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Mycobiota и Antifungal Antibodies как новые целевые показатели для диагностики и прогнозирования болезней человека.

Человеческое тело колонизируется различными микроорганизмами, при этом наиболее активно изучаются бактерии. Однако грибы, которые в совокупности известны как «микобиота», все чаще признаются в качестве составных компонентов микробиоты, населяющей почти все мукосальные поверхности. Комменсальные грибы оказывают влияние на иммунитет хост-приемника, как и бактерии, и способствуют выполнению других важных функций, включая метаболизм. В этом новом понимании грибы рассматриваются как потенциальные биомаркеры для диагностики и прогнозирования различных заболеваний. В этом обзоре мы изучаем двойную ро

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… Dominant fungal genera in healthy individuals include Candida spp., Malassezia spp., Aspergillus spp., Epicoccum spp., Saccharomyces spp., Alternaria spp., and Cladosporium spp., although their presence and abundance may vary significantly between specific individuals as they are influenced … Furthermore, next-generation sequencing has revealed the prevalence of specific fungal genera, including Alternaria spp., Botrytis spp., Candida spp., and Malassezia spp., in the brain tissue of AD patients. …

First Report of Phyllosticta capitalensis causing leaf spot on Eriobotrya japonica in China.

Loquat (Eriobotrya japonica), a member of the Rosaceae family that has been widely grown in South China, is rich in triterpenoids and has nu … (Xiong et al. 2022), lllicium difengpi (Jiang et al. 2023) and Alpinia oxyphylla (Yan et al. 2023). Alternaria spp., Colletotrichum spp., Fusarium spp., Neopestalotiopsis spp. and Pestalotiopsis spp. (Yan et al. 2024) have been previously reported as foliar pathogens of loquat, but to our knowledge, this is the first report of P. capitalensis causing leaf sp …

What are the 100 most cited fungal genera?

The global diversity of fungi has been estimated between 2 to 11 million species, of which only about 155 000 have been named. Most fungi ar … myces, Candida, Aspergillus, Fusarium, Penicillium, Trichoderma, Botrytis, Pichia, Cryptococcus and Alternaria. Case studies are presented for the 100 most cited genera with general background, notes on their ecology and economic significance and important research advances. This paper provides a historic overview of scientific research of these genera and t …

Pneumonia in the Cancer Patient

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… hyalohypho­mycosis such as Pseudallescheria boydii , Fusarium solani Varicella-zoster virus Streptococcus species Pseudomonas aeruginosa Mucorales (zygomycoses) Enterobacteriaceae Escherichia coli Klebsiella species Stenotrophomonas maltophilia Acinetobacter species Dematiaceous (Black) fungi such as Alternaria … Pseudallescheria boydii , Fusarium solani | | Varicella-zoster virus Streptococcus species | | | Pseudomonas aeruginosa | Mucorales (zygomycoses) | | Enterobacteriaceae Escherichia coli Klebsiella species Stenotrophomonas maltophilia Acinetobacter species | Dematiaceous (Black) fungi such as Alternaria …

Проверка генотипов чечевиц на предмет выявления болезни стволового ствола и молекулярная идентификация причинно-следственного организма.

Во время сезона сбора урожая 2019-20, 2020-21, и 2021-22С помощью Alpha-Lattice Design с помощью Alpha-Lattice Genoтипы чечевиц были скринингированы на Stemphilium blight. three Репликации в Исследовательском центре Пульса, БАРИ, Ишурди, Pabna-6620 в естественных и искусственных эпифитотических условиях. В случае искусственного инокулума искусственные инокулумы были разбрызганы на 1.3 × 105 Споры/мл концентрации споров для прививки споров на экспериментальных участках. Данные о серьезности заболевания были зарегистрированы следующим образом: 1-9 Кроме того, была произведена оценка шкалы рейтин

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… Phylogenetic tree was constructed using MEGA V10 where Alternaria alternata is an out group. For construction of a phylogenetic tree, sequences of Stemphylium botryosum and related species of Stemphylium were collected retrieving from GenBank. … Molecular and morphological analyses of Alternaria and Stemphylium from onion. Master Thesis. Cornell University, Ann Arbor, Michigan, United States of America (2001). 45. Chou, H. & Wu, W. …

Clinical characteristics of Mycoplasma pneumoniae pneumonia in children with atopic constitution and risk factors for disease severity: a retrospective comparative study.

OBJECTIVE: To compare the clinical characteristics and immune-inflammatory markers between Mycoplasma pneumoniae pneumonia children with and without atopic constitution, and to identify independent risk factors for severe MPP within the atopic group. METHODS: We retrospectively analyzed the medical records of 377 children diagnosed with MPP at Wuhan Children's Hospital between January 1, 2019, and December 31, 2024, who underwent allergen-specific immunoglobulin E (sIgE) testing for both inhalant and food allergens. The children were divided into two groups based on their atopic constitution:

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… Inhalant allergen panel (10 items) Short Ragweed (Ambrosia artemisiifolia), Mugwort (Artemisia vulgaris), House Dust Mite (Dermatophagoides pteronyssinus), Dust Mite (Dermatophagoides farinae), Cat dander, Dog dander, House Dust, Cockroach, Alternaria alternata, and Willow (Salix). … Other inhalant allergens included mugwort (17 cases, 5.8%), cat dander (17 cases, 5.8%), house dust (15 cases, 5.1%), and Alternaria alternata (12 cases, 4.1%). Common ragweed had 4 cases (1.4%), whereas cockroach and ryegrass each had 3 cases (1.0%). …

[Differential analysis of intestinal flora in patients with hepatic blastomycosis based on second-generation sequencing].

Exploring the variability of the intestinal flora of patients with hepatic blastocysticercosis and searching for members of the intestinal m … el. The AE group ranked the top 6 in terms of abundance of Anaplasma, Escherichiaceae, Clostridium, Alternaria, Ruminalia, and Treponema spp. at the genus level; whereas, Segatella, Prevotella, E. faecalis, Rossella, and beneficial rod-shaped bacteria were more abundant in the NC group. There were differences in the abundance and diversity of intestinal flor …

Anatomic relationship between temporomandibular joint and middle ear.

The present guideline (S2k) on allergen-specific immunotherapy (AIT) was established by the German, Austrian and Swiss professional associat … enable the prescription of rare allergen sources (e.g., pollen from ash, mugwort or ambrosia, mold Alternaria, animal allergens) for specific immunotherapy. Mixing these allergens with TAV allergens is not permitted. Allergic rhinitis and its associated co-morbidities (e. g., bronchial asthma) generate substantial direct and indirect costs. Treatment option …

Infant food allergy phenotypes and association with lung function deficits and asthma at age 6 years: a population-based, prospective cohort study in Australia.

BACKGROUND: Food allergy is considered a precursor to asthma in the context of the atopic march, but the relationship between infant food al … lk, egg, peanut, wheat, sesame, soy, shrimp, cashew, almond, and hazelnut) and eight aeroallergens (alternaria, cladasporum, house dust mite, cat hair, dog hair, bermuda grass, rye grass, and birch mix), oral food challenges, and lung function testing by spirometry. Questionnaires completed by parents (different to those completed at age 1 year) captured the …

Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab).

BACKGROUND AND OBJECTIVE: There seems to be a strong causal relationship between allergy and the origins of asthma. Susceptibility to both is determined by a combination of genetics and environment acting through a complex network of cytokines. Nearly 90% of affected children have positive skin tests indicating the presence of specific immunoglobulin E (IgE), with sensitivity to house dust mite, Alternaria, cockroach, cat, and dog most closely linked to the disease. Greater exposure to house dust mite during infancy leads to earlier onset of wheezing, and elevated serum IgE levels correlate wi…

Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study.

BACKGROUND: Atopy is defined as the genetic propensity to develop immunoglobulin E antibodies in response to exposure to allergens and asses … ormed. Allergens were house dust mite (Dermatophagoides pteronyssimus), grass pollen mix, cat, dog, Alternaria alternata, Cladosporium herbarum, cow's milk, hen's egg, soya, cod, wheat, and peanut. A mean wheal diameter of at least 3 mm greater than the negative control was taken as positive. This analysis is confined to the 981 (67% of the original populati …

Ход работы 34th Симпозиум ESVN-ECVN 23rd-24th сентябрь 2022.

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Mucosal-Associated Invariant T Cells in Health and Disease.

Mucosal-associated invariant T (MAIT) cells are a population of evolutionarily conserved, unconventional innate-like T lymphocytes that are restricted by major histocompatibility complex Class I-related (MR1) molecules. They can be activated either in a T-cell receptor-MR1- or cytokine-dependent manner. Activated MAIT cells play crucial roles in maintaining homeostasis and the fine regulation of the immune system. This review presents a systematic exploration of the development, biological characteristics, and multiple effects of MAIT cells in health and various diseases. In healthy individual

Biosynthesis of anticancer phytochemical compounds and their chemistry.

Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, and metastatic malignancies have increased. Plant-derived phytochemical compounds target different oncogenes, tumor suppressor genes, protein channels, immune cells, protein channels, and pumps, which have attracted much attention for treating cancer in preclinical studies. Despite the anticancer capabilities of these phytochemical compounds, systemic toxicity, medication resistance, and limited absorption re

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… Biotic elicitors, such as cell extract from endophytic fungi such as Alternaria sesami , were also utilized to boost the levels of alkaloids in the cell suspension culture of Catharanthus roseus ( Birat et al., 2022 ). … Enhancement of vincristine under in vitro culture of Catharanthus roseus supplemented with Alternaria sesami endophytic fungal extract as a biotic elicitor . Int. Microbiol. 25 ( 2 ), 275 – 284 . 10.1007/s10123-021-00213-w 34622356 Bojang P. Ramos K. S. ( 2014 ). …

The Controversial Role of IL-33 in Lung Cancer.

Interleukin-33 (IL-33) belongs to the interleukin-1 (IL-1) family, and its structure is similar to IL-18. When cells are damaged or undergo necrosis, mature form of IL-33 is secreted as a cytokine, which can activate the immune system and provide danger signals. The IL-33/ST2 signaling pathway is composed of IL-33, suppression of tumorigenicity 2 (ST2), and IL-1 receptor accessory protein (IL-1RAcP). IL-33 has been reported to be strongly associated with lung cancer progression, and can exhibit opposite effects on lung cancer under different conditions. In this review, we have summarized the s

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… COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice. J Immunol (2020) 205:1157–66. doi: 10.4049/jimmunol.1901544 47. Drake LY, Kita H. IL-33: Biological Properties, Functions, and Roles in Airway Disease. …

Роли глюкагонового пептида 1 Агонисты-рецепторы в биологии иммунных клеток и аутоиммунных/аутоинфлампмидативных заболеваниях.

Глукагон-подобный peptide-1 (В тыс.GLP-1) — гормон, полученный кишечником, необходимый для поддержания глюкозы гомеостаза через многочисленные физиологические пути: инсулина, ингибирующего секрецию глюкагонов, замедляющего опустошение желудочков, усиливающего чувство полноты и подавляющего аппетит. С тех пор GLP-1 может разлагаться при помощи дипептидила пептидаза 4, GLP-1 рецепторные агонисты (GLP-1RAs) были разработаны для решения этой проблемы деградации. В настоящее время GLP-1RAs стали высокоэффективными методами лечения для управления типом 2 сахарный диабет и ожирение. Помимо их хорошо

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… Findings from a 4-day Alternaria alternata extract intranasal challenge model showed that the absence of GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling exacerbated airway inflammation, characterized by increased lung ILC2s, lymphocytes, eosinophils, and neutrophils, as …

Bright Spots in The Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action.

The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable. Oceans, due to their wide diversity of marine species and environmental conditions have proven to be precious sources of potential natural drugs with active properties. As an example, in this context several studies performed on sponges, tunicates, mollusks, and soft corals have brought evidence of the interesting biological activities of the molecules derived from these species. Also, echinoderms constitute an import

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… Cerebrosides of the Halotolerant Fungus Alternaria raphani Isolated from a Sea Salt Field. J. Nat. Prod. 2009;72:1695–1698. doi: 10.1021/np9002299. 40. Flickr.com. [(accessed on 28 August 2019)]; Available online: https://www.flickr.com/photos/a_semenov/6055892593 . 41. …

Выявляется стабильная устойчивая донора диких голубей для многих доминирующих видов брухидов в Индии.

Выявление стабильных и устойчивых источников представляет собой экологически благоприятную и устойчивую стратегию борьбы с насекомыми. Sixty-eight Присоединения диких голубей систематически проверялись three Преобладающие виды брухидов (Callosobruchus analis, C. chinensis, C. maculatus) с использованием высокопроизводительного скринингового трубопровода в Канпуре, Индия, 2021 в адрес 2024. Классификация устойчивости основывается на повреждении семян и индексе уязвимости. Four Присоединения к ринкосии брактета неизменно демонстрировали конвергентное и полное сопротивление в отношении различных

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… Maesen | ICP15663 | G20 | NBPGR, ICRISAT, Chhattisgarh, West Bengal, Jharkhand and Madhya Pradesh | Tertairy | Tolerance to bruchid, pod borer and salinity, Cyst nematode resistance, resistance to Phytopthera and Alternaria blight, SMD, extra early flowering, vigour and maturity, photoperiod insensitivity …

9th Trends in Medical Mycology Held on 11-14 October 2019, Nice, France, Organized under the Auspices of EORTC-IDG and ECMM.

Dear Friends and Colleagues,It is a great honor and pleasure for us to invite you cordially to participate in the 9th Congress on Trends in Medical Mycology (TIMM-9) [...].

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… More than 400 different species of fungi have been reported from water sources intended for human consumption, with prevailing presence of ascomycetous fungi of the genera Alternaria, Acremonium, Aspergillus, Aureobasidium, Candida, Cladosporium, Exophiala, Fusarium, Penicillium, Phoma, Sarocladium, … Among the filamentous fungi Fusarium had the highest prevalence of 79.7%, followed by Cladosporium spp , Alternaria spp, Acremonium Apergillus and Penicillium respectively. There was a significant association between Fusarium and Acremonium moulds and respiratory conditions. …

Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications.

HHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was condu

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… Hu et al. for the first time reported HHT producing endophytic fungi from the bark of C. hainanensis and the fungus was identified as Alternaria tenuissima [ 36 ]. …