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Early identification of individuals at high risk for cerebral infarction after aneurysmal subarachnoid hemorrhage: the BEHAVIOR score.

Cerebral infarction (CI) is a crucial complication of aneurysmal subarachnoid hemorrhage (SAH) associated with poor clinical outcome. We aim … oints), Intracranial pressure elevation >20 mm Hg (3 points), and treatment of multiple aneurysms ('Overtreatment', 1 point). The BEHAVIOR score showed high diagnostic accuracy with respect to the absolute risk for CI (area under curve=0.806, P<0.0001) and prediction of poor clinical outcome at discharge (P<0.0001) and after 6 months (P=0.0002). Further validat …

An assessment of malaria diagnostic capacity and quality in Ghana and the Republic of Benin.

BACKGROUND: In malaria-endemic countries, the absence of parasitological confirmation of malaria infection potentially results in overtreatment of non-malaria febrile illness with antimalarial drugs; this may lead to healthcare workers (HCW) missing other treatable illness or wastage of resources. This paper presents results from nationally representative assessments of malaria diagnostic accuracy, quality and capacity in Ghana and the Republic of Benin. METHODS: Cross-sectional surveys were conducted in December 2012 among a representative sample of health facilities (n=30 per country), usin…

The "see and treat" strategy for identifying cytologic high-grade precancerous cervical lesions among low-income Brazilian women.

OBJECTIVE: To evaluate the strategy of "see and treat" by loop electrosurgical excision procedure (LEEP) for cytologic high-grade precancero … For cytologic HSIL, the benefits of the strategy of "see and treat" by LEEP outweighed the risk of overtreatment. Patients with both positive and negative margins on LEEP should be followed carefully.

QuantiFERON-TB gold in-tube implementation for latent tuberculosis diagnosis in a public health clinic: a cost-effectiveness analysis.

BACKGROUND: The tuberculin skin test (TST) has limitations for latent tuberculosis infection (LTBI) diagnosis in low-prevalence settings. Pr … to active TB disease. CONCLUSIONS: LTBI screening with TST in low-prevalence settings may lead to overtreatment and increased expenditures. In this public health clinic, additional QFT-GIT testing of individuals referred for a positive TST was cost-effective.

Symptom burden, survival and palliative care in advanced soft tissue sarcoma.

Introduction. The symptom burden and role of palliative care (PC) in patients with advanced soft tissue sarcoma (STS) are not well defined. … ecision to death is short, and prospective studies are required to determine whether this is due to overtreatment or very rapid terminal disease progression.

Clinical and molecular evaluation of acetowhite genital lesions in men.

A total of 108 male partners of women with cervical condyloma and/or dysplasia underwent evaluation for gross and subclinical condyloma via … riate histological criteria appears to be particularly relevant to management strategies that avoid overtreatment of minor epithelial abnormalities. It remains unclear whether acetowhite genital epithelia positive for human papillomavirus require treatment given the high tendency for recurrence and lack of demonstrated effect on the natural history of cervical …

Photodynamic therapy for cutaneous and subcutaneous malignant neoplasms.

Twenty-seven patients with cutaneous and subcutaneous malignant neoplasms were treated with photodynamic therapy. Therapy was administered t … t reliable spot power density readings. Straight-tipped fibers are nonhomogeneous and can result in overtreatment of the central area with necrosis and pain and in undertreatment of the periphery.

Radioiodine in Low-risk Differentiated Thyroid Cancer: Is the Pendulum Moving Again?

The management of differentiated thyroid cancer (DTC) has undergone a major paradigm shift over the past decade, with increasing emphasis on treatment de-escalation and avoidance of overtreatment in patients with low-risk disease. The 2015 American Thyroid Association guidelines marked a turning point by discouraging routine postoperative radioiodine (RAI) remnant ablation in low-risk patients, reflecting the excellent prognosis of most papillary thyroid carcinomas and concerns regarding unnecessary therapy-related morbidity. The rising incidence of thyroid cancer, largely due to increased det…

Gastroenterology/Hepatology: What You May Have Missed in 2025.

During 2025, gastroenterology and hepatology experienced advances in treatment and surveillance of common diseases. Technological innovation … eat, and follow patients with gastroenterologic conditions. Two randomized trials address potential overtreatment of patients with Barrett esophagus without high-grade dysplasia and patients with severe alcohol-associated hepatitis. For clinicians who care for patients with malignant gastric outlet obstruction, 2 new randomized trials now provide evidence that …

Primary Nodal Poroid Hidradenocarcinoma With YAP1::NUTM1 Fusion: Report of a Rare Case.

Poroid hidradenocarcinoma is a rare malignant sweat gland neoplasm. Although primary nodal hidradenoma has been reported, primary nodal poro … of this entity is important to avoid misdiagnosis as metastatic carcinoma and to prevent potential overtreatment.

Examining HbA1c in Frail Older Adults: A Linked Data Cohort Study.

OBJECTIVE: Diabetes and frailty pose a significant issue for society. Previous research has shown a mixed relationship between diabetes and … nt lessons for management. These include the possibility that HbA1c is not a useful metric and that overtreatment with hypoglycaemic agents must be considered.

Отталкиваю меняющееся управление хмурящейся множественной миеломой.

Множественная миелома (SMM) представляет собой промежуточную клиническую стадию между моноклонной гаммопатией неопределенного значения (MMUS) и симптоматической множественной миеломой (MM). ШМ сопряжена с весьма изменчивым риском перехода к ММ, что требует индивидуальной стратификации рисков для руководства управлением. Исторически модели риска основывались на статических клинических маркерах, отражающих бремя опухоли, для прогнозирования прогресса. Несмотря на свою полезность, эти модели не смогли зафиксировать лежащую в основе этого заболевания биологическую неоднородность. Последние достиже

Совпадение в аннотации оригинала
Smoldering multiple myeloma (SMM) represents an intermediate clinical stage between monoclonal gammopathy of undetermined significance (MGUS … ntions for high-risk SMM patients. However, uncertainty persists as clinicians balance the risks of overtreatment against therapeutic delay in the absence of clearly defined high-risk criteria. This review charts the evolution of SMM from a clinically defined entity to a biologically characterized precursor state, highlighting emerging tools and strategies aime …

[Superbugs Neisseria gonorrhoeae und Mycoplasma genitalium : Therapeutic challenges driven by antimicrobial resistance].

The incidence of sexually transmitted diseases continues to rise. According to the most recent European Centre for Disease Prevention and Co … resistance testing, avoidance of overdiagnosis, rational and responsible antibiotic use (preventing overtreatment), and the development and implementation of new antimicrobial agents are crucial for sustainable infection control.

Artificial intelligence in prostate cancer diagnosis and management: state-of-the-art approaches and emerging innovations.

Artificial intelligence (AI) is rapidly changing the field of medicine, and prostate cancer is no exception. The significant heterogeneity that characterizes the natural history of prostate cancer often leads to under- or overtreatment. Moreover, the already substantial burden of prostate cancer care on the health care system is predicted to rise significantly. By discerning patterns within immense, complex datasets, AI has the potential to augment the diagnosis, risk stratification, and treatment of prostate cancer beyond what is possible with existing clinical tools. In recent years, AI algo…

Serous Papillary Adenofibroma Cyst of the Ovary in a Young Woman: Case Report and Literature Review.

Background: Serous papillary adenofibroma cyst (SPAC) of the ovary is a rare benign epithelial tumor that can mimic borderline or malignant … recognition and intraoperative frozen section can guide conservative surgical strategies, avoiding overtreatment and preserving reproductive potential in young patients.

Decoding tumor-infiltrating lymphocytes heterogeneity in ductal carcinoma in situ: immune microenvironment dynamics and prognostic insights.

With the widespread use of mammography, the incidence of ductal carcinoma in situ (DCIS) has significantly increased and currently accounts for approximately 20-25% of newly diagnosed breast cancer cases. While a significant proportion of DCIS lesions exhibit long-term indolence without progression to invasive carcinoma, the current paucity of validated biomarkers for invasive potential prediction creates a therapeutic dilemma in clinical practice, potentially leading to either overtreatment of biologically inert lesions or undertreatment of high-risk precursors. Reflecting the body's adaptive…

Italian guidelines for cervical cancer screening. Multisocietal recommendations on the use of biomarkers in HPV screening with risk-based approach and GRADE methodology.

The European Council recommends adopting risk-based screening when relevant. In triaging HPV-positive women, it can be an effective strategy to reduce overtreatment and referral to colposcopy. HPV genotyping and p16/ki67 expression may allow a better risk stratification than cytology. In Italy, recommendations on their use (alone or combined) in screening were developed by a multi-professional (nine scientific societies) and multidisciplinary working group (including patients and decision makers). Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision fr…

[Research progress on the mechanism of reabsorption after massive migrated lumbar disc herniation].

Lumbar disc herniation refers to a syndrome mainly characterized by low back and leg pain caused by factors such as degeneration of the lumb … surgical evaluation criterion to avoid unnecessary social, economic, and medical burdens caused by overtreatment.

Clinical considerations for sexual and gender minorities with prostate cancer.

At every stage of the cancer continuum, the management of sexual and gender minorities with prostate cancer requires a thoughtful and multidisciplinary approach. For example, it is important to recognize that receptive anal intercourse, common among sexual minority men-i.e. gay and bisexual men-can potentially elevate prostate-specific antigen (PSA) leading to overdiagnosis and overtreatment. Additionally, it is important to understand that sexual minority men with prostate cancer might engage in insertive and/or receptive anal intercourse, as opposed to insertive vaginal intercourse, requirin…

Transcranial Doppler With Microbubbles: Screening Test to Detect and Grade Right-to-Left Shunt After an Ischemic Stroke: A Literature Review.

Right-to-left shunt, mainly due to patent foramen ovale (PFO), is likely responsible for ≈5% of all ischemic strokes and 10% of those occurr … le patients for PFO closure to prevent recurrent stroke and to avoid potentially harmful and costly overtreatment. Contrast transthoracic echocardiography has a relatively low sensitivity in detecting PFO, whereas transesophageal echocardiography is currently considered the gold standard for PFO detection. However, it is a relatively invasive procedure and may …