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The long road to recognition: a historical review of amyloidosis from early pathology to disease-modifying therapy.

Within the last several decades, great strides are being made in both the diagnosis and treatment of cardiac amyloidosis, yet the condition itself has been a severely under-recognized cause of heart failure for centuries. For much of medical history, the accumulation of these insoluble fibril deposits was an enigmatic finding, observed primarily post-mortem in patients suffering from chronic inflammatory conditions. This review traces the fascinating evolution of amyloidosis: from its origins as a botanical term mistakenly applied to human pathology, through the serendipitous discoveries of hi

Pain Experience in Oncology: A Targeted Literature Review and Development of a Novel Patient-Centric Conceptual Model.

Background and objectiveTypical endpoints in cancer clinical trials focus on standardized efficacy endpoints, such as overall survival. Pain is not always assessed, although it is a highly prevalent and distressing aspect of patients' cancer experience and plays a critical role in health-related quality of life. To inform future pain measurement strategies in oncology, this targeted literature review of pain-related qualitative publications in oncology aimed to characterize and explore the patient experience of pain, and its impact on how patients feel and function.MethodsA review of publicati

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… Glare P. Keefe F. Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline J. Clin. Oncol. 2016 34 3325 3345 10.1200/jco.2016.68.5206 27458286 7. Ośmiałowska E. Misiąg W. Chabowski M. Jankowska-Polańska B. …

MyPainPal, a Novel mHealth App to Improve Pain in Patients With Advanced Cancer: Single-Arm Pilot Study.

BackgroundPain is common among patients with advanced cancer and is often inadequately controlled. Opioids are central to treatment; yet, self-management is challenging, and clinicians lack scalable tools to monitor and support patients between visits.ObjectiveThis study aimed to evaluate the feasibility and acceptability of MyPainPal (Dana-Faber Cancer Institute), a novel mobile health app designed to optimize cancer pain management. MyPainPal combines daily surveys assessing symptoms and analgesic use, algorithmic self-management support, tailored psychoeducation, and clinician monitoring. S

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… Glare P, Walsh D, Sheehan D. The adverse effects of morphine: a prospective survey of common symptoms during repeated dosing for chronic cancer pain. Am J Hosp Palliat Care. 2006;23(3):229–235. doi: 10.1177/1049909106289068.23/3/229 10. Gunnarsdottir S, Donovan H, Serlin R, Voge C, Ward S. …

Latest Clinical Approaches in the Ocular Management of Cystinosis: A Review of Current Practice and Opinion from the Ophthalmology Cystinosis Forum.

Cystinosis, a rare autosomal recessive disease caused by intracellular cystine accumulation, occurs in an estimated 1/100,000-200,000 live births. Ocular non-nephropathic cystinosis is typically diagnosed during adulthood, when patients present with corneal crystal deposition and no systemic involvement. Due to the rarity of the condition, diagnosis is often delayed and can have a significant impact on the overall prognosis of the disease. Early diagnosis is therefore imperative to ensure successful treatment and improve quality of life, as most of its clinical manifestations can be prevented

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… Ocular Manifestations Photophobia (glare sensitivity, blepharospasm) is one of the most frequently reported ocular symptoms in patients with cystinosis [ 9 , 12 ]. …

Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study.

BACKGROUND: Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is rare life-threatening condition associated with a clonal plasma cell neoplasm. OBJECTIVE: The aim of this study is to investigate the clinical and biochemical features in patients with POEMS syndrome before and post-therapy. METHODS: Characteristics of demographic information, underlying diseases, clinical manifestations, laboratory indicators, and imaging examination were retrospectively collected when diagnosed and post-therapy in the patients POEMS syndrome between 2018 and 2024. RES

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… Autonomic symptoms were dry skin, body hair loss, sensation of glare, bladder dysfunction, diarrhea, rapid heartbeat, gastrointestinal symptoms, urogenital symptoms (e.g., impaired micturitionerectile dysfunction) ( 27 ). However, no enrolled patients had obvious autonomic symptoms. …

Церковная боль и воздействие на качество жизни пациентов с множественным склерозом.

Основная цель этого исследования заключалась в оценке воздействия шейной боли на качество жизни пациентов с множественным склерозом по сравнению с группой здоровых людей (без болезней центральной нервной системы). Материалы и методы: В период с ноября 2023 года по август 2024 года данные были собраны в специализированном госпитале Сент-Лукаша в Коньском (Польша). Критерием включения в это исследование были следующие: возраст (20-50 лет), женщины и мужчины, здоровые люди (без болезней центральной нервной системы) и люди, страдающие множественным склерозом. Лицам из исследовательской группы был

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… Discomfort glare and psychological stress during computer work: Subjective responses and associations between neck pain and trapezius muscle blood flow. Int. Arch. Occup. Environ. Health. 2020;93:29–42. doi: 10.1007/s00420-019-01457-w. 25. Safiri A., Kolahi A. …

Investigating the Analgesic Mechanisms of Acupuncture for Cancer Pain: Insights From Multimodal Bioelectrical Signal Analysis.

PurposeCancer pain management remains a significant clinical challenge. While acupuncture has shown potential in alleviating cancer pain, its underlying mechanisms are not yet fully understood. This study investigates the neurophysiological mechanisms underlying acupuncture's analgesic effects using multimodal bioelectrical signal analysis.Patients and methodsFifteen cancer pain patients underwent acupuncture while wearing portable, multi-sensor devices to capture bioelectrical signals. Pain levels were assessed using the Numerical Rating Scale (NRS) before and during needle retention. Neuroph

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… Glare PA , Davies PS , Finlay E , Feinstein D . Pain in cancer survivors . J Clin Oncol . 2014 ; 32 ( 16 ): 1739 . doi: 10.1200/JCO.2013.52.4629 24799477 PMC4031191 5. De Groef A , Vermeir S , Meeus M , Vlayen J , Nijs J . …

Efficacy of repetitive transcranial magnetic stimulation on postoperative pain in patients undergoing video-assisted thoracoscopic surgery: study protocol for a prospective, single-center, randomized controlled trial.

BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is a key treatment for many cardiothoracic issues, but intraoperative factors can lead to acute postoperative pain (APSP), impacting recovery and quality of life. While multimodal analgesic methods are used, they have notable side effects. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive pain relief option by stimulating the primary motor cortex (M1), effective in chronic pain management. However, its role in preventing and treating APSP after VATS needs confirmation through high-quality clinical trials. METHODS/

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… Glare P Aubrey KR Myles PS . Transition from acute to chronic pain after surgery. Lancet. ( 2019 ) 393 : 1537 – 46 . 10.1016/s0140-6736(19)30352-6 30983589 40. Guastella V Mick G Soriano C Vallet L Escande G Dubray C et al . …

The dark side of immunotherapy.

Immunotherapy has broadened the therapeutic scope and response for many cancer patients with drugs that are generally of higher efficacy and less toxicity than prior therapies. Multiple classes of immunotherapies such as targeted antibodies and immune checkpoint inhibitors (ICI), cell-based immunotherapies, immunomodulators, vaccines, and oncolytic viruses have been developed to help the immune system target and destroy malignant tumors. ICI targeting programmed cell death protein-1 (PD-1) or its ligand (PD-L1) are among the most effective immunotherapy agents and are a major focus of current

Adverse Events of Oncologic Immunotherapy and Their Management.

Over the past two decades, immunotherapy has emerged as a promising treatment option for patients with cancer. However, newer versions of immunotherapy, such as checkpoint inhibitors, may be associated with unusual adverse effects (AEs) that can range in severity from mild to life-threatening. Unlike common AEs of conventional chemotherapy, which have a predictable nadir or cyclic pattern after administration, AEs of these newer immunotherapies are variable, depending on the type of immunotherapy, route of administration, and mechanism of action. The onset and resolution of these AEs may be pr

Toxicity of CAR T-Cell Therapy for Multiple Myeloma.

BackgroundIdecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel) are novel chimeric antigen receptor (CAR)-T cell therapies targeting B-cell maturation antigen (BCMA), and both have recently gained approval by the US Food Drug Administration (FDA) for the treatment of relapsed and refractory multiple myeloma (RRMM).SummaryThese therapies offer unprecedented responses in RRMM but present new challenges including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), non-ICANS neurotoxicity, cytopenias, infections, and hypogammaglobul

Healing Environments for Cancer Care: Toward a Patient-Centered Design Guideline for Inpatient Settings.

ObjectivesThis study proposes an evidence-based design guideline for oncology inpatient rooms that addresses the physical, emotional, and psychosocial needs of cancer patients.BackgroundCancer inpatients frequently experience long hospital stays with emotional vulnerability and clinical stress. Growing evidence suggests environmental design can shape patient experience, comfort, and recovery. Yet, current literature lacks an integrated framework for the spatial and sensory needs of this population.MethodA systematic literature review was conducted across Web of Science, Scopus, and PubMed. Fro

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… Fit electrochromic glazing that self-tints for glare/privacy, removes curtain bioburden, and preserves continuous outdoor views (Study 18). …

Italian onco-haematological patients' preferences in bad news communication: a preliminary investigation.

BackgroundThe manner in which bad news is communicated in oncological contexts can affect patients' engagement, their coping strategies and therapeutic compliance. Although this topic has been broadly investigated since the nineties, to the best of our knowledge, little has been written about Italian patients' experiences and preferences concerning what the oncologists should disclose and how they should intimate patients about their health conditions in different stages of oncological disease.MethodsIn an attempt to fill this gap, an online self-report questionnaire was administered to a samp

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… Clayton JM, Hancock K, Parker S, Butow PN, Walder S, Carrick S, Currow D, Ghersi D, Glare P, Hagerty R, Olver IN, Tattersall MHN. Sustaining hope when communicating with terminally ill patients and their families: a systematic review. Psycho-Oncology. 2008;17(7):641–659. doi: 10.1002/pon.1288. 35. …

Care of cancer patients at the end of life in a German university hospital: A retrospective observational study from 2014.

BackgroundCancer care including aggressive treatment procedures during the last phase of life in patients with incurable cancer has increasingly come under scrutiny, while integrating specialist palliative care at an early stage is regarded as indication for high quality end-of-life patient care.AimTo describe the demographic and clinical characteristics and the medical care provided at the end of life of cancer patients who died in a German university hospital.MethodsRetrospective cross-sectional study on the basis of anonymized hospital data for cancer patients who died in the Munich Univers

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… Davis MP, Temel JS, Balboni T, Glare P. A review of the trials which examine early integration of outpatient and home palliative care for patients with serious illnesses. Ann Palliat Med. 2015;4(3): 99–121. 10.3978/j.issn.2224-5820.2015.04.04 47. Zhi WI, Smith TJ. …

Ocular adverse events associated with antibody-drug conjugates for cancer: evidence and management strategies.

Antibody-drug conjugates (ADCs) are a fast-growing class of cancer drugs designed to selectively deliver cytotoxic payloads through antibody binding to cancer cells with high expression of the target antigen, thus reducing systemic exposure and minimizing off-target effects. However, ADCs are associated with various ocular adverse events (AEs) that may impact treatment administration and patient outcomes. In this review, we provide a summary of ocular AEs associated with approved and investigational ADCs, recommendations for the mitigation and management of ocular AEs, current guidelines and e

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… decrease in visual acuity and eventual blindness if untreated | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); glare …

Seeing through "brain fog": neuroimaging assessment and imaging biomarkers for cancer-related cognitive impairments.

Advances in cancer diagnosis and treatment have substantially improved patient outcomes and survival in recent years. However, up to 75% of cancer patients and survivors, including those with non-central nervous system (non-CNS) cancers, suffer from "brain fog" or impairments in cognitive functions such as attention, memory, learning, and decision-making. While we recognize the impact of cancer-related cognitive impairment (CRCI), we have not fully investigated and understood the causes, mechanisms and interplays of various involving factors. Consequently, there are unmet needs in clinical onc

A Bibliometric Analysis and Visualization of Decision Support Systems for Healthcare Referral Strategies.

BackgroundThe referral process is an important research focus because of the potential consequences of delays, especially for patients with serious medical conditions that need immediate care, such as those with metastatic cancer. Thus, a systematic literature review of recent and influential manuscripts is critical to understanding the current methods and future directions in order to improve the referral process.MethodsA hybrid bibliometric-structured review was conducted using both quantitative and qualitative methodologies. Searches were conducted of three databases, Web of Science, Scopus

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… Glare P. Kaasa S. Bruera E. Referral criteria for outpatient specialty palliative cancer care: An international consensus Lancet Oncol. 2016 17 e552 e559 10.1016/S1470-2045(16)30577-0 27924753 27. Pittalis C. Brugha R. Gajewski J. …

Cancer Pain Is Not One-Size-Fits-All: Evolving from Tradition to Precision.

Cancer pain remains a significant challenge in oncology, profoundly affecting patients' quality of life, function, and prognosis. Historically under-recognized and managed with a uniform, opioid-centric approach, cancer pain was often inadequately treated. Advances in pain assessment, multimodal analgesia, and supportive care have improved outcomes, yet traditional algorithms frequently fail to address the complex, heterogeneous nature of cancer pain. Contemporary management is shifting toward precision and personalized medicine, integrating genetic, molecular, and biomarker data with individu

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… Paice J.A., Portenoy R., Lacchetti C., Campbell T., Cheville A., Citron M., Constine L.S., Cooper A., Glare P., Keefe F., et al. Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline. J. Clin. …

Sarcopenia in Older Adults with Hematologic Malignancies: A Comprehensive Review of Epidemiology, Prognosis, and Interventions.

Hematologic malignancies, including leukemias, lymphomas, and multiple myeloma, are diseases of older adults (age ≥ 60 years). Treatment decisions in older adults with cancer are heavily influenced by patient fitness: the ability of an individual patient to tolerate the off-target effects of anti-cancer therapy. Sarcopenia, defined as low muscle mass and strength, is increasingly recognized as an important marker of fitness. Furthermore, sarcopenia is known to be modifiable with nutrition and exercise interventions in older adults without cancer, but such evidence is limited for patients with

Mechanisms of Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically, CIPN is a mostly sensory neuropathy that may be accompanied by motor and autonomic changes of varying intensity and duration. Due to its high prevalence among cancer patients, CIPN constitutes a major problem for both cancer patients and survivors as well as for their health care providers, especially because, at the moment, there is no single effective method of preventing CIPN; moreover, the possibilities of treating t

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… Glare P.A., Davies P.S., Finlay E., Gulati A., Lemanne D., Moryl N., Oeffinger K.C., Paice J.A., Stubblefield M.D., Syrjala K.L. Pain in Cancer Survivors. J. Clin. Oncol. 2014;32:1739–1747. doi: 10.1200/JCO.2013.52.4629. 4. National Cancer Institute: Chemotherapy Side Effects Sheets. …