Результаты поиска

Systemic Lupus Erythematosus in Primary Care: An Update and Practical Messages for the General Practitioner.

Systemic Lupus Erythematosus (SLE) is a complex chronic autoimmune disease that manifests a wide range of organ involvement. Traditionally, the diagnosis and management of SLE is provided at secondary and tertiary centers to ensure prompt initiation of treatment, adequate control of flares and prevention of irreversible organ damage. Notwithstanding, the role of primary care in SLE is also emerging as there are still significant unmet needs such as the diagnostic delay at the community level and the high burden of therapy- and disease-related comorbidities. In the present review, we summarize

Совпадение в полном тексте источника
… Drug-induced lupus and other lupus-like conditions Drug-induced lupus refers to an autoimmune disorder that resembles SLE and is actually an idiosyncratic adverse effect of certain medications, particularly hydralazine, procainamide, isoniazid, minocycline, diltiazem and TNF inhibitors ( 88 ). …

Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling.

Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic prevalence between 1:400 and 1:1,000 individuals, is the third most common cause of end stage kidney disease after diabetes mellitus and hypertension. Over the last 3 decades there has been great progress in understanding its pathogenesis. This allows the stratification of therapeutic targets into four levels, gene mutation and polycystin disruption, proximal mechanisms directly caused by disruption of polycystin function, downstream regulatory and signaling pathways, and non-specific pathophysiologic processes sha

Совпадение в полном тексте источника
… A recent study in C. elegans reported that the activation of PKA by hydralazine was mediated by its binding and stabilization of a catalytic subunit of PKA, which was independent of cAMP ( Dehghan et al., 2019 ). …

Interpretability and fairness evaluation of deep learning models on MIMIC-IV dataset.

The recent release of large-scale healthcare datasets has greatly propelled the research of data-driven deep learning models for healthcare applications. However, due to the nature of such deep black-boxed models, concerns about interpretability, fairness, and biases in healthcare scenarios where human lives are at stake call for a careful and thorough examination of both datasets and models. In this work, we focus on MIMIC-IV (Medical Information Mart for Intensive Care, version IV), the largest publicly available healthcare dataset, and conduct comprehensive analyses of interpretability as w

Совпадение в полном тексте источника
… EHR | mimic_icu.inputevents 11 | Fresh frozen plasma | EHR | mimic_icu.inputevents 12 | Lorazepam (Ativan) | EHR | mimic_icu.inputevents 13 | Midazolam (Versed) | EHR | mimic_icu.inputevents 14 | Phenylephrine | EHR | mimic_icu.inputevents 15 | Furosemide (Lasix) | EHR | mimic_icu.inputevents 16 | Hydralazine …

Diffuse alveolar hemorrhage in rheumatic diseases: Clinical features, diagnosis, and management.

Diffuse alveolar hemorrhage (DAH) is a catastrophic pulmonary manifestation of systemic autoimmune and rheumatic diseases, particularly systemic lupus erythematosus (SLE), ANCA-associated vasculitis (AAV), and antiphospholipid syndrome (APS). It arises from immune-mediated injury to the pulmonary microcirculation, leading to intra-alveolar bleeding, respiratory failure, and high mortality. Despite advances in immunosuppression, DAH continues to pose major diagnostic and therapeutic challenges, with limited consensus on optimal management. We conducted an updated and comprehensive review of the

Совпадение в полном тексте источника
… Bronchoscopy with BAL confirms alveolar hemorrhage and ANCA testing (PR3 and MPO) is paramount for diagnosis. [ 31 ] Common medications that have been implicated to cause AAV include propylthiouracil, hydralazine, sulfasalazine, anti-tumor necrosis factor alpha agents, D-penicillamine, and minocycline …

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance.

Chemotherapy is an effortless and frequently used approach in cancer therapy. However, in most cases, it can only prolong life expectancy and does not guarantee a complete cure. Furthermore, chemotherapy is associated with severe adverse effects, one of the major complications of effective cancer therapy. In addition, newly published research outputs show that cancer stem cells are involved in cancer disease progression, drug resistance, metastasis, and recurrence and that they are functional in the trans-differentiation capacity of cancer stem cells to cancer cells in response to treatments.

Совпадение в полном тексте источника
… regulation via Notch, Wnt, and polycomb repressive complexes pathway 203 18 | Genistein | Anti-oxidant | Prostate | Inhibit Hh pathway 204 19 | Ginsenoside F2 | Reduce hair loss | Breast | Induce apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dysfunction 205 20 | Hydralazine …

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management.

Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous adverse reaction mainly attributed to drugs, although other triggers, including infections, vaccinations, ingestion of various substances, and spider bites, have also been described. AGEP is characterized by the development of edema and erythema followed by the eruption of multiple punctate, non-follicular, sterile pustules and subsequent desquamation. AGEP typically has a rapid onset and prompt resolution within a few weeks. The differential diagnoses for AGEP are broad and include infectious, inflammatory, a

Совпадение в полном тексте источника
… Antiarrhythmics, such as amiodarone and propafenone, and antihypertensives, including diltiazem, hydralazine, and ranolazine have also been reported [ 123 – 127 ]. …

The Critical Role of Hypoxic Microenvironment and Epigenetic Deregulation in Esophageal Cancer Radioresistance.

Esophageal cancer (EC) is the seventh most common cancer worldwide and the sixth leading cause of death, according to Globocan 2018. Despite efforts made for therapeutic advances, EC remains highly lethal, portending a five-year overall survival of just 15-20%. Hence, the discovery of new molecular targets that might improve therapeutic efficacy is urgently needed. Due to high proliferative rates and also the limited oxygen and nutrient diffusion in tumors, the development of hypoxic regions and consequent activation of hypoxia-inducible factors (HIFs) are a common characteristic of solid tumo

Совпадение в полном тексте источника
… With this purpose, Hydralazine plus Valproate or Valproic acid (VPA), an anti-epileptic drug, were used in clinical trials phase II for cervical cancer ( NCT00404326 ) [ 89 ]. Herein, patients obtained a complete response to external radiation, thus, supporting further investigation [ 89 ]. …

Cardiotoxicity of Chemotherapy: A Multi-OMIC Perspective.

Chemotherapy-induced cardiotoxicity is a critical issue in cardio-oncology, as cancer treatments often lead to severe cardiovascular complications. Approximately 10% of cancer patients succumb to cardiovascular problems, with lung cancer patients frequently experiencing arrhythmias, cardiac failure, tamponade, and cardiac metastasis. The cardiotoxic effects of anti-cancer treatments manifest at both cellular and tissue levels, causing deformation of cardiomyocytes, leading to contractility issues and fibrosis. Repeated irradiation and chemotherapy increase the risk of valvular, pericardial, or

Совпадение в полном тексте источника
… So far, the therapeutic options currently available for the handling of cardiac abnormalities in cancer patients are limited, such as Angiotensin-converting enzyme (ACE) inhibitors, beta-blockers (BB), and the hydralazine-nitrate combination, which mitigate the symptoms and signs, with little or no demonstrated …

Drug repurposing in malignant pleural mesothelioma: a breath of fresh air?

Drug repurposing is the use of known drugs for new indications. Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. So far, few treatments have been approved in this disease. However, its incidence is expected to increase significantly, particularly in developing countries. Consequently, drug repurposing appears as an attractive strategy for drug development in MPM, since the known pharmacology and safety profile based on previous approvals of repurposed drugs allows for faster time-to-market for patients and lower treatment cost. This is critical in low- and middle-in

Совпадение в полном тексте источника
… A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer. Preliminary results. Med Oncol 2011; 28: S540–S546. 104. Issa JP, Garcia-Manero G, Huang X, et al. …

Unraveling the link between cardiorespiratory fitness and cancer: a state-of-the-art review.

Cardiorespiratory fitness (CRF) not only reflects an individual's capacity to perform physical activities but also encapsulates broader effects on the basic biology of aging. This review aims to summarize the evidence on the influence of CRF on overall and site-specific cancer risks. It delves into the biological mechanisms through which CRF may exert its effects, explores the clinical implications of these findings, identifies gaps in the current evidence base, and suggests directions for future research. The synthesis of findings reveals that higher CRF levels (general threshold of > 7 METs)

Совпадение в полном тексте источника
… The use of medications such as renin–angiotensin–aldosterone system inhibitors, hydralazine, and digoxin in populations with impaired CRF, such as heart failure, have been shown to increase levels of VO2peak [ 215 , 216 ]. …

Infectious Diseases

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… , polyarteritis nodosa, Takayasu’s arteritis, Wegener’s granulomatosis, mixed cryoglobulinemia), lupus , rheumatoid arthritis DRUGS — antimicrobials (sulfonamides, penicillins, nitrofurantoin, antimalarials), antihistamines , antiepileptics (barbiturate, phenytoin), NSAIDs/ASA , antihypertensives (hydralazine …

Infectious Diseases

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… polyarteritis nodosa, Takayasu’s arteritis, granulomatosis with polyangiitis, mixed cryoglobulinemia), lupus , rheumatoid arthritis DRUGS — antimicrobials (sulfonamides, penicillins, nitrofurantoin, antimalarials), antihistamines , antiepileptics (barbiturate, phenytoin), NSAIDs / ASA , antihypertensives (hydralazine …

What nature has to offer: Opportunities for immuno-oncology.

Recent rapid development of cancer therapy has come about with the paradigm shift from the traditional goal of targeting cancer cells themselves, to reprograming the immune tumor microenvironment. Accumulating evidence shows that compounds that target epigenetic regulation, called epidrugs, play a crucial role in mediating the immunogenicity of cancer cells and in reshaping antitumor immunity. A large body of literature has recognized natural compounds as epigenetic modulators for their immunomodulatory effects and anticancer potential. Unifying our understanding of the role of these biologica

Совпадение в полном тексте источника
… Green tea polyphenol, epigallocatechin-3-gallate (EGCG), curcumin, hydralazine, procainamide, RG-108, disulfiram, and SGI-1027 were among them. Only azacytidine (Vidaza; Celgene) and decitabine (5 aza 2′-deoxycytidine) are DNMT inhibitors (azanucleosides) currently licensed by the US FDA [ 22 ]. …

Management of Potential Organ Donor: Indian Society of Critical Care Medicine-Position Statement.

This position statement is documented based on the input from all contributing coauthors from the Indian Society of Critical Care Medicine (ISCCM), following a comprehensive literature review and summary of current scientific evidence. Its objective is to provide the standard perspective for the management of potential organ/tissue donors after brain death (BD) in adults only, regardless of the availability of technology. This document should only be used for guidance only and is not a substitute for proper clinical decision making in particular circumstances of any case. Endorsement by the IS

Совпадение в полном тексте источника
… Justification Due to the transient nature of autonomic storms, antihypertensives are usually not required. 58 If needed, short-acting antihypertensives such as esmolol, sodium nitroprusside, hydralazine, labetalol, or nitroglycerine should be used. …

Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Energy metabolism in health and diseases.

Energy metabolism is indispensable for sustaining physiological functions in living organisms and assumes a pivotal role across physiological and pathological conditions. This review provides an extensive overview of advancements in energy metabolism research, elucidating critical pathways such as glycolysis, oxidative phosphorylation, fatty acid metabolism, and amino acid metabolism, along with their intricate regulatory mechanisms. The homeostatic balance of these processes is crucial; however, in pathological states such as neurodegenerative diseases, autoimmune disorders, and cancer, exten

Current State of Knowledge on Primary Sjögren's Syndrome, an Autoimmune Exocrinopathy.

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most frequent connective tissue disease after rheumatoid arthritis, affecting 0.3-3% of the population. Women are more prone to develop pSS than men, with a sex ratio of 9:1. Considered in the past as innocent collateral passive victims of autoimmunity, the epithelial cells of the saliv

Совпадение в полном тексте источника
… In fact, mice receiving an oral administration of hydralazine or isoniazid (demethylating agents) for several weeks develop a pathology similar to SS in terms of immunological features and autoantibodies production. The signs of SS pathology disappeared after discontinuation of the drug [ 46 ]. …

Emergency Care

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Inpatient Medicine

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… His medications include diltiazem, hydralazine, aspirin, and isosorbide dinitrate. On physical examination, his temperature is 37.2 °C (99 °F), blood pressure is 145/90 mmHg, pulse rate is 80 bpm, and respiration rate is 24/min. Cardiac examination is normal. … The most common drugs that cause DILE are hydralazine, procainamide, quinidine, isoniazid, diltiazem, and minocycline. He has new-onset fever, arthralgia, myalgia, nonblanching purpuric rash, pleuritis, pancytopenia, and proteinuria with active urine sediment. …

Evolving Therapeutic Strategies in ANCA-Associated Vasculitis: Current Standards and Emerging Targets for GPA and MPA.

Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are severe autoimmune disorders characterized by necrotizing small-vessel inflammation, and are classified among anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). Standard induction therapy combines glucocorticoids (GCs) with rituximab (RTX) or cyclophosphamide (CYC), with growing emphasis on GC minimization and selective use of avacopan in patients at high risk of GC toxicity. For maintenance therapy, fixed-interval RTX generally outperforms conventional oral agents and biomarker-guided re-dosin

Совпадение в полном тексте источника
… Several agents have been implicated in its pathogenesis, including hydralazine, propylthiouracil, minocycline, and particularly cocaine, especially when adulterated with levamisole [ 122 , 123 ]. …