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[Therapeutic Effect of Cang-Ai Volatile Oil on High-Altitude Rats With Cardiac Hypertrophy Through Modulation of Oxidative Stress Response].

OBJECTIVE: To explore the therapeutic effect of Cang-ai volatile oil (CAVO) on rats with myocardial hypertrophy (MH) exposed to the hypobaric hypoxic environment of the Qinghai-Tibet Plateau using 7.0-tesla (7.0T) cardiac magnetic resonance imaging (CMR). METHODS: A total of 50 male specific pathogen-free (SPF) Sprague-Dawley (SD) rats were randomly assigned to a low-altitude control (CON) group, hypobaric hypoxia (HH) group, myocardial hypertrophy modeling (MH) group, MH modeling plus CAVO treatment (MH+CAVO) group, and MH modeling plus benadryl hydrochloride treatment (MH+RX) group, with 10…

Epidemiology of alveolar echinococcosis with particular reference to China and Europe.

Human alveolar echinococcosis (AE), caused by the metacestode of the fox tapeworm Echinococcus multilocularis, is the most pathogenic zoonos … s): including Gansu Province, Ningxia Hui Autonomous Region, Sichuan Province, Qinghai Province and Tibet Autonomous Region and (3) Northwestern China: including Xinjiang Uygur Autonomous Region, bordered with Mongolia, Russia, Kazakhstan and Kyrgyzstan. The highest prevalence of the disease, up to 15 per cent of the population in some villages, is reac …

Hypertension status and its risk factors in highlanders living in Ganzi Tibetan Plateau: a cross-sectional study.

BACKGROUND: The updated status of hypertension and its risk factors are poorly evaluated in Tibetan highland areas. We initiated a large-scale cross-sectional survey to provide updated status of hypertension and its risk factors (especially salt intake) in the Ganzi Tibetan Plateau, China. METHODS: Stratified multistage random sampling was performed to obtain a representative sample of 4,036 adult residents from 4 counties in the Ganzi Tibetan area. The whole survey population was used to present the epidemiology and risk factors of hypertension. The participants with blood and urine biochemi…

Neuroprotection against cerebral ischemia/reperfusion by dietary phytochemical extracts from Tibetan turnip (Brassica rapa L.).

ETHNOPHARMACOLOGICAL RELEVANCE: The Tibetan turnip (Brassica rapa L.) has a wide array of medicine properties including heat-clearing, detoxifying and anti-hypoxia as listed in the famous centuries-old Tibetan medicine classic "The Four Medical Tantras". Evidence-based medicine also indicated the anti-hypoxic effect of turnips, suggesting a potential link to neuroprotective effect on ischemic stroke. This thereby enables turnips to serve as a novel nontoxic agent in related treatment. AIM OF THE STUDY: This study aimed to investigate the neuroprotective effect and elucidate the mechanism of a…

Burden of respiratory tract cancers in China and its provinces, 1990-2021: a systematic analysis of the Global Burden of Disease Study 2021.

BACKGROUND: Respiratory tract cancers emerged as a public health challenge with the highest incidence and mortality among all cancer types i … ortality rates, particularly Shandong, with the highest new cases at 77,225 (58,842-101,352), while Tibet, Qinghai, and Macau observed the lowest. Regarding laryngeal cancer, Guangdong reported the highest incidence at 3466 (2230-4934), with Hainan exhibiting the highest ASIR at 3.46 (2.10-5.11) per 100,000 person-years and ASMR at 2.11 (1.37-3.09) per …

Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets.

A genome-wide association study of gout in European populations identified 12 genetic variants strongly associated with risk of gout, but it is unknown whether these variants are also associated with gout risk in Chinese populations. A total of 145 patients with gout and 310 healthy control patients were recruited for a case-control association study. Twelve SNPs of CLNK and ZNF518B gene were genotyped, and association analysis was performed. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the association. Overall, we found four risk alleles for gout in patients: the

Molecular characterization and expression of TGFβRI and TGFβRII and its association with litter size in Tibetan sheep.

BACKGROUNDS: Transforming growth factor-β (TGF-β) type I receptor (TGFβRI) and type II receptor (TGFβRII) are the members of the TGFβ superfamily, which are potent regulators of cell proliferation and differentiation in many organ systems, and they play key roles in multiple aspects of follicle development. OBJECTIVES: We aimed to explore the characterization, expression analysis of TGFβRI and TGFβRII genes, and the association with litter size in Tibetan sheep. METHODS: In this study, we cloned the complete coding sequences of TGFβRI and TGFβRII genes in Tibetan sheep and analyzed their gen…

[Spatial-temporal Characteristics Evolution of Land Use Carbon Emissions in China from 2000 to 2021 and Carbon Emission Prediction].

The spatiotemporal evolution of carbon emissions and its future trend prediction， as an important scientific issue in response to global cli … tern regions will reach their peak around 2027. The potential for carbon neutrality in regions like Tibet， Qinghai， and Inner Mongolia is significant， while heavy industrial provinces such as Shandong， Liaoning， and others face notable pressure， requiring collaborative solutions of carbon-negative technologies and ecological compensation.

Tuberculosis disease burden in China: a spatio-temporal clustering and prediction study.

INTRODUCTION: The primary aim of this study is to investigate and predict the prevalence and determinants of tuberculosis disease burden in … ESULTS: This study reveals significant regional variations in PTB incidence and mortality in China. Tibet (124.24%) and Xinjiang (114.72%) in western China exhibited the largest percentage change in tuberculosis (TB) incidence, while Zhejiang Province (-50.45%) and Jiangsu Province (-51.33%) in eastern China showed the largest decreases. Regions with si …

China Stroke Statistics: an update on the 2019 report from the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations.

China faces the greatest challenge from stroke in the world. According to results from the Global Burden of Disease Study 2019, there were 3 … her proportions of interprovincial admission to other provinces were seen in Inner Mongolia, Anhui, Tibet and Beijing. Higher proportions of interprovincial admission from other provinces were seen in Beijng, Tianjin, Shanghai and Ningxia. Data from 323 601 strokes from 1337 hospitals in the Chinese Stroke Center Alliance during 2019 demonstrated that t …

Tsantan Sumtang attenuated chronic hypoxia-induced right ventricular structure remodeling and fibrosis by equilibrating local ACE-AngII-AT1R/ACE2-Ang1-7-Mas axis in rat.

ETHNOPHARMACOLOGICAL RELEVANCE: Tsantan Sumtang, which consists of Choerospondias axillaris (Roxb.) Burtt et Hill, Myristica fragrans Houtt and Santalum album L, is a traditional and common prescription of Tibetan medicine. Tsantan Sumtang originates from Four Tantra with properties of nourishing heart and has been used as a folk medicine for cardiovascular diseases and heart failure in Qinghai, Tibet and Inner Mongolia. Our previous studies found that Tsantan Sumtang showed beneficial effects on right ventricular structure in hypoxia rats, while the underling mechanism remains unclear. AIM O…

The relationship of fluorosis and brick tea drinking in Chinese Tibetans.

Brick tea-drinking fluorosis is an unusual environmental problem. As a result of an investigation of tea-drinking habits, total fluoride intakes, dental fluorosis, and skeletal fluorosis, this disease has been found in the Sichuan Province of China in Tibetans with a long history of drinking brick tea. The dental fluorosis investigation of 375 Tibetan children (213 males, 162 females) and 161 Han children (86 males, 75 females), 8-15 years of age, was carried out in Daofu County, Sichuan Province. According to the standard of the Chinese Health Ministry, a skeletal fluorosis survey of 658 Tibe…

Контрольный показатель прогресса в борьбе с раком, обусловленным конкретными причинами, в Китае: общенациональный анализ преждевременной смертности в результате 1990 в адрес 2023.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Организация Объединенных Наций достигла цели в области устойчивого развития 3.4 (ЦУР) 3.4), цель которого заключается в сокращении за счет one- третья ранняя смертность от неинфекционных заболеваний, включая рак, 2030. Однако все еще не проведена всеобъемлющая оценка исторических тенденций и прогнозов преждевременной смертности от рака на национальном, региональном уровнях и по типам рака. Мы провели оценку преждевременной смертности в разбивке по полу, возрасту и возрасту. 33 Провинции Китая с использованием результатов глобального исследования бремени болезней 2023. Ра

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… Shanxi; Northeast: Heilongjiang, Jilin, Liaoning; East: Anhui, Fujian, Jiangsu, Jiangxi, Shandong, Shanghai, Zhejiang; South: Guangdong, Guangxi, Hainan, Hong Kong, Macao; Central: Hubei, Hunan, Henan; Northwest: Ningxia, Qinghai, Shaanxi, Xinjiang, Gansu; Southwest: Chongqing, Guizhou, Sichuan, Yunnan, Tibet … Stomach cancer was the foremost cause of premature cancer-related mortality for men in several northwestern provinces, such as Qinghai, Gansu, Ningxia, and Tibet. The highest premature mortality in Tibet, Gansu and Qinghai Province was stomach cancer among both males and females. …

Polymorphism and peptide-binding specificities of porcine major histocompatibility complex (MHC) class I molecules.

The swine lymphocyte antigen class I (SLA I) is a highly polymorphic gene superfamily that plays an important role in swine anti-viral immune responses. However, an understanding of the highly variable sites and peptide-binding specificities of SLA I molecule is limited. In this study, a total of 27 SLA I alleles were identified from 3 Tibetan wild boars and 3 Heishan pigs. The phylogenetic relationship between the Tibetan wild boar and other breeds was analyzed using bioinformatics methods, and the highly variable sites were noted in the three dimensional structures of SLA I. Peptides from th…

Survey of tuberculosis drug resistance among Tibetan refugees in India.

SETTING: Tuberculosis (TB) is a major health problem among Tibetans living in exile in India. Although drug-resistant TB is considered common in clinical practice, precise data are lacking. OBJECTIVE: To determine the proportion of drug-resistant cases among new and previously treated Tibetan TB patients. DESIGN: In a drug resistance survey in five Tibetan settlements in India, culture and drug susceptibility testing (DST) for first-line drugs were performed among all consecutive new and previously treated TB cases from April 2010 to September 2011. DST against kanamycin (KM), ethionamide, p…

Post-treatment follow-up study of abdominal cystic echinococcosis in tibetan communities of northwest Sichuan Province, China.

BACKGROUND: Human cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus, with the liver as the most frequently affected organ, is known to be highly endemic in Tibetan communities of northwest Sichuan Province. Antiparasitic treatment with albendazole remains the primary choice for the great majority of patients in this resource-poor remote area, though surgery is the most common approach for CE therapy that has the potential to remove cysts and lead to complete cure. The current prospective study aimed to assess the effectiveness of community based use of cyclic al…

Prevalence, risk factors, and adverse maternal and fetal outcomes of anemia during pregnancy: a retrospective study in China, 2012-2020.

BACKGROUND: Anemia is a public world health problem among pregnant females especially in developing countries. China is a representatively d … from the National Maternal Near Miss Surveillance System (NMNMSS). The study covered 30 provinces (Tibet excluded), eastern, central, and western regions, both rural and urban areas, as well as medical institutions at all levels. A total of 438 medical institutions participated, with 12, 572, 647 singleton pregnant women and 237, 864 multiple pregnant …

National, regional, and provincial prevalence of glaucoma in China in 2020: an updated systematic review and modelling analysis.

BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide, with a significant disease burden in China. Accurate prevalen … vinces or municipalities, Shanghai had the highest POAG prevalence (0.80%, 95% CI = 0.56, 1.12) and Tibet showed the lowest (0.56%, 95% CI = 0.40, 0.80). Regarding PACG, Sichuan had the highest prevalence (0.92%, 95% CI = 0.68, 1.25), whereas Beijing exhibited the lowest (0.56%, 95% CI = 0.42, 0.76). The pooled prevalence of secondary glaucoma and conge …

[Prevalence of human soil-borne nematode infections in Yunnan Province: a cross-sectional study in 2015].

OBJECTIVE: To investigate the current prevalence of human soil-borne nematode infections in Yunnan province, so as to provide the scientific … ological zones, the highest prevalence of human soilborne nematode infections was found in the East Tibet-South Sichuan Ecological Zone (31.79%), and among the 10 survey counties (cities), the greatest prevalence was seen in Gongshan Derung and Nu Autonomous County (50.13%), while the lowest prevalence was found in Ninglang Yi Autonomous County (0.40%). …

Neural network correlates of high-altitude adaptive genetic variants in Tibetans: A pilot, exploratory study.

Although substantial progress has been made in the identification of genetic substrates underlying physiology, neuropsychology, and brain organization, the genotype-phenotype associations remain largely unknown in the context of high-altitude (HA) adaptation. Here, we related HA adaptive genetic variants in three gene loci (EGLN1, EPAS1, and PPARA) to interindividual variance in a set of physiological characteristics, neuropsychological tests, and topological attributes of large-scale structural and functional brain networks in 135 indigenous Tibetan highlanders. Analyses of individual HA adap…