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Progress and challenges in the treatment of cardiac amyloidosis: a review of the literature.

Cardiac amyloidosis is a restrictive cardiomyopathy determined by the accumulation of amyloid, which is represented by misfolded protein fragments in the cardiac extracellular space. The main classification of systemic amyloidosis is determined by the amyloid precursor proteins causing a very heterogeneous disease spectrum, but the main types of amyloidosis involving the heart are light chain (AL) and transthyretin amyloidosis (ATTR). AL, in which the amyloid precursor is represented by misfolded immunoglobulin light chains, can involve almost any system carrying the worst prognosis among amyl

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… The anticholinergic pyridostigmine can also improve neurogenic orthostatic hypotension, 59 and some centres are also using droxidopa as a support for orthosthatic blood pressure in both neurodegenerative diseases and AL. 60 , 61 Fludrocortisone can be helpful in some patients who do not show a good response …

Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?

Multiple organ dysfunction syndrome (MODS) occurs in response to major insults such as sepsis, severe haemorrhage, trauma, major surgery and pancreatitis. The mortality rate is high despite intensive supportive care. The pathophysiological mechanism underlying MODS are not entirely clear, although several have been proposed. Overwhelming inflammation, immunoparesis, occult oxygen debt and other mechanisms have been investigated, and - despite many unanswered questions - therapies targeting these mechanisms have been developed. Unfortunately, only a few interventions, usually those targeting mu

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… Annane D Sebille V Charpentier C Bollaert PE Francois B Korach JM Capellier G Cohen Y Azoulay E Troche G Chaumet-Riffaut P Bellissant E Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock JAMA 2002 288 862 871 12186604 10.1001/jama.288.7.862 …

Interactions between kidney disease and diabetes: dangerous liaisons.

BackgroundType 2 diabetes mellitus (DM) globally affects 18-20 % of adults over the age of 65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-third of the patients with DM2. In addition to the pancreas, adipocytes, liver, and intestines, the kidneys also play an important role in glycemic control, particularly due to renal contribution to gluconeogenesis and tubular reabsorption of glucose.MethodsIn this review article, based on a report of discussions from an interdisciplinary group of experts in the areas of endocrinolo

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… Regarding drug treatment, fludrocortisone and the α 1-adrenergic agonist midodrine are considered the drugs of choice in the treatment of DCAN. …

Chemistry and Pharmacology of Fluorinated Drugs Approved by the FDA (2016-2022).

Fluorine is characterized by high electronegativity and small atomic size, which provide this molecule with the unique property of augmenting the potency, selectivity, metabolic stability, and pharmacokinetics of drugs. Fluorine (F) substitution has been extensively explored in drug research as a means of improving biological activity and enhancing chemical or metabolic stability. Selective F substitution onto a therapeutic or diagnostic drug candidate can enhance several pharmacokinetic and physicochemical properties such as metabolic stability and membrane permeation. The increased binding a

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… Since the introduction of the first fluorocorticosteroid, namely fludrocortisone, in 1954 [ 9 ], the fluorinated drug market has grown exponentially, with these medicines accounting for 20% of those on the market, and approximately 30% of them becoming blockbusters, such as Lipitor, Fluoxetine, Linezolid …

Демографическая точность в онкологических оврагах, клинических и генетических детерминантах системной терапии.

Токсичность при лечении сдерживает применение эффективных методов лечения рака, однако ее клинические и генетические детерминанты по-прежнему недостаточно четко определены. Мы разработали подход, основанный на большой языковой модели, для производства MSK-Tox, панракорного ресурса, фиксирующего частотность, временнóсть и сорт токсичности для антираковой терапии в большей степени, чем 50,000 Пациенты. Анализ six Репрезентативные неблагоприятные явления - пневмонит, адренальная недостаточность, токсичность для печени, колит, гипертироидизм и гипотироидозные отдельные токсические ландшафты, опред

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… Within each window, cumulative corticosteroid exposure was computed in prednisone-equivalent mg-days using standard equivalence factors (hydrocortisone 0.25, cortisone 0.20, prednisone and prednisolone 1.0, methylprednisolone and triamcinolone 1.25, fludrocortisone 2.5, dexamethasone 6.67, betamethasone …

ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016

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Proceedings of Reanimation 2023, the French Intensive Care Society International Congress.

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… Patients and methods/materials and methods: The Activated Protein C and Corticosteroids for Human Septic Shock (APROCCHSS) trial was a placebo, controlled trial of the efficacy and safety of the corticosteroids hydrocortisone and fludrocortisone, in adults with septic shock. … Conclusion: The effects of hydrocortisone plus fludrocortisone on 90-day mortality are consistent in septic shock with and without early ARDS. Reference 1 Annane D et al. NEJM 2018. Compliance with ethics regulations: Yes in clinical research. …

POSTER PRESENTATIONS

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2022 NATIONAL CONGRESS OF THE ITALIAN SOCIETY OF HYPERTENSION (SIIA)

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Emergency Care

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ИАНКОН 2023 Выдержки из плаката

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Inpatient Medicine

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ICIMH 2022 Abstracts

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… Moreover, psychosocial support including cognitive behavioral therapy, biofeedback, and support groups were emphasized along with pharmacologic remedies such as midodrine, ivabradine, fludrocortisone, intravenous immunoglobulin, gabapentin, and topical lidocaine in additoin to interventions such as enhanced …

Selected Abstracts from the 12th Annual Meeting of the Clinical Immunology Society: 2021 Virtual Annual Meeting: Immune Deficiency and Dysregulation North American Conference.

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Proceedings of the RAMI Intern Section Meeting.

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Abstracts for NAPCON 2025

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Abstracts - IANCON 2024

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

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Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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