severe abdominal discomfort has been a concerning indicator of acute pancreatitis. We report on a male patient, age 26, who first presented with fever, vomiting, and stomach pain. Later, he developed severe pancreatitis. When an acute viral infection causes pancreatitis, ketoacidosis can occur without hyperglycemia. We emphasize that in dengue patients reporting stomach pain, it is important to rule out acute pancreatitis (AP), an uncommon…

Dengue virus infection and neurological manifestations: an update.

Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in regions with tropical and subtropical climates, with an estimated 100-400 million infections annually. Among those hospitalized, the mortality is about 1%. Neurological involvement has been reported to be about 5%. The spectrum of neurological manifestations spans both the peripheral and central nervous systems. These manifestations could possibly be categorized into those directly related to dengue infection, i.e. acute and …

Liver enzyme alteration in response to dengue virus.

Infectious diseases are extremely important in the global health landscape, specifically dengue and its severe forms. Clinical characterization is very variable due to the wide spectrum of manifestations the virus induces. Dengue is a viral infection caused by the dengue virus and is transmitted to humans by mosquitos of the Aedes family. Dengue is the most important arthropod-borne disease and if symptoms occur, could appear suddenly, characterized by biphasic fever, headache, retroocular pain, pain in various parts of the body, prostration and rash. It has also been described that the Dengue…

Utilization of machine learning for dengue case screening.

Dengue causes approximately 10.000 deaths and 100 million symptomatic infections annually worldwide, making it a significant public health concern. To address this, artificial intelligence tools like machine learning can play a crucial role in developing more effective strategies for control, diagnosis, and treatment. This study identifies relevant variables for the screening of dengue cases through machine learning models and evaluates the accuracy of the models. Data from reported dengue cases in the states of Rio de Janeiro and Minas Gerais for the years 2016 and 2019 were obtained through …

A Study of Neurological Involvement in Dengue and Chikungunya Infection.

INTRODUCTION: Chikungunya virus (CHIKV) and dengue fever have been reported for recent epidemics worldwide, with varied clinical involvement. Chikungunya was first reported to affect the nervous system in the 1960s. The clinical profile of dengue with multi-organ involvement is varied with reported involvement of the central nervous system in some. AIM: The aim of this study was to study the frequency and pattern of neurological involvement in patients admitted with dengue and chikungunya in a tertiary care hospital. MATERIALS AND METHODS: Patients admitted with confirmed chikungunya and den…