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Extraosseous Plasmacytoma Confers Poor Outcomes in Primary Plasma Cell Leukemia.

BACKGROUND: Primary plasma cell leukemia (PPCL) is one of the most aggressive diseases in oncohematology. Due to its low incidence, there is no established standard treatment, and it is considered an incurable disease. AIMS: This study presents our experience and outcomes of 92 cases of PPCL between January 2011 and December 2020. METHODS: Fat pad biopsy was positive for Congo red in six (35%) of 17 patients, solitary extraosseous plasmacytoma was observed in 30 (32.5%), and bone marrow fibrosis was identified in 81 (88%) patients. RESULTS: While most patients (69.5%) received conventional

Differential Pathways Orchestrate Plasma-Cell Infiltration in Liver Autoimmunity Diseases.

BACKGROUND & AIMS: Plasma cells (PCs) are frequently infiltrating livers from autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). However, the molecular pathway(s) implicated remain largely undefined. METHODS: A retrospective in situ study was performed to assess the cells and molecules involved in PC chemotactism and survival. Relevant in vitro assays were conducted to confirm the activity of the identified molecules. RESULTS: We found that myeloid cells producing the PC survival factor a proliferation-inducing ligand (APRIL) were present in livers from both diseases. Notably,…

Необычные образования, необычные задачи: обзор нарушений ячеек из реалистической плазмы.

Редкие расстройства плазменных клеток, включая IgD, IgE и IgM, множественные миеломы, несекретарские миэломы (NSMM), лейкемию плазмы (PCL) и тяжелые цепные заболевания (HCD), биологически неоднородны и часто присутствуют с атипичными характеристиками и агрессивным поведением. В этом обзоре обобщаются текущие данные об их эпидемиологии, патофизиологии, диагностике и лечении. Достижения в протеиновых ингибиторах, иммуномудуляторных агентах и аутологической трансплантации улучшили результаты в отдельных подтипах. Вместе с тем сохраняются проблемы, связанные с проведением различия между миэломой И

Совпадение в полном тексте источника
… Plasma Cell Leukemia (PCL) Plasma cell leukemia (PCL) ( Table 5 ) is a rare and aggressive plasma cell disorder defined by the presence of circulating plasma cells in the peripheral blood. … Traditionally, the diagnosis required either an absolute plasma cell count exceeding 2 × 10⁹/L or plasma cells comprising more than 20% of peripheral blood leukocytes. …

[Chinese expert consensus on the diagnosis and treatment of plasma cell leukemia (2025)].

Plasma cell leukemia (PCL) is a rare and highly aggressive form of plasma cell dyscrasia, distinguished by its rapid clinical course and dismal prognosis. This guideline is intended to offer clinicians evidence-based, comprehensive recommendations encompassing diagnostic criteria, risk stratification, therapeutic approaches-including frontline treatment, hematopoietic stem cell transplantation, and the incorporation of novel therapeutic agents-as well as protocols for long-term follow-up. The overarching objective is to promote standardized clinical management and ultimately enhance both survi

Совпадение в полном тексте источника
… BC Outcomes and treatment patterns in primary and secondary plasma cell leukemia: insights from a large US cohort study[J] Haematologica 2025 10.3324/haematol.2024.287158 PMC12399943 40241568 3 Jurczyszyn A Castillo JJ Avivi I Secondary plasma cell leukemia: a multicenter retrospective study of 101 … F Rihova L Plasma cell leukemia: from biology to treatment[J] Eur J Haematol 2015 95 1 16 26 10.1111/ejh.12533 25778450 10 Bezdekova R Jelinek T Kralova R Necessity of flow cytometry assessment of circulating plasma cells and its connection with clinical characteristics of primary and secondary plasma …

Diurnal Effects on the Fraction of Fetal Cell-Free DNA in Maternal Plasma.

OBJECTIVE: The discovery of fetal cell-free DNA (cfDNA) has revolutionized prenatal diagnostics through non-invasive prenatal testing (NIPT), which depends on accurately measuring the fetal fraction (FF) in maternal plasma. While FF is known to be influenced by maternal and fetal factors, the impact of intraday rhythms remains unclear. This study investigated whether FF varies based on blood draw timing. METHODS: Data from 2519 euploid singleton pregnancies undergoing NIPT were analyzed. Key variables included maternal age, BMI, gestational age, fetal sex, and blood draw timing (06:50-21:00).

The efficacy of teclistamab in patients with multiple myeloma and secondary plasma cell leukemia.

INTRODUCTION: Hepatitis E virus (HEV) is a global cause of acute viral hepatitis, for which there is currently no FDA-approved medication. This case report describes a unique instance of a healthy US female presenting with acute HEV, who was treated with ribavirin to address her acute liver injury. CASE PRESENTATION: A 36-year-old US female, nonpregnant, without liver disease, developed nonspecific symptoms post-travel to Indonesia, leading to acute liver injury with concern for failure. Liver biopsy showed severe hepatocellular necrosis (>50%) with mixed infiltrate; HEV PCR was positive (93,

CircBRIP1: a plasma diagnostic marker for non-small-cell lung cancer.

BACKGROUND: Circular RNA (circRNA), which has been demonstrated in studies to be abundantly prevalent in tumor cells and bodily fluids and to play a significant role in tumors, has the potential for biological markers to be used to assist tumor diagnosis. This study mainly discusses the potential of circBRIP1 as a biomarker for diagnosing non-small-cell lung cancer (NSCLC). METHODS: First, high-throughput sequencing screened the differentially expressed circBRIP1, and real-time fluorescence quantitative PCR (qRT-PCR) verified its expression in NSCLC. Next, sanger sequencing, agarose gel elect

Cell-Penetrating Drug Carrier by Molecular Recognition of Sphingomyelin on Plasma Membranes.

Plasma membranes not only maintain the intracellular microenvironment through their phospholipid bilayer but also eliminate exogenous compounds outside the cell membranes. Most drugs especially with high polarity are prevented from entering into cells to exert their effects. Therefore, it is of great significance to design effective drug carriers with a penetrating ability toward plasma membranes. In this study, a dual-templated MIP (dt-MIPs) carrier with controllable microstructure and high drug loading capacity was prepared using highly expressed sphingomyelin on the plasma membrane and teno

FDG PET/CT in Cutaneous Involvement of Plasmablastic Plasma Cell Myeloma.

Extraosseous manifestations are found in less than 5% of patients with multiple myeloma. They can arise in any tissue, and their presence has been associated with more aggressive disease. We present FDG PET/CT findings of immunoglobulin A κ multiple myeloma with innumerable hypermetabolic right lower extremity lesions of cutaneous and subcutaneous involvement of plasmablastic plasma cell myeloma in a 44-year-old man.

Injection Drug Use Alters Plasma Regulation of the B Cell Response.

The opioid epidemic continues to be a major public health issue that includes millions of people who inject drugs (PWID). PWID have increased incidence of serious infections, including HIV as well as metabolic and inflammatory sequelae. We sought to discern the extent of systemic alterations in humoral immunity associated with injection drug use, including alterations in the plasma proteome and its regulation of B cell responsiveness. Comprehensive plasma proteomics analysis of HIV negative/hepatitis C negative individuals with a history of recent injection heroin use was performed using mass

Retrospective Case Series of Cocaine-Associated Plasma Cell Orificial Mucositis.

IMPORTANCE: Plasma cell orificial mucositis (PCOM) associated with cocaine use is an emerging, rare condition that has become a concern in S … ions were observed in 4 (40%) of the patients. Biopsies revealed a dense inflammatory infiltrate of plasma cells in the dermis without atypia and with eosinophils. All patients reported recent cocaine use. Three urine tests detected cocaine but found no presence of amphetamines or opiates. Six patients improved with corticosteroid therapy. Up to 60% of patient …

Atypical Plasma Cell Leukemia Mistaken for Acute Leukemia: A Case Report.

The patient we present here had many clinical, morphological, and laboratory findings characteristic of acute leukemia. During the course of … mative. This patient has unusual clinical presentation, a nondescript morphology of the circulating plasma cells, as well as an immunophenotype, detected by the initial panels used for flow cytometry and immunohistochemistry, that was not entirely specific for plasma cells. Such cases present a good reminder of the diagnostic complexity of atypical plasma cell …

IgE Plasma Cell Leukemia Harboring t(11;14) and 1q Amplification.

IgE plasma cell neoplasm is the rarest subtype of plasma cell neoplasms and is known for its poor prognosis and high incidence of t(11;14). … nodes. Plasma cell infiltration was pathologically confirmed in each organ. Cytogenetic analysis of plasma cells revealed t(11;14) and amplification of 1q21. Chemotherapy, with immunomodulatory imide drugs, proteasome inhibitors, and CD38 antibodies, was unsuccessful. In IgE plasma cell neoplasm, coexistence of other cytogenetic abnormalities with t(11;14) may …

Therapeutic plasma exchange for mechanical red cell hemolysis: A case series.

We present three cases of severely elevated plasma free hemoglobin (PFH) in pediatric patients on mechanical circulatory support devices at a tertiary pediatric care center. Due to severe levels of PFH in the setting of critical illness with the inability to pursue immediate mechanical device exchange, membrane filtration therapeutic plasma exchange (TPE) was performed, which resulted in a lowering of PFH levels. However, long-term outcomes were heterogeneous across the cases. This case series reviews patient presentation, organ function before and after TPE, and the overall role of TPE as an

Plasma Cell Leukemia with Successful Upfront Venetoclax in Combination with Allogeneic Transplantation.

BACKGROUND Plasma cell leukemia (PCL) is an aggressive form of plasma cell neoplasm. We report the first case of primary PCL successfully tr … lesions. Bone marrow investigations confirmed the presence of lambda-light-chain-restricted clonal plasma cells. FISH detected t(11;14) and 17p13.1 deletion. Therefore, a final diagnosis of primary PCL was made. The patient received 1 cycle of bortezomib, cyclophosphamide, and dexamethasone (VCD) and 5 cycles of Venetoclax-VCD, followed by an unsuccessful ste …

Dietary and microbiome evidence in multiple myeloma and other plasma cell disorders.

Multiple Myeloma (MM) remains an incurable plasma cell neoplasm. Although little is known about the etiology of MM, several metabolic risk factors such as obesity, diabetes mellitus, diet, and the human intestinal microbiome have been linked to the pathogenesis of MM. In this article, we provide a detailed review of dietary and microbiome factors involved in the pathogenesis of MM and their impact on outcomes. Concurrent with treatment advancements that have improved survival in MM, focused efforts are needed to reduce the burden of MM as well as improve MM specific and overall outcomes once M

[Pathological significance of plasma cell infiltration in diagnosing lymph node diseases].

Objective: To investigate the value of plasma cells for diagnosing lymph node diseases. Methods: Common lymphadenopathy (except plasma cell neoplasms) diagnosed from September 2012 to August 2022 were selected from the pathological records of Changhai Hospital, Shanghai, China. Morphological and immunohistochemical features were analyzed to examine the infiltration pattern, clonality, and IgG and IgG4 expression of plasma cells in these lymphadenopathies, and to summarize the differential diagnoses of plasma cell infiltration in common lymphadenopathies. Results: A total of 236 cases of lympha…

The Impact of Cell-free Plasma DNA on Metastatic and Nonmetastatic Prostate Cancer.

UNLABELLED: Intorductuion: Increased cell-free DNA (cfDNA) is observed in many diseases such as cancer, myocardial infarction, and autoimmune diseases. It has the ability to alter the receptor cell phenotype, triggering events related to malignant transformation. AIMS: Our study aims at assessing the use of cell-free plasma DNA in the diagnosis of metastatic and non-metastatic prostate cancer. METHODS: The study included 180 subjects who were classified into four groups: Group I (GI) included 50 perfect health subjects as the control group, Group II (GII) included 40 patients with prostatiti