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Respiratory and Thoracic Medicine

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Interventions for preventing dengue: a mapping review.

BACKGROUND: Dengue remains a pressing global health challenge, particularly in low- and middle-income countries (LMIC). Despite a growing vo … synthesis gaps despite extensive primary studies, as existing reviews are outdated or restricted to Wolbachia-infected mosquitoes. Aquatic-stage interventions show consistent synthesis gaps across all outcome domains. For vaccines, evidence is particularly limited for implementation outcomes and entirely absent for behavioural outcomes, indicating minimal e …

Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview.

Respiratory viruses represent a major public health concern, as they are highly mutated, resulting in new strains emerging with high pathogenicity. Currently, the world is suffering from the newly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus is the cause of coronavirus disease 2019 (COVID-19), a mild-to-severe respiratory tract infection with frequent ability to give rise to fatal pneumonia in humans. The overwhelming outbreak of SARS-CoV-2 continues to unfold all over the world, urging scientists to put an end to this global pandemic through biological and

Neutrophil extracellular traps in homeostasis and disease.

Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the

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… In bacteria, Wolbachia endobacteria (W. endobacteria) can be recognized and initiate NETosis by TLR2 or TLR6. …

2020 ACVIM Forum On Demand Research Abstract Program.

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Emergency Care

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