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Cannabinoid effective targeting of atherosclerotic plaquesin vivoby optimized-PLGA nanoparticles.

AIM: While selective CB2 receptor agonists hold significant promise for mitigating inflammation and atherosclerosis, their poor physicochemical properties have hampered clinical translation. To overcome this, we engineered a sophisticated, nanoparticle-based delivery system designed for precise cannabinoid deposition at atheromatous plaque sites. Our approach utilized PEGylated PLGA nanoparticles (NPs), functionalized with a peptide ligand specifically targeting vascular cell adhesion molecule-1 (VCAM-1), a well-established biomarker of atherosclerotic lesions. METHODS: PEGylated PLGA NPs wer…

Glycolipids Substitute PEG lipids in Lipid Nanoparticles for mRNA Delivery.

Lipid nanoparticles (LNPs) have become a pivotal platform for mRNA drug delivery, yet the immunogenicity of poly(ethylene glycol) (PEG) lipids compromises efficacy upon repeated administration, making it necessary to develop PEG-free LNP formulations. Carbohydrates share the highly hydrophilic properties of PEG, making them good alternatives. Here we report a chemically driven strategy to replace PEG lipids with rationally designed glycolipids synthesized via a one-pot Borch reductive amination reaction. This method enabled conjugation of maltoheptaose (G7) to alkyl diamines, forming glycolipi…

Nitrogen fixation using metallic lithium nanoparticles formed by electrospray deposition.

Multiphase reduction of ambient dinitrogen (N2) was observed during the deposition of charged or uncharged aqueous microdroplets containing a lithium salt pre-catalyst onto conducting or inert surfaces to yield mixed lithium nanoparticles. We propose that this method leverages the high electric fields and partial solvation of ions at the gas-water-solid interface to enhance reaction rates and perform normally moisture-sensitive chemistry in aqueous droplets. Ammonia (NH3) is formed and Li+ is regenerated from the hydrolysis of transient lithium nitride Li3N, constituting a complete catalytic c…

Carbohydrate polymer-based nanoparticles in curcumin delivery for cancer therapy.

The application of natural products for cancer treatment has a long history. The safety and multifunctionality of naturally occurring substances have made them appropriate for cancer treatment and management. Curcumin affects multiple molecular pathways and is advantageous for treating both hematological and solid tumors. Nonetheless, the effectiveness of curcumin in vivo and in clinical studies has faced challenges due to its poor pharmacokinetic profile. Consequently, nanoparticles have been developed for the administration of curcumin in cancer treatment. The nanoparticles can enhance the d…

Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity.

Neutrophils are rapidly recruited to sites of infection, injury, or to immune complexes. Upon arrival, they initiate degranulation, release … ellular space could contribute to the phenotypic heterogeneity of neutrophils. To find out, we used nanoparticles composed of intracellular proteins (cell-derived nanoparticles, CDNPs) and analyzed their effects on cultured murine bone marrow neutrophils (BMN). We observed that CDNPs activate BMN transiently with an increase in the expression of CD11b without t …

Uptake and efflux of mercury sulfide nanoparticles in Escherichia coli.

Mercury sulfide nanoparticles (HgS NPs) are ubiquitous in nature and are methylated to neurotoxic methylmercury (MeHg) by microorganisms. However, there is a paucity of knowledge regarding the biokinetics of HgS NPs in microorganisms. Here, the biokinetic uptake and efflux of HgS NPs in the model bacterium (Escherichia coli) were quantified and compared with those of Hg-dissolved organic matter complexes (Hg-DOM). The results demonstrate that the uptake of HgS NPs was time- and concentration-dependent. The uptake rate constant of HgS NPs was 0.031 ± 0.006 L g-1 h-1, which was 2.4-fold higher t…

Ultrasmall Superparamagnetic Magnetite Nanoparticles as Glutamate-Responsive Magnetic Resonance Sensors.

Glutamate, the primary excitatory neurotransmitter in the central nervous system, plays a pivotal role in synaptic signaling, learning, and memory. Abnormal glutamate levels are implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and ischemic stroke. Despite the utility of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in diagnosing such conditions, the development of effective glutamate-sensitive contrast agents remains a challenge. In this study, we present ultrasmall, citric acid-coated superparamagnetic iron oxide nanoparticles…

Nephroprotective Effects of Quercetin-Selenium Nanoparticles Against Glycerol-Induced AKI.

Acute kidney injury (AKI) is defined as a quick and often reversible decline in renal performance, as shown by elevated creatinine or reduced urine volume. AKI is a common illness, particularly among hospitalized cases, and can be observed in up to 7% of hospital admissions and 30% of ICU admissions. This study was designed to explore the nephroprotective potential of eco-synthesized quercetin-selenium nanoparticles (QUR-SeNPs) against experimentally glycerol-induced rhabdomyolysis leading to AKI. Forty healthy adult male albino rats were employed in the experiment. Animals were randomly distr…

Metronidazole-Loaded Chitosan Nanoparticles with Antimicrobial Activity Against Clostridium perfringens.

Background/Objectives: Even with improvements in surgical techniques and the application of appropriate antibiotic prophylaxis, wound infections are still major public health problems in low- and middle-income countries. This study proposes the design of new particulate polymeric matrices based on chitosan (CS) for the controlled release of Metronidazole (MTZ), in order for it to be used for the treatment of Clostridium perfringens infections. Methods: The nanoparticles were prepared via inverse emulsion using tannic acid (TA) and sodium tripolyphosphate (TPP) as cross-linking agents. The rati…

Photothermal Performance of 2D Material-Based Nanoparticles for Biomedical Applications.

Photothermal therapy (PTT) is one of the rapidly developing methods for cancer treatment based on the strong light-to-heat conversion by nanoparticles. Over the past decade, the palette of photonic materials has expanded drastically, and nanoparticle fabrication techniques can now preserve the optical response of a bulk material in produced nanoparticles. This progress potentially holds opportunities for the efficiency enhancement of PTT, which have not fully explored yet. Here we study the photothermal performance of spherical nanoparticles (SNs) composed of novel two-dimensional (2D) and con…

Antioxidant polymer nanoparticles ameliorate cancer cachexia via intestinal ROS scavenging.

Cancer cachexia affects approximately 80% of patients with advanced cancer, leading to anorexia, weight loss, and severe muscle wasting that … g systemic inflammation associated with cancer cachexia. We orally administered antioxidant polymer nanoparticles (siSMAPoTN), designed to localize in the intestinal lumen and selectively scavenge reactive oxygen species (ROS), to tumor-bearing cancer cachexia model mice. As a result, siSMAPoTN treatment suppressed plasma IL-6 elevation, mitigated muscle protei …

Femtosecond laser-ablative aqueous synthesis of multi-drug antiviral nanoparticles.

BACKGROUND: Nanomedicine offers a number of innovative strategies to address major public health burdens, including complex respiratory illn … epithelial cell-air-liquid interface culture model was used to analyze the antiviral effect of our nanoparticles against Influenza Virus A. RESULTS: Our final nanoparticle exhibited a positive zeta potential with a diameter of ~73 nm. Remdesivir, baloxavir marboxil, and dexamethasone were all present in the nanoparticle suspension at a 1:1:1 ratio. Notably, t …

Myeloid cell-targeted lipid nanoparticles for B cell lymphoma immunotherapy.

We previously demonstrated that blocking tolerogenic signal transducer and activator of transcription 3 (STAT3) signaling in the tumor microenvironment can unleash Toll-like receptor 9 (TLR9)-mediated antitumor immunity. To enable systemic administration of minimally modified CpG-siSTAT3, we developed a panel of MC3-based lipid nanoparticle (LNP) formulations optimized for targeting immune cells and B cell lymphoma cells. The selected LNP2(CpG-siSTAT3) induced potent type I interferon (IFN) production in human peripheral blood mononuclear cells (PBMCs) and resulted in >50% STAT3 knockdown in h

Therapeutic potential of greenly synthesized selenium nanoparticles against experimental cyclosporiasis.

Cyclospora cayetanensis (C. cayetanensis), an opportunistic intracellular coccidian, is responsible for chronic debilitating diarrheal outbreaks possessing life-threatening penalties, especially in immunocompromised patients. The solemn therapeutic agents against cyclosporiasis are limited by their grave effects and high recurrence rate. The current study aimed to utilize greenly synthesized selenium nanoparticles (SeNPs) and evaluate their therapeutic efficacy on cyclosporiasis in immunosuppressed murine models. They were biosynthesized proficiently using Alcaligenes faecalis and characterize…

Ginsenoside Rb1/baicalein nanoparticles: a potential nanomedicine for toxoplasmosis therapy.

Toxoplasma gondii (T. gondii), a globally prevalent zoonotic parasite, infects nucleated cells in warm-blooded animals, posing major public health risks. Current treatments (sulfadiazine/pyrimethamine) for the widespread parasite T. gondii have poor cyst penetration and significant side effects. While the natural compound baicalein (BAI, C₁₅H₁₀O₅) shows potent anti-T. gondii activity, its low solubility and high toxicity limit therapeutic use. To overcome BAI's limitations, we engineered ginsenoside Rb1-based nanoparticles (GRb1/BAI NPs) via self-assembly, leveraging GRb1's dual role as a bioc…

Nano Revolution: Harnessing Nanoparticles to Combat Antibiotic-resistant Bacterial Infections.

Nanoparticles, defined as particles ranging from 1 to 100 nanometers in size, are revolutionizing the approach to combating bacterial infections amid a backdrop of escalating antibiotic resistance. Bacterial infections remain a formidable global health challenge, causing millions of deaths annually and encompassing a spectrum from common illnesses like Strep throat to severe diseases such as tuberculosis and pneumonia. The misuse of antibiotics has precipitated the rise of resistant strains like methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Mycobacterium tuberculosis …

Наночастицы на основе церия для нейродегенерации: возникающие редоксальные препараты, выходящие за рамки фармацевтических препаратов.

Доставка терапевтических агентов через барьер мозга крови (ББД) остается серьезным препятствием в лечении нейродегенеративных заболеваний, которые движутся главным образом из-за митохондриальной дисфункции, окислительного стресса и нейронного воспаления. Хотя наше понимание этих болезнетворных механизмов улучшилось, эффективные методы лечения по-прежнему ограничены из-за ограничительного характера ББД. В этом контексте нанотехнология стала многообещающим подходом, предлагающим инженерные нанокарьеры, способные пересечь ББД и обеспечить целевую доставку наркотиков в мозг. Среди различных изучен

Совпадение в аннотации оригинала
Delivering therapeutic agents across the blood-brain barrier (BBB) remains a formidable hurdle in the treatment of neurodegenerative disease … bling targeted drug delivery to the brain. Amongst the various nanomaterials explored, cerium-based nanoparticles have gained particular attention as promising candidates for neurodegenerative disease therapy. Their multifunctionality stemming from reversible redox behaviour, enzyme-mimicking activity, sustained antioxidant effects, and anti-inflammatory proper …

Counteractive Effects of Copper Nanoparticles and Betacellulin on Ovarian Cells.

Copper nanoparticles (CuNPs) are known to affect many ovarian cell functions. CuNPs, prepared using a chemical reduction method, were fully characterized by different means (TEM, DLS, XRD, Z potential, XPS, and AES). The resulting colloidal suspension contained needle-like CuNPs aggregates made of a core of metallic copper and an oxidized surface of Cu2O and CuO. The separate and coupled effects of CuNPs and the growth factor betacellulin (BTC) were analyzed on the control of some basic functions of ovarian cells. With this purpose, porcine ovarian granulosa cells, together with CuNPs, BTC, an…

Gold Nanoparticles Confined in Mesoporous Bioactive Glass for Periodontitis Therapy.

Periodontitis is a chronic disease caused by bacterial infection and is characterized with alveolar bone resorption. Bone regeneration in periodontitis remains a critical challenge because bacterial infection induced an unfavorable microenvironment for osteogenesis. Therefore, it is necessary to design proper therapeutic platforms to control bacterial infection and promote bone regeneration. Herein, mesoporous bioactive glass (MBG) with different pore sizes (3.0, 4.3, and 12.3 nm) was used as an in situ reactor to confine the growth of gold nanoparticles (Au NPs), forming MBG@Au hybrids which …

Development of solid lipid nanoparticles-loaded drugs in parasitic diseases.

Parasites cause illnesses with broad spectrum of symptoms from mild to severe, and are responsible for a significant number of outbreaks in the world. Current anti-parasitic drugs are toxic and have significant side effects. Nano-carriers are believed to obviate the limitations of conventional drugs via decreasing side effects and increasing target delivery and drug permeability with a controlled prolonged release of a drug. Solid lipid nanoparticles (SLNs) are lipid nanoparticles (LNPs), which have frequently been practiced. Suitable release rate, stability, and target delivery make SLNs a go…