Результаты поиска

Biomedical functionalities and teratogenic risks of bioengineered ZnO nanoparticles in post-fertilization zebrafish (Danio rerio) embryos.

Zinc oxide nanoparticles (ZnO NPs) are widely utilized in several commercial applications. Although their toxicity and associated oxidative stress have been extensively studied, the toxicity they induce during embryonic development remains largely unknown. In this study, ZnO NPs were fabricated via a green synthesis approach using the leaf extract of Aegle marmelos (Am@ZnO NPs), and their developmental toxicity toward post-fertilized zebrafish embryos was investigated. The synthesized Am@ZnO NPs exhibited a UV-Vis absorbance peak at 372 nm. X-ray diffraction (XRD) analysis confirmed the presen…

Unveiling the carbohydrates profile of anti-diabetic medicinal plants by a developed and validated high-performance liquid chromatography coupled with refractive index detector (HPLC-RID).

Naturally occurring carbohydrates play a crucial role in the food nutritional and medicinal properties of plants. However, measuring these s … officinalis (EO) (fruit), Azadirachta indica A. (AI) (leaves), Alstonia scholaris (L.) (AS) (bark), Aegle marmelos (L.) (AM) (bark), Aloe barbadensis Mill. (ALV) (leaves pulp). We developed a method based on an ACE Excel 5 NH2 column using an acetonitrile-water (85:15, v/v) mobile phase at a flow rate of 1.0 mL/min and a detection temperature of 35 °C. …

Inhibitory activity of traditional plants against Mycobacterium smegmatis and their action on Filamenting temperature sensitive mutant Z (FtsZ)-A cell division protein.

The study was designed to assess whether plant extracts / phytochemical (D-Pinitol) synergistically combine with antituberculosis drugs and … ntitative Polymerase Chain Reaction (qPCR). The Hexane-methanolic plant extract of Acacia nilotica, Aegle marmelos and Glycyrrhiza glabra showed antimycobacterial activity at 1.56 ± 0.03, 1.32 ± 0.02 and 1.25 ± 0.03 mg/mL respectively and that of INH and RIF were 4.00 ± 0.06 μg/mL and 2.00 ± 0.04 μg/mL respectively. These plant extracts and major phytoc …

Common garlic (Allium sativum L.) has potent Anti-Bacillus anthracis activity.

ETHNOPHARMACOLOGICAL RELEVANCE: Gastrointestinal anthrax, a disease caused by Bacillus anthracis, remains an important but relatively neglected endemic disease of animals and humans in remote areas of the Indian subcontinent and some parts of Africa. Its initial symptoms include diarrhea and stomachache. In the current study, several common plants indicated for diarrhea, dysentery, stomachache or as stomachic as per traditional knowledge in the Indian subcontinent, i.e., Aegle marmelos (L.) Correa (Bael), Allium cepa L. (Onion), Allium sativum L. (Garlic), Azadirachta indica A. Juss. (Neem), B…

Open-set combustion-fingerprint classification with out-of-distribution alerting for environmental fire-hazard screening.

Fire effluent gases - carbon monoxide (CO), hydrogen cyanide (HCN), hydrogen chloride (HCl), and nitrogen oxides (NOx) - are hazardous environmental contaminants released during structural and emerging fire incidents; rapid identification is critical for environmental hazard assessment and respiratory protection. The present framework does not measure these species directly; it classifies fire-material class and flags novel scenarios from bulk combustion-fingerprint features (CO, CO2, smoke extinction, and heat release rate), and is therefore a combustion-fingerprint screening tool rather than

β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties.

Natural bicyclic sesquiterpenes, β-caryophyllene (BCP) and β-caryophyllene oxide (BCPO), are present in a large number of plants worldwide. Both BCP and BCPO (BCP(O)) possess significant anticancer activities, affecting growth and proliferation of numerous cancer cells. Nevertheless, their antineoplastic effects have hardly been investigated in vivo. In addition, both compounds potentiate the classical drug efficacy by augmenting their concentrations inside the cells. The mechanisms underlying the anticancer activities of these sesquiterpenes are poorly described. BCP is a phytocannabinoid wit

Совпадение в полном тексте источника
… Sain et al. 46 evaluated an influence of BCP and BCPO fractions from Aegle marmelos extract on IMR‐32 human neuroblastoma and Jurkat cell lines. They found that treatment of the cells with these chemical fractions led to induction of p53‐dependent apoptosis. … Arrigo , et al. 2014 Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti‐inflammatory agents against lymphoma and neuroblastoma cells . AntiInflamm. AntiAllergy Agents Med. …

Editorial: Cancer therapy: The challenge of handling a double-edged sword.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Tayarani-Najaran et al. in their comprehensive review described recent studies on the anticancer effects of Auraptene, a bioactive monoterpene coumarin isolated from Citrus aurantium and Aegle marmelos that belong to the Rutaceae family. …

Antioxidant effects of Spirulina platensis (Arthrospira platensis) on cyclophosphamide-induced testicular injury in rats.

Cyclophosphamide (CP) is known to reduce fertility. The protective effects of Spirulina plantesis (SP) against CP-induced testicular toxicity were investigated. Male Wistar rats were categorized into eight groups (n = 7). Four groups of rats were administered CP at a dose of 5 mg in 5 mL distilled water kg-1 per day orally. Two of these groups were received SP (500 and 1000 mg kg-1 per day) orally after CP administration. One of these groups was also received vitamin E (100 mg kg-1 per day) intraperitoneally. A vehicle treated control group, two SP control groups (500 and 1000 mg kg-1 per day)

Совпадение в полном тексте источника
… stress. 11 Several studies have shown the beneficial effects of antioxidants on CP induced damages. 12 , 13 Accordingly, in a review study, Afkhami-Ardakani et al . have indicated that more than 20 types of plant compounds and antioxidants such as Nigella sativa , Camellia sinensis , American ginseng, Aegle …

Applications of Curcumin and Its Nanoforms in the Treatment of Cancer.

Due to the diverse medicinal and pharmacokinetic properties of turmeric, it is well-known in the therapeutic, pharmaceutic, nutraceutical, cosmetic, and dietary industries. It gained importance due to its multitude of properties, such as wound-healing, anti-inflammatory, anti-oxidant, anti-microbial, cytoprotective, anti-aging, anti-cancer, and immunomodulatory effects. Even though the natural healing effect of turmeric has been known to Indians as early as 2500 BCE, the global demand for turmeric has increased only recently. A major reason for the beneficiary activities of turmeric is the pre

Совпадение в полном тексте источника
… For example, Aegle marmelos , commonly known as Bael, is found abundantly in the Indian Subcontinent. It is known to have digestive, anti-inflammatory, anti-ulcerative, wound-healing, and anti-dote properties [ 14 ]. … Aegle marmelos: A review on its medicinal properties Int. J. Pharm. Phytopharm. Res. 2012 1 332 341 15. Akaberi M. Sahebkar A. Emami S.A. …

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence.

Chemoprevention is referred to as a strategy to inhibit, suppress, or reverse tumor development and progression in healthy people along with high-risk subjects and oncologic patients through using pharmacological or natural substances. Numerous phytochemicals have been widely described in the literature to possess chemopreventive properties, although their clinical usefulness remains to be defined. Among them, caryophyllane sesquiterpenes are natural compounds widely occurring in nature kingdoms, especially in plants, fungi, and marine environments. Several structures, characterized by a commo

Совпадение в полном тексте источника
… The authors hypothesized that an inhibition of 15-LOX can be involved in the pro-apoptotic effects highlighted for β-caryophyllene and β-caryophyllene oxide-enriched fractions of Aegle marmelos extract in lymphoma and neuroblastoma cells, and suggest better characterizing the possible role of these compounds …

The journey of boswellic acids from synthesis to pharmacological activities.

There has been a lot of interest in using naturally occurring substances to treat a wide variety of chronic disorders in recent years. From the gum resin of Boswellia serrata and Boswellia carteri, the pentacyclic triterpene molecules known as boswellic acid (BA) are extracted. We aimed to provide a detailed overview of the origins, chemistry, synthetic derivatives, pharmacokinetic, and biological activity of numerous Boswellia species and their derivatives. The literature searched for reports of B. serrata and isolated BAs having anti-cancer, anti-microbial, anti-inflammatory, anti-arthritic,

Совпадение в полном тексте источника
… The most recent double-blind RCT investigated the effect of B. serrata gum resin extract (30% β-AKBA) in asthmatic patients, yet, in combination with Aegle marmelos fruit extract in a 1:1 ratio; a formula known as AlvioLife® or LI13109F (Yugandhar et al. 2018 ). …

Molecular Diversity of Lupane Hybrids in Drug Design and Materials Science.

The need for new, more effective drugs to treat cancer, infectious diseases, various parasitic infestations, and metabolic disorders requires innovative approaches to the design of promising molecules. One of these areas is the creation of hybrid structures. Lupane triterpenoids are of significant interest for such research due to their high abundance in natural sources and their renewable nature, their molecular architecture, presence of several easily modifiable functional groups, enantiomeric purity, broad spectrum of biological activity, and low toxicity. Active research into the biologica

Совпадение в полном тексте источника
… BE, BA, and lupeol are present in medicinal plants with reported anti-diabetic properties such as Aegle marmelos and Bacopa monnieri . Research involving both in vivo and in vitro models has investigated the anti-diabetic effects of lupanoids. …

Гибридные композитные соединения с оксидами металлов: всеобъемлющий обзор синтеза и многофункциональных видов применения.

В ряде передовых технологий может использоваться разнообразное семейство композитных полимерных (CP) составов с особыми физико-химическими свойствами (MO x). В настоящем исследовании представлен всеобъемлющий обзор комплексных подходов к этим гибридным композитным материалам с уделением особого внимания синергической интеграции оксидов металлов с ХП в целях укрепления их структурной основы, а также их электрических и каталитических свойств. Изучается многофункциональное применение этих материалов, в частности в таких областях, как биомедицинское зондирование, энергосберегающие модули и техноло

Эпигенетика и метаболическая метаболическая дисфункция при многоразовом склерозе: обзор подходов к травяным лекарствам и текущих клинических испытаний.

Множественный склероз (MS) — сложная аутоиммунная болезнь, характеризующаяся воспалением, обезвоживанием и нейродегенерацией в центральной нервной системе (КНС). Хотя точные причины остаются неясными, недавние исследования подчеркивают важную роль эпигенетических изменений и митохондриальной дисфункции в начале и развитии болезни. Эпигенетические изменения, такие, как метилация ДНК, модификация гистона и регулирование микроРНК, влияют на генное выражение, не изменяя последовательности ДНК, что приводит к иммунной дисрегуляции и воспалению. Аналогичным образом, митохондриальная дисфункция, отме

ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.