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Lenalidomide maintenance after delayed or salvage autologous stem cell transplantation.

Lenalidomide (Len) maintenance improves survival after upfront autologous stem cell transplantation (autoHCT) in multiple myeloma (MM), but its role after delayed/salvage autoHCT is less defined. We performed a retrospective study of 163 MM patients who received delayed (n = 102) or salvage (n = 61) autoHCT between 2009 and 2023, followed by Len maintenance. After median follow-up of 50 months, median progression-free survival (PFS) and overall survival (OS) were 23 (95% CI, 20-26) and 62 (95% CI, 50-80) months, respectively. Patients with high-risk cytogenetic abnormalities had inferior outco…

Correction: Editorial: CNS immunity - paradox of maintenance, repair and destruction.

[This corrects the article DOI: 10.3389/fimmu.2026.1954884.].

Knowledge-guided multimodal reasoning framework for intelligent power grid maintenance.

Power grid infrastructure maintenance requires reliable integration of heterogeneous data sources including historical fault records, technical documents, and visual inspection imagery. Existing approaches face challenges in ensuring output completeness, consistency verification, and systematic multimodal data integration-critical requirements for high-stakes operational decisions. This paper presents an integrated multimodal reasoning system designed to address these reliability requirements through systematic quality assurance mechanisms. The system architecture comprises three components: (…

Cannabis Use among People Receiving Maintenance Hemodialysis with Chronic Pain.

BACKGROUND: Legalization of cannabis across several US states may increase its use by individuals on hemodialysis, particularly among those with chronic pain. Contemporary data on frequency or factors associated with cannabis use by this population are limited. METHODS: We conducted a secondary analysis of the HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis, a randomized trial that tested whether a cognitive behavioral therapy intervention lowered pain interference in people with chronic pain receiving hemodialysis at 103 US dialysis facilities. We analyzed baseline demogr

Preventive Care, Screening, and Health Care Maintenance for Transgender Populations.

Transgender and gender diverse (TGD) people weather stigma and discrimination and experience significant barriers to preventive health care, contributing to disproportionate burdens of chronic diseases. Affirming approaches to preventive care improve trust, and every encounter presents an opportunity to support affirming clinical relationships with TGD patients. This article reviews best practices in preventive health in TGD populations including cancer screening, bone health, vaccinations, sexual health, cardiovascular risk, and behavioral health. Given limited data specific to trans patients

Large Language Models for Oncology Guideline Maintenance: Prospective Case Study.

BACKGROUND: Maintenance of oncology clinical practice guidelines (CPGs) is increasingly challenged by the rapid growth of trial data and therapeutic complexity. While large language models (LLMs) have shown promise in information retrieval, their utility in the rigorous, end-to-end workflow of guideline maintenance remains underexplored. OBJECTIVE: This case study aimed to systematically evaluate the performance of frontier LLMs in supporting oncology guideline maintenance. We sought to determine their reliability in predicting necessary guideline updates based on new evidence, their accuracy…

Predictors of Higher Mavacamten Maintenance Dose in Obstructive Hypertrophic Cardiomyopathy.

Mavacamten has emerged as an effective therapy for obstructive hypertrophic cardiomyopathy (oHCM); however, interindividual variability in maintenance dosing remains a practical challenge in clinical practice. We conducted a multicenter retrospective study of adults with oHCM treated with mavacamten across 3 tertiary sites to identify baseline predictors of higher maintenance dose requirements. Patients with at least 1-year follow-up and stable dosing for 6 months or more were included and categorized into low-dose (2.5-5 mg) and high-dose (10-15 mg) maintenance groups. Among 77 patients (mean…

Непрерывное обслуживание линалидомида: учет экологической ценности в множестве миеломы.

Данные отсутствуют.

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… maintenance improved progression -free survival but did not improve overall survival, while grade ≥3 nonhematologic adverse events were more frequent.1 These findings contribute to the ongoing discussion regarding the optimal duration of maintenance therapy. … This may be particularly relevant in hematology, where maintenance strategies can expose large numbers of patients to anticancer medicines for several years. …

Maintenance of neuronal TDP-43 expression requires axonal lysosome transport.

TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate TDP-43 in neurons are not well understood. We generated a Halo-TDP-43 knock-in human induced pluripotent stem cell (iPSC) line and performed a genome-wide CRISPR interference FACS-based screen to identify modifiers of TDP-43 levels in neurons. A meta-analysis of our screen and publicly available screens identified both specific hits and pathways present across multiple screens, the latter likely responsible for generic protein level maintenance. We identified BORC, a complex…

Dietary Macronutrient Composition and Protein Concentration for Weight Loss Maintenance.

OBJECTIVE: To examine the association between dietary macronutrient composition and 12-month weight loss maintenance (WLM) in adults who achieved initial weight loss (≥ 5%). METHODS: This prospective cohort analysis used 12-month follow-up data from the Navigating to a Healthy Weight trial. Macronutrient composition (%) was assessed using a 4-day, 24-h dietary recall. Food sources were categorized as discretionary foods, lean meat, vegetables, fruit, grains, and dairy. Primary outcomes included 12-month changes in body weight, fat mass index (FMI), waist-to-height ratio (WHtR), and hip-to-hei…

Hemispheric lateralization during maintenance of verbal and visuospatial working memory.

Early studies separate verbal working memory (VWM) in the left hemisphere from visuospatial working memory (SWM) in the right hemisphere, but later studies found inconsistent results. Functional transcranial Doppler sonography (fTCD) offers a cost-effective and portable alternative, measuring changes in cerebral blood flow velocity as an index of lateralized brain activity. This study aimed to investigate how material type influences hemispheric lateralization in WM. We used fTCD to measure blood flow velocity in the bilateral middle cerebral arteries of 39 healthy, right-handed volunteers (ag

Minichromosome Maintenance Complex Genes Are Candidate Biomarkers of Retinal Degeneration.

Purpose: Retinal degeneration is the primary cause of blindness and is characterized by progressive dysfunction and death of retinal cells, … ed on DNA replication in the enrichment analysis. PPI network analysis revealed that minichromosome maintenance complex genes associated with DNA replication were core genes for retinal degeneration. qPCR and immunohistochemistry assays showed that the expression levels of hub genes were downregulated in the NaIO3-treated cell and animal models. Conclusions: …

Exploring Maintenance Therapy in Pediatric Embryonal Tumor With Multilayered Rosettes.

Embryonal tumors with multilayered rosettes (ETMR) represent a distinct entity characterized by aggressive behavior. Historical retrospectiv … rapy, achieving a disease-free status after completing standard treatment. Subsequently, a 12-month maintenance regimen comprising intrathecal topotecan, oral sodium valproate, and oral cis-retinoic acid was administered. The maintenance therapy was well tolerated, with manageable adverse effects. The patient remains progression-free for 32 months postmainten …

PICC Maintenance Challenges Among Esophageal Cancer Patients: A Qualitative Study.

BACKGROUND: Esophageal cancer is a prevalent malignancy worldwide, often accompanied by dysphagia and malnutrition that necessitate long-term intravenous nutritional support. Peripherally Inserted Central Catheters (PICCs) have become a standard nursing practice to facilitate chemotherapy and parenteral nutrition in these patients. However, maintaining PICCs poses significant challenges that can affect patient adherence and outcomes. OBJECTIVE: This study aims to explore the experiences and needs of esophageal cancer patients regarding PICC maintenance after hospital discharge, with the goal …

Fibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population.

BACKGROUND: Sarcopenia is defined as the loss of muscle mass, strength, and/or performance. It is strongly associated with all-cause mortality. Fibroblast growth factor 23 (FGF23) is markedly elevated in patients with chronic kidney disease, especially those receiving maintenance dialysis. FGF23 has previously been shown to have a direct role in cardiac dysfunction mediated through left ventricular hypertrophy. However, its role in the development of (or protection from) sarcopenia is uncertain. This study is aimed at determining the relationship between FGF23 and muscle-related parameters and…

Soma-germline communication drives sex maintenance in the Drosophila testis.

In adult gonads, disruption of somatic sexual identity leads to defective gametogenesis and infertility. However, the underlying mechanisms by which somatic signals regulate germline cells to achieve proper gametogenesis remain unclear. In our previous study, we introduced the chinmoSex Transformation (chinmoST ) mutant Drosophila testis phenotype as a valuable model for investigating the mechanisms underlying sex maintenance. In chinmoST testes, depletion of the Janus Kinase-Signal Transducer and Activator of Transcription downstream effector Chinmo from somatic cyst stem cells (CySCs) femini…

Dialysate Sodium Lowering in Maintenance Hemodialysis: A Randomized Clinical Trial.

KEY POINTS: Treatment to dialysate sodium 135 versus 138 mEq/L led to no difference in the rate of change in intradialytic hypotension, but symptoms were greater in the low arm. Use of a dialysate sodium concentration of 135 versus 138 mEq/L led to a small reduction in interdialytic weight gain, but had no effect on predialysis BP. Raising dialysate sodium concentration from 135 to 140 mEq/L reduced intradialytic hypotension and was associated with a marked increase in BP. BACKGROUND: Lowering dialysate sodium concentration may improve volume and BP control in patients on maintenance hemodial…

Lupus activity and outcomes in lupus patients undergoing maintenance dialysis.

OBJECTIVES: Lupus activity has long been considered to decline after initiation of maintenance dialysis (MD). This assumption is based on limited historical data. We aimed to describe the natural history of lupus in patients undergoing MD. METHODS: We assembled a national retrospective cohort of lupus patients who started dialysis between 2008 and 2011, included in the REIN registry with a 5-year follow-up. We analysed healthcare consumption from the National Health Data System. We evaluated the proportion of patients 'off-treatment' (i.e. receiving 0-5 mg/d of corticosteroids, without any im…

Be SMART About Asthma Management: Single Maintenance and Reliever Therapy.

Single maintenance and reliever therapy (SMART) is an asthma treatment approach that utilizes combined inhaled corticosteroids and long-acting β-agonists for maintenance and quick relief therapy. Despite the evidence for its benefits in asthma treatment and its adoption into American and international asthma guidelines and recommendations, SMART remains a practice of some debate. This article reviews the available evidence for SMART and offers guidance for its integration into comprehensive asthma management. Overall, short-acting β-agonist-only asthma therapy regimens should be avoided, regar…