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Evaluation of bioactivities of zinc oxide, cadmium sulfide and cadmium sulfide loaded zinc oxide nanostructured materials prepared by nanosecond pulsed laser.

The present study reports the preparation of cadmium sulfide (CdS) loaded zinc oxide (ZnO) nanostructured semiconductor material and its anti-bioactivity studies against cancerous and fungus cells. For composite preparation, two different mass ratios of CdS (10 and 20%) were loaded on ZnO (10%CdS/ZnO, 20%CdS/ZnO) using a 532 nm pulsed laser ablation in water media. The structural and morphological analyses confirmed the successful loading of nanoscaled CdS on the surface of ZnO particles, ZnO particles were largely spherical with average size ~50 nm, while CdS about 12 nm in size. The elementa…

Zinc uptake system ZnuACB is essential for maintaining pathogenic phenotype of F4ac+ enterotoxigenic E. coli (ETEC) under a zinc restricted environment.

Zinc is the second trace element of living organisms after iron. Given its crucial importance, mammalian hosts restrict the bioavailability of Zinc ions (Zn2+) to bacterial pathogens. As a countermeasure, pathogens utilize high affinity Zn2+ transporters, such as ZnuACB to compete with the host for zinc. It is essential for bacteria to maintain zinc homeostasis and thus maintain their physiology and pathogenesis. In an attempt to uncover the zinc transporter in F4+ enterotoxigenic E. coli (ETEC) C83902, we analyzed two RNA-seq data sets of bacteria samples when different zinc treatments (restr…

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.

Airway mucus hyperproduction and fluid imbalance are important hallmarks of cystic fibrosis (CF), the most common life-shortening genetic di … rway epithelial cells specifically and highly expressed a unique, alternative splice isoform of the zinc importer ZIP2/SLC39A2 (ΔC-ZIP2), which lacks the C-terminal domain. Importantly, ΔC-ZIP2 levels correlated inversely with wild-type ZIP2 and intracellular Zn2+ levels. Moreover, the splice switch to ΔC-ZIP2 as well as decreased expression of other Z …

Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial.

OBJECTIVE: Serum zinc level might be related to pathogenesis of febrile seizure (FS). The purpose of this study was to evaluate efficacy and safety of oral zinc supplementation on FS recurrence prevention in non-zinc-deficient children. MATERIALS AND METHODS: In a randomized clinical study, one hundred 18 to 60 mo old children with normal zinc level with first simple FS were referred to Shahid Sadoughi Hospital, Yazd, Iran from May 2012 to June 2013, were randomly assigned to two groups to receive 2 mg/kg/d zinc sulfate for six consecutive months or placebo as control group and were followed …

Effects of high zinc diets using zinc propionate on molt induction, organs, and postmolt egg production and quality in laying hens.

This study was conducted to determine the ability of an alternative salt form of 1% Zn, Zn propionate, to induce molt in 66-wk-old hens. The … from each other, but all were (P < 0.05) lighter than the ovary weights of nonmolted control hens. Zinc concentrations in the kidney and liver were (P < 0.05) increased in Zn acetate and Zn propionate molted hens when compared with nonmolted hens on the control diet or hens molted by feed withdrawal. Bone ash values were (P < 0.05) increased for Zn ac …

Poplar metal tolerance protein 1 confers zinc tolerance and is an oligomeric vacuolar zinc transporter with an essential leucine zipper motif.

Cation diffusion facilitator (CDF) proteins are a recently discovered family of cation efflux transporters that might play an essential role … to the vacuolar membrane both in yeast and in plant cells, consistent with a function of PtdMTP1 in zinc sequestration. Overexpression of PtdMTP1 in Arabidopsis confers Zn tolerance. We show that PtdMTP1, when expressed in yeast and Arabidopsis, forms homooligomers, a novel feature of CDF members. Oligomer formation is disrupted by reducing agents, ind …

Maternal essential fatty acid supplementation increases zinc absorption in neonatal rats: relevance to the defect in zinc absorption in acrodermatitis enteropathica.

Pregnant zinc deficient and zinc adequate rats were injected subcutaneously with evening primrose oil throughout gestation and for 3 days post partum. The nursing pups were injected intragastrically with zinc-65 on day 3 of live and sacrifices 4 h later. The % of the total injected zinc recovered in the carcass (minus the gut and gut contents) was significantly increased in those pups nursed by mothers injected with evening primrose oil, regardless of their dietary zinc intake. The fatty acid composition of the total lipid extract of the gut and gut contents of the neonates with increased zinc…

Длительное использование цинка для дисгейзии, вызывающее нехватку меди.

Цинк является микроэлементом, необходимым для восприятия вкуса и может быть прописан для дисгейзии у больных раком, проходящих лечение. Однако чрезмерное потребление цинка может привести к дефициту меди, который, скорее всего, недооценивается и может представлять собой усталость, тошноту, анемию и миэлопатию. КИСЛОТА: Пациент в 70-летнем возрасте с несколькими миэломой и гастропарезом, принимающий добавки цинка для лечения дисгейсии в прошлом. 2 Годы, порожденные общей усталостью, головокружением, тошнотой, нейтрализмом, анемией, походом, а также ухудшением онемения и покалыванием в нижних кон

Совпадение в аннотации оригинала
BACKGROUND: Zinc is a micronutrient essential for taste perception and may be prescribed for dysgeusia in cancer patients undergoing treatment. However, overconsumption of zinc can lead to copper deficiency, which is likely under-recognized and can present as fatigue, nausea, anemia, and myelopathy. CASE PRESENTATION: A patient in his 70s with multiple myel…

GTP hydrolysis-powered zinc metallochaperones as molecular switches.

Late d-block first row transition metals from manganese to copper and zinc are present in all cells at high abundance and typically cofactor approximately one-third of the proteome. The integrity of this metalloproteome must be functionally resilient to changes in metal bioavailability induced by metal toxicity and metal scarcity, such that cellular processes dependent on these metalloenzymes are maintained. An emerging hypothesis is that the cellular response to zinc scarcity involves the expression of one or more GTP hydrolysis-dependent zinc metallochaperones, which are proposed to allocate…

Lattice Engineering Novel 2D Monolayer in Zinc Pnictides.

In this work, the structural, electronic, and thermodynamic stabilities in the novel two-dimensional monolayer (2D-ML) structure of IIB-VA zinc pnictides, ZnX (X = As, Sb, Bi), have been systematically investigated via lattice engineering. We utilize the geometries of 3D bulk structures of ZnX in orthorhombic symmetry with space group Pbca(No.61) as parental material to model three different 2D monolayers of ZnX, denoted as 2D-(L1, L2, and L3). Their total relative energies and stabilities have been investigated and compared with the 2D monolayer geometries of tetragonal, hexagonal (planar hon…

Lighting up zinc: switchable probes for biological imaging.

Individual condensation of salicylaldehyde and a variety of different pyridines (equimolar concentration) in polar solution results in a yellowish-orange precipitate (imine-derived product). The study shows that these small-molecule compounds possess turn off and on fluorescence properties upon chelation with Zn2+ ions. When reacted with other metal ions, there was no significant increase in the fluorescence intensity of the probes. However, there was multi-fold increase in fluorescence intensity when the probes reacted with Zn2+ ions. The probes can be employed as zinc-specific sensors in mul…

Anemia Due to Unexpected Zinc-Induced Copper Deficiency.

Anemia due to acquired copper deficiency is most commonly the result of malabsorption or dietary deficiency. However, it can occasionally be due to excess zinc intake, which impairs the absorption of copper. Copper deficiency may result in vacuolated erythroid and myeloid precursors in the bone marrow, and sometimes features resembling myelodysplasia that, although not specific, may be an important clue to the diagnosis. Background and Clinical Significance: We report bone marrow findings in a child with anemia due to zinc-induced copper deficiency. Case Presentation: An 18-year-old female wit…

Rash decisions: diagnosing zinc deficiency in unexplained dermatitis .

Zinc is an essential micronutrient for the body and plays a crucial role in skin integrity, yet zinc deficiency remains an under-recognised cause of dermatitis, particularly in patients with predisposing risk factors. A male in his mid-30s with alcohol-related liver disease and ulcerative colitis presented with a widespread rash. Initial treatment for contact dermatitis and possible herpes simplex virus infection with topical steroids, antivirals and emollients was unsuccessful. His condition worsened, requiring intensive care admission. Imaging revealed bilateral pneumonia, and a skin biopsy …

Unveiling childhood asthma: Exploring biomarkers, zinc, and beyond.

This editorial discusses a case-control study by Ibrahim et al, published in the recent issue of the World Journal of Clinical Pediatrics. C … esponse in asthma, the supplementation of anti-oxidants can be one strategy to manage this disease. Zinc is one such antioxidant that has attracted much attention about asthma and airway inflammation. Zinc is a crucial trace element for human metabolism that helps to regulate gene expression, enzyme activity, and protein structure. Apart from zinc, fre …

Torsional flexibility in zinc-benzenedicarboxylate metal-organic frameworks.

We explore the role and nature of torsional flexibility of carboxylate-benzene links in the structural chemistry of metal-organic frameworks (MOFs) based on Zn and benzenedicarboxlyate (bdc) linkers. A particular motivation is to understand the extent to which such flexibility is important in stabilising the unusual topologically aperiodic phase known as TRUMOF-1. We compare the torsion angle distributions of TRUMOF-1 models with those for crystalline Zn/1,3-bdc MOFs, including a number of new materials whose structures we report here. We find that both periodic and aperiodic Zn/1,3-bdc MOFs s

Cinnamoyl Dipyrromethenes as Fluorescence Zinc(II) Ion Sensor.

Friedel-Crafts acylation of dipyrromethane with cinnamoyl chloride was conducted to obtain dicinnamoyl dipyrromethane compounds 3 and 4. Both compounds were subsequently oxidized by DDQ to produce dicinnamoyl dipyrromethene ligands (DC-1 and DC-2). A large bathochromic shift compared to dipyromethene (D) was observed at 95 nm for DC-1 and 67 nm for DC-2. Both compounds showed remarkable chelation-enhanced fluorescence (CHEF) upon addition of zinc(II) ions. Similar to the quadrupolar system, DC-1 exhibited absorption and emission near the optical windows of the tissue. However, asymmetrical DC-…

Zinc/Cerium-Substituted Magnetite Nanoparticles for Biomedical Applications.

Numerous studies have reported the possibility of enhancing the properties of materials by incorporating foreign elements within their crystal lattice. In this context, while magnetite has widely known properties that have been used for various biomedical applications, the introduction of other metals within its structure could prospectively enhance its effectiveness. Specifically, zinc and cerium have demonstrated their biomedical potential through significant antioxidant, anticancer, and antimicrobial features. Therefore, the aim of the present study was to develop a series of zinc and/or ce…

C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies.

In humans, specific aberrations in β-globin results in sickle cell disease and β-thalassemia, symptoms of which can be ameliorated by increased expression of fetal globin (HbF). Two recent CRISPR-Cas9 screens, centered on ∼1500 annotated sequence-specific DNA binding proteins and performed in a human erythroid cell line that expresses adult hemoglobin, uncovered four groups of candidate regulators of HbF gene expression. They are (1) members of the nucleosome remodeling and deacetylase (NuRD) complex proteins that are already known for HbF control; (2) seven C2H2 zinc finger (ZF) proteins, inc…